Imiphumela emibi ye-Risperdal nokuthi ungayibalekela kanjani

Ukukhathazeka Ngolwazi Lwezidakamizwa, isiyezi, nokuqaqanjelwa yikhanda yimiphumela emibi ejwayelekile yeRisperdal, evamise ukuba yesikhashana. Kodwa-ke, imiphumela ethile emibi efana nezinkinga ezihlobene nemisipha ihlala unomphela.

Imiphumela emibi yeRisperdal | Ukuzuza kwesisindo | Ukucindezeleka | Gynecomastia | Ukuhoxa | Kwenze isikhathi esingakananiokuqhamuka uma udla imishanguzookokugcina? | Ukusebenzisana | Ungakugwema kanjaniokuqhamuka uma udla imishanguzo

I-RisperdalkuyintoI gama le-brandimithi kadokotela ekhiqizwa yiJanssen Pharmaceuticals. Ingasetshenziselwa ukwelapha ukuphazamiseka kwemizwelo njengeschizophrenia,ukuphazamiseka kwengqondo okuguquguqukayo, noma ukucasuka okuhlobene ne-ukuphazamiseka kwe-autistic.I-Risperdaliyatholakala njengenguqulo ejwayelekile, ebizwaI-Risperidone. Lo mbhalo uhlanganisaImiphumela emibi yeRisperdal, izexwayiso, nokusebenzisana.

OKUSHIWO: Funda kabanzi mayelana I-Risperdal

Imiphumela emibi ejwayelekileyeI-Risperdal

Imiphumela emibi ejwayelekileyeI-Risperdalfaka i- okulandelayoimiphumela emibi :

• Ukozela
• Ukukhathazeka
• Isiyezi
• Ubuhlungu bekhanda
• Ukwanda kwesifiso
• Ukozela
• Ukukhathala
• Ukuqwasha
• I-Rhinitis
• Ukutheleleka okuphezulu okuphefumula
• Khwehlela
• Ukungakwazi ukubamba umchamo
• Ukweqa amathe ngokweqile
• Ukuqunjelwa
• Imfiva
• I-Dystonia
• Ubuhlungu besisu
• Isicanucanu
• Ukukhubazeka komthetho wokushisa komzimba
• Ukuhlanza
• I-Rash
• I-Akathisia
• I-Dyspepsia
• I-Tachycardia
• Xerostomia
• Ukuthuthumela
• Ukuzuza kwesisindo
• Hyperprolactinemia
• Ukudideka
• Gynecomastia
• Ukuzwela kwe-photosensitivity
• I-Epistaxis
• Ukuphazamiseka okubonakalayo
• I-dyslipidemia
• Ubuhlungu besifuba

Imiphumela emibi kakhuluyeI-Risperdal

Imiphumela emibi kakhuluyeI-Risperdalfaka okulandelayo:

• Isifo i-Stevens-Johnson
• I-Hypothermia
• Umfutho wegazi ophezulu
• I-Hypotension, ezinzima
• I-Syncope
• Isifo esibuhlungu se-Neuroleptic
• I-Hyperglycemia
• Isifo sikashukela se-Mellitus
• Ukuquleka
• Ukuhlasela Kwe-Ischemic Okudlulayo (TIA)
• I-Dysphagia, enzima
• Ukusabela kwe-Hypersensitivity
• Angioedema
• I-Anaphylaxis
• Izimpawu ze-Extrapyramidal, ezinzima
• I-dyskinesia yamuva
• I-Erythema multiforme
• I-necrolysis enobuthi enobuthi
• I-Leukopenia
• I-Neutropenia
• Ukubheka phambili
• Unhlangothi
• I-Agranulocytosis

Ukuzuza kwesisindo

Ucwaningo luphakamisa ukuthiI-Risperdalixhunywe ku-ukuzuza kwesisindo. Isifundo esisodwa okushicilelwe ngumkhiqizi kuqhathaniswaukuzuza kwesisindoeqenjini lokuhlola labantu abadala be-schizophrenic abathathayoI-Risperdalkuqhathaniswa neqembu le-placebo labantu abadala be-schizophrenic abangathathiI-Risperdal.

Imiphumela ikhombise ukwanda okuphawulekayo ngokwezibalo ezehlakalweni zeukuzuza kwesisindoeqenjini labantu abadala abathathayoI-Risperdal, ne-18% yalezo ziguli ezithola isisindo esikhulu. Uma kuqhathaniswa, yi-9% kuphela yabantu abadala eqenjini le-placebo abathole isisindo esikhulu. Kulolu cwaningo, kubalulekileukuzuza kwesisindoichazwe njengenzuzo engaphezu kuka-7% wesisindo somzimba womuntu esikhathini esiyiminyaka eyisithupha kuya kwayisishiyagalombili.

Ngenkathiukuzuza kwesisindokukodwa kungahle kungagunyazi ukunakwa ngokushesha, ukukhuluphala ngokweqile kwandisa ingozi yezifo ezahlukahlukene , kufaka phakathi isifo senhliziyo, isifo sikashukela, i-apnea yokulala, i-osteoarthritis, nomdlavuza. Abantu abathintekile kufanele babonisane ne-aochwepheshe bezempilomaqondana nezinketho zokuphathwa kwesisindo esinempilo.

Ukucindezeleka

Ngokusho kwe- INational Alliance iyaqhubekaUkugula Ngengqondo ,I-Risperidonekwesinye isikhathi kungahle kunqunywe ngaphandle kwelebula njengokwelashwa okuhambisanayo kwezifo zokudangala (isb., kunqunyelwe ngaphezu kwei-antidepressant). Ngaphandle kwelebula kusho ukuthi Ukuphathwa Kwezokudla Nezidakamizwa (I-FDA)ayikagunyazi umuthi wokwelashwa kwalesi simo esithile.

Ucwaningo olushicilelwe ku Ijenali ye-Clinical Psychiatry kuhlolweI-Risperidonenokuzibulala kubantu abanenkinga enkulu yokudangala, i-MDD. Ucwaningo lubheke ukusebenza ngempumelelo kwe-I-Risperidonenjengesengezoi-antidepressantukwelashwa kwabantu abane-MDD ngemicabango yokuzibulala. Imiphumela ikhombisa ukuthiI-RisperidoneKungaba wusizo ekwandiseni ukwelashwa kweziguli ze-MDD ezinombono wokuzibulala onobungozi obukhulu futhi kungasiza kakhulu ekuphatheni izimpawu zokucindezeleka ezinzima.

Ucwaningo olushicilelwe ku-PLOS ONE uphenye yonke imbangela yokufa kwengcuphe yokwengezwa kwe-antipsychotic yokudangala kwabantu abadala. Kuphethe ukuthi ukwengezwa ngama-antipsychotic amasha kuhlotshaniswa nengozi enkulu yokufa uma kuqhathaniswa nenye indlela yokwengeza umzuzwanai-antidepressant.

Yize isifundo sodwa singenakufakazela ukuthi siyimbangela, iziphetho zocwaningo zincoma abahlinzeki bezokunakekelwa kwezempilo ukuthi bazi leli thuba lokufa okubaluleke kakhulu okuhambisana nokwengezwa okusha kwe-psychotic.

Izimpawu zokucindezeleka, ikakhulukazi umbono wokuzibulala, ziyinkinga yezempilo enobungozi obukhulu. Abantu abathintekile kufanele babike ku-ochwepheshe bezempilongokushesha ngangokunokwenzeka.

Gynecomastia

Ucwaningo luphakamisa ukuthiI-Risperdalixhunywe ku-gynecomastia, igama lobuchwepheshe lokukhulisa amabele wesilisa.

Isifundo esisodwa enyatheliswa yiUkuphathwa Kwezokudla Nezidakamizwakusikisela ukuthiI-Risperdalukudla kungahle kuhlotshaniswe nobungozi obukhuphuke kancanegynecomastia. Isivivinyo somtholampilo sifunde intsha nezingane ezingama-1885.Gynecomastiakubikwe ku-2.3% walezo ziguli ezelashwa ngazoI-Risperdal.

Gynecomastiakungakhuphula kancane ubungozi bomuntu ukukhula kwamadodaumdlavuza webele (shintsha insiza?). Yize ingozi ekhuphukile incane, kuyalulekwa ukuthi uthintane ne-ochwepheshe bezempilouma kwenzeka kuba nezinkinga.

Ukuhoxa

Ucwaningo luphakamisa ukuthiI-Risperdalkungaba okwakha umkhuba. Izimpawu ezingaba khona zokuhoxa zifaka isiyezi, ukulala, isicanucanu, nokubuyisa izimpawu ze-schizophrenic.

TO isifundo sokuhoxa enyatheliswa yiumkhiqiziwahlola iziguli ezazikhombise impendulo enhleI-Risperdal(kuchazwe njengokuthuthuka okungenani okungama-25% ngokwesilinganiso esichaziwe) ngaphezu kwezinyanga ezine kuya kweziyisithupha. Iziguli zabelwa ngokungahleliwe endaweni ye-placebo naseqenjini lokuhlola ukuhlola ukuhoxa. Ukuhlaziywa kweziguli eziqede ucwaningo lokuhoxa kukhombise izinga eliphansi kakhulu lokubuyela emuva ku-I-Risperdaliziguli kuqhathaniswa neqembu le-placebo.

Ucwaningo lwamacala olushicilelwe ku- I-Psychopharmacology Bulletin ihlolisise isibonelo se-akathisia esibangelwe ngokuzumayoI-Risperidoneukuhoxa. Akathisia kuyintoukuphazamiseka kokuhambalokho phambilini bekuhlotshaniswa nokuhoxiswa kokwelapha i-antipsychotic.

Uma kunezimpawu zokuhoxa, abantu kufanele babonisane ne-ochwepheshe bezempilo. Iziguli zivuliweI-Risperdalkufanele abonane nodokotela wabo mayelana nokwenza noma yiziphi izinguquko kumthamo noma ekudleni.

Kwenze isikhathi esingakananiImiphumela emibi yeRisperdalokokugcina?

Ngokusho kweNational Alliance kuImpilo Yengqondo(njengoba kushiwo ngenhla), someImiphumela emibi yeRisperdalkungaba okwesikhashana, kanti ezinye zingahlala unomphela.

Imiphumela emibi ejwayelekilezivame ukuba zesikhashana. Okunye okunzima ngokwengeziweokuqhamuka uma udla imishanguzoingahlala isikhathi eside. Lokhu kufaka phakathiizimpawu ze-extrapyramidal,I-EPS, nomai-tardive dyskinesia, TD. Lezi yizinkinga ezihlobene nemisipha ezingadala ukuthuthumela, ukuqina, nokuphumula. UJanssen Pharmaceuticals, umkhiqizi we-I-Risperdal, kwembula ukuthi kwezinye izimo, leziokuqhamuka uma udla imishanguzoingahlala unomphela, ikakhulukazi ngokusetshenziswa komjovo I-RisperdalIqukethe .

I-Risperdalukuphikisana nezixwayiso

I-Risperdalayifanele wonke umuntu. Imithi iphikisiwe kwiziguli ezine-hypersensitivity kumuthi / ekilasini / entweni kanye / noma ku-hypersensitivity to paliperidone.

Ngaphezu kwalokho, Ukuqapha kuyanxuswa zeziguli ezihlangabezana nale mibandela elandelayo:

• Ukukhulelwa 3 trimester
• I-PKU (amafomu aqukethe i-phenylalanine)
• Iziguli esezikhulile
• I-psychosis ehlobene nokuwohloka komqondo
• Ukuwohloka komqondo w / imizimba ye-Lewy
• Isifo se-Parkinson
• Isifo esibuhlungu se-Neurolepticumlando
• Isifo sikashukela se-Mellitus
• Ingozi yesifo sikashukela
• Isifo se-cerebrovascular
• I-Hypotension
• I-Hypovolemia
• Ukushisa okuphezulu kwemvelo
• Ingozi yokuphefumula i-pneumonia
• Umlando we-leukopenia owenziwe izidakamizwa noma umlando we-neutropenia
• Leukopenia noma neutropenia
• Ukukhubazeka kwezinso
• Ukukhubazeka kwe-hepatic
• Umlando wokuthatha
• Ubungozi bokubamba
• Isifo senhliziyo

Iziguli ezindala ezine-psychosis ehlobene nokuwohloka komqondo eziphathwe ngama-antipsychotic, kufaka phakathi iRisperdal, zisengozini enkulu yokufa. Lo muthi, nganoma yiluphi uhlobo lwawo, awuvunyelwe ukuthi usetshenziswe ezigulini ezine-psychosis ehlobene nokuwohloka komqondo.

Ukweqisa ngokweqile kwe-I-Risperdalkungaba yingozi. Icala elilodwa yokweqisa ngokweqile kuka-36 mg othathwe ngomlomo kwakuhlotshaniswa nokuquleka, isigameko sezempilo esingaba yingozi.

I-Risperdalitholakala ngezindlela ezahlukahlukene zokulinganisa namandla. Amathebulethi ayatholakala ku-0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, naku-4 mg doses. Izixazululo zomlomo ziyatholakala ku-1 mg / mL dose. Ekugcineni, ngomlomoukuhlakazekaamaphilisi ayatholakala ku-0.5 mg, 1 mg, 2 mg, 3 mg, naku-4 mg doses.

Kukhona nezindlela zokujova ze-I-Risperdal.I-RisperdalUConsta noPerseris. Le mijovo esebenza isikhathi eside iqukethe i- umuthi ofanayo Njengefomu lethebulethi, kepha kunezinto ezahlukahlukene ezisetshenziswa yi-FDA ezivunyiwe kunokwakhiwa ngomlomo.

Izincomo zesilinganiso i-Risperidone yomlomo imi ngale ndlela elandelayo:

Isimo	Umthamo wokuqala	Ukuhlukaniswa	I-Target Dose	I-Dose Range Ephumelelayo
Ischizophreniakubantu abadala	2 mg / ngosuku	1-2 mg nsuku zonke	4-8 mg nsuku zonke	4-16 mg / ngosuku
Ischizophreniaebusheni	0.5 mg / ngosuku	0.5- 1 mg nsuku zonke	3 mg nsuku zonke	1-6 mg / ngosuku
I-bipolar mania kubantu abadala	2-3 mg / ngosuku	1mg nsuku zonke	1-6 mg nsuku zonke	1-6 mg / ngosuku
I-bipolar mania ezinganeni / ebusheni	0.5 mg / ngosuku	0.5-1 mg nsuku zonke	2.5 mg nsuku zonke	0.5-6 mg / ngosuku
Ukuthukuthela okuhambisana ne-ukuphazamiseka kwe-autistic	0.25 mg / ngosuku (<20 kg) 0.5 mg /day (≥20 kg)	0.25-0.5 mg ku- weeks 2 amasonto	0.5 mg nsuku zonke (uma<20 kg) or 1 mg /day (≥20 kg)	0.5-3 mg / ngosuku

I-Risperdalukuxhumana

I- Ilebula evunyelwe i-FDA yeRisperdaluphawula okulandelayoukuxhumana kwezidakamizwa:

• Kuyalulekwa ukuthi usebenzise ukuqaphela lapho uphathaI-Risperdalnezinye izidakamizwa ezisebenza ohlelweni lwezinzwa oluphakathi (CNS) ngenxa yemiphumela ekhuphukile ye-CNS.
• Ukusetshenziswa kotshwala kufanele kugwenywe ngoba futhi kukhulisa imiphumela ye-CNS ye-risperidone.
• Imiphumela ephezulu yezinye izidakamizwa noma izidakamizwa ezinamandla we-hypotensive zingathuthukiswa ngenxa ye-I-RisperdalImiphumela ye-hypotensive.
• ULevodopa noi-dopamineimiphumela yama-agonists ingahle iphikisane.
• Ukutholakala kwe-bioavailability ofI-Risperidoneyanda nge-Cimetidine ne-Ranitidine.
• Ukususwa kweI-Risperidonekungehla ngeI-Clozapine.
• Ukugxila kwe-Plasma kwe-sibusisiweukwanda ngeFluoxetine kanyeI-Paroxetine.
• Ukugxila kwe-Plasma kwe-sibusisiwencipha ngeICarbamazepinenezinye inducers enzyme.

I-Risperidoneingaxhumana nezidakamizwa ezithile, nge izici zokuxhumana kufaka phakathi :

• Inciphisa imiphumela emaphakathi ye-histamine
• Imiphumela ye-Hyperglycemic
• Ukudangala kwe-CNS
• I-substrate ye-CYP2D6
• Imiphumela ye-Extrapyramidal
• I-substrate ye-CYP3A4
• Imiphumela ephezulu
• Imiphumela ye-Hyperprolactinemic, eqinile
• Ukwehlisa umkhawulo wokubamba

Njalo bonana nodokotela weimininingwane yezidakamizwakanye nokuphikisana okungenzeka ngaphambi kokuthatha noma imuphi umuthi omusha noma ukuxuba noma yimiphi imithi, kufaka phakathiphezu kwekhawuntaizidakamizwa, izithasiselo, namalungiselelo wamakhambi.

Ungakugwema kanjaniImiphumela emibi yeRisperdal

Abantu kufanele bathathe kuphelaI-Risperdalngokuholwa ngakunye, nangemithi kadokotela. Izinyathelo ezithile zingasiza ekunciphiseni amathuba noma ukuqina kwe-okuqhamuka uma udla imishanguzo, kufaka phakathi:

1. Ukuthatha isilinganiso esifanele: I-Risperdalkufanele kuthathwe njengoba kuvunyelwene nodokotela wesiguli. Ngokuvamile, amaphilisi ahlanganiswe kufanele agwinywe ngokuphelele ngamanzi. Amaphilisi we-Orodispersible kufanele avunyelwe ukuncibilika olimini bese ugezwa ngamanzi uma kudingeka. Isixazululo somlomo singahlanjululwa esiphuzweni esingeyona i-alcohol noma sigwinye njengoba sinjalo. Kodwa-ke, isisombululo somlomo akufanele sixutshwe neziphuzo ezinama-tannins, kufaka phakathi itiye noma i-cola.
2. Ukunikeza udokotela ohlinzekayo ngomlando wezokwelapha oningiliziwe: Iziguli kufanele zinikeze yonke imininingwane yomlando wazo wezempilo ophelele kudokotela wazo ngaphambi kokuthathaI-Risperdal.I-Risperdalkuyaphikiswa nganoma yisiphi isiguli esine-hypersensitivity toI-Risperidone.
3. Ukubukeza konke ukuxhumana okungenzeka nodokotela: Iziguli kufanele ziqhubeke nokubonisana nodokotela bazo ukuthi iziphi izidakamizwa noma ukudla okungabathinta kabi ngenkathi bethathaI-Risperdal. Ngokwesibonelo,I-Risperdalakufanele neze kuthathwe notshwala.

Ikakhulu, ukuqapha kufanele kuthathwe uma kwenzeka ukuphikisana kanye / noma izexwayiso zisebenza.

Imibuzo evame ukubuzwa

IngabeI-Risperdaludinga ukuthathwa nsuku zonke?

Ukuze iRisperdone isebenze kahle, kufanele ithathwe njengokuyalelwa ngumhlinzeki wezokunakekelwa kwezempilo. Kubantu abathatha ifomu lethebhulethi, lokhu kungasho ukuthathaI-Risperdalkanye kuya kabili ngosuku.

Yiziphi ezinye izinhlobo zeI-Risperdal?

Ifomu elinomjovo weI-Risperdal, waziwa ngoI-RisperdalUConsta, uyatholakala. Lokhu ngokuvamile kuhloswe ukuthi kuhlinzekwe ngumhlinzeki wezokunakekelwa kwempilo njalo emavikini amabili. IPerseris olunye uhlobo lwefomu lokujova olusebenza isikhathi eside futhi kumele lukhishwe njalo ngenyanga.

Kuphephe kangakanani ukuthathaI-Risperdal?

Ngokusho kwe-Ukuphathwa Kwezokudla Nezidakamizwa , akwaziwa ukuthi isiguli esine-schizophreniakufanele iqhubeke nokuthathaI-Risperdal. I-Risperdal ivunyelwe ukusetshenziswa kwesikhathi eside lapho welapha i-schizophrenia noma ukucasuka okuhambisana nokuphazamiseka kwe-autistic. Ukuhlolwa ngezikhathi ezithile kunconywa ukuthola isidingo sokwelashwa kwesondlo nokulungisa umthamo njengoba kudingeka.

Lapho isetshenziswa ezinganeni zezingane, i-Rispderal ivunyelwe ukusetshenziswa isikhathi eside lapho welapha i-schizophrenia ezinganeni ezineminyaka engu-13-17 ubudala, noma ukucasuka okuhambisana nokuphazamiseka kwe-autistic ezinganeni ezineminyaka engu-5-16 ubudala. Kuvunyelwe ukusetshenziswa kwesikhashana lapho welapha iziqephu ze-Bipolar I Disorder ezinganeni ezineminyaka eyi-10-17.