Funda imiphumela emibi ye-finasteride nokuthi ungayibalekela kanjani

Imininingwane Yezidakamizwa

I-Finasteride ngumuthi ofana ne-steroid ovame ukwelashwa ukwelapha i-benign prostatic hyperplasia (i-prostate ekhulisiwe) nempandla yephethini yabesilisa. Cishe uzoyithola kumakhabethe emithi nasemakhemisi njengamagama ezimpawu I-Proscar noma I-Propecia , yize i- uhlobo olujwayelekile iyatholakala.

Isidakamizwa sisebenza ngokuvimbela ukuguqulwa kwe-testosterone ibe yi-dihydrotestosterone (DHT), ebangela ukukhula kwendlala yesinye kanye nokuncipha kwezinwele. Iphumelele ekwehliseni usayizi wendlala yeziguli eziningi futhi okubili kokuthathu kwamadoda ayithathayo ukuthola umbiko wokulahleka kwezinwele , ngokusho kukaHarvard. Ngenkathi izifundo ezithile ze-finasteride baphakamise ukubuyiselwa kwezinwele zabesifazane futhi, akujwayelekile ukuthi kunikezwe abesifazane noma izingane, ikakhulukazi abesifazane abakhulelwe, ngoba kungadala ukukhubazeka kokuzalwa.

Ngasikhathi sinye ukwelapha ukulahleka kwezinwele zamaphethini wesilisa ne-BPH, ukukhathazeka okubili okusabalele kwabesilisa, kwenza i-finasteride ibonakale njengedrug yezempilo yabesilisa. Ingabe kunjalo? Yize ilusizo ngokumangazayo, i-finasteride ayiphelele. Bheka ngale kwezinzuzo ezisezingeni eliphezulu, futhi uzothola imiphumela emibi eyahlukahlukene ye-finasteride, izexwayiso, nokuhlangana kwezidakamizwa. Funda ukuze ubheke ngokujulile kuwo womathathu.

OKUSHIWO: Yini iProscar? | Kuyini iPropecia? | Yini iFinasteride?

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Imiphumela emibi ye-finasteride

I-Propecia ne-Proscar ngokuvamile zibekezeleleka kahle, kepha ziza nemiphumela emibi eminingi engaba khona. I-Finasteride ingeyesigaba sezidakamizwa esibizwa nge-5-alpha reductase inhibitors, esithinta amazinga e-hormone futhi sinciphise ukusebenza kwamahomoni wesilisa, kwesinye isikhathi okudala imiphumela emibi yokuzala efana:

• Ukungasebenzi / ukungasebenzi kahle kwe-erectile (kuguqulwa ngokuyekiswa kwemithi)
• Ukuphazamiseka kokuchama
• Ukwehla kwevolumu ye-ejaculate
• Kwehlisiwe isibalo sesidoda
• Ukuncipha kocansi

Ngaphezu kwemiphumela emibi ebhalwe ngenhla, eminye imiphumela emibi ejwayelekile ebikwe ngezehlakalo ezibalelwa ku-1% -10% yeziguli ezithatha umuthi zifaka:

• I-Orthostatic hypotension (umfutho ophansi wegazi lapho umile)
• Isiyezi
• Ubuhlungu bekhanda
• Ubuthakathaka

Ekugcineni, imiphumela emibi ejwayelekile, evame ukubonwa ngaphansi kwe-1% -2% yeziguli ezithatha i-finasteride, zifaka:

• Iphunga eligijimayo
• Ukuqhuma kwesikhumba
• Umfutho wegazi ophansi
• Ubuhlungu besende
• Ubumnene besifuba

Iziguli ezithatha i-finasteride nazo zingathola ukwanda kokuchama. Kodwa-ke, ekwelapheni i-BPH (okuvame ukuvimbela ukuchama), lokhu kungabonisa ukubuyela ekugelezeni okunempilo komchamo.

Zama ikhadi lesaphulelo le-SingleCare

Imiphumela emibi ye-finasteride

Imiphumela emibi ejwayelekile ye-finasteride yanele ukuba ibe yinto ephazamisayo, kepha ayilutho olujwayelekile emithini kadokotela. Ezimweni ezingavamile, noma kunjalo, imiphumela emibi kakhulu engaba khona edinga ukwelashwa. Lokhu kufaka phakathi:

• Ukungasebenzi kahle kwe-erectile okuqhubekayo : Phakathi ku isifundo sakamuva , 1.4% wamadoda aqala ukwelashwa kwe-5-alpha reductase inhibitor athuthukise ukungasebenzi kahle kocansi okwaqhubeka okungenani ezinsukwini ezingama-90 ngemuva kokuyeka umuthi. Akukona ukungabi namandla okuhlala njalo njengoba eminye imithombo yezindaba ibikile, kodwa ingathinta impilo yocansi yansuku zonke ngesikhathi nangemva kokwelashwa.
• Ukungabi nenzalo: Ukucaca, lokhu akuyona inzalo impilo yonke. Amanye amadoda angathola ikhwalithi yesilisa engeyinhle ngenkathi ethatha i-finasteride, evame ukuba ngcono ngemuva kokuyekiswa komuthi.
• Ukudangala: I-Finasteride kungadala ushintsho ku-hippocampus , ecubungula izimpendulo ezingokomzwelo, okuholela ezimweni zokudangala nemicabango yokuzibulala. Ingcindezi nokukhathazeka nakho kungavela ekusebenzeni kocansi okungahle kuvinjelwe.
• Ingozi eyengeziwe yomdlavuza webele: Izifundo ezithile bangabaze ukuxhumana phakathi kokwelapha i-finasteride nomdlavuza wamabele wesilisa, kanti abanye abakatholanga ukuhlangana. Noma kunjalo, noma ngubani odla lesi sidakamizwa kufanele azi izinkomba zomdlavuza njengokukhuliswa kwebele, ukuvuvukala, ubuhlungu, izigaxa, noma ukukhishwa kwengono, futhi avakashele udokotela uma le miphumela emibi iqhubeka.
• Ingozi ephezulu yomdlavuza wesibeletho osezingeni eliphakeme : Ngokuya nge- isifundo esenziwe yiNew England Journal of Medicine , i-finasteride inciphisa ubungozi besifo somdlavuza wesibeletho esisezingeni eliphansi, kepha ingakhuphula ubungozi besifo somdlavuza wendlala ephezulu. Imiphumela yesikhathi eside iveze ukuthi akukho mehluko emiphumeleni yokusinda ngokuqhathanisa iziguli ezithola i-finasteride kuqhathaniswa ne-placebo, futhi okucatshangwa ukuthi banikeli kulokhu okutholwayo ukuthi i-finasteride empeleni ithuthukisa ikhono lokuthola lolu hlobo lomdlavuza.
• Ukusabela okweqile: Ezimweni ezingavamile, i-finasteride ingadala ukusabela okweqile komzimba. Izinkomba ezinjengezinyosi, ukuphefumula kanzima, nokuvuvukala kolimi noma komphimbo kugunyaza ukwelashwa ngokushesha.

Izinkinga zombono aziwona umphumela ojwayelekile we-finasteride side, yize isifundo esisodwa ithole ukuhlangana. Kodwa-ke, bekungusayizi wesampula omncane, ngakho-ke ukuhlolwa okuqhubekayo kungadingeka ekuqinisekisweni. Kepha lokhu akusho ukuthi akunangozi ngokuphelele kumbono wakho. Ngokusho kukaDkt. Yuna Rapaport, MD, MPH, umqondisi we IManhattan Eye , i-finasteride uqobo ingadala ukulimala okungaphansi kwe-retina kanye ne-optic nerve, engahle ingathinti umbono wakho wangempela, kepha ingatholwa esithombeni esikhethekile. Ngokwengeziwe, imishanguzo efanayo ye-Prostate efana neFlomax ingathinta indlela i-iris evimba ngayo futhi yenze ukuhlinza okuthile, ikakhulukazi ukuhlinzwa kwe-cataract, kube nzima kakhulu.

Ukuwohloka komqondo kungakhathaza, ikakhulukazi ngoba i-dihydrotestosterone ithinta ukusebenza kwengqondo. I- Ijenali Yezesayensi Yezinzwa ithole ubungozi obuphakeme bokuwohloka komqondo phakathi neminyaka emibili yokuqala yokwelashwa kwe-5-alpha reductase inhibitor, kepha akukho bungozi obengeziwe ngemuva kwalokho.

Ngemuva kokuthola (noma ukufunda mayelana) neminye yale miphumela emibi, amanye amadoda azofuna ukunquma ukwelashwa kwawo nge-finasteride. Ayikho imiphumela emibi noma ukuhoxiswa ngemuva kokuyeka i-finasteride abandayo turkey, kepha ukulahleka kwezinwele nokukhula kwe-prostate kungenzeka kuqale kabusha ngaphandle kokuthi kungene okunye ukwelashwa.

Izexwayiso nge-Finasteride

Ngokuvamile, i-finasteride iyindlela yokwelashwa ephephile. Lokho kusho, mhlawumbe ukuthatha okukhulu kunakho konke okuvela emiphumeleni emibi ukuthi akukhona okwabo bonke abantu. Ngokusho kwe- Imininingwane yezidakamizwa zePropecia kumenzi wayo, uMerck, kanye ne-FDA, i-finasteride ayikhonjisiwe ukuthi ingasetshenziswa kwabesifazane noma ezigulini zezingane. Futhi lokhu kunjalo ikakhulukazi kwabesifazane abakhulelwe. Umphumela wesidakamizwa ezinganeni zesilisa ezingakazalwa ungaba yingozi kakhulu kangangokuba i-FDA ixwayisa omama abalindele ukuthi bangaze baphathe ngisho namaphilisi e-Propecia aphukile noma agayiwe.

Noma ngubani onesifo esivele sikhona sesibindi noma ukusebenza kwesibindi ngokungajwayelekile kufanele aqaphele lapho esebenzisa i-finasteride ngoba ngokuyinhloko ihlanganiswe emzimbeni wesibindi. Akukho ukulungiswa komthamo othile okwelulekayo.

Kunemithamo emibili ejwayelekile ye-finasteride: 1 mg no-5 mg. Lapho isetshenziselwa ukukhula kwezinwele ezigulini ezinempandla yamadoda noma i-androgenetic alopecia, odokotela bajwayele ukubeka imithamo engu-1 mg, kanti iziguli ze-BPH zivame ukudinga u-5 mg. Ukweqiwa okungaphezu kwe-5 mg akunconyiwe.

Yize i-finasteride ingaphatha ukulahleka kwezinwele, ukusetshenziswa okuqhubekayo kuyadingeka ukugcina imiphumela yayo. Isiguli esiqala ukwelashwa nge-finasteride sibona imiphumela, bese siyama, sizobona leyo miphumela ibuyela emuva. Umthamo we-1 mg ngu iphephile ukusetshenziswa isikhathi eside , kodwa futhi kungadala imiphumela emibi enwetshiwe.

Ukusebenzisana kwe-Finasteride

Yize kunemiphumela engemihle kanye nezixwayiso, i-finasteride ayikhombisanga ukusebenzisana okuphawulekayo nanoma iziphi ezinye izidakamizwa ekuhlolweni kwemitholampilo. Noma kunjalo, kunemibuzo ejwayelekile mayelana nokuthatha imithi ethile ejwayelekile eceleni kwePropecia noma iProscar.

Iziguli ezikhathazeka ngokuthambekela kwe-finasteride ukudala ukungasebenzi kahle kwe-erectile (ED) nezinye izinkinga zokuzala zingazibuza ukuthi zingakuthatha ngasikhathi sinye neViagra, Cialis, noma ezinye izidakamizwa ze-ED. Impendulo inguyebo. Hhayi kuphela ukuthi zingasetshenziswa ndawonye, ​​kepha ukusetshenziswa ngasikhathi sinye kungasiza ukunciphisa noma ukuvimbela imiphumela ethile emibi yocansi.

Kepha kuthiwani ngezinye izindlela zokwelapha zokukhulisa izinwele ezifana Rogaine ( I-minoxidil ) noma i-biotin ? Yebo, zombili lezi ziphephile ukusetshenziswa ngasikhathi sinye ne-finasteride . Khumbula, noma kunjalo, ukuthi iRogaine inemiphumela yayo emibi, isiguli esingaba nayo eceleni kwemiphumela emibi ye-finasteride.

Ukwelashwa kokushintshwa kwe-testosterone kuphephile ukusetshenziswa ne-finasteride ezigulini ezine-testosterone ephansi.

Kuthiwani ngotshwala? Ngokuvamile, utshwala ne-finasteride kuyinhlanganisela ephephile. Noma kunjalo, izifundo ezithile kukhombisa ukuthi nsuku zonke, ukuphuza ngokweqile kungakhuphula ubungozi besifo somdlavuza wesibeletho osezingeni eliphezulu, njengoba kwenza ne-finasteride. Ngakho-ke, ukusebenzisa lesi sidakamizwa ngokusetshenziswa kotshwala okuphezulu nsuku zonke ngokweqile kungenza ubungozi.

Ungayigwema kanjani imiphumela emibi ye-finasteride

Ngeshwa, imiphumela emibi ayivikeleki ngaso sonke isikhathi. Kwesinye isikhathi, ziyenzeka nje. Noma kunjalo, ezinye izinyathelo nezinyathelo zokuqapha zinganciphisa ubungozi bemiphumela emibi ye-finasteride.

Ukuqapha okuyisisekelo kakhulu ukuthatha imithi njengoba kunqunywe uchwepheshe wezokunakekelwa kwempilo. Iziguli zingakuthatha nokudla noma ngaphandle kokudla, kepha kufanele zithathe kuphela umthamo owodwa ngosuku (nganoma yisiphi isikhathi sosuku). Imvamisa, imiphumela yesidakamizwa ayibonakali izinyanga ezintathu, ngemuva kwalokho ukusetshenziswa okungaguquki kuyadingeka ezinzuzweni eziqhubekayo.

Futhi, khumbula ukuthi eminye imiphumela emibi ingahle ibe yesikhashana. Imiphumela engemihle ingancipha njengoba uqhubeka nokuphuza umuthi, futhi ayaphela ngokuphelele ngemuva kokuyeka imithi, ngokusho kukaDkt Rapaport. Ngakho-ke, iziguli ezihlangabezana nezehlakalo ezimbi zivame ukubamisa ngokuyeka imithi. Kunezimo ezithile zokungasebenzi kahle kwezocansi ezingaphikelela isikhathi eside ngaphambi kokuthi ziphele ekugcineni.

Okusemqoka yilokhu: Ngabe izinzuzo ze-finasteride zidlula imiphumela emibi engaba khona? Kodwa impendulo ayilula. Kuyahluka kumuntu ngamunye, kuya ngesimo sabo, umlando wezokwelapha, izinto eziza kuqala, nokuningi. Isinyathelo esihle kakhulu kunoma ngubani ocabanga umuthi ofana nePropecia noma iProscar ukuthola izeluleko kudokotela.