Main >> Izidakamizwa Vs. Umngani >> I-Amitiza vs. Linzess: Umehluko, ukufana, futhi okungcono kuwe

I-Amitiza vs. Linzess: Umehluko, ukufana, futhi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Amitiza neLinzess yimithi emibili kadokotela esetshenziswa ekwelapheni ukuqunjelwa okungapheli kwe-idiopathic (CIC) ne-irritable bowel syndrome ngokuqunjelwa (IBS-C). Ukuqunjelwa okungapheli kwe-idiopathic kubonakala esikhathini esiyizinyanga eziyisithupha noma ngaphezulu ngokuhamba kwamathumbu okuzenzekelayo kathathu noma okuncane ngesonto. I-irritable bowel syndrome iyiqembu lezimpawu ezahlukahlukene ezenzeka ndawonye kubandakanya ubuhlungu besisu kanye nezinguquko ekuhambeni kwamathumbu: uhudo, ukuqunjelwa, noma kokubili. I-Amitiza neLinzess zisetshenziswa ikakhulukazi ku-IBS ngokuqunjelwa. Sizokhuluma ngokufana nokwehluka phakathi kwe-Amitiza neLinzess lapha.

Yini umehluko omkhulu phakathi kwe-Amitiza neLinzess?

I-Amitiza (i-lubiprostone) ngumuthi kadokotela olapha ukuqunjelwa ngokwandisa uketshezi lwamathumbu emathunjini. Kuyinto etholakala nge-bicyclic fatty acid ne-prostaglandin E1 (PGE 1) esebenzisa iziteshi ze-chloride kulwelwesi lwamathumbu. Ukwanda okubangelwa yimfihlo kuguqula ukungaguquguquki kwesitulo futhi kukhuthaze ukuhamba kwamathumbu njalo. I-Amitiza iyatholakala njenge-capsule yomlomo ethambile emandleni we-8 mcg no-24 mcg.

I-Linzess (i-linaclotide) ngumuthi kadokotela okhonjisiwe ukwelapha ukuqunjelwa. I-agonist ye-guanylate cyclase C (GC-C) ebangela ukwanda kwe-cyclic guanosine monophosphate (cGMP). Isenzo ku-receptor ye-GC-C siphumela ekwandeni kwezimfihlo zamathumbu. Lokhu kubangela ukwanda koketshezi lwamathumbu futhi kwenyuse ukunyakaza kokuqukethwe kwamathumbu ngepheshana. Kukwacatshangwa ukuthi amazinga e-cGMP akhuphukile acubungula ubuhlungu obunciphile besisu esiswini esivamile ku-IBS. ILinzess iyatholakala njenge-capsule yomlomo emandleni we-72 mcg, 145 mcg, naku-290 mcg.

Umehluko omkhulu phakathi kwe-Amitiza neLinzess
	Amitiza	Linzess
Isigaba sezidakamizwa	I-Bicyclic fatty acid / i-PGE 1 isisebenzisi sesiteshi se-derivative / chloride	Ama-agonists eGuanylate cyclase C
Isimo somkhiqizo / ejwayelekile	Umkhiqizo kuphela	Umkhiqizo kuphela
Ngubani igama elijwayelekile?	I-Lubiprostone	Linaclotide
Izidakamizwa zingena ngaziphi izinhlobo?	Umlomo we-softgel capsule	Ama-capsules omlomo
Uyini umthamo ojwayelekile?	24 mcg kabili ngosuku	145 mcg kanye ngosuku
Yelashwa isikhathi esingakanani?	Akupheli, isikhathi eside	Akupheli, isikhathi eside
Ubani ovame ukusebenzisa umuthi?	Abantu abadala	Abantu abadala

Izimo ezilashwa ngu-Amitiza noLinzess

U-Amitiza noLinzess baboniswa ngamunye ekwelapheni ukuqunjelwa okungamahlalakhona okungapheli kanye nesifo samathumbu esibuhlungu ngokuqunjelwa. I-Amitiza iphinde yamukelwa yi-Food and Drug Administration (FDA) ekwelapheni ukuqunjelwa okubangelwa ukusetshenziswa kwe-opioid pain reliever in pain chronic, non-cancer. Lokhu kwesinye isikhathi kubizwa ngokuthi yi-OIC, ukuqunjelwa okubangelwa i-opioid.

I-Amitiza neLinzess ziboniswa kuphela ukuthi zingasetshenziswa kubantu abadala, futhi ukusetshenziswa ezinganeni nasebusheni akuvunyelwe. Udokotela wakho kuphela onganquma ukuthi le mithi iyindlela efanelekile yesimo sakho.

Isimo	Amitiza	Linzess
Ukuqunjelwa okungapheli kwe-idiopathic	Yebo	Yebo
Isifo samathumbu esingathukuthele ngokuqunjelwa	Yebo	Yebo
Ukuqunjelwa okubangelwa yi-opiate agonist (okungamahlalakhona, okungewona umdlavuza)	Yebo	Akunjalo

Ngabe i-Amitiza noma iLinzess isebenza kangcono?

TO ukubuyekeza okuhlelekile kwezivivinyo zomtholampilo ezilawulwa ngokungahleliwe ezingama-21 ziqhathanisa izithako ezisebenzayo ze-Amitiza, iLinzess, nezinye izindlela zokwelashwa ezivamile zokuqunjelwa. Ezinye izindlela zokwelapha ezifakiwe kulolu cwaningo kwakuyi-prucalopride, i-tegaserod, i-bisacodyl, ne-polyethylene glycol (i-PEG). Lokhu kuhlaziywa kuphethe ngokuthi konke okubandakanya izidakamizwa kukhombisa ukusebenza ngokufana kwe-placebo lapho kuhlolwa ukuphela kokuphela kokuhamba kwamathumbu amathathu noma ngaphezulu ngesonto. I-Bisacodyl, i-laxative yokuvuselela i-over-the-counter, yayingcono kunabo bobabili i-Amitiza neLinzess ngokuya ngoshintsho kwinani lokuhamba kwamathumbu ngesonto. Ama-laxatives ashukumisayo angadala ukungalingani kwe-electrolyte futhi athambekele ekukhuleni kokubekezelelana ngokuhamba kwesikhathi.

Ummemezeli angahle adinge ukubheka izinto ezinjengezehlakalo ezimbi, ukuxhumana kwezidakamizwa, nokuhambisana nomthamo owodwa nsuku zonke noma kabili nsuku zonke lapho ethatha isinqumo sokuthi imuphi umuthi olungele isiguli.

Ukuqhathaniswa nokuqhathaniswa kwezindleko ze-Amitiza vs. Linzess

I-Amitiza imbozwa yizinhlelo zezidakamizwa ezentengiselwano kanye ne-Medicare Part D, noma kwezinye izimo kungadinga nokuvunyelwa kwangaphambili kokutholakala. Inani elikhishwa ephaketheni le-Amitiza lingafinyelela ku- $ 282, kepha isigqebhezana esivela kwa-SingleCare singehlisa intengo ifike ku- $ 176 ngokuthengwa kwezinsuku ezingama-30.

ILinzess imbozwa ngazo zombili izinhlelo zezidakamizwa zezohwebo nezeMedicare Part D, noma kwezinye izimo kungadinga nokuvunywa kwangaphambilini kokutholakala. Ngaphandle kwanoma yiluphi uhlobo lokumbozwa, iLinzess ingabiza cishe u- $ 640. Isigqebhezana se-Linzess esivela ku-SingleCare sizokusiza ukuthi wonge ku-Linzess, futhi ungakhokha imali engange- $ 395.

	Amitiza	Linzess
Ngokuvamile embozwe umshwalense?	Yebo, kwesinye isikhathi kudingeka ukugunyazwa kwangaphambili	Yebo, kwesinye isikhathi kudingeka ukugunyazwa kwangaphambili
Imbozwe ngokwejwayelekile yi-Medicare Part D?	Yebo, kwesinye isikhathi kudingeka ukugunyazwa kwangaphambili	Yebo, kwesinye isikhathi kudingeka ukugunyazwa kwangaphambili
Ubuningi	30, 24 mcg amaphilisi	30, 145 mcg amaphilisi
I-Medicare copay ejwayelekile	Iyahluka kuya ngohlelo	Iyahluka kuya ngohlelo
Izindleko ze-SingleCare	$ 176- $ 204	$ 395- $ 470

Thola ikhadi lesaphulelo sekhemisi

Imiphumela emibi ejwayelekile ye-Amitiza vs. Linzess

I-Amitiza neLinzess banezehlakalo ezithile ezibi phakathi kwabo, kepha futhi ezinye zihlukile kakhulu kumuthi ngamunye. Uhudo yisona sizathu esivame kakhulu sokuyekisa ukwelashwa kwazo zombili izidakamizwa, futhi kungumphumela ohlangothini ovamile kuzo zombili izidakamizwa.

Amitiza kungenzeka kakhulu ukuthi ibangele isicanucanu, esenzeka cishe kwesinye seziguli ezintathu ezithatha umuthi. Lokhu kubonakala kwenzeka kaningi uma kuthathwa esiswini esingenalutho. Kwesinye isikhathi lokhu kucanuzela kwenhliziyo kuba nzima futhi kuyaqeda amandla, kugcina iziguli emisebenzini ejwayelekile yansuku zonke. Iziguli zase-Amitiza zibike izehlakalo ezimbi njengesizungu, ukukhathala, nobuhlungu besifuba, kanti iziguli zaseLinzess azibikanga le miphumela emibi.

Lokhu akuhloselwe ukuthi kube uhlu olubanzi lwemiphumela emibi, sicela uthintane nodokotela wakho noma usokhemisi ukuthola uhlu oluphelele.

	Amitiza	Linzess
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Isicanucanu	Yebo	29%	Yebo	<2%
Uhudo	Yebo	12%	Yebo	16-20%
Ubuhlungu bekhanda	Yebo	ishumi nanye%	Yebo	4%
Ubuhlungu besisu	Yebo	8%	Yebo	7%
Ukuhlukaniswa kwesisu / ukuqunjelwa	Yebo	6%	Yebo	2-3%
Ukuqhuma kwesisu	Yebo	6%	Yebo	4-6%
Ukuhlanza	Yebo	3%	Yebo	<2%
I-Edema	Yebo	3%	Akunjalo	n / a
Ukungakhululeki esiswini	Yebo	3%	Akunjalo	n / a
Isiyezi	Yebo	3%	Akunjalo	n / a
Ubuhlungu besifuba	Yebo	amaphesenti amabili	Akunjalo	n / a
I-Dyspnea	Yebo	amaphesenti amabili	Akunjalo	n / a
I-Dyspepsia	Yebo	amaphesenti amabili	Yebo	<2%
Ukukhathala	Yebo	amaphesenti amabili	Akunjalo	n / a
Umlomo owomile	Yebo	1%	Akunjalo	n / a

Umthombo: Amitiza ( I-DailyMed I-Linzess ( I-DailyMed )

Ukusebenzisana kwezidakamizwa kwe-Amitiza vs. Linzess

I-Amitiza neLinzess kufanele zisetshenziswe ngokuqapha ezigulini ezidla izidakamizwa ezinezakhi ze-anticholinergic. Izidakamizwa ze-Anticholinergic zingakhuthaza ukuqunjelwa futhi ziphikisane nezenzo zekhemisi zika-Amitiza noLinzess.

Iziguli ezisebenzisa i-loop diuretics, njenge-furosemide (Lasix), kufanele zigweme i-Amitiza ngoba zingaba sengozini yokulahlekelwa yi-potassium eningi (hypokalemia). Kulezi ziguli, iLinzess kungaba yindlela ekhethwayo.

Lolu akulona uhlu oluphelele lokuhlangana kwezidakamizwa okungenzeka. Ukuze uthole uhlu oluphelele, sicela ufune iseluleko sezokwelapha kuchwepheshe wakho wokunakekelwa kwezempilo we-gastroenterology.

Izidakamizwa	Isigaba sezidakamizwa	Amitiza	Linzess
I-Atropine UBelladonna I-Benztropine I-Chlordiazepoxide Dicclomine I-Flavoxate I-Glycopyrrolate I-Homatropine IHyoscyamine IMethscopolamine I-Oxybutynin I-Scopolamine	Ama-anticholinergics	Yebo	Yebo
I-Bismuth salicylate I-Loperamide	Ama-antidiarrhea	Akunjalo	Yebo
I-Bumetanide UFurosemide I-Torsemide	I-Loop diuretics	Yebo	Akunjalo
I-Lactulose	I-Laxative	Yebo	Akunjalo
I-Solifenacin	I-Antimuscarinic	Yebo	Akunjalo
I-Methadone	I-opioid	Yebo	Akunjalo

Izexwayiso ze-Amitiza neLinzess

I-Amitiza ingadala isicanucanu esinzima. Ukuvela kwesicanucanu kungancipha ngokuthatha i-Amitiza nokudla.

I-Amitiza neLinzess akufanele zinikezwe iziguli ezinesifo sohudo esibi ngoba lokhu kungadala ukuthi isifo sohudo sibhebhethekise. Uma isifo sohudo siqala ngemuva kokuqala ukwelashwa, yeka ukwelashwa, futhi uxhumane nomhlinzeki wakho wezokunakekelwa kwempilo.

I-Syncope, noma isiyezi lapho umile, kanye ne-hypotension, noma umfutho wegazi ophansi, kungenzeka ngemuva kokuqala kokuqala kwe-Amitiza. Iziguli kufanele ziqaphele umfutho wegazi lazo futhi zikhuphuke kancane ukusuka endaweni yokuhlala ukugwema ukuwa. Yazisa udokotela wakho nganoma yiziphi izimo zezokwelapha noma ezinye izidakamizwa ongazithatha ezingadala i-syncope ibe nzima.

I-Dyspnea, noma umuzwa wokuqina kwesifuba nokuphefumula okuncane, kungenzeka nge-Amitiza. Lesi sibonakaliso ngokuvamile sihlala ngaphakathi kwemizuzu engama-30 kuya kwengu-60 yedosi futhi singahlala amahora ambalwa. Uma lokhu kwenzeka, kufanele uxhumane nodokotela wakho.

I-Linzess ithwala isexwayiso esikhutshiwe kanye nesitatimende mayelana nokusetshenziswa ezigulini zezingane ngenxa yekhono lazo lokubangela ukuphelelwa amandla emzimbeni. Imininingwane engaphezulu ngalesi sexwayiso ingatholakala ku- fda.gov .

Imibuzo ebuzwa njalo nge-Amitiza vs. Linzess

Yini i-Amitiza?

I-Amitiza ngumuthi kadokotela osetshenziselwa ukwelapha ukuqunjelwa okungamahlalakhona kwe-idiopathic kanye nasekwelapheni i-irritable bowel syndrome ngokuqunjelwa. I-Amitiza nayo ivunyelwe ukwelapha ukuqunjelwa okubangelwa i-opioid ngenxa yobuhlungu obungapheli, obungewona umdlavuza. Isebenza ngokwandisa uketshezi lwamathumbu ukushintsha ukungaguquguquki kwesitulo. Iyatholakala njenge-capsule yomlomo emandleni we-8 mcg naku-24 mcg.

Yini iLinzess?

I-Linzess ngumuthi kadokotela okhonjisiwe ekwelapheni ukuqunjelwa okungapheli kwe-idiopathic kanye nesifo samathumbu esibuhlungu ngokuqunjelwa. Iyakwandisa okuqukethwe uketshezi lwamathumbu nokuhamba. Iyatholakala kuma-capsule womlomo ngamandla we-72 mcg, 145 mcg, ne-290 mcg.

Ngabe u-Amitiza noLinzess bayafana?

Ngenkathi u-Amitiza noLinzess belapha ukuqunjelwa, abafani. I-Amitiza iyi-bicyclic fatty acid ne-prostaglandin E1 (PGE 1), futhi idosiwa kabili ngosuku. ILinzess ingeyesigaba sama-agonists we-guanylate cyclase C (GC-C), futhi idosiwa kanye nsuku zonke.

Ngabe u-Amitiza noma uLinzess ungcono?

U-Amitiza noLinzess bakhombise ukusebenza okufanayo ekuqedeni ukuqunjelwa. Ababhali bangabheka izinto ezinjengama-dosing regimens nemicimbi emibi lapho bethatha isinqumo sokuthi imuphi umuthi olungele isiguli. I-Amitiza neLinzess bancanyelwa ukuqunjelwa okungamahlalakhona ngoba okunye ukwelashwa kwendabuko okufana nezithambisi zendle (isb. I-docusate), ama-osmotic laxatives (isb. I-Miralax), noma ama-laxatives ashukumisayo (isb. I-senna) angadala ukungalingani okukhulu kwe-electrolyte futhi athuthukise ukubekezelelana ngokusetshenziswa kwesikhathi eside.

Ngingasebenzisa i-Amitiza noma i-Linzess ngenkathi ngikhulelwe?

Izingozi ezihlobene nezidakamizwa zokusetshenziswa kwe-Amitiza noma iLinzess azikanqunywa ngoba azikho izivivinyo zokwelashwa ezanele ezilawulwa ukufakazela ukuphepha kwazo. Ukusetshenziswa kwale mithi ekukhulelweni kufanele kukhawulelwe ezimeni lapho izinzuzo zidlula ngokusobala izingozi.

Ngingasebenzisa i-Amitiza noma i-Linzess ngotshwala?

Akukho ukuphikisana okuqondile ngokuthatha le mithi nokuphuza utshwala, noma kunjalo, kubalulekile ukukhumbula ukuthi utshwala bungaholela ekuphelelweni yigciwane nasifo sohudo, njengoba nayo le mithi, ibeka iziguli engcupheni yokuphelelwa amandla kakhulu emzimbeni.

Ngabe i-Amitiza ibangela ukuzuza kwesisindo?

I-Amitiza ayiboniswanga ukuthi ibangela ukukhuluphala.

Kuthatha isikhathi esingakanani ukuthi uLinzess asebenze?

Ukusizwa kokuqunjelwa kuvame ukwenzeka kungakapheli isonto elilodwa noma amabili, ngokuqhubeka ngokuthuthuka kwezimpawu ezenzeka kuze kube amasonto ayi-12.

Ngubani ongafanele athathe i-Amitiza?

Iziguli ezinokuvinjelwa komshini emgudwini wazo wamathumbu (GI) akufanele zithathe i-Amitiza. Futhi, iziguli ezibhekene nohudo olulinganiselayo kuya kolubi akufanele zithathe i-Amitiza. Abesifazane abakhulelwe noma abancelisayo, kanye neziguli zezingane, kufanele bagweme i-Amitiza.