Main >> Izidakamizwa Vs. Umngani >> I-Pravastatin vs. Lipitor: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Pravastatin vs. Lipitor: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Pravastatin ne-Lipitor (i-atorvastatin) yimithi kadokotela esetshenziselwa ukwelapha i-cholesterol ephezulu. Amazinga e-cholesterol aphezulu kunokujwayelekile angakhuphula ubungozi besifo senhliziyo, isifo semithambo yegazi, isifo senhliziyo nokushaywa unhlangothi. I-cholesterol ikhiqizwa ngokuyinhloko esibindini nge-enzyme ye-HMG-CoA reductase.

I-Pravastatin ne-atorvastatin yizidakamizwa ezihlukaniswa njenge-HMG-CoA reductase inhibitors. Eyaziwa nangokuthi izidakamizwa ze-statin, i-pravastatin ne-atorvastatin inhibit, noma i-block, i-HMG-CoA reductase enzyme, eholela ekwehliseni ukukhiqizwa kwe-cholesterol esibindini. Ukusetshenziswa kwama-statins futhi kwandisa inani lama-LDL (low-density lipoprotein) receptors esibindini, okusiza amazinga aphansi we-LDL, noma uhlobo olubi lwe-cholesterol, egazini.

Kokubili i-pravastatin ne-atorvastatin kusebenza ngezindlela ezifanayo, kepha banokuhluka okuthile okufanele bazi.

Uyini umehluko omkhulu phakathi kwe-pravastatin ne-Lipitor?

I-Pravastatin yigama elijwayelekile le-Pravachol. Ngokungafani nezinye izidakamizwa ze-statin, i-pravastatin ayihlanganisi kakhulu, noma icutshungulwe, ngu-CYP3A4 enzyme esibindini. Esikhundleni salokho, i-pravastatin iyi ephukile esiswini .

Amaphilisi ejwayelekile ePravastatin ayatholakala ngamandla ka-10 mg, 20 mg, 40 mg, no-80 mg. I-Pravastatin ivame ukunqunywa ukuthi ithathwe kanye ngosuku kusihlwa. Kubonisiwe ukuthi i-pravastatin iyasebenza kakhulu uma ithathwa ebusuku kunasekuseni.

I-Lipitor ngumuthi wegama lomkhiqizo futhi uyatholakala kunguqulo ejwayelekile ebizwa nge-atorvastatin. Ngokungafani ne-pravastatin, i-atorvastatin icutshungulwa kakhulu yi-CYP3A4 enzyme esibindi. Ngakho-ke, i-atorvastatin ingahle isebenzisane nemithi eminingi kune-pravastatin.

I-Lipitor iyatholakala kumathebulethi womlomo ngamandla we-10 mg, 20 mg, 40 mg, no-80 mg. I-Lipitor ingathathwa ekuseni noma kusihlwa, futhi ivame ukuthathwa kanye ngosuku.

Umehluko omkhulu phakathi kwe-pravastatin ne-Lipitor
	I-Pravastatin	Lipitor
Isigaba sezidakamizwa	I-HMG-CoA reductase inhibitor	I-HMG-CoA reductase inhibitor
Isimo somkhiqizo / ejwayelekile	Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala	Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala
Ngubani igama elijwayelekile? Ngubani igama lomkhiqizo?	Igama lomkhiqizo: Pravachol Igama elijwayelekile: Pravastatin	Igama lomkhiqizo: Lipitor Igama elijwayelekile: Atorvastatin
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi yomlomo	Ithebhulethi yomlomo
Uyini umthamo ojwayelekile?	10 kuya ku-80 mg kanye ngosuku	10 kuya ku-80 mg kanye ngosuku
Yelashwa isikhathi esingakanani?	Isikhati eside	Isikhati eside
Ubani ovame ukusebenzisa umuthi?	Abantu abadala; izingane nentsha eneminyaka engu-8 kuya kwengu-18 ubudala	Abantu abadala; izingane nentsha eneminyaka engu-10 kuya kwengu-17

Izimo eziphathwe yi-pravastatin ne-Lipitor

I-Pravastatin ne-atorvastatin kungasiza ekunciphiseni ubungozi bokuhlaselwa yisifo senhliziyo futhi imivimbo kubantu abanesifo senhliziyo. Yomibili le mithi ingasiza futhi ekunciphiseni ubungozi bokufa Isifo senhliziyo . Izici ezinobungozi besifo senhliziyo zifaka umfutho wegazi ophakeme, ukubhema, namazinga aphezulu e-cholesterol.

Kokubili i-pravastatin ne-atorvastatin kuvunyelwe i-FDA ukunciphisa amazinga aphakeme we-cholesterol kanye ne-LDL (eyaziwa nangokuthi yi-hyperlipidemia noma i-hypercholesterolemia). Imithi ye-Statin nayo ingasiza ekwelapheni amazinga aphakeme we-triglycerides , Olunye uhlobo lwamafutha noma ama-lipids emzimbeni. Umuntu onamazinga aphakeme we-triglycerides une-hypertriglyceridemia.

I-Pravastatin ne-Lipitor nazo zingakhuphula amazinga e-HDL egazini. I-cholesterol ye-HDL yilokho okwaziwa ngokuthi yi-cholesterol enhle esegazini.

Isimo	I-Pravastatin	Lipitor
Hyperlipidemia	Yebo	Yebo
I-Hypercholesterolemia	Yebo	Yebo
I-Hypertriglyceridemia	Yebo	Yebo

Ingabe i-pravastatin noma i-Lipitor isebenza kangcono?

Kokubili i-pravastatin ne-atorvastatin yimithi ephumelelayo yokwelapha i-cholesterol ephezulu yegazi. Isidakamizwa esisebenza kangcono sincike esimeni sakho sonke, ubunzima besimo sakho, ezinye izidakamizwa okungenzeka uzithatha, nezinye izinto.

Eyodwa isifundo sokuqhathanisa kutholakale ukuthi awukho umehluko ophawulekayo phakathi kwe-pravastatin, i-simvastatin, ne-atorvastatin yokuvimbela imicimbi yenhliziyo. Ngamanye amagama, le mithi ye-statin yayisebenza ngokufanayo ekwehliseni ukuhlaselwa yinhliziyo kanye nesifo senhliziyo.

TO ukubuyekeza okuhlelekile ehlanganise izivivinyo zokwelashwa ezingaphezu kuka-90 uma kuqhathaniswa nezidakamizwa ezinjenge-fluvastatin, i-atorvastatin, i-pravastatin, i-simvastatin, ne-rosuvastatin. Ukubuyekezwa kuphethe ngokuthi i-atorvastatin, i-fluvastatin, ne-simvastatin zazinamathuba aphakeme kakhulu okwelashwa okungcono kakhulu ekuvimbeleni imicimbi yenhliziyo.

Xhumana nomhlinzeki wezokunakekelwa kwezempilo ukunquma umuthi ongcono kakhulu we-statin. Ngemuva kokwenza ukuhlolwa kwegazi nokuhlola isimo sakho sonke, umhlinzeki uzokwazi ukunquma ukuthi ingabe i-pravastatin noma i-atorvastatin iyisidakamizwa esisebenza kangcono kuwe. Bangaphinde banikeze umuthi ohlukile we-statin onjengeZocor (simvastatin) noma iCrestor (rosuvastatin).

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kwe-pravastatin vs. Lipitor

I-Pravastatin ngumuthi ojwayelekile ovame ukumbozwa yi-Medicare nezinhlelo zomshuwalense. Intengo emaphakathi yemali ye-pravastatin icishe ibe ngu- $ 129.99 ngokunikezwa kwezinsuku ezingama-30. Ikhadi lokonga le-SingleCare lingakwazi ukwehlisa izindleko zemithi kadokotela we-pravastatin ibe ngaphansi kwama- $ 15.

I-Lipitor ngumuthi wegama lomkhiqizo otholakala ngohlobo olushibhile, olujwayelekile. Uhlobo olujwayelekile lweLipitor, i-atorvastatin, luvame ukumbozwa yizinhlelo eziningi zeMedicare nezinhlelo zomshuwalense. Igama elithi Brand Lipitor lingahlanganiswa nezinhlelo zomshuwalense nge-copay ephezulu. Intengo yemali yeLipitor icishe ibe ngu- $ 249.99. Amakhuphoni e-SingleCare anganciphisa izindleko ziye ku- $ 15 kuma-pharmacy abambe iqhaza.

	I-Pravastatin	Lipitor
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokwejwayelekile yi-Medicare Part D?	Yebo	Yebo
Ubuningi	Amaphilisi angama-30 (40 mg)	Amaphilisi angama-30 (40 mg)
I-Medicare copay ejwayelekile	$ 0– $ 20	$ 0– $ 16
Izindleko ze-SingleCare	$ 12 +	$ 15 +

Imiphumela emibi ejwayelekile ye-pravastatin vs. Lipitor

Imiphumela emibi kakhulu ye-pravastatin yizinhlungu zemisipha noma zemisipha, isicanucanu, ukuhlanza, isifo sohudo nekhanda. Imiphumela emibi kakhulu ye-atorvastatin yizinhlungu zemisipha noma zemisipha, isifo sohudo, nobuhlungu obuhlangene (i-arthralgia). Kokubili i-pravastatin ne-atorvastatin nakho kungadala eminye imiphumela emibi njengokugaya ukudla, isiyezi, ukukhathala, ukuqubuka, kanye nezifo zomgudu womchamo.

Sína imiphumela emibi yezidakamizwa ze-statin kufaka phakathi isifo semisipha (i-myopathy) nokonakala okusheshayo kwezicubu zemisipha (i-rhabdomyolysis). Xhumana nomhlinzeki wezokunakekelwa kwempilo ngokushesha uma uhlangabezana nobuhlungu bemisipha obuqhubekayo noma obungachazeki, ubuthakathaka, noma isisa.

I-Pravastatin ne-atorvastatin nakho kungadala ama-enzyme wesibindi aphakeme. Amazinga e-enzyme yesibindi angadinga ukuthi ahlolwe ngaphambi futhi aqashwe kulo lonke ukwelashwa.

	I-Pravastatin	Lipitor
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ubuhlungu bemisipha	Yebo	10%	Yebo	4%
Isicanucanu / ukuhlanza	Yebo	7%	Yebo	4%
Uhudo	Yebo	7%	Yebo	7%
Ukugaya ukudla	Yebo	3%	Yebo	5%
Isiyezi	Yebo	4%	Yebo	*
Ubuhlungu bekhanda	Yebo	6%	Akunjalo	-
Ukukhathala	Yebo	3%	Yebo	*
I-Rash	Yebo	5%	Yebo	*
I-Arthralgia	Yebo	*	Yebo	7%
Ukutheleleka ngomgudu womchamo	Yebo	3%	Yebo	6%

Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( I-Pravastatin ), IDailyMed ( Lipitor )
* akubikiwe

Ukusebenzisana kwezidakamizwa kwe-pravastatin vs. Lipitor

I-Pravastatin ne-atorvastatin zihlangana nemithi efanayo. Kodwa-ke, njengoba i-atorvastatin ihlanganiswa ngokuyinhloko yi-enzyme ye-CYP3A4 esibindi, ingahle ihlanganyele nezidakamizwa eziningi ezithinta ama-enzyme e-CYP3A4 esibindi.

Ukuthatha imishanguzo efana ne-cyclosporine, i-clarithromycin, noma i-ritonavir nge-pravastatin noma i-atorvastatin kungaholela ekukhuleni kwamazinga e-statin egazini, okungakhuphula ubungozi bemiphumela emibi.

Ama-Antacids angaphazamisa ukumuncwa kwemithi ye-statin futhi anciphise ukusebenza kwawo. Ukuphathwa kwama-antacids nama-statin kufanele kwehlukaniswe okungenani amahora amabili. I-Cholestyramine nayo inganciphisa ukumuncwa nokusebenza kwama-statins. Ukuphathwa kwe-cholestyramine ne-statins kufanele kwehlukaniswe ngamahora amane.

I-Niacin nama-fibrate kungakhuphula ubungozi be-myopathy kanye ne-rhabdomyolysis lapho ithathwa nge-pravastatin noma i-atorvastatin.

Ukusetshenziswa kwe-atorvastatin kufanele kugwenywe noma kubhekwe ngenkathi kudliwa Ijusi lamagilebhisi . Ijusi lamagilebhisi lisebenza njenge-CYP3A4 inhibitor engaholela ekukhuleni kwamazinga e-atorvastatin egazini futhi kwandise ubungozi bemiphumela emibi.

Izidakamizwa	Isigaba sezidakamizwa	I-Pravastatin	Lipitor
ICyclosporine	Ama-immunosuppressants	Yebo	Yebo
I-Clarithromycin I-Erythromycin	Imithi elwa namagciwane	Yebo	Yebo
Ketoconazole I-Itraconazole Voriconazole I-Posaconazole	Izikhunta	Akunjalo	Yebo
I-Ritonavir Simeprevir ULedipasvir I-Boceprevir I-Darunavir	Amagciwane	Yebo	Yebo
I-Niacin	Ama-Antilipemic agents	Yebo	Yebo
I-Fenofibrate Gemfibrozil	Ama-Fibrates	Yebo	Yebo
I-Digoxin	Ama-glycosides enhliziyo	Yebo	Yebo
I-Cholestyramine	Ama-sequestrants we-Bile acid	Yebo	Yebo
Aluminium hydroxide Magnesium hydroxide	Ama-Antacids	Yebo	Yebo

Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka.

Izexwayiso ze-pravastatin ne-Lipitor

I-Pravastatin ne-atorvastatin kufanele kugwenywe kulabo abanesifo esisebenzayo sesibindi noma amazinga aphezulu e-enzyme yesibindi. Imithi ye-Statin ingadala ukuqhubeka kokulimala kwesibindi kumuntu onesifo sesibindi.

I-Pravastatin ne-atorvastatin akufanele isetshenziswe kulabo abanomlando wokusabela kwe-hypersensitivity kumithi ye-statin. Izimpawu nezimpawu zokuphendula kwe-hypersensitivity zibandakanya ukuqubuka, ukulunywa, ukuvuvukala, nenkinga yokuphefumula.

Imithi ye-Statin inobungozi bokulimala kanzima kwemisipha nobuhlungu bemisipha. Kungaba nobungozi obandayo bezinhlungu zemisipha kulabo abaneminyaka engaphezu kwengama-65 ubudala noma abane-hypothyroidism engalawulwa noma izinkinga zezinso.

I-Pravastatin ne-atorvastatin akufanele isetshenziswe kulabo abakhulelwe noma abancancisayo.

Khuluma nomhlinzeki wezokunakekelwa kwezempilo ukuze nixoxe ngezinye izixwayiso noma izindlela zokuzivikela ezihlobene ne-pravastatin noma i-atorvastatin.

Imibuzo ebuzwa njalo mayelana ne-pravastatin vs. Lipitor

Yini i-pravastatin?

I-Pravastatin ngumuthi ojwayelekile osetshenziselwa ukwehlisa i-cholesterol futhi uvimbele izinkinga ezibangelwa amazinga aphezulu e-cholesterol. Igama lomkhiqizo le-pravastatin yi-Pravachol. Kunqunyelwe ukuthi kuthathwe kanye nsuku zonke kusihlwa. I-Pravastatin iyatholakala njengethebhulethi yomlomo.

Yini iLipitor?

ILipitor ngumuthi wegama lomkhiqizo owenziwe yiPfizer. Igama elijwayelekile likaLipitor yi-atorvastatin. Isetshenziselwa ukwelapha amazinga aphezulu e-cholesterol nokunciphisa ubungozi bokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. I-Lipitor inqunyelwe ukuthi ithathwe kanye nsuku zonke ekuseni noma kusihlwa. Iyatholakala njengethebhulethi yomlomo.

Ngabe i-pravastatin ne-Lipitor ziyafana?

Kokubili i-pravastatin ne-atorvastatin yimithi esetshenziselwa ukunciphisa amazinga aphezulu we-cholesterol. Noma kunjalo, azifani. I-Atorvastatin ngokuyinhloko ihlanganiswe ngohlelo lwe-CYP P450 enzyme esibindini ngenkathi i-pravastatin yehle esiswini. I-Pravastatin ivame ukuthathwa ebusuku ngenkathi i-Lipitor ithathwa ekuseni noma kusihlwa.

Ngabe i-pravastatin noma i-Lipitor ingcono?

Kokubili i-pravastatin neLipitor kuyindlela ephumelelayo yokwelashwa kwe-statin. Yomibili le mithi ingasiza ekuvikeleni ubunzima bezinga eliphezulu le-cholesterol, njenge-atherosclerosis, isifo senhliziyo, nohlangothi. Ezinye izifundo ezivela ku- omagazini benhliziyo bathole ukuthi i-atorvastatin, isithako esisebenzayo eLipitor, sisebenza kangcono kunezinye izidakamizwa ze-statin zokuvimbela imicimbi yenhliziyo efana nokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Umhlinzeki wezokunakekelwa kwempilo angakunikeza iseluleko sezokwelapha emithini yokwelapha engcono kakhulu kuwe.

Ngingayisebenzisa i-pravastatin noma i-Lipitor ngenkathi ngikhulelwe?

I-Pravastatin ne-atorvastatin akunconywa ukuthi kuthathwe ngenkathi ukhulelwe. Yomibili le mithi inobungozi obukhulu bokubangela ukukhubazeka kokuzalwa. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ukuze uthole ukuqondiswa ekwelashweni okungcono kakhulu kwe-cholesterol ephezulu ngenkathi ukhulelwe.

Ngingayisebenzisa i-pravastatin noma i-Lipitor ngotshwala?

Abukho ubungozi bezempilo obubalulekile obusetshenziswa ekuphuzeni utshwala ngokulinganisela kanye nezitatimende. Izidakamizwa ze-Statin nokuphuza ngokweqile utshwala kungalimaza isibindi . Khuluma nomhlinzeki wezokunakekelwa kwezempilo ukuze ahlole ukuthi kuphephile yini kuwe ukuphuza utshwala ngenkathi uthatha umuthi we-statin.