ICymbalta vs. Effexor: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
ICymbalta (duloxetine) ne-Effexor (venlafaxine) yimithi enegama lomkhiqizo esetshenziselwa ukwelapha izimo zengqondo ezinjengokudangala nokukhathazeka. Imvamisa kunqunywa njenge-anti-depressants ukusiza ukukhulula izimpawu zesifo sokucindezeleka okukhulu. Izimpawu zesifo sokucindezeleka ezinkulu zingafaka ukudabuka okuqhubekayo kanye nokulahlekelwa okukhulu kwesithakazelo emisebenzini yansuku zonke.
ICymbalta ne-Effexor bobabili basekilasini lezidakamizwa ezibizwa nge-serotonin ne-norepinephrine reuptake inhibitors (SNRIs). Zisebenza ngokwandisa ukutholakala kwe-serotonin ne-norepinephrine ebuchosheni. Lawa makhemikhali, noma ama-neurotransmitters, kukholakala ukuthi adlala indima lapho kwenzeka ukuphazamiseka kwempilo yengqondo.
Ngenhloso yokuqhathanisa, igama i-Effexor lingabhekisa naku-Effexor XR, okuwukuphela kwegama lomkhiqizo i-Effexor okwamanje elitholakala emakethe.
Uyini umehluko omkhulu phakathi kweCymbalta ne-Effexor?
ICymbalta
ICymbalta yigama lomkhiqizo le-duloxetine. Iyatholakala njenge-capsule ekhishwe ngomlomo ebambezelekile ngamandla we-20 mg, 30 mg, noma i-60 mg. Imvamisa ithathwa njengephilisi elilodwa ngomlomo kanye nsuku zonke kuye ngesimo esiphathwayo. Umthamo omkhulu ngosuku ngu-120 mg yize kungekho bufakazi bokuthi imithamo mkhulu kune-60 mg unikeze ukwanda okuphawulekayo kwenzuzo.
ICymbalta ine-half-life yamahora angama-12. Ihlanganiswe ngokuyinhloko futhi isuswe ngesibindi nezinso. Ukusetshenziswa kwayo kufanele kugwenywe kulabo abanokukhubazeka okukhulu kwesibindi noma kwezinso.
I-Effexor
I-Effexor igama lomkhiqizo le-venlafaxine. Kodwa-ke, igama lomkhiqizo i-Effexor litholakala kuphela njenge-Effexor XR, noma amaphilisi wokukhishwa enwetshiwe e-venlafaxine. Ukukhishwa ngokushesha i-Effexor kunqanyuliwe ngoba kudinga ukuthi kukhishwe izikhathi eziningi usuku lonke futhi kubangele isicanucanu esiningi kunenguqulo ekhishwe isikhathi eside.
I-Effexor XR iza ngamaphilisi omlomo ngamandla we-37.5 mg, 75 mg, no-150 mg. Umthamo ungahluka ngokuya ngesimo esiphathwayo. Kodwa-ke, i-Effexor XR ivame ukuthathwa kanye nsuku zonke ngomthamo wansuku zonke ohlosiwe ongu-75 mg kanye nomthamo omkhulu wansuku zonke ka-225 mg.
NjengeCymbalta, i-Effexor ihlanganiswa nesibindi futhi inengxenye yengxenye yempilo ye- kufika emahoreni ayi-11 . Ingasetshenziswa kulabo abanesibindi noma ukukhubazeka kwezinso uma kuthathwa amanani aphansi.
| Umehluko omkhulu phakathi kweCymbalta ne-Effexor | ||
|---|---|---|
| ICymbalta | I-Effexor | |
| Isigaba sezidakamizwa | ISerotonin ne-norepinephrine reuptake inhibitor (SNRI) | ISerotonin ne-norepinephrine reuptake inhibitor (SNRI) |
| Isimo somkhiqizo / ejwayelekile | Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala |
| Ngubani igama elijwayelekile? | I-Duloxetine | I-Venlafaxine |
| Izidakamizwa zingena ngaziphi izinhlobo? | I-capsule yomlomo, ukukhishwa okude | I-capsule yomlomo, ukukhishwa okude |
| Uyini umthamo ojwayelekile? | 60 mg kanye ngosuku | 75 mg kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Isikhati eside | Isikhati eside |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nentsha | Abantu abadala nentsha |
Izimo eziphathwe yiCymbalta ne-Effexor
ICymbalta yi-FDA evunyelwe ukwelapha ukucindezeleka okukhulu (MDD) kanye ne-generalized anxiety disorder (GAD). Ingasetshenziselwa ukwelapha ubuhlungu obuvela ku-fibromyalgia kanye nesifo sikashukela se-neuropathy, kanye nobuhlungu obujwayelekile emisipheni, emisipheni, emigudwini nasemathanjeni. I-Cymbalta kwesinye isikhathi ingasetshenziswa ngaphandle kwelebula kwezinye izinkinga zokukhathazeka.
I-Effexor XR ivunyelwe yi-FDA ukwelapha ukucindezeleka okukhulu (MDD), ukukhathazeka okujwayelekile (GAD), ukukhathazeka komphakathi (SAD), ne-panic disorder (PD). Kwesinye isikhathi kuyasetshenziswa ngaphandle kwelebuli ukwelapha ukukhathazeka ngokweqile (OCD), premenstrual dysphoric disorder (PMDD), nobuhlungu.
| Isimo | ICymbalta | I-Effexor |
| Ukucindezeleka okukhulu | Yebo | Yebo |
| Isifo sokukhathazeka esijwayelekile | Yebo | Yebo |
| Inkinga yokukhathazeka komphakathi | Ngaphandle kwelebula | Yebo |
| Ukuphazamiseka kovalo | Ngaphandle kwelebula | Yebo |
| Ubuhlungu bezinzwa zesifo sikashukela | Yebo | Ngaphandle kwelebula |
| I-Fibromyalgia | Yebo | Ngaphandle kwelebula |
| Ubuhlungu obungapheli bemisipha | Yebo | Ngaphandle kwelebula |
| Ukuphazamiseka okubangelwa ukucindezela | Akunjalo | Ngaphandle kwelebula |
| Ukuphazamiseka kwangaphambi kokuya esikhathini | Akunjalo | Ngaphandle kwelebula |
Ngabe iCymbalta noma i-Effexor isebenza kangcono?
Ukusebenza kweCymbalta noma i-Effexor kuya ngesimo eselashwa. Izifundo ezimbalwa kakhulu eziqhathanise ngqo iCymbalta ne-Effexor. Kodwa-ke, uma kuqhathaniswa ne-placebo, iCymbalta ne-Effexor zombili zisebenza kakhulu ekwelapheni izimo ezinjengokudangala okukhulu.
Ucwaningo olulodwa lwahlanganisa izivivinyo eziningi zokwelashwa futhi lwathola ukuthi i-venlafaxine ingcono inketho yokwelashwa yesikhashana ngokudangala okukhulu kune-duloxetine. I-Venlafaxine, isithako esisebenzayo se-Effexor, nayo ingakhethwa kulabo abangaphenduli kahle ekwelashweni kokuqala ngama-serotonin reuptake inhibitors (SSRIs) akhethiwe noma ama-trideclic antidepressants (TCAs). Kodwa-ke, ucwaningo luthole ukuthi bekungekho mehluko omkhulu ekuphenduleni nasezingeni lokuphendula phakathi kwe-duloxetine ne-venlafaxine.
Okunye ukubuyekeza okuhlelekile kuqhathaniswa i-venlafaxine, i-duloxetine, nezinye izidakamizwa zokulwa nengcindezi njenge-paroxetine, i-fluoxetine, ne-fluvoxamine. Uma kuqhathaniswa nezinye izinketho, i-venlafaxine itholwe njengenye ye-anti-depressants esebenza kahle kakhulu. Kodwa-ke, i-venlafaxine ne-duloxetine babalwa njengezinye ze-anti-depressants ezingabekezeleleki kakhulu, maqondana nemiphumela emibi.
Xhumana nomhlinzeki wezokunakekelwa kwezempilo ogxile ekunakekeleni izifo zengqondo ukuze uthole ukwelashwa okungcono kakhulu kuwe.
Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweCymbalta ne-Effexor
ICymbalta ngumuthi kadokotela osetshenziswa ukucindezela ukucindezelwa. Uhlobo olujwayelekile, i-duloxetine, imvamisa luhlanganiswa yiMedicare nezinhlelo zomshuwalense. Ngokunikezwa kwezinsuku ezingama-30, intengo emaphakathi yokuthengisa ingaphezulu kwe- $ 470. Ngekhuphoni le-SingleCare Cymbalta, intengo yenguqulo ejwayelekile iqala ku- $ 15 kuma-pharmacy abambe iqhaza.
Amathebulethi e-Effexor XR ayatholakala ukuthi angathengwa ngomuthi kadokotela. Amaphilisi weGeneric Effexor XR avame ukumbozwa ngabakwaMedicare nezinhlelo zomshuwalense. Ngamanani aphakathi kwe- $ 145, i-Effexor XR ishibhile kuneCymbalta. Kodwa-ke, ukusebenzisa isigqebhezana se-Effexor XR kusuka ku-SingleCare kungaletha izindleko ngisho nangaphezulu. Buza usokhemisi wakho ngomuthi ojwayelekile bese uwuthola cishe u- $ 15.
| ICymbalta | I-Effexor | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Ubuningi | Amaphilisi angama-30 | Amaphilisi angama-30 |
| I-Medicare copay ejwayelekile | $ 0– $ 89 | $ 0– $ 1 |
| Izindleko ze-SingleCare | $ 15 + | $ 15 + |
Imiphumela emibi ejwayelekile yeCymbalta vs. Effexor
Imiphumela emibi kakhulu yeCymbalta ifaka isicanucanu, ikhanda, umlomo owomile, ukudinwa noma ukozela, ukuqunjelwa, nokukhathala. ICymbalta nayo ingadala isifo sohudo, ukuncipha kwesifiso sokudla, ukujuluka okwandayo, nobuhlungu besisu, phakathi kweminye imiphumela emibi.
Imiphumela emibi evame kakhulu ye-Effexor yisicanucanu, ikhanda elibuhlungu, umlomo owomile, ubuthakathaka kanye nokudangala komzimba. I-Effexor nayo ingadala ukuqwasha, ukuqunjelwa, isiyezi, isifo sohudo, nokwehla kwesifiso sokudla.
Kokubili iCymbalta ne-Effexor nakho kungadala ukwehla kwe-sex drive (libido). Kodwa-ke, i-Effexor ikhonjisiwe ukuthi ibangele izinkinga zokungasebenzi kahle ngokocansi kuneCymbalta.
Bona ithebula elingezansi ngeminye imiphumela emibi ejwayelekile yeCymbalta ne-Effexor.
| ICymbalta | I-Effexor | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Isicanucanu | Yebo | 2. 3% | Yebo | 4% |
| Ubuhlungu bekhanda | Yebo | 14% | Yebo | amaphesenti amabili |
| Umlomo owomile | Yebo | 13% | Yebo | ishumi nanhlanu% |
| Ukozela | Yebo | 10% | Yebo | amaphesenti amabili |
| Ubuthakathaka | Akunjalo | - | Yebo | amaphesenti amabili |
| Ukukhathala | Yebo | 9% | Akunjalo | - |
| Ukuqwasha | Yebo | 9% | Yebo | amaphesenti amabili |
| Ukuqunjelwa | Yebo | 9% | Yebo | 9% |
| Isiyezi | Yebo | 9% | Yebo | 16% |
| Uhudo | Yebo | 9% | Yebo | 8% |
| Ukwehla kwesifiso sokudla | Yebo | 7% | Yebo | * |
| Ukujuluka okwengeziwe | Yebo | 6% | Yebo | 1% |
| Ubuhlungu besisu | Yebo | 5% | Yebo | * |
| Kwehlisiwe i-libido | Yebo | 3% | Yebo | 5% |
| Umbono ongajwayelekile | Yebo | 3% | Yebo | 4% |
| Inhliziyo ishaya ngamandla | Yebo | amaphesenti amabili | Yebo | amaphesenti amabili |
* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( ICymbalta ), IDailyMed ( I-Effexor )
Ukusebenzisana kwezidakamizwa kweCymbalta vs. Effexor
ICymbalta ne-Effexor akumele isetshenziswe nge-monoamine oxidase inhibitors (MAOIs) efana ne-selegiline ne-phenelzine. ICymbalta noma i-Effexor akufanele isetshenziswe kungakapheli izinsuku eziyi-14 zokuyekisa i-MAOI. Uma kungenjalo, kunengozi eyengeziwe ye-serotonin syndrome, isimo esibi esingadinga usizo oluphuthumayo lwezokwelapha.
Kungaba nobungozi be-serotonin syndrome lapho iCymbalta noma i-Effexor ithathwa kanye nomunye umuthi we-serotonergic. Izidakamizwa zeSerotonergic zifaka phakathi ama-serotonin reuptake inhibitors (SSRIs) akhethiwe kanye nama-tricyclic antidepressants (TCAs). Ukuqapha kufanele kusetshenziswe uma usebenzisa izidakamizwa ze-serotonergic ngeCymbalta noma i-Effexor.
Izidakamizwa ezifana ne-paroxetine noma i-fluoxetine zingaphazamisa imetabolism yeCymbalta futhi zikhuphule amazinga egazi layo. Lokhu kungaholela engcupheni eyengeziwe yemiphumela emibi ngeCymbalta.
ICymbalta ne-Effexor kufanele isetshenziswe ngokuqapha noma igwenywe ngemithi elwa nokuvuvukala (ama-NSAID) kanye nama-anticoagulants. Ukusebenzisa le mithi ndawonye kungandisa ingozi yokopha.
| Izidakamizwa | Isigaba sezidakamizwa | ICymbalta | I-Effexor |
| USelegiline I-Phenelzine I-Rasagiline | I-Monoamine oxidase inhibitors (MAOIs) | Yebo | Yebo |
| I-Paroxetine Sertraline I-Fluoxetine | I-serotonin reuptake inhibitors ekhethiwe (SSRIs) | Yebo | Yebo |
| Amitriptyline I-Clomipramine I-Nortriptyline | I-Tricyclic antidepressants (TCAs) | Yebo | Yebo |
| I-Aspirin Ibuprofen I-Naproxen I-Diclofenac | Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) | Yebo | Yebo |
| I-Warfarin | Ama-anticoagulants | Yebo | Yebo |
Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka
Izexwayiso zeCymbalta ne-Effexor
Ukwehluleka kwesibindi kubikwe ngokusetshenziswa kweCymbalta. Kulabo abanomlando wokusebenzisa kabi utshwala noma ukungasebenzi kwesibindi, iCymbalta kufanele igwenywe. Ukusetshenziswa kweCymbalta kufanele kuyekwe kulabo abahlakulela izimpawu zokuhluleka kwesibindi, njenge-jaundice.
Ukusetshenziswa kweCymbalta noma i-Effexor kunengozi ye-serotonin syndrome, eyenzeka lapho kune-serotonin eyeqile ebuchosheni. Izimpawu ze-serotonin syndrome zingafaka ukushaya kwenhliziyo okusheshayo, umfutho wegazi okhuphukile, ukujuluka, ukundindizela, nomkhuhlane.
ICymbalta ne-Effexor kungadala ukwanda komfutho wegazi. Labo abanomlando we-high blood pressure kufanele babhekwe ngenkathi belashwa ngeCymbalta noma i-Effexor.
ICymbalta ne-Effexor kufanele zisetshenziswe ngokuqapha kulabo abanomlando wokuphazamiseka kwe-bipolar noma ukuquleka. Lezi zidambisamagciwane zingenza kusebenze i-mania, i-hypomania, noma ukuquleka kwabanye abantu.
Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuthola ezinye izexwayiso nokuqapha ngeCymbalta ne-Effexor.
Imibuzo ebuzwa njalo mayelana neCymbalta vs. Effexor
Kuyini iCymbalta?
ICymbalta yigama lomkhiqizo le-duloxetine. Isetshenziselwa ukwelashwa kokucindezeleka okukhulu nokuphazamiseka kokukhathazeka. Ibuye isetshenziselwe ukwelapha ubuhlungu obuvela ku-neuropathy yesifo sikashukela kanye ne-fibromyalgia. ICymbalta itholakala kumaphilisi akhishwe isikhathi eside ngamandla we-20 mg, 30 mg, noma ama-60 mg.
Kuyini i-Effexor?
I-Effexor igama lomkhiqizo le-venlafaxine. Isetshenziselwa ukwelashwa kwengcindezi enkulu yokudangala, ukukhathazeka okujwayelekile, ukuphazamiseka kokukhathazeka komphakathi, nokuphazamiseka kwesifo. I-Effexor ejwayelekile imisiwe; kodwa-ke, amaphilisi e-Effexor XR ayatholakala ngamandla ka-37.5 mg, 75 mg, kanye no-150 mg.
Ngabe iCymbalta ne-Effexor ziyefana?
ICymbalta ne-Effexor zombili i-serotonin ne-norepinephrine reuptake inhibitors (SNRIs). Kepha awawona umuthi ofanayo. Ngaphezu kokwelapha ukudangala okukhulu nokukhathazeka, iCymbalta nayo i-FDA ivunyelwe ukwelapha izinhlobo ezithile zobuhlungu bezinzwa. Ngakolunye uhlangothi, i-Effexor yi-FDA evunyelwe ukuphatha ukwethuka nokukhathazeka komphakathi.
Ngabe iCymbalta noma i-Effexor ingcono?
I-anti-depressant engcono incike esimweni sokuphathwa kanye neminye imithi umuntu angayiphuza. IVenlafaxine ingaba yindlela yokwelashwa yesikhashana ephumelela kakhulu yokudangala. Kodwa-ke, ingahle ibe nokubekezelelana okuphansi kuneCymbalta ngokwemiphumela emibi, njengokungasebenzi kahle kwezocansi.
Ngingayisebenzisa iCymbalta noma i-Effexor ngenkathi ngikhulelwe?
Azikho izifundo eziqinisekisile eziveze ukuthi iCymbalta noma i-Effexor ingahle iphephe ngesikhathi sokukhulelwa. I-antidepressant kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma izinzuzo zidlula izingozi ezingaba khona. Kwezinye izimo, iCymbalta noma i-Effexor kungadingeka ukuthi isetshenziselwe ukulawula izimpawu zokudangala ngesikhathi sokukhulelwa. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ngezeluleko ngaphambi kokusebenzisa iCymbalta noma i-Effexor ngenkathi ukhulelwe.
Ngingayisebenzisa iCymbalta noma i-Effexor ngotshwala?
Utshwala ngokulinganisela kungenzeka buphephile ngenkathi uthatha iCymbalta noma i-Effexor. Kodwa-ke, ukuphuza utshwala ngenkathi uqala ukwelashwa ngeCymbalta noma i-Effexor kungaholela ekwandeni isiyezi noma ukozela. Kungalulekwa ukuthi uyeke ukuphuza utshwala kuze kube sekuphele izinsuku ezimbalwa uqale ukwelashwa.
Ingabe i-Effexor iyayithinta inkumbulo?
Akunabufakazi bokuthi i-Effexor iyithinta ngqo inkumbulo. I-Effexor XR yaziwa ngokubangela i-hyponatremia, noma amazinga aphansi e-sodium egazini, ikakhulukazi uma kuthathwa umchamo. Izimpawu nezimpawu ze-hyponatremia zifaka ikhanda, ukudideka nokukhubazeka kwememori. Udokotela wakho angancoma ukumisa i-Effexor XR kuze kube yilapho i-hyponatremia isixazulula.
Yini enye into enhle kuneCymbalta?
ICymbalta iyi-serotonin ekhethiwe ne-norepinephrine reuptake inhibitor (SNRI). Amanye ama-SNRI afaka phakathi i-Effexor (venlafaxine), I-Pristiq (desvenlafaxine) , kanye neSavella (milnacipran). Khuluma nomhlinzeki wezokunakekelwa kwezempilo mayelana nezinketho zokwelashwa ezilwa nokucindezelwa kwakho.
Kukubi kangakanani ukuhoxa kwe-Effexor?
Umthamo we-Effexor kufanele uthanjiswe kancane ukusiza ukuvimbela izimpawu ezinzima zokuhoxa. Ukuyekiswa okungazelelwe kwe-Effexor kungaholela ezimpawu ezifana nesicanucanu, isiyezi, ukuhlanza, amaphupho amabi, ukucasuka, nokuphathwa yikhanda. Izimpawu zokuhoxa ze-Effexor zingafaka futhi i-paresthesias, noma ukuzwa imizwa esikhunjeni.
