IHydrocodone vs. oxycodone: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
I-Hydrocodone ne-oxycodone yizinto ezimbili i-opioid imishanguzo kadokotela ikhonjiswe ekwelashweni kobuhlungu obulinganiselayo kuya kobunzima, imvamisa ubuhlungu obunzima. Zombili lezi zidakamizwa zihlukaniswa njengezidakamizwa, okusho ukuthi ziyalutha futhi zinamandla amakhulu okuhlukumeza. Zombili lezi zidakamizwa zisebenza ngokuzibophezela kuma-receptors wezinhlungu, abizwa ngama-mu receptors, ebuchosheni, okwenza buthakathaka noma kuvimbele amasiginali wezinhlungu, futhi kuphumele ekunciphiseni ubuhlungu. Ngoba yomibili le mithi inamandla amakhulu, ijwayele ukusetshenziswa ngemuva kokuhlinzwa, noma ezimeni lapho isidambisi sezinhlungu esithe xaxa ngeke sisebenze noma singabekezeleleki.
Uyini umehluko omkhulu phakathi kwe-hydrocodone ne-oxycodone?
Kunezindlela eziningi ezahlukahlukene zokwenziwa kwe-hydrocodone ne-oxycodone. Zombili lezi zidakamizwa ziyimithi yezinhlungu zoHlelo II; lokhu kusho ukuthi umuthi ungaba ne- amandla aphezulu okuhlukunyezwa.
IHydrocodone (Amakhuphoni e-Hydrocodone | Yini i-Hydrocodone?) Itholakala kakhulu njengamagama ezimpawu uNorco noma i-Vicodin, equkethe i-hydrocodone ngokuhlangana ne-Tylenol ejwayelekile (i-acetaminophen, evame ukufushaniswa njenge-APAP). I-Hydrocodone / APAP ingatholakala kwifomu lephilisi kanye nefomu le-liquid. I-Hydrocodone ingatholakala futhi ihlanganiswe ne-ibuprofen, kanye nemithi ehlanganisiwe yokukhwehlela, efana nesiraphu ye-Hycodan noma amaphilisi (i-hydrocodone / i-homatropine) noma ukumiswa kwe-Tussionex (i-hydrocodone / i-chlorpheniramine). Uwedwa, i-hydrocodone ingatholakala emithini ekhishwe isikhathi eside iZohydro ER (enwetshiwe) noma iHysingla ER.
I-Oxycodone (amakhuphoni e-Oxycodone | Yini i-Oxycodone?) Ijwayele ukubekwa yodwa, njenge-generic ye-OxyIR (ukukhishwa ngokushesha). Iphinde itholakale yodwa kumuthi osebenza isikhathi eside obizwa nge-OxyContin. I-Oxycodone nayo ivame ukutholakala ngokuhlangana, njengePercocet, equkethe i-oxycodone ne-APAP.
Zombili lezi zidakamizwa ziyahlukahluka kumthamo ngokweminyaka nangesimo futhi ngokuvamile zinqunywa kumthamo ophansi kakhulu isikhathi esifushane ngangokunokwenzeka. Zonke izifundazwe zinemithetho ephathelene nemiyalo ye-opioid, ngenxa yamandla azo okuhlukumeza.
| Umehluko omkhulu phakathi kwe-hydrocodone ne-oxycodone | ||
|---|---|---|
| I-Hydrocodone | I-Oxycodone | |
| Isigaba sezidakamizwa | I-opiate (narcotic) analgesic | I-opiate (narcotic) analgesic |
| Isimo somkhiqizo / ejwayelekile | Umkhiqizo nokujwayelekile | Umkhiqizo nokujwayelekile |
| Ngubani igama elijwayelekile? Ngubani igama lomkhiqizo? | Okujwayelekile: i-hydrocodone, i-hydrocodone / i-APAP, njll. Umkhiqizo: I-Zohydro ER, i-Hysingla ER Umkhiqizo: kuhlanganiswe ne-APAP: Norco, Lortab, Vicodin | Okujwayelekile: i-oxycodone, i-oxycodone / i-APAP, njll. Umkhiqizo: OxyIR, OxyContin Umkhiqizo: kuhlanganiswe ne-APAP: Percocet |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi, ithebhulethi ekhishwa isikhathi eside, isiraphu njengomuthi ohlangene | Ithebhulethi, ithebhulethi ekhishwa isikhathi eside, isisombululo somlomo |
| Uyini umthamo ojwayelekile? | Isibonelo: I-Hydrocodone / APAP 5/325 mg: 1-2 amaphilisi / amaphilisi njalo emahoreni ama-4 kuye kwayi-6 njengoba kudingeka ngobuhlungu (amaphilisi ayisishiyagalombili ngosuku) | Isibonelo: Ithebhulethi ekhishwa ngokushesha: 5 kuya ku-15 mg njalo emahoreni ama-4 kuye kwayi-6 njengoba kudingeka I-OxyContin: 20 mg njalo emahoreni ayi-12 |
| Yelashwa isikhathi esingakanani? | Isikhathi esifushane, singasetshenziswa isikhathi eside ngokuya ngesimo esiphathwe (njengobuhlungu obungapheli) nempendulo | Isikhathi esifushane, singasetshenziswa isikhathi eside ngokuya ngesimo esiphathwe (njengobuhlungu obungapheli) nempendulo |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala | Abantu abadala |
Izimo eziphathwa yi-hydrocodone ne-oxycodone
I-Hydrocodone ne-oxycodone zombili zikhonjisiwe ukuphathwa kobuhlungu lokho kunzima ngokwanele ukudinga i-opioid, lapho ezinye izindlela zokwelapha (ezingewona ama-opioid) zinganele noma zingabekezelelwa
| Isimo | I-Hydrocodone | I-Oxycodone |
| Ukuphathwa kobuhlungu obunzima ngokwanele ukudinga i-opioid analgesic nokuthi yiziphi ezinye izindlela zokwelashwa ezinganele | Yebo | Yebo |
Ingabe i-hydrocodone noma i-oxycodone isebenza kangcono?
Ku-blind-blind, elawulwa yi-placebo funda ye-hydrocodone vs i-oxycodone endaweni yezimo eziphuthumayo, ukukhululeka kobuhlungu kwakufana, ngemizuzu engama-30 nangemizuzu engama-60 kuwo womabili ama-hydrocodone noma i-oxycodone. Zombili lezi zidakamizwa zibe nemiphumela emibi efanayo, ne-hydrocodone ebangela ukuqunjelwa okuthe xaxa kune-oxycodone.
Enye funda ikhombise i-hydrocodone / i-APAP ne-oxycodone / APAP ukuthi ibe nemiphumela efanayo maqondana nokudambisa izinhlungu, kepha leyo oxycodone / APAP ibinamandla aphindwe ka-1.5 kune-hydrocodone / APAP.
Kokubili i-hydrocodone ne-oxycodone kungamaphilisi ezinhlungu aqinile futhi anamandla amakhulu okuhlukumeza, asetshenziswa lapho amaphilisi ezinhlungu aqatha enganikanga ukudambisa izinhlungu okusebenzayo, noma engenakubekezelelwa. Umuthi osebenza kahle kakhulu kufanele unqunywe udokotela wakho kuphela, ozobheka isithombe sonke sesimo sakho sempilo, umlando, neminye imithi oyiphuzayo.
Ukuhlanganiswa nokuqhathaniswa kwezindleko kwe-hydrocodone kuqhathaniswa ne-oxycodone
Ngenxa yemithetho ehlukahlukene yezwe, uma uthola i-opioid okokuqala ngqa, kungenzeka ukuthi uthole inani elincane.
Umuthi ojwayelekile wamaphilisi angama-20 we-generic hydrocodone-acetaminophen ungabiza ngaphezu kuka- $ 100. Ngekhuphoni le-SingleCare, i-generic Vicodin noma i-Norco ingaqhuba u- $ 26- $ 41. Umuthi ojwayelekile wamaphilisi e-oxycodone-acetaminophen 20 ngu- $ 25- $ 50. Intengo ephuma ephaketheni ingu- $ 10- $ 15 enekhuphoni le-SingleCare.
Thola ikhadi lesaphulelo sakwaSingleCare
| I-Hydrocodone | I-Oxycodone | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokwejwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | # 20, amaphilisi e-hydrocodone / APAP 5/325 mg | # 20, amaphilisi e-oxycodone / APAP 5/325 mg |
| Inkokhelo ejwayelekile yeMedicare Part D | $ 3-73 | $ 3-90 |
| Izindleko ze-SingleCare | $ 26- $ 41 | $ 10- $ 15 |
Imiphumela emibi ejwayelekile ye-hydrocodone vs. oxycodone
Imiphumela emibi kakhulu ye-hydrocodone ukukhanya-ikhanda, isiyezi, isisu, isicanucanu nokuhlanza. Eminye imiphumela engemihle ingafaka ukuqunjelwa, ukukhathazeka, ukuqubuka kwesikhumba, ukukhathala nokuthembela.
Imiphumela emibi kakhulu ye-oxycodone yisicanucanu, ukuqunjelwa, ukuhlanza, ikhanda elibuhlungu, i-pruritus (ukulunywa), ukuqwasha, isiyezi, ukuba buthakathaka kanye nokozela. Eminye imiphumela emibi ingafaka ukushaya kwenhliziyo, umlomo owomile, ukukhathazeka, ukuqubuka kwesikhumba, kanye nokuncika.
Eminye imiphumela emibi ingavela. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ngolwazi oluthe xaxa maqondana nemiphumela emibi.
Ukusebenzisana kwezidakamizwa kwe-hydrocodone kuqhathaniswa ne-oxycodone
Ukuthatha i-hydrocodone noma i-oxycodone ngemithi ethile ehlanganiswa ne-enzyme ebizwa nge-CYP3A4 noma i-CYP2D6 kungahle kuholele ekusebenzisaneni kwezidakamizwa. Le mithi yaziwa ngama-enzyme inhibitors futhi ifaka ama-macrolide antibiotic, ama-azole antifungals, kanye ne-protease inhibitors. Ukuzisebenzisa ndawonye ne-hydrocodone noma i-oxycodone kungaholela emazingeni aphezulu e-opioid, angaba yingozi kakhulu.
Ezinye izidakamizwa, ezaziwa ngokuthi ama-inducers, zinomphumela ophambene, zehlisa izinga le-opioid ukuze zingasebenzi noma zingadala izimpawu zokuhoxa.
Usebenzisa i-benzodiazepines noma amanye ama-CNS depressants (kufaka phakathi eminye imishanguzo ye-opioid) ngokuhlangana ne-hydrocodone noma i-oxycodone kungaholela ku-hypotension, ukudangala kokuphefumula, i-sedation ejulile, ikhoma nokufa.
Ukuthatha i-hydrocodone noma i-oxycodone ngezidakamizwa ezandisa i-serotonin nakho kungandisa ubungozi be-serotonin syndrome. Le mithi ifaka i-SSRI kanye ne-SNRI antidepressants, tricyclic antidepressants, relaxant muscle, MAO inhibitors (MAO inhibitors akufanele isetshenziswe ezinsukwini eziyi-14 ze-hydrocodone noma i-oxycodone), kanye nama-triptans e-migraine. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola uhlu oluphelele lokuhlangana kwezidakamizwa.
| Izidakamizwa | Isigaba Sezidakamizwa | I-Hydrocodone | I-Oxycodone |
| I-Erythromycin I-Biaxin (i-clarithromycin) | Ama-antibiotic e-Macrolide | Yebo | Yebo |
| I-Diflucan (fluconazole) I-Nizoral (ketoconazole) | Ama-antifungal we-Azole | Yebo | Yebo |
| I-Norvir (ritonavir) | Ama-Protease inhibitors | Yebo | Yebo |
| I-Rifampin I-Tegretol (carbamazepine) I-Dilantin (phenytoin) | Ama-inducers we-CYP3A4 | Yebo | Yebo |
| I-Xanax (alprazolam) I-Valium (diazepam) I-Ativan (lorazepam) I-Klonopin (clonazepam) | I-Benzodiazepines | Yebo | Yebo |
| I-Methadone I-Tylenol ene-codeine (APAP / ikhodi) I-Duragesic (fentanyl) I-Morphine Noma yiziphi ezinye izinhlobo ze-hydrocodone noma i-oxycodone | Ama-opioid | Yebo | Yebo |
| Utshwala | Utshwala | Yebo | Yebo |
| I-Flexeril (cyclobenzaprine) I-Skelaxin (metaxalone) | Ukuphumula kwemisipha | Yebo | Yebo |
| I-Imitrex (sumatriptan) I-Maxalt (rizatriptan) | Ama-Triptans | Yebo | Yebo |
| I-Prozac (fluoxetine) I-Paxil (paroxetine) I-Zoloft (sertraline) I-Celexa (citalopram) I-Lexapro (escitalopram) | Izidakamizwa ze-SSRI | Yebo | Yebo |
| I-Pamelor (nortriptyline) U-Elavil (amitriptyline) | I-Tricyclic antidepressants | Yebo | Yebo |
| ICymbalta (duloxetine) I-Effexor (venlafaxine) I-Pristiq (desvenlafaxine) | Izidakamizwa ze-SNRI | Yebo | Yebo |
| I-Hydrochlorothiazide I-Lasix (furosemide) | Izidakamizwa | Yebo | Yebo |
| I-Azilect (rasagiline) I-Eldepryl (selegiline) I-Parnate (i-tranylcypromine) | Ama-inhibitor e-MAO | Yebo | Yebo |
| I-Cogentin (benztropine) I-Benadryl (diphenhydramine) I-Ditropan (oxybutynin) I-Detrol (tolterodine) | Izidakamizwa ze-Anticholinergic | Yebo | Yebo |
Izexwayiso nge-hydrocodone ne-oxycodone
Kukhona isexwayiso esibhokisi ku-hydrocodone ne-oxycodone, okuyisixwayiso esiqine kakhulu esidingwa yi-FDA. Ezinye izexwayiso zifaka:
- Ama-opioid asengozini yokuba umlutha, ukuhlukunyezwa, nokusetshenziswa kabi, okungaholela ekudluleni ngokweqile nasekufeni. Iziguli kufanele zihlolwe ubungozi ngaphambi kokuthatha i-opioid futhi kufanele ziqashwe njalo.
- Ukuqinisekisa ukuthi izinzuzo zama-opioid zidlula ingozi yokuba umlutha, ukusetshenziswa kabi kwezidakamizwa, nokusetshenziswa kabi, izinkampani zezidakamizwa kumele zifundise abahlinzeki bezokunakekelwa kwempilo. Abahlinzeki bezokunakekelwa kwezempilo kumele bagcwalise uhlelo oluhambisana nemfundo lwe-REMS (Risk Evaluation and Mitigation Strategy), beluleke kahle iziguli nabanakekeli ngemithi ngayinye kadokotela, futhi bagcizelele ukubaluleka kokufunda umhlahlandlela wemithi, onikezwa umuthi ngamunye.
- Ama-opioid angadala ukucindezeleka okukhulu, okusongela impilo, noma okubulalayo. Iziguli kufanele ziqashwe, ikakhulukazi ekuqaleni kokwelashwa nokulandela ushintsho lomthamo.
- Ukungeniswa ngengozi, ikakhulukazi yizingane, kungaholela ekweqeni okweqile okubulalayo. Iziguli kufanele zifundiswe ukuthi zivikele ama-opioid lapho izingane zingafinyeleli khona.
- Isifo sokuhoxiswa kwe-opioid se-Neonatal singaholela ekusetshenzisweni isikhathi eside kwe-opioid ngesikhathi sokukhulelwa futhi kungasongela impilo uma kungaziwa nokwelashwa.
- Kusetshenziswa ama-opioid ngemithi ethile ehlanganiswe ne-enzyme cytochrome P 450 3A4 kungakhuphula amazinga e-opioid futhi kudale imiphumela emibi eyengeziwe kanye nokudangala okungabulala ukuphefumula.
- Usebenzisa imishanguzo ye-benzodiazepine efana ne-Xanax (alprazolam), i-Valium (diazepam), noma ezinye izidambisi ze-CNS, ezinjengamanye ama-opioid (noma utshwala), kungaholela ekudambiseni okujulile, ukucindezeleka kokuphefumula, ikhoma nokufa, futhi kufanele kugwenywe uma kungenzeka. Iziguli ezithatha le nhlanganisela ngenxa yezinye izindlela ezingasebenzi kumele ziqashwe ngeso elibukhali.
Ezinye izexwayiso nokuphikisana kufaka:
- I-Hydrocodone noma i-oxycodone akufanele isetshenziswe ezigulini ezinokucindezeleka okukhulu kokuphefumula, i-asthma ebucayi noma ebucayi e-bronchial esimweni esingabhekiwe, ukuvinjelwa kwamathumbu, noma i-hypersensitivity kunoma yiziphi izithako.
- I-Hydrocodone noma i-oxycodone akufanele isetshenziswe ezigulini ezinesifo samaphaphu esingamahlalakhona noma ezigugile noma ezigulayo.
- Ukwehluleka kwe-adrenal kungenzeka, imvamisa ngemuva kwenyanga eyodwa. Funa ukwelashwa uma kukhona kulezi zimpawu: isicanucanu, ukuhlanza, i-anorexia, ukukhathala, ubuthakathaka, isiyezi, nomfutho wegazi ophansi.
- IHydrocodone noma i-oxycodone ingadala umfutho wegazi ophansi kakhulu.
- Ungasebenzisi i-hydrocodone noma i-oxycodone ezigulini ezingakhubazekile noma ezikwi-coma.
- IHydrocodone noma i-oxycodone ingakhuphula ubungozi bokuquleka ezigulini ezinenkinga yokubanjwa.
- I-Hydrocodone noma i-oxycodone akufanele ihoxiswe ngokungazelelwe kodwa kufanele ithayishwe kancane.
- Ungashayeli noma usebenzise imishini uze wazi ukuthi umuthi ukuthinta kanjani.
- Ama-opioid angaphephile angaba yingozi ebulalayo kunoma ngubani omunye ekhaya, kufaka phakathi izivakashi. Gcina ngokuvikelekile, lapho kungabonakali futhi kufinyeleleke ezinganeni, nasendaweni lapho abanye bengatholakali khona. Buza uchwepheshe wakho wezokunakekelwa kwezempilo ukuthi angawalahla kanjani ama-opioid angasetshenziswanga endaweni yangakini.
Ngoba azikho izifundo ezilawulwa kahle kwabesifazane, i-hydrocodone noma i-oxycodone akufanele isetshenziswe ekukhulelweni ngaphandle kokuthi izinzuzo zidlula izingozi. Ukusetshenziswa isikhathi eside kwama-opioid ngesikhathi sokukhulelwa, kungaba kwenzelwa ukusetshenziswa kwezokwelapha noma okungezona ezokwelapha, kungadala ukuncika emzimbeni enganeni, okuholele ekukhuculweni kwe-neonatal opioid syndrome ngemuva nje kokuzalwa.
Izexwayiso eziqondene ne-acetaminophen (APAP) ezivame ukutholakala ngokuhlanganiswa ne-hydrocodone noma i-oxycodone yilezi:
- I-Acetaminophen ingadala ukusabela okungathi sína kwesikhumba njenge-acute generalized exanthematous pustulosis (AGEP), iStevens-Johnson Syndrome (SJS), kanye ne-epidermal necrolysis (TEN) enobuthi, engabulala. Iziguli kufanele zifune ukwelashwa okuphuthumayo uma kwenzeka ukusabela kwesikhumba.
- Kukhona ingozi yokuhluleka kwesibindi ngenxa ye-APAP. Udokotela wakho kufanele akutshele isilinganiso esiphezulu sansuku zonke se-APAP ongasithatha, futhi kufanele uhlole eminye imishanguzo oyiphuzelayo ye-APAP (njenge-NyQuil).
- I-Hypersensitivity noma i-anaphylaxis kungenzeka. Funa ukwelashwa okuphuthumayo uma kwenzeka noma yiziphi zalezi zimpawu nezimpawu: ukuvuvukala kobuso, umlomo, nomphimbo, ukucindezeleka kokuphefumula, i-urticaria, ukuqubuka, i-pruritus, nokuhlanza.
Imibuzo ebuzwa njalo nge-hydrocodone vs. oxycodone
Yini i-hydrocodone?
I-Hydrocodone iyi-painkiller ye-opioid esetshenziselwa ukwelapha ubuhlungu obungaphenduli kuma-painkillers aqatha. Itholakala ngezindlela ezahlukahlukene, imvamisa nge-acetaminophen ngendlela yeNorco.
Yini i-oxycodone?
I-Oxycodone isidambisi sobuhlungu se-opioid esisetshenziselwa ukwelapha ubuhlungu obungaphenduli kuma-painkillers aqatha. Itholakala ngezinhlobonhlobo zokwakheka, imvamisa iyodwa (kuzo zombili izinhlobo zokukhishwa ngokushesha nezikhishwe isikhathi eside) futhi ngokujwayelekile ne-acetaminophen ngendlela yePercocet.
Ngabe i-hydrocodone ne-oxycodone ziyefana?
Yomibili le mithi ingama-analgesics anamandla e-opioid. Ngenkathi zifana kakhulu, zinokungafani okuthile, njengokufakwa, okuchazwe ngenhla.
Ngabe i-hydrocodone noma i-oxycodone ingcono?
Ezifundweni, yomibili le mithi ikhombisile ukuhlinzeka ngokuqedwa kobuhlungu. Kodwa-ke, yomibili imishanguzo inamandla amakhulu futhi inamandla amakhulu okuhlukumeza. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ukuthola izeluleko ezenziwe zaba ngezakho.
Ngingasebenzisa i-hydrocodone noma i-oxycodone ngenkathi ngikhulelwe?
Akufanele usebenzise i-hydrocodone noma i-oxycodone ngenkathi ukhulelwe ngaphandle kokuthi udokotela wakho anqume ukuthi inzuzo yakho idlula ingozi enganeni. Futhi, ukusebenzisa ama-opioid isikhathi eside kakhulu ngesikhathi sokukhulelwa kungadala ukuncika embungwini, futhi kungaholela ekukhuculweni kwe-neonatal opioid syndrome.
Ngingasebenzisa i-hydrocodone noma i-oxycodone ngotshwala?
Cha. I-Hydrocodone noma i-oxycodone akufanele isetshenziswe notshwala. Inhlanganisela ingaholela ekudambiseni okujulile, ukucindezeleka kokuphefumula, i-coma, noma ukufa.
Ungakwazi yini ukuthatha i-hydrocodone ne-oxycodone ndawonye?
Cha. I-Hydrocodone ne-oxycodone akufanele zisetshenziswe ndawonye. Inhlanganisela ingaba yingozi kakhulu futhi iholele ekucindezelekeni kokuphefumula noma ekufeni. Lesi ngesinye sezizathu esenza kubaluleke kakhulu ukulahla ama-opioid akudala kadokotela lapho engasadingeki. Buza usokhemisi wakho ukuthi ungayilahla kanjani imithi endaweni eseduze nawe.
Kungani abanye abantu basebenzisa i-hydrocodone ngemiphumela yokuzijabulisa?
Ngenkathi kunciphisa ubuhlungu, ama-opioid afana ne-hydrocodone noma i-oxycodone nawo angakhipha i- umphumela euphoric . Ama-opioid anamandla amakhulu okusebenzisa kabi izidakamizwa. Lapho uthatha umuthi we-opioid, sebenzisa kuphela njengoba kunqunyiwe. Ungathathi imithamo eyengeziwe, futhi ungazihlanganisi notshwala. Buza udokotela wakho noma usokhemisi ngokusebenzisana kwezidakamizwa. Lahla imithi lapho ungasayidingi; ungayilondolozi kwesinye isikhathi. Kungaba yingozi kunoma ngubani ekhaya.
