Main >> Izidakamizwa Vs. Umngani >> I-Levalbuterol vs. Albuterol: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Levalbuterol vs. Albuterol: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Levalbuterol ne-albuterol yizidakamizwa ezimbili ezisetshenziswa ekwelapheni i-bronchospasm ehlobene nesifo se-asthma nesifo esingapheliyo se-pulmonary disease (COPD). Isifuba somoya yisifo sokuphefumula esihlasela abantu bayo yonke iminyaka. Kubonakala ngokushayana, ukukhwehlela, ukuphefumula okuncane, nokuqina kwesifuba. Kulinganiselwa ukuthi isifuba somoya kuthinta cishe abantu abayizigidi ezingama-24 e-United States, kubandakanya nezingane eziyizigidi eziyi-7.

I-COPD , kwesinye isikhathi ibizwa ngokuthi yi-emphysema, inezici ezifanayo nesifuba somoya, kodwa futhi ifaka phakathi ukukhiqizwa kwamafinyila aminyene emoyeni. Imbangela ngqo yesifo somoya ayaziwa, kepha iningi leziguli ezakha i-COPD zinomlando wokubhema noma ukuvezwa isikhathi eside kuma-lung irritants.

I-Bronchospasm ichaza inqubo eyenzeka kokubili i-asthma ne-COPD lapho inkontileka yezindiza, okwenza kube nzima ukudlula umoya. Lokhu kwesinye isikhathi kubizwa ngokuthi yi-bronchoconstriction. ILevalbuterol ne-albuterol bobabili baphatha i-bronchospasm, kepha basebenza ngokuhlukile.

Uyini umehluko omkhulu phakathi kweLevalbuterol ne-Albuterol?

ILevalbuterol ngumuthi kadokotela okhetha ngokulingene, osebenza ngamafuphi we-beta-2-receptor agonist (SABA). ILevalbuterol iyi-R-enantiomer esebenzayo kakhulu yenhlanganisela ye-albuterol racemic. I-Levalbuterol ivuselela ama-beta receptors okuholela ekuphumuleni kwemisipha ebushelelezi ne-tracheal bushelelezi kanye nomoya ovulekile ngokwengeziwe. ILevalbuterol iyatholakala njenge-metered-dose inhaler (MDI) eletha umthamo we-45 mcg nge-actuation ngayinye. Futhi iyatholakala njengesisombululo okufanele sisetshenziswe emshinini we-nebulizer. Lesi sixazululo se-nebulizer siyatholakala ngokugxila ku-0.31 mg / 3 ml, 0.63 mg / 3 ml, naku-1.25 mg / 3ml.

I-Albuterol ngumuthi kadokotela obuye ukhethe ngokulingene, osebenza ngesikhashana i-beta-2-receptor agonist (SABA). I-Albuterol iyinhlanganisela yobuhlanga yama-R-enantiomers kanye nama-S-enantiomers ane-R-enantiomer okuyi-isomer esebenzayo kakhulu nesithako esisebenzayo ku-levalbuterol. I-Racemic albuterol iyatholakala kumathebulethi womlomo ngamandla wokukhishwa ngokushesha okungu-2 mg no-4 mg kanye nokukhishwa okunwetshiwe okungu-4 mg no-8 mg. I-Albuterol iyatholakala futhi kwisisombululo somlomo ekugxileni kwe-2 mg / 5 ml. I-Albuterol ibuye ifike nge-metered-dose inhaler eletha ama-90 mcg ku-actuation ngayinye kanye nezixazululo ezahlukahlukene ze-nebulizer.

Umehluko omkhulu phakathi kweLevalbuterol ne-Albuterol
	Levalbuterol	I-Albuterol
Isigaba sezidakamizwa	I-beta-2-agonist ekhetha ngokulingene esebenza ngokulingene	I-beta-2-agonist ekhetha ngokulingene esebenza ngokulingene
Isimo somkhiqizo / ejwayelekile	I-Brand ne-generic iyatholakala	I-Brand ne-generic iyatholakala
Ngubani igama lomkhiqizo?	Elaphonex	I-ProAir, i-Proventil, i-Ventolin, i-Accuneb, i-Vospire
Izidakamizwa zingena ngaziphi izinhlobo?	I-metered-dose inhaler, isisombululo se-nebulizer	I-metered-dose inhaler, isisombululo se-nebulizer, amaphilisi omlomo, isisombululo somlomo
Uyini umthamo ojwayelekile?	0.63 mg nge-nebulizer noma i-45 mcg nge-MDI njalo ngamahora angu-4-6	2.5 mg nge-nebulizer noma i-90 mcg nge-MDI njalo ngamahora ama-4-6
Yelashwa isikhathi esingakanani?	Isikhathi esiphakathi, esifushane	Okuphakathi, isikhathi esifushane
Ubani ovame ukusebenzisa umuthi?	Izingane ezineminyaka engu-4 ubudala nangaphezulu, abantu abadala	Izinsana, izingane, abantu abadala

Izimo eziphathwe yiLevalbuterol ne-Albuterol

ILevalbuterol ne-albuterol womabili asebenza ngokuvuselela ama-beta receptors ukudala ukuphumula kwemisipha ebushelelezi ezindleleni zomoya, ngaleyo ndlela kuvunyelwe izindlela zomoya ukuvula futhi zithwale umoya omningi emaphashini ngokungazweli okuncane.

Kokubili i-levalbuterol ne-albuterol kuvunyelwe i-FDA ekwelapheni ukukhushulwa kwesifuba somoya, ama-bronchospasms wesikhashana noma ukuphefumula, kanye ne-bronchospasm ehlobene ne-COPD. Kubalulekile ukuthi wazi ukuthi akukho muthi ovunyelwe njenge-prophylaxis, noma ukuvimbela, kulezi zinkomba. Kodwa-ke, i-albuterol ivunyelwe ukuthi isetshenziswe ekuvinjelweni kwe-bronchospasm ebangelwa ukuzivocavoca umzimba. Imvamisa, i-albuterol ibizonikezwa imizuzu eyi-15 ngaphambi kokuvivinya umzimba okulindelwe ukunciphisa amathuba e-bronchospasm abangelwa ukuzivocavoca umzimba. I-Levalbuterol kwesinye isikhathi isetshenziswa ngaphandle kwelebula ngale nkomba. Ngaphandle kwelebula kusho ukuthi umuthi awuvunyelwe ukuthi usetshenziswe kulokhu kukhonjiswa yi-Food and Drug Administration (FDA).

Ishadi elilandelayo libala ukusetshenziswa okwaziwa kakhulu kwale mithi. Umhlinzeki wakho wezokunakekelwa kwempilo kuphela onganquma ukuthi le mithi ilungele isimo sakho. Ezimweni ze-asthma ne-COPD bronchospasm, sicela ufune ukwelashwa emnyangweni wezimo eziphuthumayo oseduzane.

Isimo	Levalbuterol	I-Albuterol
Ukukhuphuka kwesifuba somoya	Yebo	Yebo
Isikhathi esifushane se-bronchospasm / episodic wheezing	Yebo	Yebo
I-bronchospasm prophylaxis ebangelwa ukuzivocavoca	Ngaphandle kwelebula	Yebo
I-bronchospasm ehambisana ne-COPD	Yebo	Yebo
Ukwelashwa okunamandla kwe-hyperkalemia	Ngaphandle kwelebula	Ngaphandle kwelebula
Ukwelashwa okuhlanganisayo kwezifo zokuphefumula ezisanda kuzalwa	Akunjalo	Ngaphandle kwelebula

Ingabe iLevalbuterol noma i-Albuterol isebenza kangcono?

ILevalbuterol ne-albuterol ziqhathaniswe kakhulu maqondana nemiphumela yesifuba somoya kanye neye-COPD. U-2015 funda abantu abadala abahloliwe ababelaliswe esibhedlela i-asthma noma i-COPD exacerbations abaphathwa nge-levalbuterol noma i-albuterol elawulwa yi-nebulization. Imiphumela yalolu cwaningo lomtholampilo ithole ukuthi imiphumela yomtholampilo ibifana phakathi kwale mithi emibili futhi yomibili ibisebenza ekwehliseni izimpawu ze-bronchospasm. Kodwa-ke, izindleko zokwelashwa kwe-levalbuterol zazibiza kakhulu kunezindleko zokwelashwa kwe-albuterol, kanti iziguli eziseqenjini levalbuterol zazilaliswe esibhedlela isikhathi eside kakhulu kuneziguli eziseqenjini le-albuterol. Ukuhlala isikhathi eside esibhedlela futhi kukhuphula izindleko zokungenelela.

TO ukuhlaziywa kwe-meta nokubuyekezwa okuhlelekile kwezivivinyo eziyisikhombisa ezehlukene, kufaka phakathi iziguli ezingaphezu kwe-1,600, kwenziwa ukuqhathanisa i-levalbuterol ne-albuterol ku-asthma enamandla. Lolu cwaningo alutholanga mehluko obalulekile phakathi kwezidakamizwa uma kuqhathaniswa imiphumela yomtholampilo efana nesilinganiso sokuphefumula, ukugcwaliswa komoya-mpilo, kanye noshintsho kumthamo wamaphaphu. Ivolumu yamaphaphu kwesinye isikhathi ibizwa ngevolumu yokuphoqelelwa yokuphefumula, noma i-FEV1, ezincwadini zezokwelapha. Lolu cwaningo luphethe ukuthi abukho ubufakazi obusekela ukukhetha i-levalbuterol kune-albuterol ekwelapheni i-asthma.

Yize yomibili imishanguzo isebenza ngempumelelo, abakwa-prescribers bangalinganisa ukungabi bikho kobufakazi bokuphakama kwe-levalbuterol nezindleko eziphakeme lapho kunqunywa ukuthi imuphi umuthi okufanele unikezwe. ILevalbuterol ivunyelwe kuphela ezigulini zezingane ezineminyaka emine nangaphezulu, ngakho-ke i-albuterol ingancanyelwa kubantu abancane bezingane. Udokotela wakho kuphela ongakhetha umuthi ofanele wesimo sakho.

Thola isigqebhezana somuthi

Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweLevalbuterol vs. Albuterol

I-Levalbuterol isidakamizwa esikhishwe ngodokotela esivame ukumbozwa yizinhlelo zomshuwalense wezohwebo. Kungambozwa uhlelo lweMedicare Part D noma lweNgxenye B ngokuya ngokutholakala kwesifo. Ngaphandle kokumbozwa, i-levalbuterol ingakubiza ngaphezu kwe- $ 170. Isigqebhezana se-SingleCare se-Levalbuterol ejwayelekile singanciphisa intengo iye ku- $ 30 emakhemisi abambe iqhaza.

I-Albuterol ingambozwa uhlelo lweMedicare Part D noma lweNgxenye B ngokuya ngesifo. Iphinde imbozwe ngezinhlelo zomshuwalense wezohwebo. I-Albuterol ingabiza imali engange- $ 40 ngaphandle kokumbozwa, kepha ngesigqebhezana esivela kwaSingleCare, ungathola ifomu elijwayelekile ngaphansi kwama- $ 10 emakhemisi abambe iqhaza.

	Levalbuterol	I-Albuterol
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokwejwayelekile yi-Medicare Part D?	Kuya ngesifo	Kuya ngesifo
Umthamo ojwayelekile	25, 0.63 mg / 3 ml	25, 2.5 mg / 3 ml
I-Medicare copay ejwayelekile	Kuncike ohlelweni	Kuncike ohlelweni
Izindleko ze-SingleCare	$ 30- $ 130	$ 10- $ 20

Imiphumela emibi ejwayelekile yeLevalbuterol vs. Albuterol

Ngenkathi i-levalbuterol ne-albuterol zikhetha ngokulinganisela ama-beta receptors emisipheni ebushelelezi ehlosiwe yezindiza, kungahle kube nokugqugquzela kwenhliziyo kwe-beta-receptor okubangela ukwanda kokushaya kwenhliziyo, okwaziwa nge-tachycardia. Kokubili i-levalbuterol ne-albuterol kungadala ukwethuka nokuthuthumela. I-Migraine nesiyezi kwaphawulwa nge-levalbuterol, kepha hhayi i-albuterol.

Lokhu akuhloselwe ukuthi kube uhlu olubanzi lwemiphumela emibi engaba khona. Sicela uthinte umhlinzeki wakho wezokunakekelwa kwempilo ukuthola uhlu oluphelele lwemiphumela emibi.

	Levalbuterol	I-Albuterol
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
I-Tachycardia	Yebo	2.7%	Yebo	2.7%
Migraine	Yebo	2.7%	Akunjalo	n / a
I-Dyspepsia	Yebo	2.7%	Yebo	1.4%
Amajaqamba omlenze	Yebo	2.7%	Yebo	1.4%
Isiyezi	Yebo	2.7%	Akunjalo	n / a
Umfutho wegazi ophezulu	Akunjalo	n / a	Yebo	2.7%
Ukwesaba	Yebo	9.6%	Yebo	8.1%
Ukuthuthumela	Yebo	6.8%	Yebo	2.7%
Ukukhathazeka	Yebo	2.7%	Akunjalo	n / a
Ukukhwehlela okwandayo	Yebo	4.1%	Yebo	2.7%
Ukutheleleka ngegciwane	Yebo	12.3%	Yebo	12.2%
I-Rhinitis	Yebo	2.7%	Yebo	6.8%
Isinusitis	Yebo	1.4%	Yebo	2.4%
I-edema ephendukayo	Yebo	1.4%	Akunjalo	n / a

Umthombo: Levalbuterol ( I-DailyMed I-Albuterol ( I-DailyMed )

Ukusebenzisana kwezidakamizwa kweLevalbuterol vs. Albuterol

Ngenxa yokufana kwamakhemikhali, ukuhlangana okungenzeka kwezidakamizwa kwe-levalbuterol ne-albuterol kuyefana kakhulu. I-Azithromycin, i-antibiotic ejwayelekile kakhulu esetshenziswa kaningi ezifweni zokuphefumula eziphezulu, kufanele igwenywe ngokuhlanganiswa ne-levalbuterol noma i-albuterol uma kungenzeka. I-Azithromycin, lapho ilawulwa ngama-beta-agonists asebenza okufushane, inengozi eyengeziwe yokubanga ukwandiswa kwe-QT, uhlobo lwe-arrhythmia yenhliziyo. Uma le nhlanganisela kufanele isetshenziswe, umsebenzi wenhliziyo yesiguli kufanele ubhekwe eduze. Kubalulekile ukuthola isisekelo sokusebenza kwenhliziyo ngaphambi kokufaka le mithi ngasikhathi sinye.

Ama-beta blockers, ajwayele ukusetshenziselwa ukulawula ukushaya kwenhliziyo nomfutho wegazi, asebenza ngokuphambene nama-beta-agonists. Imisebenzi yabo izophikisana. Uma isiguli kufanele sibe kokubili i-beta blocker ne-beta-agonist, ukusebenzisa i-cardioselective beta blocker kuyathandwa. Izibonelo ze-beta blockers ye-cardioselective zifaka i-atenolol ne-metoprolol, phakathi kwabanye.

Lolu akulona uhlu oluphelele lokuhlangana kwezidakamizwa okungenzeka. Sicela ufune izeluleko zezokwelapha ukuze uthole ukuqonda okuphelele kokuhlangana kwezidakamizwa okungenzeka.

Izidakamizwa	Isigaba sezidakamizwa	Levalbuterol	I-Albuterol
Ikhafeyini	Isuselwa ku-Xanthine / CNS evuselelayo	Yebo	Yebo
I-Phenylephrine I-Pseudoephedrine	Ama-decongestants	Yebo	Yebo
I-Acebutolol I-Atenolol I-Betaxolol I-Bisoprolol ICarvedilol I-Metoprolol UNadolol Nebivolol I-Propranolol I-Sotalol	Ama-beta blockers (abaphikisi be-beta)	Yebo	Yebo
Amiodarone I-Dronedarone	Ama-anti-arrhythmics	Yebo	Yebo
Amitriptyline I-Clomipramine I-Nortriptyline	I-Tricyclic antidepressants	Yebo	Yebo
I-Citalopram I-Escitalopram I-Fluoxetine Sertraline	I-serotonin reuptake inhibitors ekhethiwe (SSRIs)	Yebo	Yebo
I-Azithromycin I-Clarithromycin	Imithi elwa namagciwane	Yebo	Yebo
I-Fluconazole I-Itraconazole Ketoconazole	Izikhunta	Yebo	Yebo

Izexwayiso zeLevalbuterol ne-Albuterol

I-Levalbuterol ne-albuterol kungadala i-bronchospasm eyindida, isimo lapho i-bronchospasm yesiguli noma isondo liba libi kakhulu esikhundleni sokuthuthuka. Uma lokhu kwenzeka, ukwelashwa kufanele kumiswe ngokushesha futhi kufanele kuqale ukwelashwa okusha.

Ukwehliswa kwesifuba somoya kungenzeka esikhathini, amahora, noma isikhathi eside. Uma isiguli se-asthmatic siqala ukudinga inani elandayo le-bronchodilator ukulawula izimpawu ze-asthma, lokhu kungaba uphawu lokuthi ukwenziwa buthaka kuyenzeka. Iziguli ezikuthola lokhu zingadinga imishanguzo elwa nokuvuvukala efana ne-corticosteroids noma ushintsho kuhlobo lwemithi yesondlo.

I-Levalbuterol ne-albuterol, ikakhulukazi kumanani angaphezu kwenani elinconyiwe, kungadala imiphumela emibi yenhliziyo njengokunyuka kwenhliziyo nomfutho wegazi. Kwezinye izimo ezinzima, ukuboshwa kwenhliziyo kwenzeke. Ungalokothi weqe umthamo ophakanyisiwe udokotela wakho awunqume.

Izinga eliphansi le-serum potassium, noma i-hypokalemia, liye labonwa nge-levalbuterol ne-albuterol. Lokhu kungabangelwa yi-intracellular shunting. Ngenkathi le mithi kwesinye isikhathi isetshenziswa ngaphandle kwelebula ukwehlisa amazinga e-potassium ngamabomu, lo mphumela kufanele ubhekwe.

Imibuzo ebuzwa njalo ngeLevalbuterol vs. Albuterol

Yini iLevalbuterol?

ILevalbuterol ngumuthi kadokotela osebenza ngamafuphi we-beta-agonist, owaziwa nangokuthi yi-bronchodilator. Isetshenziselwa ukwelapha i-bronchospasm ehlobene ne-asthma ne-COPD. Ibuye isetshenziswe ngaphandle kwelebula ukusiza ukuvimbela i-bronchospasm ebangelwa ukuzivocavoca umzimba. Itholakala ngesimo se-metered-dose inhaler kanye nezixazululo ezizosetshenziswa kwi-nebulizer.

Yini i-Albuterol?

I-Albuterol nayo iyisidakamizwa esikhuthazwa yi-beta-agonist esebenza okwesikhashana. Yaziwa nangokuthi yi-bronchodilator futhi isetshenziselwa ukwelapha i-bronchospasm ehlobene nesifuba somoya kanye ne-COPD kanye nokuvikela i-bronchospasm ebangelwa ukuzivocavoca umzimba. Kutholakala ngezindlela ezahlukahlukene kufaka phakathi amaphilisi omlomo, izixazululo zomlomo, ama-inhalers we-metered-dose, nezixazululo ezizosetshenziswa ku-nebulizer.

Ngabe iLevalbuterol ne-Albuterol ziyafana?

ILevalbuterol ne-albuterol ziyafana ngokwamakhemikhali, kepha azifani ncamashi. I-Albuterol iyinhlanganisela yobuhlanga yama-enantiomers amabili amakhemikhali, i-R-albuterol ne-S-albuterol. Kwesinye isikhathi kubizwa ngokuthi yi-albuterol yobuhlanga. ILevalbuterol yakhiwe nge-R-albuterol nje, lapho kusebenza khona lezi zinhlanganisela ezimbili.

Ngabe iLevalbuterol noma i-Albuterol ingcono?

Ukuqhathanisa okubuyela emuva izifundo Sekukonke kukhombisile ukuthi i-levalbuterol ne-albuterol inemiphumela efanayo yomtholampilo. Ababhali bangabheka izici ezinjengezindleko nemiphumela emibi engaba khona lapho bekhetha omunye komunye.

Ngingayisebenzisa iLevalbuterol noma i-Albuterol ngikhulelwe?

ILevalbuterol ne-albuterol zombili zibhekwa njengesigaba C sokukhulelwa yi-FDA. Lokhu kusho ukuthi azikho izifundo ezinhle zokwelashwa ezibonisa ukuphepha ekukhulelweni. Le mithi kufanele isetshenziswe kuphela lapho izinzuzo zidlula ngokusobala izingozi. Kulezi zimo, i-albuterol ingakhethwa ngenxa yokuba khona kwemininingwane eminingi yomlando ekusetshenzisweni kwayo ekukhulelweni.

Ngingayisebenzisa iLevalbuterol noma i-Albuterol ngotshwala?

Akukho ukuphikisana okuqondile ne-albuterol notshwala. Kodwa-ke, utshwala bunganciphisa izinga lokuphefumula futhi buphazamise ukusebenza kwamaphaphu, okuphikisana nokwelashwa kwe-bronchospasm.

Ngabe iLevalbuterol iyinhalera yokutakula?

Yebo, i-levalbuterol HFA i-inhaler yokutakula eboniswe ukuthi isetshenziswe ekwelapheni ukuqina kwesifuba somoya noma ama-bronchospasms ngenxa ye-COPD.

Ingabe iLevalbuterol iyi-steroid?

I-Levalbuterol akuyona i-steroid noma i-anti-inflammatory futhi akufanele isetshenziswe esikhundleni se-steroid lapho kukhonjiswa ukusetshenziswa kwe-steroid, njengokuncishiswa kwesifuba somoya.

Uhlala isikhathi esingakanani uLevalbuterol?

Ngokwesilinganiso, imiphumela yomthamo owodwa we-levalbuterol ingahlala amahora amahlanu kuya kwayisithupha. ILevalbuterol iqala ukusebenza cishe imizuzu eyi-15 ngemuva kokuphathwa.