I-Eliquis vs. Xarelto: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
I-Eliquis ne-Xarelto yimithi emibili enegama lomkhiqizo esetshenziselwa ukwelapha ukuphazamiseka okuhlukahlukene kokuqina kwamakhemikhali. Zombili lezi zidakamizwa zingama-anticoagulants omlomo ahlukaniswe eqenjini lemithi ebizwa nge-factor Xa inhibitors. Zisebenza ngokuvimba i-factor Xa, ekhiqiza i-thrombin, isithako esidingekayo ekukhiqizeni ama-clot. Ngokuvimbela i-factor Xa, imithi inciphisa ukukhiqizwa kwamahlule. Qhubeka ufunde ngezansi ukuze ufunde kabanzi ngo-Eliquis noXarelto.
Uyini umehluko omkhulu phakathi kuka-Eliquis noXarelto?
I-Eliquis (apixaban) ne-Xarelto (i-rivaroxaban powder) yi-NOACs (i-anticoagulants yomlomo yenoveli), okuyiqembu labanciphisi begazi abasha. Zaziwa nangokuthi i-DOAC (i-anticoagulants yomlomo eqondile). Ngokungafani neCoumadin (warfarin), i-anticoagulant ethandwayo futhi endala, iziguli ezithatha i-Eliquis noma iXarelto azidingi ukuhlolwa kwegazi okujwayelekile ukuqapha amazinga. Bobabili u-Eliquis noXarelto baziwa njenge-factor Xa inhibitors, kepha banokuhluka okuthile.
U-Eliquis no-Xarelto bobabili bavunyelwe yi-FDA ngokusetshenziswa kwemithi kadokotela futhi batholakala ngegama lomkhiqizo kuphela. Ayikho i-generic etholakalayo okwamanje kumuthi othile; kodwa-ke, kufanele kube ngu-Eliquis ojwayelekile itholakala maduzane . I-Eliquis yenziwa yiBristol-Myers Squibb. IXarelto yenziwa yiJanssen Pharmaceuticals. Zombili lezi zidakamizwa zisetshenziswa ngabantu abadala, futhi umthamo uyahluka ngokukhombisa.
| Umehluko omkhulu phakathi kuka-Eliquis noXarelto | ||
|---|---|---|
| U-Eliquis | Xarelto | |
| Isigaba sezidakamizwa | Isici se-factor Xa | Isici se-factor Xa |
| Isimo somkhiqizo / ejwayelekile | Umkhiqizo | Umkhiqizo |
| Ngubani igama elijwayelekile? | I-Apixaban | I-Rivaroxaban powder |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi, iphakethe lokuqalisa | Ithebhulethi, iphakethe lokuqalisa |
| Uyini umthamo ojwayelekile? | 2.5 mg noma 5 mg kabili ngosuku Isilinganiso siyahluka ngokukhomba | 10 mg kuya ku-20 mg kanye ngosuku Isilinganiso siyahluka ngokukhomba |
| Yelashwa isikhathi esingakanani? | Iyahlukahluka | Iyahlukahluka |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala | Abantu abadala |
Ufuna intengo engcono ku-Eliquis?
Bhalisela izaziso zentengo ze-Eliquis bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Izimo eziphathwe ngu-Eliquis noXarelto
U-Eliquis no-Xarelto banezinkomba eziningana ezifanayo — ukunciphisa ubungozi bokushaywa unhlangothi nokufakwa embolism ezigulini ezine-nonvalvular atrial fibrillation (AFib, noma ukushaya kwenhliziyo okungajwayelekile), ukuvimbela i-vein thrombosis (DVT) ejulile ezigulini ezishintshwe inqulu noma idolo, phatha i-DVT, phatha i-PE, futhi wehlise ubungozi be-DVT ephindaphindiwe noma i-PE kulandela ukwelashwa kokuqala.
Ngokwengeziwe, iXarelto inezinye izinkomba ezimbili. I-Xarelto ingavimbela i-venous thromboembolism (VTE) nokufa okuhlobene ne-VTE. I-Xarelto ingahle inqunywe ngesikhathi sokulaliswa esibhedlela nangemva kokukhishwa ezigulini zabantu abadala ezisengozini yezinkinga ngenxa yokuhamba okunomkhawulo nezinye izinto ezinobungozi. Kodwa-ke, iXarelto akufanele inikezwe iziguli ezisengozini enkulu yokopha. IXarelto isetshenziswa futhi ne-aspirin ukwehlisa ubungozi bezehlakalo ezinkulu zenhliziyo njengokufa, isifo senhliziyo, nokushaywa unhlangothi ezigulini ezinesifo esingamahlalakhona semithambo yenhliziyo (CAD) noma isifo semithambo yegazi (PAD).
| Isimo | U-Eliquis | Xarelto |
| Nciphisa ubungozi bokushaywa unhlangothi nokufakwa embolism ezigulini ezine-nonvalvular atrial fibrillation | Yebo | Yebo |
| I-Prophylaxis ye-vein thrombosis ejulile (i-DVT), engaholela embolism ye-pulmonary embolism (PE), ezigulini ezihlinzwe i-hip noma idolo | Yebo | Yebo |
| Ukwelashwa kwe-DVT | Yebo | Yebo |
| Ukwelashwa kwe-PE | Yebo | Yebo |
| Nciphisa ubungozi be-DVT ephindaphindiwe ne-PE kulandela ukwelashwa kokuqala | Yebo | Yebo |
| I-Prophylaxis ye-venous thromboembolism (VTE) kanye nokufa okuhlobene ne-VTE ngesikhathi sokulaliswa esibhedlela kanye nokukhishwa kwangemva kwesibhedlela kwiziguli ezindala ezivunyelwe ukugula okwedlulele kwezokwelapha ezisengozini yezinkinga ze-thromboembolic ngenxa yokuvinjelwa kokuhamba / ezinye izinto ezinobungozi hhayi engcupheni enkulu yokopha | Akunjalo | Yebo |
| Ngokuhambisana ne-aspirin, ukunciphisa ubungozi bemicimbi emikhulu yenhliziyo: ukufa kwenhliziyo, i-myocardial infarction (MI) kanye nokushaywa yisifo ezigulini ezinesifo esingapheliyo se-coronary artery disease (CAD) noma i-peripheral artery disease (PAD) | Akunjalo | Yebo |
Ngabe u-Eliquis noma uXarelto usebenza kangcono?
TO ukubuyekeza kanye nokuhlaziywa kwemeta ka-Eliquis noXarelto we-acous venous thromboembolism (VTE) baphetha ngokuthi zombili lezi zidakamizwa zisebenza ngendlela efanayo kodwa i-Eliquis ingaphepha. Iziguli ezelashwa ngeXarelto zathola ukopha kakhulu — kokubili okukhulu nokuncane.
Esinye isifundo kubuyekezwe i-Eliquis neXarelto, kanye nePradaxa (enye i-anticoagulant entsha) neCoumadin (warfarin, i-anticoagulant endala). Ababhali baphethe ngokuthi u-Eliquis wayenokuphumelela okuhle kakhulu, ukuphepha nokuthobela iziguli.
Isidakamizwa esingcono kakhulu kuwe singanqunywa kuphela ngumhlinzeki wakho wezokunakekelwa kwempilo, ongabheka isithombe esigcwele sesimo (se) sakho sezokwelapha, umlando wezokwelapha, neminye imishanguzo oyisebenzisayo engaxhumana no-Eliquis noma i-Xarelto.
Ufuna intengo engcono kakhulu kuXarelto?
Bhalisela izexwayiso zentengo yeXarelto bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kwe-Eliquis vs. Xarelto
U-Eliquis uvame ukumbozwa umshwalense kanye ne-Medicare Part D, kepha ama-copays ahlukahluka kakhulu. Umuthi ojwayelekile ka-Eliquis wokuhlinzekwa ngenyanga eyodwa (amaphilisi angama-60 we-5 mg) angabiza cishe ama- $ 700 uma ukhokha uphuma ephaketheni. Ungasebenzisa ukuthenga ikhadi le-SingleCare i-Eliquis ngaphansi kwe- $ 450.
IXarelto ivame ukumbozwa umshuwalense kanye ne-Medicare Part D, kepha ama-copays ayahluka. Umuthi ojwayelekile we-Xarelto wokuhlinzekwa ngenyanga eyodwa (amaphilisi angama-30 we-20 mg) angabiza cishe u- $ 620 ngentengo yokuthengisa. Ungasebenzisa isigqebhezana se-SingleCare ukuthenga i-Xarelto cishe ngama- $ 430.
| U-Eliquis | Xarelto | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokwejwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | # 60, 5 mg amaphilisi | # 30, 20 mg amaphilisi |
| Inkokhelo ejwayelekile yeMedicare Part D | $ 19- $ 541 | $ 19- $ 508 |
| Izindleko ze-SingleCare | $ 447- $ 483 | $ 428- $ 471 |
Imiphumela emibi ejwayelekile ye-Eliquis vs. Xarelto
Imiphumela emibi kakhulu yezidakamizwa zombili ihlobene nokuphuma kwegazi, njengokuphuma kwegazi, ukuxubana (ukulimaza), igazi emchameni, noma izinsini ezophayo. Isimo semiphumela emibi yokopha singahluka. Ezimweni ezingavamile, ukopha kungaba kubi noma kusongele nokuphila.
Eminye imiphumela engemihle engahle yenzeke nge-Eliquis ifaka ukukhathala, ukuphelelwa amandla, ubuthakathaka, ukuphefumula okuncane, nesicanucanu.
Eminye imiphumela emibi engahle yenzeke ngeXarelto ifaka phakathi ubuhlungu besisu noma beqolo, ukukhathala, isiyezi, ukulunywa, ukukhathazeka, ukudangala, kanye / noma ukuqwasha.
Lolu akulona uhlu oluphelele lwemiphumela emibi. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ngolwazi oluthe xaxa mayelana nokusabela okungathandeki kuka-Eliquis noXarelto.
| U-Eliquis | Xarelto | |||
| Imiphumela emibi | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ukopha | Yebo | Iyahlukahluka | Yebo | Iyahlukahluka |
| Ubuhlungu besisu | Yebo | Okuvamile | Yebo | 2.7% |
| Ukukhathala | Yebo | Okuvamile | Yebo | 1.7% |
| Ukuphela kwamandla | Yebo | Okuvamile | Akunjalo | - |
| Ubuthakathaka | Yebo | Okuvamile | Akunjalo | - |
| Ukuphelelwa umoya | Yebo | Okuvamile | Akunjalo | - |
| Ukuhlungu obusemhlane | Akunjalo | - | Yebo | 2.9% |
| Isiyezi | Yebo | Okuvamile | Yebo | 2.2% |
| Ukukhathazeka | Akunjalo | - | Yebo | 1.4% |
| Isicanucanu | Yebo | Okuvamile | Akunjalo | - |
| Ukucindezeleka | Akunjalo | - | Yebo | 1.2% |
| Ukuqwasha | Akunjalo | - | Yebo | 1.6% |
| Ukulunywa | Yebo | <1% | Yebo | 2.2% |
Umthombo: DailyMed ( U-Eliquis ), Umkhiqizo Monograph ( U-Eliquis ), IDailyMed ( Xarelto )
Ukusebenzisana kwezidakamizwa kuka-Eliquis noXarelto
U-Eliquis noXarelto basebenzisana nezidakamizwa ezithile ezihlanganiswa ne-enzyme efanayo. Lapho kusetshenziswa izidakamizwa ze-enzyme inhibitor ne-Eliquis noma i-Xarelto, amazinga e-Eliquis noma i-Xarelto emzimbeni wakho angakhuphuka, okuzokubeka engcupheni yokopha kakhulu. Uma kufanele uthathe le nhlanganisela yezidakamizwa, kungenzeka ukuthi udokotela wakho anciphise umthamo wakho we-Eliquis noma i-Xarelto ngenkathi usebenzisa imishanguzo yomibili.
Ngakolunye uhlangothi, lapho ama-enucme enucme ethathwa ne-Eliquis noma i-Xarelto, kuba nokuxhumana lapho leyo mithi yenza i-Eliquis noma i-Xarelto igaye umzimba ngokushesha, futhi ngeke uthole okwanele ngomthamo we-Eliquis noma we-Xarelto.
Futhi, ukusebenzisa i-Eliquis noma i-Xarelto namanye ama-anticoagulants, ama-antiplatelet drugs, ama-NSAID (izidakamizwa ezingezona ukuvuvukala), kanye nemithi ethile yokulwa nengcindezi ingakhuphula ingozi yokopha.
Lolu akulona uhlu olugcwele lokusebenzisana kwezidakamizwa. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola eminye imininingwane.
| Izidakamizwa | Isigaba Sezidakamizwa | U-Eliquis | Xarelto |
| I-Itraconazole Ketoconazole I-Ritonavir | Ama-enzyme inhibitors anamandla (CYP3A4 ne-P-gp) | Yebo | Yebo |
| I-Carbamazepine Phenytoin I-Rifampin ISt. John's Wort | Ama-inducers anamandla we-enzyme (CYP3A4 ne-P-gp) | Yebo | Yebo |
| I-Citalopram I-Desvenlafaxine I-Duloxetine I-Escitalopram I-Fluoxetine I-Fluvoxamine I-Paroxetine Sertraline I-Venlafaxine | Ama-SSRI kanye ne-SNRI antidepressants | Yebo | Yebo |
| I-Clopidogrel Enoxaparin I-Heparin Ama-NSAID (isikhathi eside) ● I-Aspirin ● Ibuprofen ● I-Meloxicam ● UNabumetone ● INaproxen I-Warfarin (coumadin) | Ama-anticoagulants nama-antiplatelets | Yebo | Yebo |
Izexwayiso zika-Eliquis noXarelto
U-Eliquis noXarelto banesixwayiso esibhokisi (ibhokisi elimnyama), okuyisixwayiso esiqine kakhulu esidingwa yi-FDA. Ezinye izexwayiso zifaka:
- Ukuyeka i-Eliquis noma iXarelto ngaphambi kwesikhathi kwandisa ingozi yomcimbi wokujiya.
- I-Epidural noma i-hematoma yomgogodla kungenzeka ezigulini ezithola i-neuraxial (phakathi kwe-vertebrae) i-anesthesia noma ukubhoboza umgogodla. I-hematoma ingaholela ekukhubazekeni kwesikhathi eside noma unomphela. Ingozi iphezulu ezigulini ezinama-catheters we-epidural, iziguli ezithatha eminye imithi ethinta ukugeleza kwegazi, iziguli ezinomlando wokugcotshwa okubuhlungu / okuphindaphindwayo, kanye / noma iziguli ezinomlando wokukhubazeka komgogodla noma ukuhlinzwa. Iziguli kufanele zihlolwe njalo ngezimpawu / izimpawu zokukhubazeka kwemizwa (ukuba ndikindiki / ukubuthakathaka kwemilenze, izinkinga zamathumbu / zesinye), futhi uma kukhona izinkinga ezenzekayo, isiguli kufanele sifune usizo oluphuthumayo lwezokwelapha.
- Ukopha kungahle kwenzeke futhi kungaba kubi (ukuphuma kwegazi okukhulu) noma kube yingozi. Ukusebenzisa i-Eliquis noma i-Xarelto ngemithi ethile (ama-anticoagulants, antiplatelet drug, NSAIDs, SSRI kanye ne-SNRI antidepressants) kwandisa ingozi yokopha. Iziguli ezinegazi kufanele zifune ukwelashwa okuphuthumayo. Umuthi kufanele umiswe ezigulini ezinokopha okusebenzayo.
- Umenzeli oguqukayo uyatholakala, ukuhlehlisa imiphumela ye-factor Xa inhibition.
- I-Eliquis noma i-Xarelto ayinconywa ezigulini ezinama-valve enhliziyo okufakelwa.
- I-Eliquis noma i-Xarelto ayinconywa njengenye indlela ye-heparin yokwelashwa kokuqala kweziguli ze-PE ezinokungazinzi kwe-hemodynamic (ukushaqeka / ukwehluleka kwenhliziyo).
- I-Eliquis noma i-Xarelto akufanele isetshenziswe ezigulini ezine-antiphospholipid syndrome (APS) ephindwe kathathu ngenxa yengozi eyengeziwe yokujiya.
- Uma unezinkinga zesibindi noma zezinso, khuluma nomhlinzeki wakho wezokunakekelwa kwempilo ngaphambi kokuthatha i-Eliquis noma iXarelto.
Ukusetshenziswa kokukhulelwa:
- Kunemininingwane elinganiselwe ekusetshenzisweni kwe-Eliquis noma i-Xarelto ekukhulelweni. Ukwelashwa nge-Eliquis noma i-Xarelto kungakhuphula ingozi yokopha ngesikhathi sokukhulelwa nokubeletha, futhi kwandise nengozi yokopha embungwini / kosana olusanda kuzalwa. Ukusebenzisa i-Eliquis noma i-Xarelto ngesikhathi sokubeletha noma sokubeletha kwabesifazane abathola i-epidural kungadala i-epidural noma i-hematoma yomgogodla I-anticoagulant emfushane esebenza uma ingasetshenziswa uma kudingeka. Xhumana ne-OB-GYN yakho ngokusetshenziswa kwe-Eliquis noma iXarelto ngesikhathi sokukhulelwa. Ngokuvamile, umuthi usetshenziswa kuphela uma izinzuzo zidlula izingozi (ngokwesibonelo, ekukhulelweni okunobungozi obukhulu), kanye nokuqapha ngokucophelela. Uma usuvele usebenzisa i-Eliquis noma i-Xarelto bese uthola ukuthi uyiyo ukhulelwe , thintana ne-OB-GYN yakho ukuthola isiqondiso.
Imibuzo ebuzwa njalo nge-Eliquis vs. Xarelto
Uyini u-Eliquis?
I-Eliquis yigama lomkhiqizo elithi anticoagulant (igazi elinciphile) elisetshenziselwa ukuvimbela noma ukwelapha amahlule egazi.
Yini iXarelto?
I-Xarelto yigama lomkhiqizo i-anticoagulant, futhi iyasiza ukuvimbela noma ukwelapha amahlule egazi.
Ngabe u-Eliquis noXarelto bayafana?
U-Eliquis noXarelto bobabili baziwa njenge-factor Xa inhibitors. Ziyafana kakhulu, kepha azifani ncamashi. Umehluko uchazwe ngenhla. Ezinye izinto i-Xa inhibitors yi-Pradaxa (dabigatran), i-Arixtra (fondaparinux), i-Savaysa (edoxaban), ne-Bevyxxa (amandlaxaban).
Ngabe u-Eliquis noma uXarelto bangcono?
Izifundo (bheka ngenhla ngemininingwane) zikhombisile ukuthi u-Eliquis noXarelto basebenza ngokufanayo, noma ukuthi i-Eliquis ingasebenza ngempumelelo ethe xaxa. U-Eliquis ubonakala enengozi ephansi yokopha kune-Xarelto. Buza udokotela wakho ukuthi u-Eliquis noma uXarelto ukufanele yini.
Ngingamsebenzisa u-Eliquis noma uXarelto ngikhulelwe?
Ngokuvamile, i-Eliquis neXarelto azisetshenziswa ekukhulelweni. Kodwa-ke, okunye okuhlukile kungenzeka kwiziguli ezithile ezisengozini enkulu yamahlule. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo.
Ngingasebenzisa i-Eliquis noma iXarelto ngotshwala?
Utshwala bunganciphisa igazi. Uma uthatha i-Eliquis noma iXarelto uphuza utshwala, lokhu kungakhuphula ubungozi bokuphuma kwegazi. Futhi, utshwala bungabhebhethekisa izimo ezithile zezokwelapha. Ungabuza umhlinzeki wakho wezokunakekelwa kwezempilo ukuthi ngabe kuphephile yini ukuphuzwa, nokuthi kangakanani, ngemithi oyiphuzayo kanye nezimo zezempilo onazo.
Ngabe iXarelto ishibhile kune-Eliquis?
Ngokunikezwa kwenyanga eyodwa, intengo yeXarelto nentengo ka-Eliquis ziyefana kakhulu. Intengo ka-Eliquis neXarelto enekhuphoni le-SingleCare iqala ku- $ 447 naku- $ 428. Okujwayelekile kuka-Eliquis kufanele kutholakale maduzane.
Yiliphi igazi elinciphe kunawo wonke ongalisebenzisa?
Ama-thinner egazi aphephile uma esetshenziswa njengoba kushiwo. Kodwa-ke, nganoma yiliphi igazi elincanyana, kunengozi yokuphuma kwegazi, noma ukuphuma kwegazi elikhulu noma okusongela impilo. Abanciphisi begazi bangaphinde bahlanganyele nemithi ethile. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola ukuthi iliphi i-blood thinner elifanele wena.
Ingabe i-Eliquis iyasithinta isibindi?
Ngaphansi kwe 1% yeziguli ku-Eliquis ekuhlolweni kwemitholampilo kwaba nokuhlolwa kwesibindi okungavamile. Kufanele wazise udokotela wakho ngaphambi kokuthatha i-Eliquis noma iXarelto uma unezinkinga zesibindi.
