Main >> Izidakamizwa Vs. Umngani >> I-Tramadol vs. oxycodone: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Tramadol vs. oxycodone: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Tramadol ne-Oxycodone kungukunciphisa izinhlungu okuyalelwa yizinhlungu ongazinikwa wena ukuze uthole ubuhlungu obulinganiselayo nobunzima lapho ezinye izindlela zokwelapha zingasebenzi. I-Tramadol ne-oxycodone zihlangana nama-opioid receptors ebuchosheni ukunciphisa ukudluliswa kwesiginali yobuhlungu. Zingasetshenziselwa ukwelapha izinhlobo ezahlukahlukene zobuhlungu kufaka phakathi ubuhlungu be-musculoskeletal kanye nobuhlungu obuthunyelwe ngemuva kokuhlinzwa. Ngenkathi ingasetshenziswa ezinhlotsheni ezifanayo zobuhlungu, le mithi emibili ihlukile futhi yehlukile komunye nomunye.

Uyini umehluko omkhulu phakathi kwe-tramadol ne-oxycodone?

I-Tramadol (amakhuphoni e-Tramadol | Yini i-Tramadol?) I-analgesic ye-opioid kadokotela esetshenziselwa ukwelapha ubuhlungu obuchazwa njengobuphakathi nendawo obunzima lapho i-counter-the-counter noma ezinye izinketho ezingezona ze-opioid zehlulekile ukusiza. Ingasetshenziswa futhi ezinhlungwini ezibuhlungu ezifana nobuhlungu be-post-operative lapho kunengqondo ukucabanga ukuthi izinketho ezinamandla amancane zingashiya isiguli ebuhlungwini obungenangqondo. I-Tramadol ihlangana nama-mu-opioid receptors ohlelweni lwezinzwa oluphakathi (CNS). Lokhu kuguqula ukubona komzimba nokuphendula ebuhlungwini ngezindlela ezikhuphukayo zobuhlungu. I-Tramadol ibuye ivimbe ukutholwa kabusha kwe-norepinephrine ne-serotonin neurotransmitters, nayo ebandakanyekayo endleleni eyehlayo.

Lapho i-tramadol ekuqaleni ifika emakethe, yayingabhekwa njengezinto ezilawulwayo. Ngo-2014, i-Drug Enforcement Administration (DEA) iphinde yahlukanisa i-tramadol njengezinto ezilawulwa yiSheduli IV. I-Tramadol inamandla okuhlukunyezwa noma ukusetshenziswa kabi, futhi ukusetshenziswa kwayo kufanele kuhlolwe eduze.

I-Tramadol iyatholakala njengethebhulethi yomlomo kukho konke ukukhishwa okusheshayo nokukhululwa kokukhishwa. Iyatholakala futhi kuthebhulethi ihlanganiswe ne-acetaminophen, isithako esisebenzayo ku-counter-the-counter Tylenol.

I-Oxycodone (amakhuphoni e-Oxycodone | Yini i-Oxycodone?) Ibuye ibe yisidakamizwa sokunciphisa izinhlungu se-opioid. I-Oxycodone ibophezela kuma-opioid receptors endleleni ye-CNS ebangela ukuvinjelwa kwendlela ebuhlungu ekhuphukayo. Lokhu kuguqula umbono nokuphendula ebuhlungwini futhi kubangele ukucindezeleka okujwayelekile kwe-CNS.

I-Oxycodone yinto elawulwa yiSheduli II. Inamandla aphakeme kakhulu okulutha, ukuhlukumeza nokusetshenziswa kabi.

I-Oxycodone iyatholakala njengethebhulethi yomlomo kukho konke ukukhishwa okusheshayo nokukhululwa kokukhishwa. Iyatholakala futhi ekwakhiweni okuyihlanganisa ne-acetaminophen, i-aspirin, ibuprofen, naloxone, noma i-naltrexone.

Umehluko omkhulu phakathi kwe-tramadol ne-oxycodone
	I-Tramadol	I-Oxycodone
Isigaba sezidakamizwa	I-analgesic ye-Mu-opioid	I-analgesic ye-opioid
Isimo somkhiqizo / ejwayelekile	I-Brand ne-generic iyatholakala	I-Brand ne-generic iyatholakala
Ngubani igama lomkhiqizo?	I-Ultram, i-Ultram ER, i-ConZip	Roxicodone, Oxycontin, Oxaydo, Xtampza ER
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi ekhishwa ngokushesha kanye ne-extended-release	Ithebhulethi ekhishwa ngokushesha kanye ne-release-release, i-concentrate yomlomo womlomo
Uyini umthamo ojwayelekile?	50 mg njalo emahoreni amane kuya kwayisithupha	5 mg kuya ku-15 mg njalo emahoreni amane kuya kwayisithupha
Yelashwa isikhathi esingakanani?	Izinsuku eziyi-7 noma ngaphansi	Izinsuku eziyi-7 noma ngaphansi
Ubani ovame ukusebenzisa umuthi?	Izingane ezineminyaka engu-12 ubudala nangaphezulu, abantu abadala	Izinsana, izingane, abantu abadala

Izimo eziphathwa yi-tramadol ne-oxycodone

I-Tramadol ikhonjisiwe ekuphathweni kobuhlungu obuhlukaniswe njengobulinganiselwe kabuhlungu. Ingasetshenziselwa ubuhlungu obukhulu, njengobuhlungu be-postoperative, noma ukusetshenziswa kwayo kufanele kukhawulelwe ekusetshenzisweni kwesikhashana, ngokuvamile izinsuku ezintathu kuya kweziyisikhombisa. I-Tramadol ingasetshenziswa ekuphathweni kobuhlungu obungapheli, noma kunjalo akuyona into yokuqala ongayikhetha kulokhu.

I-Tramadol isetshenziselwe ukukhululeka ku-restless leg syndrome ezigulini ezinempumelelo encane noma ezingazange ziphumelele ngokwelashwa kwendabuko. Lokhu kusetshenziswa kuthathwa njengokungekho ilebula, okusho ukuthi akuvunyelwe yi-Food and Drug Administration (FDA) yalolu hlobo lokusetshenziswa.

I-Oxycodone ibuye ikhonjiswe ekuphathweni kobuhlungu obuhlukaniswe njengobulinganiselwe kuya kobunzima. Ingasetshenziswa ebuhlungu obukhulu, kepha ukusetshenziswa kwayo kufanele kukhawulelwe ezinsukwini ezintathu kuya kweziyisikhombisa. I-Oxycodone nayo ingasetshenziswa ebuhlungwini obungapheli. Ngenxa yemiphumela yayo emibi yokudangala kwe-CNS, i-oxycodone kumele ibhalwe kancane ngomthamo.

Isimo	I-Tramadol	I-Oxycodone
Ubuhlungu obukhulu obuhlukaniswa njengobulinganiselwe kuya kobunzima	Yebo	Yebo
Ubuhlungu obungapheli	Yebo	Yebo
Ukuphuma ngaphambi kwesikhathi	Ngaphandle kwelebula	Akunjalo
Isifo somlenze esingenasiphetho	Ngaphandle kwelebula	Akunjalo

Ngabe i-tramadol noma i-oxycodone isebenza kahle kakhulu?

Sekuyisikhathi eside i-Oxycodone ibhekwa njengamandla amakhulu kune-tramadol. Ukudambisa izinhlungu kuvame ukuqhathaniswa ngesisekelo se- morphine nokulinganisa okulinganayo . I-Oxycodone inamandla aphindwe ka-1.5 kune-morphine, kuyilapho i-tramadol inamandla amancane uma iqhathaniswa ne-morphine.

Eyodwa funda kuqhathaniswa nokulawulwa kobuhlungu ngemuva kokuhlinzwa ebusweni usebenzisa i-tramadol ne-oxycodone. Kulolu cwaningo, izidakamizwa zanikezwa ngemithambo yegazi ngedivayisi elawulwa yisiguli. Ukulawulwa kobuhlungu kutholakale kufana phakathi kwala maqembu womabili, kungekho mehluko wezibalo phakathi kwalawa amabili. I-Tramadol ayibangeli ukucindezeleka kokuphefumula kuze kufike ezingeni i-oxycodone eyenzayo. Kodwa-ke, iziguli zathola isicanucanu esithe xaxa nge-tramadol. Abaphenyi baphetha ngokuthi i-tramadol inikeze ukuphumula kobuhlungu okuqhathaniswa ne-oxycodone ngaphandle kwengozi yokudangala okukhulu kokuphefumula.

Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kwe-tramadol vs. oxycodone

I-Tramadol ivame ukumbozwa yi-Medicare nezinhlelo zomshuwalense wezidakamizwa ezentengiso, yize eminye imikhawulo ingasebenza. Ukuphendula ubhadane lwe-opioid, abaningi bayabhala ukulinganiselwa nemihlahlandlela kwaqala ukusebenza ngo-2019. Abazuzi be-Medicare Part D abangama-opiate naive banqunyelwe kumuthi kadokotela wezinsuku eziyisikhombisa lapho kugcwaliswa i-opiate okokuqala. (I-opiate naive ichazwa njengongazange uyithathe i-opiate ezinsukwini ezingama-60 ezedlule.) Ngemuva kwezinsuku eziyisikhombisa, uma kudingeka imishanguzo eyengeziwe, abakwa-prescribers banganquma isikhathi eside. Kukhona okuhlukile kule mithetho, njenge-hospice nokunakekelwa okuhlobene nomdlavuza. Okunye ukuxilongwa kobuhlungu obungapheli kuyafaneleka ukunquma okuhlukile futhi. Izinhlelo eziningi zomshuwalense wezentengiselwano zamukele ukulinganiselwa okufanayo kwabahlomulayo. Amakhemisi nawo angaba nezinqubomgomo zawo eziqondene nokugcwaliswa kwemithi ye-opiate.

Izindleko ze-tramadol zingabiza izindleko ezingaphezulu kuka- $ 60 kumathebulethi angama-60 wamandla we-50 mg. Ngesigqebhezana esivela kwaSingleCare, ungathenga lo muthi ngemali engaphezu kuka- $ 12.

Intengo emaphakathi yokuthengisa ye-Oxycodone ingaba ngaphezu kwe- $ 150 yamathebulethi ayi-120 amandla angu-10 mg. Ngesigqebhezana esivela kwaSingleCare, ungagcwalisa lo muthi ngemali engaphansi kuka- $ 40 kuma-pharmacy akhethiwe.

Thola ikhadi lesaphulelo se-SingleCare

	I-Tramadol	I-Oxycodone
Ngokuvamile embozwe umshwalense?	Yebo, ngokulinganiselwa	Yebo, ngokulinganiselwa
Imbozwe ngokujwayelekile yi-Medicare?	Yebo, ngokulinganiselwa	Yebo, ngokulinganiselwa
Umthamo ojwayelekile	60, 50 mg amaphilisi	Amaphilisi angu-120, 10 mg
I-Medicare copay ejwayelekile	Imvamisa ingaphansi kwe- $ 10	Imvamisa ingaphansi kwe- $ 10
Izindleko ze-SingleCare	$ 12- $ 30	$ 37- $ 52

Imiphumela emibi ejwayelekile ye-tramadol ne-oxycodone

Imiphumela emibi ye-tramadol ne-oxycodone ngokuyinhloko ibangelwa ukuxhumana kwabo nohlelo oluphakathi lwezinzwa. Zombili lezi zidakamizwa kungenzeka zidale ikhanda, ukozela, nesiyezi ngenxa yemiphumela yazo yokudangala kwe-CNS. Izenzakalo ezimbi zingaba nzima futhi zingavimbela umsebenzi ojwayelekile wansuku zonke.

Ukudambisa izinhlungu kwe-opiate kuyaziwa ukuthi kubangela ukuqunjelwa, kwesinye isikhathi kubi kakhulu. Kungadingeka ukuthatha izithambisi zendle ngenkathi kudambisa izinhlungu. Ukuqunjelwa isikhathi eside kungadinga ama-laxatives abukhali ngokwengeziwe.

Ishadi elilandelayo alihloselwe ukuthi libe uhlu olubanzi lwemiphumela emibi. Uyacelwa ukuthi ubonane nodokotela noma udokotela wemithi ukuthola uhlu oluphelele.

	UNorco	Vicodin
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ukozela	Yebo	16% -25%	Yebo	Akuchaziwe
Ubuhlungu bekhanda	Yebo	18% -32%	Yebo	Akuchaziwe
Isiyezi / Inwele elikhanyayo	Yebo	26% -33%	Yebo	Akuchaziwe
Ukuqunjelwa	Yebo	24% -46%	Yebo	Akuchaziwe
Isicanucanu	Yebo	24% -40%	Yebo	Akuchaziwe
Ukuhlanza	Yebo	9% -17%	Yebo	Akuchaziwe
Pruritus	Yebo	8% -11%	Yebo	Akuchaziwe
Ukujuluka	Yebo	6% -9%	Yebo	Akuchaziwe
I-Dyspepsia	Yebo	5% -13%	Yebo	Akuchaziwe
Umlomo owomile	Yebo	5% -10%	Yebo	Akuchaziwe
Uhudo	Yebo	5% -10%	Yebo	Akuchaziwe

Umthombo: I-Tramadol ( I-DailyMed I-Oxycodone (I-DailyMed )

Ukusebenzisana kwezidakamizwa kwe-tramadol vs. oxycodone

Ukusetshenziswa kwe-tramadol ne-oxycodone nezinye izidakamizwa ze-CNS ezicindezelayo kufanele kugwenywe lapho kungenzeka. Izidakamizwa ezifana ne-alprazolam ne-diazepam, kanye namanye ama-opiate painkillers, angadala izinga eliyingozi lokudangala kwe-CNS lapho isetshenziswa ne-tramadol noma i-oxycodone. Iziguli zingabonisa ukucindezeleka okukhulu kokuphefumula, ukukhukhumeza okukhulu, umfutho wegazi ophansi, ikhoma noma ukufa.

Izidakamizwa ezithinta ama-serotonergic receptors, njenge-fluoxetine noma i-sertraline, kufanele zisetshenziswe ngokuqapha ezigulini ezithatha i-tramadol noma i-oxycodone. Kukhona amathuba okwanda kwe-serotonin syndrome, engabonakala ngokunyuka kwenhliziyo, umfutho wegazi ophakeme, ukudideka nokuzamazama.

Ithebula elilandelayo alihloselwe ukuthi libe uhlu oluphelele lokuhlangana kwezidakamizwa okungahle kwenzeke. Xhumana nodokotela wezokwelapha ukuthola uhlu oluphelele nezeluleko ngokusebenzisana.

Izidakamizwa	Isigaba Sezidakamizwa	I-Tramadol	I-Oxycodone
I-Alprazolam Clonazepam I-Diazepam I-Midazolam I-Triazolam I-Temazepam	I-Benzodiazepines	Akunjalo	Yebo
I-Cannabidiol (CBD) Insangu Dronabinol	Ama-cannabinoids	Yebo	Yebo
ICarbamazepine I-Phenobarbital	Ama-anti-epileptics	Yebo	Yebo
Dabrafenib Erdafitinib	Ama-immunosuppressive agents	Yebo	Yebo
Unyazi	I-Vasopressor	Yebo	Yebo
I-Aprepitant I-Fosaprepitant	Ama-antiemetics	Akunjalo	Yebo
IGranisetron Dolasetron I-Ondansetron I-Palonosetron I-Ramosetron I-Tropisetron	Abaphikisi be-5HT3	Yebo	Akunjalo
I-Hydrochlorothiazide UFurosemide I-Torsemide Spironolactone	Izidakamizwa	Yebo	Yebo
Isoniazid	I-Antitubercular	Akunjalo	Yebo
I-Naltrexone	Ophikisana naye	Yebo	Yebo
I-Phenelzine I-Linezolid	I-Monoamine oxidase inhibitors	Yebo	Yebo
I-Oxycodone	Opiate	Yebo	Yebo
Pramipexole URopinirole	Ama-agonists eDopamine	Yebo	Yebo
I-Probenecid	I-Uricosuric	Akunjalo	Yebo
I-Ritonavir Ombitasvir I-Paritaprevir Dasabuvir	Amagciwane	Yebo	Yebo
Zolpidem	Ukuthula	Yebo	Yebo
I-Fluoxetine Sertraline I-Paroxetine	I-serotonin reuptake inhibitors ekhethiwe	Yebo	Yebo

Izexwayiso ze-tramadol ne-oxycodone

Ukusetshenziswa kotshwala kufanele kugwenywe ezigulini ezithatha i-oxycodone. Utshwala bungakhuphula ukugcwala kwe-serum kwe-oxycodone ngakho-ke kuthuthukise imiphumela ecindezelayo ye-CNS. Lokhu kungaholela emazingeni ayingozi wokudangala kokuphefumula.

Ababhali bangadinga ukulungisa isilinganiso somthamo noma sokulinganisa kokubili i-tramadol noma i-oxycodone ezigulini ezinokulimala kwesibindi noma ukusebenza kwezinso okungasebenzi kahle.

I-Tramadol ne-oxycodone yizigaba C zokukhulelwa, okusho ukuthi azikho izifundo zabantu ezifakazela ukulimala noma ukuphepha ezigulini ezikhulelwe. Ukusetshenziswa kwale mithi kufanele kukhawulelwe ekusetshenzisweni okudingekayo kuphela. I-Oxycodone ikhona obisini lwebele lomama abancelisayo; kanjalo, omama abancelisayo kufanele basebenzise i-oxycodone kuphela lapho inzuzo isobala ukuthi ingaphezu kwengozi. I-Tramadol akufanele isetshenziswe komama abancelisayo ngoba i-metabolite yayo esebenzayo inamandla kakhulu futhi ingaholela ekuhoxisweni kwe-opioid ezinganeni.

I-Tramadol ne-oxycodone ngayinye inamandla amakhulu okuhlukumeza, ukusebenzisa kabi, ukuthembela emzimbeni nokulutha. Kufanele zisetshenziswe kuphela lapho zonke ezinye izindlela zokwelashwa ezingekho opiate seziphelile. Ukusetshenziswa kwabo kufanele kube nomkhawulo wesikhashana ngangokunokwenzeka. Uma isiguli besithatha ama-opiate pain relievers isikhathi eside, bangahle babe nezimpawu zokuhoxa uma bema ngokungazelelwe. Ukuyekiswa ngemuva kwedosi ephezulu nokusetshenziswa kwesikhathi eside kwama-opioid analgesics kufanele kwenziwe ngokuqapha kodokotela.

Ukudambisa izinhlungu kwe-opiate kufanele kusetshenziswe kuphela ezinganeni uma kunesidingo; imvamisa kusimo sesiguli lapho zingabhekwa khona. Ingozi enkulu yokudangala kokuphefumula yenza le mishanguzo ibe yingozi kakhulu ezinganeni.

Imibuzo ebuzwa njalo nge-tramadol vs. oxycodone

Yini i-tramadol?

I-Tramadol isidambisi sobuhlungu se-mu-opioid agonist esitholakala ngudokotela kuphela. Kuyinto elawulwa yiSheduli IV. Iyatholakala njengethebhulethi yomlomo ekwakhiweni okushesha-kokukhishwa nokwandiswa.

Yini i-oxycodone?

I-Oxycodone iyi-opioid agonist pain reliever etholakala ngemithi kadokotela kuphela. Kuyisidakamizwa seSheduli II futhi kubangela ukucindezeleka okukhulu kwe-CNS. Iyatholakala njengethebhulethi yomlomo ekwakhiweni okushesha-kokukhishwa nokwandiswa.

Ngabe i-tramadol ne-oxycodone ziyefana?

Ngenkathi zombili i-tramadol ne-oxycodone kungukunciphisa izinhlungu ze-opiate, akufani. I-Oxycodone iyi-narcotic yeSheduli II futhi ibangela ukucindezeleka okukhulu kwe-CNS, kufaka phakathi ukucindezeleka kokuphefumula. I-Tramadol yinto elawulwa ngoHlelo IV futhi ayibangeli inani elikhulu lokudangala kokuphefumula.

Ngabe i-tramadol noma i-oxycodone ingcono?

I-Oxycodone iphindwe ka-1.5 amandla e-morphine, kuyilapho i-tramadol iyingxenyana nje yamandla e-morphine. Kodwa-ke, ucwaningo olwenziwe ezigulini ezangemva kokuhlinzwa lwathola ukukhululeka kobuhlungu obufanayo ngazo zombili izidakamizwa. I-Tramadol ibanga ukudangala kokuphefumula okuncane, kepha eminye imiphumela emibi, efana nesicanucanu, ingaba yimbi kakhulu nge-Tramadol.

Ngingayisebenzisa i-tramadol noma i-oxycodone ngenkathi ngikhulelwe?

Ukusetshenziswa kwe-tramadol noma i-oxycodone lapho ukhulelwe kufanele kukhawulelwe kuphela lapho kunesidingo esikhulu njengoba kungazange kube khona ukuhlolwa kwabantu okungahleliwe, okulawulwa ukufakazela ukuphepha kwabo. Inzuzo yokusetshenziswa kumele idlule ubungozi, futhi izinsana kufanele ziqashwe i-opioid syndrome yokuhoxiswa uma le mithi isetshenziswa isikhathi eside.

Ngingayisebenzisa i-tramadol noma i-oxycodone ngotshwala?

Iziguli ezithatha i-tramadol noma i-oxycodone kufanele zigweme ukusebenzisa utshwala. Utshwala bungathuthukisa imiphumela edabukisayo ye-CNS yalezi zidakamizwa, engaholela ezenzakalweni ezimbi kakhulu njengokucindezelwa ukuphefumula, ikhoma noma ukufa.

Ingabe i-tramadol iyi-opiate?

Yebo. I-Tramadol ixhumana ne-mu-opioid receptor ukunciphisa ukudluliswa kwesiginali yezinhlungu ku-CNS. Yenziwe ngokuhlanganiswa, futhi kucatshangwa ukuthi ayilutha kangako kunezinye izinhlungu ezithambisa opioid.

Ingabe i-tramadol iyisithambisi semisipha?

Cha, i-tramadol ayisona isidambisi semisipha. Indlela esebenza ngayo ifaka ukudluliswa kwesiginali yobuhlungu kepha ayithinti ngqo ukusebenza kwemisipha.