Main >> Imininingwane Yezidakamizwa >> Imiphumela emibi ye-Propranolol nokuxhumana, nokuthi ungakugwema kanjani

Imiphumela emibi ye-Propranolol nokuxhumana, nokuthi ungakugwema kanjani

Imininingwane Yezidakamizwa

I-Propranolol (i-generic Inderal) umuthi kadokotela owelapha izimpawu zomfutho wegazi ophezulu, njengobuhlungu besifuba. Ngaphambi kokuthatha lo muthi, iziguli kufanele zazi imiphumela engemihle yepropranolol, izixwayiso, kanye nokusebenzisana. Funda ukuthi ungayibalekela kanjani le miphumela engezansi ngezansi.

Yini i-propranolol?

I-Propranolol ngumuthi ojwayelekile futhi othengiswa njengegama lomkhiqizo Inderal LA , Inderal XL, InnoPran XL, neHemangeol. Kungokwama-beta-adrenergic block agents (noma beta-blocker ) isigaba sezidakamizwa, esisiza ukushaya kwenhliziyo kalula nangamandla amancane. I-Propranolol itholakala kuphela ngemithi kadokotela. Nazi ezinye zezimo zezempilo ezivunyiwe yi-Food and Drug Administration (FDA) i-propranolol ukwelapha:

I-Arrhythmia: Ukushaya kwenhliziyo okungajwayelekile okuhamba kancane kakhulu noma okushesha kakhulu.
U-Angina: Ubuhlungu besifuba obenzeka lapho igazi lingahambi kahle enhliziyweni.
Ukuthuthumela: Ukunyakaza okungazinikeli nokunesigqi kwezitho, ubuso, izintambo zezwi, noma ikhanda.
Umfutho wegazi ophezulu: Umfutho wegazi ophezulu ngenxa yamandla egazi ngokumelene nezindonga zemithambo ephezulu kakhulu. Izinga lomfutho wegazi ophezulu lingaphezu kuka-140/90. I-Propranolol-HCTZ , umuthi ohlanganisa i-propranolol ne-diuretic, welapha umfutho wegazi ophezulu.
Ukuhlaselwa yinhliziyo: Ukuhlaselwa yinhliziyo (i-myocardial infarction) kwenzeka lapho ukugeleza kwegazi kuya enhliziyweni kuvinjelwe. I-Propranolol ingasiza ekuvikeleni nasekwelapheni ukuhlaselwa yinhliziyo.
Ikhanda le-Migraine: Imigraines yikhanda elibuhlungu ngokweqile i-propranolol engasiza ekuvimbeleni. Abaphenyi bacabanga ukuthi i-propranolol ilungele i-migraines ngoba ivimba i-hormone adrenaline ekubangeleni impendulo ekucindezelekeni emzimbeni.
I-hemangioma yezinsana: Isigaxa semithambo yegazi esinobungozi esingathinta izinsana kuze kufike ezinyangeni ezinhlanu ubudala.

I-Propranolol ingaphatha ezinye izimo, njenge ukukhathazeka nokwethuka , ecaleni ngamacala. Abaphenyi bahlola ukuthi i-propranolol ingazelapha kanjani izinhlobo ezithile ze- umdlavuza . Imithamo yepropranolol izohluka ngokuya ngesimo futhi ingahle isuke ku-10 mg iye ku-160 mg.

OKUSHIWO: Yini i-Inderal LA? | Kuyini iPropranolol?

Imiphumela emibi ejwayelekile yepropranolol

Njenganoma imuphi umuthi, kuhlale kunamandla emiphumela emibi. Nayi eminye imiphumela emibi ejwayelekile yepropranolol:

Isiyezi
Ubumhlophe
Ukukhathala
Ukwehla kobulili
Isicanucanu
Ubuhlungu besisu
Uhudo
Ukuqunjelwa

Imiphumela emibi ye-propranolol

Ukuthatha i-propranolol kungadala imiphumela emibi kakhulu. Nayi eminye yemiphumela emibi futhi engahle ibe yesikhathi eside okufanele uyiqaphele lapho ucabanga noma uthatha iprranranol:

Ukusangana
Izandla noma izinyawo ezibandayo
Ubuthakathaka bemisipha
Amajaqamba emisipha
Ukuphelelwa umoya
Ukulahleka kwememori
Ukugcinwa kwamanzi
Ushukela wegazi uyashintsha
Ukuqwasha namaphupho amabi
Ukusabela okweqile
Ukuhlanza
Ukunyakaza
Ukuzuza kwesisindo
Ukuqhuma kwesikhumba

Abanye abantu bazizwa bekhathazekile ngokuthi ubuntu babo buzoshintsha ekuthatheni i-propranolol, futhi yize kungavamile, lokhu kungenzeka. I-Propranolol ingadala ukuguquka kwemizwelo nokudangala. Kungadala nezinkinga zememori ngenxa yendlela ethinta ngayo i-norepinephrine ne-epinephrine, eboshelwe ekusebenzeni kwememori. Noma yikuphi ukushintsha kwemizwelo kufanele kukhulunywe kudokotela ngokushesha okukhulu.

Imiphumela emibi yepropranolol edinga ukunakekelwa ngokushesha ibandakanya ukuphefumula kanzima, ukuhefuzela, ukuvuvukala kwezandla noma ubuso, nokuqubuka kwesikhumba. Lezi zimpawu zikhombisa ukusabela okweqile, okungasongela impilo.

Kufanele uyeke ukuthatha i-propranolol uma kwenzeka imiphumela emibi kakhulu, kepha ngaphansi kokuqondiswa udokotela, ngokuya ngomthamo nemiphumela engemihle, udokotela wakho angafuna ukuthi wehlise kancane ipropranolol, kusho uReuben Elovitz, MD, umsunguli futhi Umphathi omkhulu we Ezempilo Ezizimele zaseDallas . Kunemiphumela engaba khona ngokumisa isigubhukane umuthi kuye ngesizathu sokuthi uqalwe emithini.

Noma ukuthatha i-propranolol kungaholela emiphumeleni emibi, kusengumuthi ongenza okuhle kakhulu. Isiza ukusebenza kwenhliziyo, ngeke ilimaze inhliziyo, futhi iba nomthelela omuhle emasosheni omzimba ngokwandisa inani lama-T cell emzimbeni. Kuzohlala kunezinzuzo nezingozi kuyo yonke imithi, futhi kubantu abaningi, izinzuzo ze-propranolol zikudlula kude ukwehla.

Ihlala isikhathi esingakanani imiphumela emibi ye-propranolol?

Imiphumela emibi ye-propranolol ingahlala noma kuphi kusukela ezinsukwini kuye emasontweni. Imiphumela emibi eminingi izophela ezinsukwini ezimbalwa njengoba umzimba ulungisa umuthi. Kwabanye, lesi sikhathi sokulungisa singathatha isikhathi eside. Imiphumela emibi ingahle ibe yimbi noma ibe ngcono njengoba imithamo ikhula noma yehla. Imiphumela emibi yesikhathi eside yepropranolol iyenzeka, kepha lokhu akwenzeki kuwo wonke umuntu.

Izexwayiso ze-Propranolol

I-Propranolol akuyona eyabo bonke abantu. UDkt. Elovitz uchaza ukuthi abantu abanezimo zezokwelapha ezilandelayo akufanele bathathe i-propranolol:

I-Bradycardia (ukushaya kwenhliziyo okungasheshi ngokweqile)
I-asthma (ukuphefumula kanzima kusuka ezindleleni zomoya)
Ukwehluleka kwenhliziyo okungalawulwa (inhliziyo ayishayi kahle)
Isifo semithambo yegazi (ivinjiwe noma iqhume imithambo yegazi)
Isifo sikashukela (isifo samazinga aphezulu kashukela egazini)
I-Pheochromocytoma (isimila sezicubu ze-adrenal gland)
I-Myasthenia gravis (isifo semisipha esibuthakathaka)
I-Hypotension (umfutho ophansi wegazi)
I-Orthostatic hypotension (umfutho wegazi ophansi owenzeka lapho umile uhleli noma ulele phansi)

Abantu abaphila ne-hyperthyroidism (i-thyroid engasebenzi ngokweqile), isifo sikaRaynaud, isifo sesibindi, isifo sezinso, isifo samaphaphu, noma isifo senhliziyo, kufanele bakhulume nomhlinzeki wabo wezempilo ngaphambi kokuthatha i-propranolol. Ukuba nalezi zimo zezokwelapha kungadala ukusabela okungalungile ku-propranolol, okuholele ezinkingeni ezengeziwe zezempilo.

I-Propranolol ngesikhathi sokukhulelwa

I-Propranolol kungenzeka ingaphephi ukuthi abesifazane abakhulelwe bayithathe. Akuzange kwenziwe izifundo ezanele ukuqinisekisa ukuthi i-propranolol ithinta kanjani imibungu, kepha ucwaningo lukhombisa ukuthi umuthi ungadlula usuke kumama uye kosana ngobisi lwebele. Abesifazane abakhulelwe noma labo abangakhulelwa kufanele babonisane nomhlinzeki wabo wezokunakekelwa kwempilo ngaphambi kokuthatha noma ngokuyeka ngokungazelelwe i-propranolol.

Imikhawulo yobudala

I-Propranolol kwesinye isikhathi isetshenziselwa ukwelapha izimo zezokwelapha njenge-infantile hemangioma yezinye izingane, kodwa lokhu akusho ukuthi isidakamizwa esifanele zonke izingane. Udokotela uzonikeza ingane ipropranolol uma kudingeka.

I-Propranolol inikezwa abantu abadala asebekhulile ngokuqapha, ikakhulukazi kulabo abanezimo zesibindi, izinso, nenhliziyo. Abanye izifundo ziphakamisa ukuthi abantu abadala abaneminyaka engaphezu kwengama-60 abane-hypertension akufanele bathathe i-propranolol, kodwa ezinye iziguli ezinokuhluleka kwenhliziyo zingayidinga. Odokotela bazohlala benikeza i-propranolol ngokuya ngamacala ngamacala.

Ukusetshenziswa kwesikhathi eside kwe-propranolol

Njenge-beta-blocker, ukusetshenziswa kwesikhathi eside kwepropranolol kungavimbela ukuhlaselwa yinhliziyo futhi kugcine amazinga omfutho wegazi onempilo. Akuvamile ukuthi umuntu athathe i-beta-blockers iminyaka eminingana, ikakhulukazi kulandela isifo senhliziyo, kepha odokotela baqala umbuzo noma ngabe ukusetshenziswa kwesikhathi eside kuyadingeka.

Ukusetshenziswa kwesikhathi eside kwe-beta-blockers kungadala imiphumela emibi ejwayelekile ku iba yimbi . Ingaphinde ifihle izimpawu zoshukela ophansi wegazi kubantu abanesifo sikashukela, okungasongela impilo. Ukweqiwa okuphezulu kwe-propranolol ethathwa isikhathi eside kungenza izinkinga zenhliziyo zibe zimbi kakhulu futhi kudale ukushaya kwenhliziyo okungajwayelekile.

I-Propranolol ayisona isidakamizwa umuntu angayeka ukusithatha ngokushesha, noma ngabe eba nemiphumela emibi. Ukumisa isigubhukane i-propranolol kungadala ukuhlaselwa yinhliziyo nobuhlungu besifuba obukhulu. Ukubonisana nodokotela kuyindlela engcono kakhulu yokwenza lokhu kungenzeki.

OKUSHIWO: Ungayinciphisa kanjani umfutho wegazi ngokushesha futhi ngokwemvelo

Ukusebenzisana kwePropranolol

Njenge-propranolol ayenzelwe ukuthathwa yiwo wonke umuntu, nayo akufanele ithathwe ngemithi ethile. Ukuthatha i-propranolol ngale mithi kungadala ukuxhumana okungekuhle:

I-Alpha blockers: I-Prazosin
Ama-anticholinergics: I-Scopolamine
Eminye imithi yomfutho wegazi ophezulu: Clonidine , acebutolol , nebivolol, I-digoxin , metoprolol
Eminye imithi yenhliziyo: I-Quinidine , I-digoxin , sibongile
Imithi ye-steroid: Prednisone
Izidakamizwa ezingezona ukuvuvukala (ama-NSAID): I-Aspirin , ibuprofen
Izidakamizwa ezithile zokucindezeleka: I-Fluoxetine , i-fluvoxamine

Lolu hlu lwemithi aluphelele. Ochwepheshe bezokunakekelwa kwezempilo banganikeza uhlu olugcwele lokusebenzisana kwezidakamizwa. Amavithamini amaningi nezithasiselo ziphephile ukuwathatha ngepropranolol, kepha amanye afana neSt.

Ngaphandle kwemithi, i-propranolol akufanele ithathwe ngotshwala. Utshwala bungakhuphula amazinga egazi e-propranolol, buwenze ungaphephi. Ukuphuza kakhulu i-caffeine nakho kufanele kugwenywe ngoba i-caffeine ingakhuphula izinga lokukhathazeka nomfutho wegazi.

Thola ikhadi lesaphulelo sakwaSingleCare

Imiphumela emibi yepropranolol vs.propranolol ER

I-Propranolol iza ngezindlela ezimbili ezihlukile ezisebenza ngokuhluka kancane. I-propranolol ekhishwa ngokushesha ejwayelekile kufanele ithathwe izikhathi eziningi ngosuku ukuqinisekisa ukuthi iyasebenza. I-Propranolol enwetshiwe-ukukhishwa (i-ER) idinga kuphela ukuthathwa kanye ngosuku ngoba ikhipha kancane kancane i-propranolol hydrochloride emzimbeni.

I-Propranolol ER iyatholakala ukuze ithengwe njengama-60 mg, 80 mg, 120 mg, nama-capsules ayi-160 mg. I- isilinganiso esijwayelekile we-propranolol ER ngu-80 mg othathwa kanye ngosuku, okuphezulu kunomthamo we-propranolol ekhishwa ngokushesha ngoba uthathwa kanye kuphela.

Abanye abantu bathanda inguqulo ekhishwe isikhathi eside ngoba kufanele bakhathazeke kuphela ngokuthatha imishanguzo yabo kanye ngosuku. Kodwa-ke, udokotela uzokwazi ukunquma ukuthi iyiphi inguqulo elungele umuntu othile ngokuya ngezidingo nezimpawu zakhe.

U-Actavis Elizabeth wenza uhlobo olujwayelekile lokukhishwa okwandisiwe kwepropranolol. Igama lomkhiqizo wepropranolol HCl ER yiHemangeol. Izinhlobo zemithi ejwayelekile ngokuvamile zishibhile kunezinguqulo zamagama, kodwa zisebenza ngokufanayo futhi zisebenza ngokulinganayo.

Imiphumela emibi yepropranolol ejwayelekile kanye nepropranolol enwetshiwe-icishe ifane. Izexwayiso ezifanayo, izinyathelo zokuqapha, kanye nokusebenzisana kwezidakamizwa kwe-propranolol nakho kumele i-propranolol ER.

Ungayigwema kanjani imiphumela emibi yepropranolol

Indlela engcono yokugwema imiphumela engemihle yepropranolol ukulandela imiyalelo yabakhiqizi kanye nanoma imiphi imiyalo enikezwe ngudokotela.

Imithamo yepropranolol izoncika eminyakeni yobudala yesiguli, izimpawu zomuntu ngamunye, nomlando wezokwelapha, kepha isilinganiso esijwayelekile ngu-40 mg othathwe kabili ngosuku. Amaphilisi e-propranolol akhishwa njalo ngokushesha kufanele athathwe esiswini esingenalutho ukuqinisekisa ukumuncwa okuhle emzimbeni. Amaphilisi wepropranolol anwetshiwe (i-ER) angathathwa ngokudla noma ngaphandle kokudla, kepha kufanele athathwe ngokungaguquguquki, kungaba ngokudla noma ngaphandle kokudla, ukuqinisekisa ukuthi imithamo engaguquguquki imuncwa umzimba. Futhi, ukuthatha i-propranolol ER ngokudla kungasiza ekuvikeleni isisu esithukuthele futhi ukhumbule UKUTHI ungahlafuni noma uchoboze la mathebhulethi e-ER noma umthamo wonke ungangena ngokushesha okukhulu. I-Propranolol ivame ukuthathwa kanye ekuseni futhi ngaphambi kokulala, kodwa lokhu kungashintsha ngokuya ngesincomo somhlinzeki wezokunakekelwa kwempilo.

Umthamo ongabanjwanga wepropranolol nawo ungadala imiphumela emibi. Ukuthatha umthamo ongabanjwanga ngokushesha ngemuva kokuwukhumbula kuzosiza ukuvimbela imiphumela emibi ukuthi ingenzeki noma ibe yimbi. Kodwa-ke, uma sekuyisikhathi sokuthatha umthamo olandelayo, isiguli akufanele sithathe umthamo owengeziwe ukwenza inani elilahlekile.

I-Propranolol kufanele igcinwe ekamelweni lokushisa kude nokushisa, ilanga eliqondile, namazinga okushisa afudumele. Lezi zinto zemvelo zingashintsha umuthi nokuthi usebenza kanjani. Gcina izidakamizwa zingafinyeleleki ezinganeni. Funa iseluleko esisheshayo sezokwelapha uma ingane ithathe ngephutha i-propranolol.

Uma imiphumela emibi ye-propranolol inzima kakhulu, odokotela bangakunikeza umuthi ohlukile. Ngenxa yokuthi othile uqala ukuthatha i-beta-blocker njengepropranolol, akusho ukuthi kuzofanele ayithathe unomphela. Imithi efana Ama-ACE inhibitors futhi ama-ARB aphatha ezinye zezimo ezifanayo ezenziwa yi-beta-blockers, futhi angasebenza kangcono kubantu abathile. Nawa amanye ama-ACE inhibitors nama-ARB anqunywe kakhulu: