ILosartan vs Valsartan: Umehluko Omkhulu nokufana

Izidakamizwa Vs. Umngani

ILosartan ne-valsartan yimithi emibili esetshenziselwa ukwelapha umfutho wegazi ophezulu. Bobabili bahlukaniswa njengama-angiotensin receptor blockers (ama-ARB) asebenza ngendlela efanayo. Le mithi isebenza ngokuvimba isenzo se-angiotensin II, i-molecule ye-hormone ebangela imithambo yegazi ukuthi icindezeleke. Ngenxa yalesi senzo, imithambo yegazi iyakwazi ukunwebeka okusiza ukwehlisa umfutho wegazi nokunciphisa ukucindezeleka enhliziyweni. Ngenkathi yomibili le mithi isebenza ngokufanayo, yomibili inokwehluka okufanele ikwazi.

ILosartan

ILosartan yigama elijwayelekile noma lamakhemikhali likaCozaar. Kungumuthi okhonjiswe ukwelapha umfutho wegazi ophakeme (umfutho wegazi ophakeme) nesifo sezinso sikashukela (nephropathy yesifo sikashukela). Kuyasiza futhi ukunciphisa ubungozi bokushaywa unhlangothi ezigulini ezithile.

ILosartan ingene emzimbeni futhi ifinyelela amazinga aphezulu egazini kungakapheli amahora amane. Ihlanganiswa, noma yehlukaniswe, ibe kwesinye isithako esisebenzayo esinengxenye yempilo cishe yamahora ayisithupha kuye kwayi-9. Le nqubo ye-metabolism yenzeka ikakhulukazi esibindini.

Amaphilisi omlomo ojwayelekile aseLosartan afika ngamandla ka-25 mg, 50 mg, no-100 mg. Ijwayele ukukhishwa ku-50 mg kanye ngosuku. Noma kunjalo, lokhu kungahluka ngokuya ngesimo esiphathwayo. Imiphumela yomuthi ingahlala emahoreni angama-24.

Umsebenzi wezinso kufanele ubhekwe lapho usebenzisa i-losartan ngoba ingadala ukulimala kwezinso kubantu abathile abasengozini. Laba bantu bahlanganisa labo abanesifo esingapheliyo sezinso, i-renal artery stenosis, nokwehluleka okukhulu kwenhliziyo yokucinana. ILosartan nayo ingadala i-hyperkalemia, noma amazinga aphezulu ngokweqile e-potassium, okungaholela ezinkingeni zenhliziyo ezingavamile.

Valsartan

IValsartan igama elejwayelekile noma lamakhemikhali likaDiovan. Ngokungafani ne-losartan, ngenkathi isetshenziselwa ukwelapha umfutho wegazi ophakeme, ibuye isetshenziselwe ukwelapha ukwehluleka kwenhliziyo kubantu abathile. Kubuye kuboniswe ukunciphisa ingozi yesikhathi eside yokufa ngemuva kokuhlaselwa yinhliziyo.

Njenge-losartan, i-valsartan nayo ifinyelela amazinga aphezulu egazi amahora amabili kuya kwayi-4 ngemuva kokuphathwa. Ihlukaniswe ngokuyinhloko esibindini ngempilo engaba yingxenye yamahora angaba yisithupha. Imiphumela ingahlala emahoreni angama-24.

IValsartan iza ngamathebulethi anikezwa amandla angama-40 mg, 80 mg, 160 mg, kanye nama-320 mg. Amandla okulinganisa ayahluka ngokuya ngesimo esiphathwayo.

Umsebenzi wezinso namazinga we-potassium kufanele abhekwe njalo ezigulini ezithile ezithatha i-valsartan. Ukulimala kwezinso namazinga aphezulu e-potassium yizingozi ezingenzeka ezihambisana nokuthatha i-valsartan ne-losartan.

ILosartan vs Valsartan Side by Ukuqhathanisa Okuseceleni

ILosartan ne-valsartan yimithi emibili efanayo engaphatha izimo ezifanayo. Ukufana nokwehluka kwazo kungahlolwa kuthebula lokuqhathanisa elingezansi.

ILosartan	Valsartan
Okumiselwe i
Umfutho wegazi ophezulu I-nephropathy yesifo sikashukela Ingcuphe yokushaywa unhlangothi	Umfutho wegazi ophezulu Ukwehluleka kwenhliziyo Ukufa kwenhliziyo ngemuva kokuhlaselwa yinhliziyo
Ukuhlukaniswa Kwezidakamizwa
I-Angiotensin receptor blocker (i-ARB) Umfutho wegazi ophakeme	I-Angiotensin receptor blocker (i-ARB) Umfutho wegazi ophakeme
Umkhiqizi
Okujwayelekile	Okujwayelekile
Imiphumela emibi ejwayelekile
Isiyezi Ukutheleleka okuphezulu okuphefumula Ukuminyana emakhaleni Ukuhlungu obusemhlane Khwehlela	Isiyezi Ubuhlungu bekhanda Ukutheleleka ngegciwane Ukukhathala Ubuhlungu besisu Ukuhlungu obusemhlane Uhudo I-Arthralgia Khwehlela I-Hypotension
Ingabe kukhona okujwayelekile?
ILosartan igama elejwayelekile	IValsartan igama elejwayelekile
Ngabe ihlanganiswe ngumshwalense?
Iyahluka kuya ngomhlinzeki wakho	Iyahluka kuya ngomhlinzeki wakho
Amafomu Esikali
Ithebhulethi yomlomo	Ithebhulethi yomlomo
Inani lentengo emaphakathi
204 (ngamathebulethi angu-30)	$ 130.09 ngamathebulethi angu-30 (160 mg)
Intengo Yesaphulelo Esingabodwa
Intengo yeLosartan	Intengo yeValsartan
Ukusebenzisana Kwezidakamizwa
Ama-ejenti akhulisa i-potassium ILithium Ama-NSAID (i-aspirin, ibuprofen, naproxen) I-COX-2 inhibitors (celecoxib, rofecoxib) Amanye ama-ARB I-ACE inhibitors (lisinopril, enalapril, benazepril) I-Aliskiren I-Fluconazole I-Rifampin ICyclosporine	Ama-ejenti akhulisa i-potassium ILithium Ama-NSAID (i-aspirin, ibuprofen, naproxen) I-COX-2 inhibitors (celecoxib, rofecoxib) Amanye ama-ARB I-ACE inhibitors (lisinopril, enalapril, benazepril) I-Aliskiren I-Fluconazole I-Rifampin ICyclosporine
Ngingakwazi ukusebenzisa ngenkathi ngihlela ukukhulelwa, ngikhulelwe, noma ngincelisa ibele?
ILosartan isesigabeni sokukhulelwa D. Ngakho-ke, akufanele ithathwe ngesikhathi sokukhulelwa. Xhumana nodokotela mayelana nezinyathelo okufanele uzithathe ngenkathi uhlela ukukhulelwa. ILosartan akufanele ithathwe ngenkathi incelisa.	IValsartan isesigabeni sokukhulelwa D. Ngakho-ke, akufanele ithathwe ngesikhathi sokukhulelwa. Xhumana nodokotela mayelana nezinyathelo okufanele uzithathe ngenkathi uhlela ukukhulelwa. IValsartan akufanele ithathwe ngenkathi incelisa.

Isifinyezo

ILosartan ne-valsartan yizindlela ezimbili ezingasebenza ukwelapha umfutho wegazi ophakeme. Bobabili basesigabeni esifanayo semithi eyaziwa ngokuthi ama-ARB. Ngenkathi bobabili belapha umfutho wegazi ophakeme, bayehluka kancane ezinhlotsheni zezimo eziphathwayo. ILosartan ingazuzisa labo abane-nephropathy yesifo sikashukela kanye nengozi ephezulu yokushaywa unhlangothi. IValsartan ingaba wusizo kulabo abanokwehluleka kwenhliziyo noma ingozi eyengeziwe ngemuva kokuhlaselwa yinhliziyo.

Yomibili le mithi ikhishwa ngokufanayo nemiphumela engahlala amahora angama-24. Ngenkathi i-losartan ivame ukugcotshwa kanye nsuku zonke kuzo zonke izinkomba, i-valsartan ithathwa kabili nsuku zonke ngenxa yokwehluleka kwenhliziyo. Amandla wamathebulethi omlomo ahlukile phakathi kwale mithi emibili yize zombili zivela ngendlela efanayo.

Enye into ebalulekile okufanele uyiqaphele ukuthi yomibili le mithi ingadala i-hypotension, noma yehlise umfutho wegazi, lapho ithathwa nezinye izidakamizwa ezifanayo. Futhi kungadala ukulimala kwezinso noma amazinga aphezulu we-potassium angaholela ezinkingeni uma engabhekwa ngeso elibukhali. Ngakho-ke, kubalulekile ukuxoxa ngalezi zinketho nodokotela ukuze unqume ukuthi imuphi umuthi olungele isimo sakho. Lolu lwazi luhloselwe ukukufundisa ngemithi emibili esebenza ngokufana okufanele ithathwe ngaphansi kweso lochwepheshe wezokunakekelwa kwempilo.