I-Metoprolol tartrate vs. metoprolol succinate: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Uma uke wahlaselwa yisifo senhliziyo noma njengamanje uhlala nomfutho wegazi ophakeme, udokotela wakho angakunika umuthi onjenge-metoprolol tartrate (Lopressor) noma i-metoprolol succinate (Toprol XL). Yize yomibili le mithi inezithako ezifanayo ezisebenzayo, ingasetshenziswa ngezindlela ezihlukile.
Kokubili i-metoprolol tartrate ne-metoprolol succinate kungokwesigaba semithi ebizwa beta blocker . Ngezinye izikhathi zaziwa nangokuthi i-beta-1 selective adrenoceptor blockers kanye ne-beta antagonists.
Le mithi isebenza ngokuvimba imiphumela yamahomoni afana ne-epinephrine ne-norepinephrine ohlelweni lwemizwa oluzwelayo. Isistimu yezinzwa ezwelayo inoxanduva lokuphendula okujwayelekile kokulwa noma kwendiza. I-Metoprolol ingasiza ekwehliseni ukucindezeleka enhliziyweni, yehlisa imithambo yegazi ukunciphisa umfutho wegazi, futhi yehlise nobuhlungu besifuba.
Uyini umehluko omkhulu phakathi kwe-metoprolol tartrate ne-metoprolol succinate?
Umehluko omkhulu phakathi kwe-metoprolol tartrate (Yini i-metoprolol tartrate?) Kanye ne-metoprolol succinate (Yini i-metoprolol succinate?) Isezakhiweni zazo. I-Metoprolol tartrate inguqulo ekhishwa ngokushesha ye-metoprolol ngenkathi i-metoprolol succinate inguqulo ekhishwe isikhathi eside. Lokhu kusho ukuthi i-metoprolol succinate ikhishwa ngokuhamba kwesikhathi emzimbeni okuholela emiphumeleni yokusebenza isikhathi eside.
I-Metoprolol tartrate ingadinga ukuthathwa kaningi ngosuku. I-Metoprolol succinate ingathathwa kanye nsuku zonke ngoba ihlala isikhathi eside kunefomu le-tartrate. I-Metoprolol succinate nayo ingasetshenziswa ezinganeni ezineminyaka engu-6 nangaphezulu kanti i-metoprolol tartrate ingasetshenziswa kuphela kubantu abadala.
| Umehluko omkhulu phakathi kwe-metoprolol tartrate ne-metoprolol succinate | ||
|---|---|---|
| I-Metoprolol Tartrate | Metoprolol Succinate | |
| Isigaba sezidakamizwa | I-beta blocker | I-beta blocker |
| Isimo somkhiqizo / ejwayelekile | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala |
| Ngubani igama lomkhiqizo? | Lopressor | ITrolrol XL |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo | Ithebhulethi yomlomo, ukukhishwa okunwetshiwe |
| Uyini umthamo ojwayelekile? | 100 mg kuya ku-400 mg nsuku zonke ngemithamo ehlukanisiwe | 100 mg kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Ukusetshenziswa kwesikhashana noma kwesikhathi eside njengoba kuqondiswe udokotela | Ukusetshenziswa kwesikhashana noma kwesikhathi eside njengoba kuqondiswe udokotela |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala | Abantu abadala nezingane ezineminyaka engu-6 nangaphezulu |
Ufuna intengo engcono kakhulu ku-metoprolol tartrate?
Bhalisela izexwayiso zentengo ye-metoprolol futhi uthole ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Izimo eziphathwa yi-metoprolol tartrate ne-metoprolol succinate
Izinhlobo ze-tartrate kanye ne-succinate ze-metoprolol zivunyelwe yi-FDA ukwelapha umfutho wegazi ophakeme (umfutho wegazi ophezulu) nobuhlungu besifuba (angina pectoris).
I-Metoprolol tartrate nayo ivunyelwe yi-FDA njengokwelashwa ngemuva nje kwe- isifo senhliziyo (i-infarction ye-myocardial acute). Ukuthatha i-metoprolol tartrate ngemuva kokuhlaselwa yinhliziyo kungasiza ekunciphiseni ubungozi bokuqhubeka kwemicimbi yenhliziyo nokufa ikakhulukazi kulabo abanesifo semithambo yenhliziyo. Ukwelashwa kufanele kuvame ukuqala zingakapheli izinsuku ezintathu kuya kwezingu-10 ngemuva kokuhlaselwa yinhliziyo.
Ngaphezu kwengcindezi ephezulu yegazi nobuhlungu besifuba, i-metoprolol succinate nayo ivunyelwe yi-FDA ukwelapha ukuhluleka kwenhliziyo . Ngokuqondile, i-metoprolol succinate iphatha ukwehluleka kwenhliziyo okungapheli okungukuthi I-New York Heart Association isigaba II noma III. Njengoba inikezwe njengomthamo wansuku zonke, i-metoprolol succinate ingathuthukisa imiphumela futhi yehlise ubungozi bokufa kweziguli ezihluleka yinhliziyo.
Ngaphandle kwelebula ukusetshenziswa kwe-metoprolol kufaka phakathi i-supraventricular tachycardia (isilinganiso esisheshayo senhliziyo) nesiphepho segilo (isimo esiyingozi esibangelwa ukukhiqizwa ngokweqile kwehomoni yegilo). Okunye ukusetshenziswa okungekho kwelebula kungafaka ukwelashwa kwesigqi senhliziyo esingajwayelekile (arrhythmia) kanye ukukhathazeka kokusebenza .
| Isimo | I-Metoprolol Tartrate | Metoprolol Succinate |
| Umfutho wegazi ophakeme | Yebo | Yebo |
| Ubuhlungu besifuba obungapheli | Yebo | Yebo |
| Isifo senhliziyo esibuhlungu | Yebo | Ngaphandle kwelebula |
| Ukwehluleka kwenhliziyo | Ngaphandle kwelebula | Yebo |
| I-tachycardia engaphezulu | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Isiphepho sendlala yegilo | Ngaphandle kwelebula | Ngaphandle kwelebula |
| I-Arrhythmia | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukukhathazeka kokusebenza | Ngaphandle kwelebula | Ngaphandle kwelebula |
Ingabe i-metoprolol tartrate noma i-metoprolol succinate isebenza kahle kakhulu?
I-Metoprolol tartrate ne-metoprolol succinate zombili ziyefana ekusebenzeni ekwelapheni umfutho wegazi ophakeme kanye nobuhlungu besifuba obungapheli. Kodwa-ke, i-metoprolol tartrate ingasebenza ngempumelelo njengokwelashwa kokuhlaselwa yinhliziyo okuyingozi ngenkathi i-metoprolol succinate ingasebenza ngempumelelo njengokwelashwa kokuhluleka kwenhliziyo okungamahlalakhona.
Umtholampilo izilingo kubonise ukuthi i-metoprolol tartrate iyasebenza ekucindezelweni kwegazi okuphezulu futhi ivimbele imiphumela emibi ngemuva kokuhlaselwa yinhliziyo. Ngokuphambene nalokho, izifundo ezibandakanya ukuhlolwa kwe-Merit-HF ngibonisile ukuthi i-metoprolol succinate iphakeme kune-metoprolol tartrate yokwehluleka kwenhliziyo okungamahlalakhona.
I-Metoprolol succinate inganciphisa ukuvakashelwa kwesibhedlela okuphindaphindiwe nokufa ngokuhluleka kwenhliziyo. Noma kunjalo, isithombe , enye i-beta blocker ejwayelekile, ingahle isebenze kakhulu kune-metoprolol succinate, ngokusho kwesilingo esishicilelwe ku- I-Lancet .
Ngoba i-metoprolol tartrate ithathwa izikhathi eziningi usuku lonke, amazinga ezidakamizwa emzimbeni kungenzeka angalingani. Lokhu kungaholela emiphumeleni emibi kanye nokubekezelelana okuncane uma kuqhathaniswa nefomu le-succinate ekhishwe isikhathi eside. Eyodwa ukuhlaziywa ithole ukuthi imiphumela emibi efana nokushaya kwenhliziyo okuhamba kancane (i-bradycardia) kungenzeka ukuthi yenzeke ngokukhipha i-metoprolol tartrate ngokushesha.
Ukuhlanganiswa nokuqhathaniswa kwezindleko kwe-metoprolol tartrate vs. metoprolol succinate
I-Metoprolol tartrate ingathengwa njengesidakamizwa esijwayelekile esivame ukumbozwa yi-Medicare nezinye izinhlelo zomshuwalense. Ngaphandle komshuwalense, intengo yemali ejwayelekile ye-generic metoprolol tartrate icishe ibe ngu- $ 5. Amakhadi esaphulelo e-SingleCare angasetshenziswa emakhemisi abamba iqhaza ukunciphisa izindleko zalo muthi. Ungathola inani eliseduze ne- $ 4 ngesigqebhezana sokonga.
I-Metoprolol succinate noma i-metoprolol ekhishwe isikhathi eside iyatholakala njengemithi ejwayelekile embozwe iningi le-Medicare nezinhlelo zomshuwalense. I-generic metoprolol succinate kungenzeka ukuthi imbozwe kunegama lomkhiqizo iToprol XL. Intengo emaphakathi yokuthengisa ye-generic Toprol XL icishe ibe ngu- $ 56. Buza ekhemisi lakho ukubona ukuthi ungonga kakhulu ngekhadi lokonga le-SingleCare. Uma kwamukelwa, unganciphisa izindleko ziye ku- $ 9.
| I-Metoprolol Tartrate | Metoprolol Succinate | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare? | Yebo | Yebo |
| Umthamo ojwayelekile | 50 mg amaphilisi | Amaphilisi ayi-100 mg |
| I-Medicare copay ejwayelekile | $ 0- $ 65 | $ 0- $ 20 |
| Izindleko ze-SingleCare | $ 4 | $ 9 |
Thola ikhadi lesaphulelo sekhemisi
Imiphumela emibi ejwayelekile ye-metoprolol tartrate vs. metoprolol succinate
I-Metoprolol tartrate ne-metoprolol succinate kungadala imiphumela emibi efanayo. Imiphumela emibi kakhulu ye-metoprolol ifaka ukukhathala noma ukukhathala, isiyezi, ukudangala, ukuphefumula (dyspnea), nokushaya kwenhliziyo okuhamba kancane (bradycardia). Eminye imiphumela emibi ifaka phakathi isifo sohudo, isicanucanu, ukuhlanza nomlomo owomile.
Ukusabela kwe-Hypersensitivity okufana nokuqubuka noma ukulunywa kungenzeka futhi lapho uthatha noma yiluphi uhlobo lwe-metoprolol. Ngokuya nge Ilebula le-FDA , i-metoprolol tartrate ingaba namathuba amaningi okudala imiphumela ethile emibi.
| I-Metoprolol Tartrate | Metoprolol Succinate | |||
| Imiphumela emibi | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ukukhathala | Yebo | 10% | Yebo | > 2% |
| Isiyezi | Yebo | 10% | Yebo | > 2% |
| I-Rash | Yebo | 5% | Yebo | > 2% |
| Ukucindezeleka | Yebo | 5% | Yebo | > 2% |
| Uhudo | Yebo | 5% | Yebo | > 2% |
| Ukuphelelwa umoya | Yebo | 3% | Yebo | > 2% |
| Ukushaya kwenhliziyo okuhamba kancane | Yebo | 3% | Yebo | > 2% |
| Umlomo owomile | Yebo | 1% | Yebo | * akubikiwe |
| Isicanucanu | Yebo | 1% | Yebo | * |
| Isilungulela | Yebo | 1% | Yebo | * |
| Ukuqunjelwa | Yebo | 1% | Yebo | * |
Lokhu kungenzeka kungabi uhlu oluphelele. Xhumana nodokotela wakho noma usokhemisi ngemiphumela engemihle engaba khona.
Umthombo: I-DailyMed (metoprolol tartrate) , I-DailyMed (metoprolol succinate)
Ukusebenzisana kwezidakamizwa kwe-metoprolol tartrate vs. metoprolol succinate
I-Metoprolol tartrate ne-metoprolol succinate zingasebenzisana nemithi eminingi efanayo. Eminye imithi enezenzo ezifanayo noma ethinta imetabolism ye-beta blockers ingaxhumana nazo zombili izinhlobo ze-metoprolol.
I-Metoprolol akufanele ithathwe ngemithi eqeda i-catecholamine. Ukuthatha le mithi ndawonye kungakhuphula imiphumela ye-beta blockers futhi kubangele izehlakalo ezimbi ezifana nomfutho wegazi ophansi ( i-hypotension ) nokushaya kwenhliziyo okuhamba kancane (bradycardia). Eminye imiphumela emibi ingafaka isiyezi nokuquleka.
I-Metoprolol icutshungulwa kakhulu yi-CYP2D6 enzyme. Ngakho-ke, izidakamizwa ezivimbela le enzyme zingadala amazinga we-metoprolol akhuphukile emzimbeni. Ukukhuphuka kwamazinga we-metoprolol kungakhuphula ubungozi bemiphumela emibi.
I-Digoxin nezidakamizwa ezibizwa nge-calcium channel blockers zingaba nemiphumela yokwengeza lapho zinikezwa nge-metoprolol. Ukuthatha noma imuphi wale mithi nge-metoprolol kungadala imiphumela emibi enhliziyweni.
| Izidakamizwa | Isigaba Sezidakamizwa | I-Metoprolol Tartrate | Metoprolol Succinate |
| Hlanganisa kabusha I-Tetrabenazine | Isidakamizwa esinciphisa i-Catecholamine | Yebo | Yebo |
| I-Quinidine I-Fluoxetine I-Fluvoxamine Sertraline I-Bupropion I-Paroxetine I-Propafenone I-Haloperidol I-Diphenhydramine I-Hydroxychloroquine I-Terbinafine | CYP2D6 inhibitor | Yebo | Yebo |
| I-Digoxin | I-glycoside yenhliziyo | Yebo | Yebo |
| Diltiazem I-Verapamil | Isivimbeli sesiteshi seCalcium | Yebo | Yebo |
| Clonidine IGuanethidine I-Betanidine | I-ejenti ye-alpha-adrenergic | Yebo | Yebo |
Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.
Izexwayiso ze-metoprolol tartrate ne-metoprolol succinate
Kokubili i-metoprolol tartrate ne-metoprolol succinate akufanele kuyekwe ngokungazelelwe. Uma ukwelashwa nge-metoprolol kumiswa ngokungazelelwe, abanye abantu bangathola ingozi ephezulu yokuhlaselwa yisifo senhliziyo, okungavamile isigqi senhliziyo , nobuhlungu besifuba. Ubungozi bale micimbi bukhulu kulabo abanezifo zenhliziyo ezingaphansi.
Ama-beta blockers afana ne-metoprolol akufanele asetshenziswe kunoma ngubani onale mibandela elandelayo:
- I-bradycardia enamandla
- Inhliziyo ivimba kakhulu kuneziqu zokuqala
- Ukushaqeka kwe-Cardiogenic
- Ukwehluleka kwenhliziyo okunciphisiwe
- I-sinus syndrome egulayo ngaphandle kwe-pacemaker
- Ukuzwela ngokweqile kunoma yiziphi izithako kule mithi
Xhumana nodokotela ukuze ubone ukuthi ungaba yini nalezi zimo ngaphambi kokuqala ukwelashwa.
Ama-beta blockers angazifihla izimpawu nezimpawu ze-hypoglycemia, noma ushukela wegazi ophansi. Labo abanesifo sikashukela bangadinga ukuqapha ushukela wegazi labo ngenkathi bethatha ama-beta blocker.
Imibuzo ebuzwa njalo mayelana ne-metoprolol tartrate vs. metoprolol succinate
Yini i-metoprolol tartrate?
I-Metoprolol tartrate igama elijwayelekile le-Lopressor. I-beta blocker esetshenziselwa ukwelapha umfutho wegazi ophakeme kanye nobuhlungu besifuba obungapheli. Kuphinde kuvunyelwe ukwelashwa kwesifo esibi senhliziyo ukwehlisa ubungozi bokufa.
Kuyini i-metoprolol succinate?
I-Metoprolol succinate yaziwa nangokuthi igama lomkhiqizo iToprol XL. Kuyindlela ekhishwe isikhathi eside ye-metoprolol. I-Metoprolol succinate ivunyelwe ukwelapha umfutho wegazi ophezulu, ubuhlungu besifuba obungapheli, kanye nokucinana ukuhluleka kwenhliziyo .
Ngabe i-metoprolol tartrate ne-metoprolol inciphisa okufanayo?
Cha. IMetoprolol tartrate iyithebhulethi ekhishwa ngokushesha ngenkathi i-metoprolol succinate iyithebhulethi ekhishwa isikhathi eside. Zingasetshenziswa ngezindlela ezihlukile.
Ingabe i-metoprolol tartrate noma i-metoprolol igcizelela kangcono?
I-Metoprolol tartrate ne-metoprolol succinate zombili ziyasebenza ngokuya ngesimo esiphathwayo. I-Metoprolol succinate isebenza kangcono ekwelapheni ukwehluleka kwenhliziyo. I-Metoprolol succinate nayo kungenzeka ingabi namathuba amancane okudala imiphumela emibi.
Ngingayisebenzisa yini i-metoprolol tartrate noma i-metoprolol succinate ngenkathi ngikhulelwe?
I-Metoprolol kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma izinzuzo zidlula ngokusobala izingozi. Azikho izifundo ezanele ezenziwe ukukhombisa ukuthi le mithi iphephile ngo-100% ngesikhathi sokukhulelwa. Xhumana nodokotela uma ukhulelwe noma uncelisa.
Ngingasebenzisa i-metoprolol tartrate noma i-metoprolol succinate ngotshwala?
Ukuphuza utshwala ngenkathi uthatha i-metoprolol kungakhuphula ubungozi bokuzela kanye nesiyezi. Akunconywa ngokuvamile ukusebenzisa i-metoprolol nge utshwala .
Ngabe ungashintsha kusuka ku-metoprolol tartrate uye ekunciphiseni?
Kwezinye izimo, i-metoprolol tartrate ingashintshelwa ku-metoprolol succinate. I-Metoprolol succinate ingancanyelwa umthamo wayo wansuku zonke. Xhumana nodokotela wakho ukuthola ukuthi yini ongakhetha kuyo lapho welapha imithi.
Kufanele ungayithathi nini i-metoprolol?
I-Metoprolol akufanele ithathwe uma uhlangabezana nezinga eliphansi kakhulu lenhliziyo, umfutho wegazi ophansi, noma ukwehluleka okukhulu kwenhliziyo. Kubalulekile ukuxoxa ngomlando wakho wezokwelapha nodokotela ukuze unqume ukuthi kufanele yini ube kwi-metoprolol.
Yini okufanele ngiyigweme ngenkathi ngithatha i-metoprolol?
Utshwala nemithi ethile kufanele kugwenywe ngenkathi uthatha i-metoprolol. Eminye imishanguzo kufaka phakathi i-calcium channel blockers, iqinisekile imishanguzo , futhi lezo ezicutshungulwa ngendlela efanayo ne-metoprolol zingakhuphula ubungozi bemiphumela emibi nge-metoprolol.
Ingabe i-metoprolol imithi eyingozi kakhulu?
Yebo. I-Metoprolol ingabhekwa njengomuthi onobungozi obukhulu. Uma isetshenziswe ngendlela engafanele, i-metoprolol ingadala ingozi enkulu.
