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Imiphumela emibi ye-Furosemide nokuthi ungayibalekela kanjani

I-Drug Info Furosemide iyi-diuretic elapha i-edema ne-hypertension kepha ingaveza imiphumela emibi. Bheka uhlu lwethu lwemiphumela emibi ejwayelekile futhi emibi.

I-Furosemide (igama lomkhiqizo: I-Lasix ) i-diuretic kadokotela ojwayelekile ophatha i-edema (ukugcinwa koketshezi) ngenxa yokwehluleka kwenhliziyo okucinana, ukuqina kwesibindi, noma isifo sezinso. UFurosemide ubuye alaphe umfutho wegazi ophakeme (umfutho wegazi ophakeme) kanye ne-pulmonary edema (uketshezi emaphashini).

IFurosemide inyusa inani lamanzi nosawoti okukhishwe emchameni, kunciphisa uketshezi lwezicubu zomzimba kanye nasegazini. Njenge-loop diuretic, i-furosemide isebenza endaweni eyodwa yokwakheka ezinso, ikwenza kuphumelele kubantu abanokukhubazeka kwezinso.

Njengawo wonke ama-diuretics, i-furosemide ingaveza imiphumela emibi, ihlanganyele nezinye izidakamizwa, futhi yenze izimo zezempilo zibe zimbi kakhulu.

OKUSHIWO: Funda kabanzi nge-furosemide

Imiphumela emibi ejwayelekile ye-furosemide

I-Furosemide ineminye imiphumela emibi engathinta uhlelo olulodwa noma eziningi emzimbeni.Twesikhashana esivame kakhulu okuqhamuka uma udla imishanguzo faka:

Ukwanda kokuchama
Amazinga aphansi e-electrolyte (amazinga aphansi e-sodium, magnesium, calcium, noma i-potassium)
Isiyezi
Isicanucanu
Ukuhlanza
Uhudo
Amajaqamba esiswini
Ukuphelelwa isifiso sokudla
Yehla ngokungazelelwe umfutho wegazi lapho usukuma (i-orthostatic hypotension)
Amajaqamba emisipha
Ubuthakathaka
Ubudikadika
Kukhala ezindlebeni
Ubuhlungu bekhanda
Ukubona okufiphele
Izinga eliphakeme likashukela egazini (i-hyperglycemia)
I-cholesterol ephakeme kanye namafutha (triglycerides) egazini
I-uric acid eyeqile (hyperuricemia)
Ukwenyuka kwama-enzyme wesibindi
Ubuhlungu besiza sokujova (lapho unikezwa umjovo we-furosemide)
Ukuqhuma noma ukuluma
Ukuzwela ekukhanyeni (photosensitivity)

Imiphumela emibi ye-furosemide

IFurosemide inemiphumela emibi ethile ebucayi futhi engaba yingozi. Lokhu kufaka phakathi:

Ukuphela kwamanzi emzimbeni
Ukwehla okukhulu kwe-electrolyte
Ivolumu yegazi ephansi (hypovolemia)
Igazi eliphakeme le-pH (i-metabolic alkalosis)
Ukulimala kwendlebe (ototoxicity) nokulahlekelwa ukuzwa
Ukwehla noma ukulahleka kobuchopho ngenxa yokungasebenzi kwesibindi (i-hepatic encephalopathy) kubantu abanesifo sesibindi
Ukuvuvukala kwamanyikwe ( isifo sokuqaqamba kwamalunga )
I-jaundice
Ukuphazamiseka kwegazi kufaka i-anemia, i-aplastic anemia, i-hemolytic anemia, i-agranulocytosis, i-eosinophilia, i-thrombocytopenia, ne-leukopenia
Ukusabela okweqile okufana ne-anaphylaxis, ukusabela okunzima kwesikhumba, kanye nemithambo yegazi evuvukile (systemic vasculitis)

Ihlala isikhathi esingakanani imiphumela emibi ye-furosemide?

Imiphumela eminingi emibi ye-furosemide, njengokunyuka kokuchama noma izinkinga zohlelo lokugaya ukudla, iba ngcono njengoba umuthi uphela, amahora ayisithupha kuya kwayisishiyagalombili . Ezinye izinkinga ezinjengokuphelelwa amanzi emzimbeni, ukungalingani kwe-electrolyte, i-hyperglycemia, i-cholesterol ephakeme, kanye nokusabela okuncane kokungezwani komzimba kuthatha isikhathi eside ukuxazulula futhi kungadinga ukwelashwa.

Eminye imiphumela emibi efana ne-pancreatitis noma ukuphazamiseka kwegazi kungadinga ukwelashwa esibhedlela. Ukulahleka kokuzwa kanye ne-tinnitus kungaguqulwa lapho i-furosemide inqanyuliwe, kepha ingahle ibe yizimo ezihlala njalo kwabanye abantu. I-hepatic encephalopathy ingumphumela oyingozi osongela impilo odinga ukulaliswa esibhedlela futhi uphikelela ngokwesilinganiso se- Amahora angu-48 . I-hepatic encephalopathy yi kuyabuyiselwa emuva isimo, kepha izinga lokusinda liphansi.

Ukuphikisana nezixwayiso ze-Furosemide

IFurosemide ingahle ingalungeli wonke umuntu. Ukusetshenziswa kabi, ukweqisa izidakamizwa, kanye nezinguquko ezimweni zezokwelapha ezikhona konke kuyizici zokunquma ukuphepha kwalomuthi.

Ukuhlukumeza nokuncika

IFurosemide ayibangeli ukuxhomeka ngokomzimba noma ngokwengqondo. I-Furosemide, noma kunjalo, ingadala izimpawu zokuhoxa okwesikhashana lapho iyekiwe. UFurosemide ushintsha indlela yomzimba yokulawula ukuchama (i-diuresis), ebizwa nge-renin-angiotensin-aldosterone system, noma i-RAAS. Lapho i-furosemide ithathwa isikhathi eside futhi imisiwe ngokungazelelwe, umzimba weqa ngokweqile ngokugcina amanzi nosawoti omningi, okwenza uketshezi lwakhiwe noma umfutho wegazi ophakeme . Imiphumela iyaphela ezinsukwini ezimbalwa, kepha abantu abanesifo esibi senhliziyo bangadinga ukuqashwa ngalesi sikhathi.

Ukweqisa ngokweqile

Ukweqisa ngokweqile kwe-furosemide kuzodala i-diuresis esheshayo (ukuqedwa kwamanzi) okuholele ekuqedeni ukoma emzimbeni nasekunciphiseni kwe-electrolyte. Izimpawu zifaka ukoma okukhulu, ukuzwa ukushisa, ubuthakathaka, ukujuluka, noma ukuquleka. Ukweqisa ngokweqile kuphakamisa nengozi yokulahlekelwa ukuzwa. Uma kusolwa ukweqisa okweqile, iya ngokushesha ekamelweni labezimo eziphuthumayo.

Imikhawulo

IFurosemide igunyazwe yi-FDA ukuthi isetshenziswe kubantu abahlukahlukene, kusuka ezinganeni ezisanda kuzalwa kuya kubantu asebekhulile. Ngenxa yamandla okuphelelwa amanzi emzimbeni nokuncipha kwe-electrolyte, wonke umuntu othatha i-furosemide uzobhekwa ngevolumu le-fluid namazinga we-electrolyte. Umhlinzeki wezokunakekelwa kwempilo uzofundisa iziguli izimpawu zokuphelelwa amandla kwamanzi noma ukuncipha kwe-electrolyte. Izithako ze-potassium zinganconywa ukuvimbela i-potassium yegazi ephansi (i-hypokalemia).

IFurosemide ayikaze inikezwe abantu:

Izinso zikabani ezingakhiqizi umchamo (anuria)
Obani ababa nomthelela omubi wokungezwani komzimba nomuthi

IFurosemide isetshenziswa ngokuqapha kumaqembu athile eminyaka noma izimo zezokwelapha:

Izinsana ezisanda kuzalwa kungadinga ukuqashwa ngenxa yengozi ye- amatshe ezinso (nephrolithiasis) noma i-calcium deposits ezinso (nephrocalcinosis).
Abantu abadala kuneminyaka engama-65 ingaqalwa ngomthamo ophansi kakhulu futhi ibhekwe njalo.
Abantu abanomlando we-arrhythmias yenhliziyo kufanele babhekwe.
Abantu abane Izinkinga zezinso (ukukhubazeka kwezinso) noma izinkinga zesibindi inganikezwa imithamo emincane futhi ibhekwe njalo.
Abantu abane izinkinga zokugcina umchamo angabona izimpawu zazo ziba zimbi ngenxa yokwanda kwevolumu yomchamo esinyeni.
I-Furosemide ingahle ingasebenzi kahle futhi ibe namathuba amaningi okudala ukulahleka kokuzwa kubantu abane isifo se-nephrotic .
Abantu abane isifo sikashukela uzoxwayiswa ngokwanda okungenzeka kushukela wegazi. Bangacelwa ukuthi baqaphe amazinga kashukela egazini njalo.
Abantu abane ukuvuvukala bangabona izimpawu zabo ziba zimbi. Amazinga e-uric acid egazini angadinga ukubhekwa.
I-Furosemide ingasebenza noma ibe yimbi lupus .

IFurosemide ayitholakalanga njengokuphephile ukuyithatha ngenkathi ukhulelwe noma uncelisa. Odokotela bayelulekwa ukuthi baqaphe ngokucophelela ukukhula kombungu kwabesifazane abathatha i-furosemide. Ukuqapha kuzodingeka futhi lapho uthatha i-furosemide ngenkathi unesi. I-Furosemide yomibili idlula obisini lwebele futhi inciphisa ukuncelisa. Kuzo zonke izimo, udokotela uzobeka ngokucophelela izingozi nezinzuzo zokuthatha i-furosemide ngenkathi ukhulelwe noma unesi.

Ukusebenzisana kwe-Furosemide

Eminye imishanguzo kadokotela kanye ne-over-the-counter (OTC) inokuxhumana okuphawulekayo ne-furosemide. Udokotela, usokhemisi, noma umhlinzeki wezokunakekelwa kwempilo uzokwazi kahle lokhu kuhlangana kwezidakamizwa futhi akwazi ukulungiselela abantu ukuhlangana okungenzeka kube khona kwezidakamizwa.

Ngenxa yokuhlangana kwezidakamizwa, i-furosemide ayikaze isetshenziswe nayo umabhebhana noma IMarplan (isocarboxazid). Ukuhlanganisa i-furosemide ne-desmopressin kungadala amazinga aphansi e-sodium, kuyilapho i-isocarboxazid ne-furosemide kungahle kube nomfutho wegazi ophansi oyingozi.

Okunye ukuxhumana kwezidakamizwa kuzodinga ukuqapha nokuqapha ngokucophelela. Le mithi ihlanganisa:

Ama-laxatives, ama-corticosteroids, ama-proton-pump inhibitors, nama-bronchodilators (ama-beta-2 agonists): Ukuhlanganisa i-furosemide nanoma iyiphi yale mithi kuzophakamisa ingozi yokwehla komzimba nokungalingani kwe-electrolyte.
Ama-antibiotic e-Aminoglycoside: Ukuhlanganisa i-furosemide nezinye izidakamizwa ze-ototoxic kwandisa ingozi yokulimala kwezindlebe nokulahleka kokuzwa.
Ama-NSAID (izidakamizwa ezingezona ukuvuvukala) kanye nama-salicylates
Izidakamizwa zomdlavuza ezisekelwe ePlatinamu: Ukuhlanganisa i-furosemide nezidakamizwa ezifana umabhebhana noma I-carboplatin kwandisa amathuba okuba leyo mithi ilimaze izinso, umnkantsha, noma izindlebe.
Izidakamizwa zengcindezi yegazi: Ukuhlanganisa i-furosemide nezinye izidakamizwa ezehlisa umfutho wegazi kungadala umfutho wegazi oyingozi (hypotension).
Ama-antipsychotic, sedatives, barbiturates, opioid, kanye nemithi yokungasebenzi kwe-erectile: Ukuhlanganisa le mithi ne-furosemide kwandisa ubungozi be-hypotension, ngakho-ke abantu abanengcindezi yegazi ephansi kungadingeka ukuthi bahlolwe njalo noma imithamo iguqulwe.

Ungayigwema kanjani imiphumela emibi ye-furosemide

I-Furosemide ivame ukunikezwa ngemithambo yegazi ezibhedlela, kepha iningi labantu lizothatha umuthi njengethebhulethi noma isisombululo somlomo kanye noma ngaphezulu ngosuku. Akukho mkhawulo kubude besikhathi i-furosemide engathathwa, kepha abantu abathatha i-furosemide njalo kufanele balandele amathiphu ambalwa okusiza ukuphatha imiphumela emibi.

1. Tshela udokotela ngazo zonke izimo zokwelashwa nemithi

Ngaphambi kokuba kubekwe i-furosemide, tshela udokotela obeka noma uchwepheshe wezokunakekelwa kwempilo mayelana:

Zonke izimo zezokwelapha zamanje, ikakhulukazi isifo sezinso, isifo sesibindi, izinkinga zokuchama (njenge-prostate enwetshiwe noma ukuvinjelwa kwesinye), i-gout, i-lupus, isifo sikashukela, ukungalingani kwe-electrolyte, i-arrhythmias yenhliziyo, umfutho wegazi ophansi, noma ukungezwani komzimba ne-sulfonamides (izidakamizwa ze-sulfa)
Ukukhulelwa, ukuncelisa, noma yiziphi izinhlelo zokukhulelwa
Noma yikuphi ukuhlolwa kwegazi kweglucose okuzayo
Noma yikuphi ukuskena kwezokwelapha okuzayo okuzofaka odayi bokuqhathanisa abanemisebe ye-radioactive
Noma yikuphi ukuhlinzwa okuzayo
Yonke imithi ye-OTC nemithi kadokotela, izithasiselo, namakhambi ayathathwa, ikakhulukazi i-desmopressin noma iMarplan (isocarboxazid)

2. Thatha i-furosemide njengoba kuqondisiwe

Landela yonke imikhombandlela kwilebula kadokotela noma enikezwe uchwepheshe wezokunakekelwa kwempilo. Ungathathi okungaphezulu noma okuncane kunalokho obekiwe kuze kube yilapho ubonisene nodokotela noma nochwepheshe bezokunakekelwa kwempilo.

3. Gwema ukuphelelwa amanzi emzimbeni noma ukwehlisa ama-electrolyte

IFurosemide ingadala uketshezi nama-electrolyte emzimbeni ukwehla kakhulu. Ukwehla kwamanzi emzimbeni ngokweqile kungadala ukulimala kwezinso nokuwa kwegazi emzimbeni. Ukuncipha kwe-Electrolyte kungakhuphuka kube yizinkinga ezinkulu kubandakanya i-coma, ukuquleka nokuhlaselwa yinhliziyo. Buza uchwepheshe wezokunakekelwa kwempilo ukuthi ungakanani futhi ungaluhlobo luni lwamanzi angathathwa ngemuva komthamo we-furosemide. I-Potassium noma ezinye izithako zingadingeka.

Lapho uthatha i-furosemide, bheka izimpawu zokoma emzimbeni ezifana nomlomo owomile, amehlo omile, amajaqamba, ubuhlungu bemisipha, ukozela, ukukhathala nobuthakathaka. Ungakwazi ukuphuza iziphuzo ukuxazulula inkinga, kodwa uma uketshezi lukhawulelwe, shayela uchwepheshe wezokunakekelwa kwezempilo ukuze uthole iseluleko sezokwelapha.

4. Monitor imiphumela

Abanye abantu bangacelwa ukuthi baqaphe izimo zabo zokwelashwa ezifana nengcindezi yegazi noma amazinga eglucose egazi. Hlola lawa magugu ngokwethembeka bese uwaqopha kwidayari yemithi. Uma amanani angajwayelekile, shayela udokotela noma omunye umhlinzeki wezokunakekelwa kwezempilo ukuze uthole usizo.

5. Gwema ama-NSAID nama-laxatives

Ukudambisa izinhlungu okudumile okufana ne-aspirin ne-ibuprofen kunganciphisa ukusebenza kwe-furosemide futhi kwandise ubungozi ezinso noma ekuzweni. Okufanayo kuyasebenza ku- i-bismuth subsalicylate , isithako esisebenzayo ku UPepto-Bismol . Ihlobene ne-aspirin futhi izodala izinkinga ezifanayo lapho ihlanganiswa ne-furosemide.

Ama-laxatives akhulisa ukulahleka kwamanzi, ngakho-ke andisa amathuba okuphelelwa amanzi emzimbeni, ukuncipha kwe-electrolyte, nokulimala kwezinso lapho uthatha i-furosemide. Khuluma nodokotela noma omunye uchwepheshe wezokunakekelwa kwezempilo ngaphambi kokuthatha noma iyiphi yalezi zidakamizwa ze-OTC ngenkathi uthatha i-furosemide.

6. Sukuma kancane

Uma ukusukuma kubanga isiyezi, zama ukusukuma kancane. Isiyezi singadinga ukuhlala phansi isikhathi esithile. Lala phansi uma isiyezi siba sibi kakhulu.