Main >> Izidakamizwa Vs. Umngani >> I-Protonix vs. Nexium: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Protonix vs. Nexium: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Protonix (pantoprazole) ne-Nexium (esomeprazole) yimithi emibili esetshenziselwa ukwelapha izinkinga zomgudu wokugaya ukudla, njengesifo se-reflux se-gastroesophageal (GERD). I-GERD yisimo esingelapheki esivelayo lapho i-asidi yesisu igeleza njalo ibuyele esiswini kusuka esiswini. Lokhu kungaholela ezimpawu ezifana nesilungulela kanye nezinkinga ezinkulu njenge-esophagitis erosive.

Kokubili iProtonix neNexium bayingxenye yesigaba sezidakamizwa esibizwa ngeproton pump inhibitors (PPIs). Basebenza ngokuvimba amaphampu we-proton esiswini, abhekele ukukhiqizwa kwe-asidi. Empeleni, iProtonix neNexium zisiza ukunciphisa ukukhiqizwa kwe-asidi jikelele esiswini.

Uyini umehluko omkhulu phakathi kweProtonix neNexium?

I-Protonix, eyenziwe yiPfizer, yigama lomkhiqizo le-pantoprazole. Kungumuthi kadokotela osetshenziselwa ukwelapha i-esophagitis ekhukhumezayo kubantu abadala nezingane ezineminyaka engu-5 nangaphezulu. Itholakala njengethebhulethi yokukhishwa okulibazisekile engama-20 mg kanye no-40 mg, kanye nokumiswa ketshezi okungama-40 mg. Kwezinye izimo, i-Protonix ingaphathwa njengomjovo we-intravenous (IV).

INexium yenziwa yi-AstraZeneca futhi yigama lomkhiqizo le-esomeprazole. Itholakala njengomuthi kadokotela noma we-over-the-counter (OTC) osetshenziselwa ukwelapha i-GERD kubantu abadala, izingane, nezinsana ezineminyaka engu-1 nangaphezulu. Ngokungafani ne-Protonix, i-Nexium iza njenge-20 mg ne-40 mg yokubambezeleka kokukhipha iphilisi. I-Nexium iyatholakala futhi njenge-2.5 mg, 5 mg, 10 mg, 20 mg, kanye no-40 mg ukumiswa ketshezi.

Umehluko omkhulu phakathi kweProtonix neNexium
	I-Protonix	I-Nexium
Isigaba sezidakamizwa	IProton pump inhibitor (PPI)	IProton pump inhibitor (PPI)
Isimo somkhiqizo / ejwayelekile	Uhlobo lomkhiqizo nolwejwayelekile luyatholakala	Uhlobo lomkhiqizo nolwejwayelekile luyatholakala
Ngubani igama elijwayelekile?	I-Pantoprazole	Esomeprazole
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi yokukhishwa ebambezelekile Iphakethe le-Granules lokumiswa ketshezi I-powder efakwa ngomjovo	I-capsule yokukhishwa okulibazisekile Iphakethe le-Granules lokumiswa ketshezi I-powder efakwa ngomjovo
Uyini umthamo ojwayelekile?	40 mg kanye ngosuku	20 noma 40 mg kanye ngosuku
Yelashwa isikhathi esingakanani?	Kuze kube amasonto ayi-8	Amaviki ama-4 kuye kwayi-8 kuya ngesimo esiphethwe
Ubani ovame ukusebenzisa umuthi?	Abantu abadala nezingane ezineminyaka engu-5 nangaphezulu	Abantu abadala, izingane, nezinsana ezineminyaka engu-1 nangaphezulu

Izimo eziphathwa yiProtonix neNexium

I-Protonix neNexium zingaphatha i-GERD nezimo ezihambisana ne-GERD, njenge-acid reflux (isilungulela). Yomibili le mithi nayo i-FDA ivunyelwe ukwelapha i-esophagitis erosive, noma ukuvuvukala kolwelwesi lwe-esophagus.

I-Nexium nayo i-FDA ivunyelwe ukwelapha ukutheleleka kwe-Helicobacter pylori (H. pylori). Lolu hlobo lokutheleleka luqala lapho ama-bacterium eH. Pylori engena emgudwini wokugaya ukudla, ongaholela ezilondeni. Ngaphezu kwezilonda ezidalwa nguH. Pylori, iNexium ingavimbela ubungozi bezilonda ezihambisana nezidakamizwa ezingezona ukuvuvukala (ama-NSAID).

Kokubili iProtonix neNexium kungasetshenziswa ukwelapha izimo ze-hypersecretory, njengeZollinger-Ellison syndrome. Lezi zimo zibonakala ngokukhiqizwa ngokweqile kwesisu esiswini. I-Protonix ne-Nexium nayo ingasetshenziselwa ukwelapha izilonda ezinama-peptic, ezihlanganisa zombili izilonda ze-duodenal nezesisu.

I-Protonix ne-Nexium zinconywa kuphela ukusetshenziswa kwesikhashana, noma kuze kube amasonto ayisishiyagalombili ezimweni eziningi.

Isimo	I-Protonix	I-Nexium
Isifo se-reflux se-gastroesophageal (GERD)	Yebo	Yebo
Ukuqothuka kwesisu	Yebo	Yebo
Izimo ze-hypersecretory	Yebo	Yebo
H. pylori ukutheleleka	Ngaphandle kwelebula	Yebo
Ukunciphisa ubungozi bezilonda zesisu ezihlobene ne-NSAID	Ngaphandle kwelebula	Yebo
Izilonda ze-duodenal	Ngaphandle kwelebula	Ngaphandle kwelebula
Izilonda zesisu	Ngaphandle kwelebula	Ngaphandle kwelebula
Isilungulela	Ngaphandle kwelebula	Yebo

Ingabe iProtonix noma i-Nexium isebenza kangcono?

Ukuhlolwa komtholampilo kukhombisile ukuthi i-pantoprazole ne-esomeprazole ziyasebenza ngokufanayo. Isivivinyo esisodwa somtholampilo kuqhathaniswa nokusebenza ka-40 mg we-pantoprazole kuya ku-40 mg we-esomeprazole ezigulini ezine-GERD. Cishe iziguli ezingama-580 zenziwa ngokungahleliwe ukuthola i-pantoprazole noma i-esomeprazole ngaphezulu kwamasonto ama-4, 8, noma ama-12 okwelashwa. Ukuxolelwa okuphelele kwe-GERD kufinyelelwe ngazo zombili i-PPI ngamanani afanayo.

Esivivinyweni somtholampilo esingahleliwe, esiyimpumputhe, ukusebenza kwe-pantoprazole ne-esomeprazole kwaqhathaniswa nokwelapha i-GERD. Cishe iziguli ezingama-200 zenziwa ngokungahleliwe ukuthola noma i-40 mg ye-pantoprazole nsuku zonke noma i-40 mg ye-esomeprazole nsuku zonke. Womabili ama-PPI atholakele ekhona kusebenza ngokulinganayo ngokuphepha nokubekezelela okungaqhathaniswa.

Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuze uthole ukwelashwa okungcono kakhulu kuwe. Umhlinzeki wakho wokunakekelwa okuyisisekelo angakudlulisela kudokotela ogxile ku-gastroenterology ukuthola izeluleko ezengeziwe zezokwelapha.

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kweProtonix vs. Nexium

Iningi le-Medicare nezinhlelo zomshuwalense zizofaka uhlobo olujwayelekile lweProtonix, i-pantoprazole. Ama-copay ama-Medicare angahle kusuka ku- $ 0 kuye ku- $ 17 we-pantoprazole. Ngaphandle komshuwalense, inani lentengo lemali le-Protonix lingu- $ 522. Kodwa-ke, ngesigqebhezana seProtonix esivela ku-SingleCare, izindleko ezijwayelekile cishe zingama- $ 11.

Amanye ama-Medicare nezinhlelo zomshuwalense zingamboza i-Nexium noma uhlobo lwayo olujwayelekile, i-esomeprazole. Ama-Medicare copays we-esomeprazole angahle kusuka ku- $ 1 kuye ku- $ 41. Intengo emaphakathi yokuthengisa yeNexium ingu- $ 478 kuye ngobungako namandla anqunyiwe. Ngekhuphoni le-SingleCare Nexium, intengo emaphakathi ingancishiswa ibe cishe ngama- $ 27.

	I-Protonix	I-Nexium
Ngokuvamile embozwe umshwalense?	Yebo, njengenguqulo ejwayelekile	Yebo, njengenguqulo ejwayelekile
Imbozwe ngokujwayelekile yi-Medicare Part D?	Yebo, njengenguqulo ejwayelekile	Yebo, njengenguqulo ejwayelekile
Ubuningi	Amaphilisi angama-30 (40 mg)	Amaphilisi angama-30 (40 mg)
I-Medicare copay ejwayelekile	$ 0– $ 17	$ 1– $ 41
Izindleko ze-SingleCare	$ 11 +	$ 27 +

Imiphumela emibi ejwayelekile ye-Protonix vs. Nexium

Imiphumela emibi kakhulu ye-Protonix yikhanda, isifo sohudo, isicanucanu, ubuhlungu besisu, ukuhlanza, igesi, isiyezi, nobuhlungu bamalunga.

Imiphumela emibi ejwayelekile yeNexium ifaka ikhanda, isifo sohudo, isicanucanu, igesi, ubuhlungu besisu, ukuqunjelwa, nomlomo owomile.

Imiphumela emibi ye-PPIs ivame ukuhlotshaniswa nokusetshenziswa kwesikhathi eside. Imiphumela emibi ingabandakanya ukuphuka kwamathambo ahlobene ne-osteoporosis, ukuntuleka kwe-vitamin B12, namazinga aphansi we-magnesium (hypomagnesemia).

	I-Protonix	I-Nexium
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ubuhlungu bekhanda	Yebo	12%	Yebo	≥1%
Uhudo	Yebo	9%	Yebo	≥1%
Ukuqunjelwa	Yebo	<2%	Yebo	≥1%
Umlomo owomile	Yebo	<2%	Yebo	≥1%
Isicanucanu	Yebo	7%	Yebo	≥1%
Ubuhlungu besisu	Yebo	6%	Yebo	≥1%
Ukuhlanza	Yebo	4%	Yebo	<1%
Isiyezi	Yebo	3%	Yebo	<1%
Igesi	Yebo	4%	Yebo	≥1%
Ubuhlungu obuhlangene	Yebo	3%	Akunjalo	-

Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( I-Protonix ), IDailyMed ( I-Nexium )

Ukusebenzisana kwezidakamizwa kweProtonix vs. Nexium

I-Protonix ne-Nexium, njengamanye ama-PPI, ahlangana nemithi eminingi efanayo. Lawa ma-PPI kufanele abhekwe noma agwenywe nezinye izidakamizwa ezincike ku-asidi wesisu ukuze umunce. Izidakamizwa ezincike ku-asidi esiswini ukuze zimuncwe zifaka usawoti wensimbi, i-erlotinib, i-ketoconazole, ne-mycophenolate mofetil.

IProtonix neNexium nazo zingasebenzisana nemishanguzo yokuthithibalisa igciwane lengculazi, noma imishanguzo ejwayele ukusetshenziselwa ukwelapha i-HIV. Ama-PPI angakhuphula noma anciphise amazinga egazi emishanguzweni, engaholela engcupheni eyengeziwe yobuthi noma yehle ukusebenza ngemithi yezidambisigciwane.

Ukusetshenziswa kwe-Protonix noma i-Nexium ene-warfarin kungakhuphula ingozi yokuphuma kwegazi.

I-Nexium kufanele ihlolwe noma igwenywe nge-diazepam ngoba ingakhuphula amazinga egazi e-diazepam futhi iholele engcupheni eyengeziwe yemiphumela emibi. Ukusetshenziswa kwe-Nexium ne-clopidogrel ndawonye kufanele futhi kugwenywe. I-Nexium inganciphisa ukusebenza kahle kwe-clopidogrel emzimbeni, okungakhuphula ubungozi bamahlule egazi.

Izidakamizwa	Uhlobo lwezidakamizwa	I-Protonix	I-Nexium
Atazanavir I-Rilpivirine UNelfinavir I-Saquinavir	Izidambisigciwane	Yebo	Yebo
Ketoconazole	I-Antifungal	Yebo	Yebo
Idoyelo le-sulfate Idoyiphu yegluconate Umfutho fumarate	Usawoti wensimbi	Yebo	Yebo
IMycophenolate mofetil IMethotrexate	I-Immunosuppressant	Yebo	Yebo
U-Erlotinib	Ukwelashwa ngamakhemikhali	Yebo	Yebo
I-Digoxin	I-glycoside yenhliziyo	Yebo	Yebo
I-Warfarin	I-Anticoagulant	Yebo	Yebo
I-Diazepam	I-Benzodiazepine	Akunjalo	Yebo
I-Clopidogrel	I-Antiplatelet	Akunjalo	Yebo

Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka

Izexwayiso zeProtonix neNexium

Ukusetshenziswa kwesikhathi eside kwama-PPIs kungaholela engcupheni yokwanda kwamathambo, ikakhulukazi kubantu asebethole ukuthi bane-osteoporosis. Ubuningi bamathambo bungadinga ukubhekwa ngesikhathi sokwelashwa kwesikhathi eside ngama-PPIs.

Ezinye iziguli zithole i-acute tubulointerstitial nephritis (TIN) ngenkathi ithatha iProtonix noma i-Nexium. I-Nephritis ukuvuvukala kwezinso, okungaholela ekwehliseni ukusebenza kwezinso.

Ukusetshenziswa kwama-PPIs kungaxhunyaniswa nengozi eyengeziwe yesifo sohudo esihambisana neClostridium difficile. Labo ababhekana nesifo sohudo esiqhubekayo bangadinga ukuqashwa, ikakhulukazi esimweni esibhedlela.

Ukuthatha iProtonix noma i-Nexium kungakhuphula ubungozi bamazinga egazi aphansi we-magnesium (hypomagnesemia) noma i-vitamin B12 (ukuntula uvithamini B12). Kukhona ingozi eyengeziwe ye-hypomagnesemia nokuntuleka kwe-vitamin B12 kulabo abelashwa isikhathi eside ngama-PPIs.

Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola ezinye izexwayiso nezinyathelo zokuzivikela ngaphambi kokuthatha i-PPI.

Imibuzo ebuzwa njalo mayelana ne-Protonix vs. Nexium

Kuyini iProtonix?

I-Protonix yimithi kadokotela kuphela ye-PPI esetshenziswa kakhulu ekwelapheni i-esophagitis erosist ehambisana ne-GERD. I-Protonix iyatholakala njengethebhulethi ekhishwe ukubambezeleka nokumiswa kuketshezi. Igama elijwayelekile leProtonix yi-pantoprazole.

Yini i-Nexium?

I-Nexium ngumuthi we-PPI osetshenziselwa ukwelapha i-acid reflux nesilungulela, kanye ne-esophagitis erosive ehambisana ne-GERD. Iyatholakala ngomuthi kadokotela noma ekhawunteni. I-Nexium ngokuyinhloko iza njenge-capsule ekhishwe ukubambezeleka noma ukumiswa ketshezi. Igama elijwayelekile le-Nexium yi-esomeprazole.

Ingabe iProtonix neNexium ziyafana?

I-Protonix ne-Nexium yimithi emibili ye-PPI ekwazi ukwelapha i-GERD, izimo ze-hypersecretory, kanye nezilonda ze-peptic. Kodwa-ke, aqukethe izithako ezahlukahlukene ezisebenzayo futhi eza ngezindlela ezahlukahlukene. I-Protonix iqukethe i-pantoprazole kanti i-Nexium iqukethe i-esomeprazole. I-Protonix ingaphatha i-GERD kubantu abadala kanye nezingane ezineminyaka engu-5 nangaphezulu ngenkathi i-Nexium ingaphatha i-GERD kubantu abadala, izingane, nezinsana ezinenyanga eyodwa nangaphezulu.

Ingabe iProtonix noma i-Nexium ingcono?

I-Protonix ne-Nexium ziyafana ngokusebenza. I-PPI efaneleke kakhulu izonqunywa ngokuya ngeminyaka, isimo sezokwelapha, izindleko, umshuwalense, kanye neminye imithi ethathwayo.

Ngingayisebenzisa i-Protonix noma i-Nexium ngenkathi ngikhulelwe?

I-Protonix noma i-Nexium ingaphepha ukuyithatha ngenkathi ukhulelwe. Kodwa-ke, kufanele zisetshenziswe kuphela uma izinzuzo zidlula izingozi. Njengamanje, azikho izifundo ezanele ukukhombisa ukuthi iProtonix noma i-Nexium iphephe ngokuphelele ukuyisebenzisa ngesikhathi sokukhulelwa. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ukuthola ukwelashwa okungcono kwe-GERD ngenkathi ukhulelwe.

Ngingasebenzisa i-Protonix noma i-Nexium ngotshwala?

Ngenkathi utshwala bungaziwa ukuthi buhlangana neProtonix noma i-Nexium, bungalimaza i-acid reflux nezimpawu zokushiswa yinhliziyo kwabanye abantu. Ukusetshenziswa kotshwala kungaphepha ngokulinganisela ngenkathi uthatha iProtonix noma i-Nexium, kepha ngokuvamile akunconywa.

Yini ephumelela kunazo zonke iproton pump inhibitor?

I-PPI ephumelela kunazo zonke izoncika esimweni esiphathwayo, isilinganiso se-PPI, neminye imithi umuntu angayiphuza. Izindleko ze-PPI kufanele futhi zicatshangelwe lapho kunqunywa inketho esebenza kahle kakhulu.

Yini engingayithatha esikhundleni se-Nexium?

I-Nexium (esomeprazole) iyi-proton pump inhibitor. Amanye ama-proton pump inhibitors afaka phakathi i-Prilosec (omeprazole), i-Prevacid (lansoprazole), i-Aciphex (rabeprazole), ne-Protonix (pantoprazole). Uma izimpawu ze-GERD zingathuthuki nge-PPI, umhlinzeki wezokunakekelwa kwempilo angancoma umuthi we-H2 blocker esikhundleni salokho. Izibonelo ze-H2 blockers zifaka iPepcid (famotidine), iZantac (ranitidine), neTagamet (cimetidine).

Ingabe i-Nexium ingenza i-reflux ibe yimbi kakhulu?

I-Nexium isetshenziselwa ukwelapha i-acid reflux. Ukuyeka ukwelashwa kwe-Nexium ngaphambi kokunconywa ngumhlinzeki wezokunakekelwa kwempilo kungaholela ekubuyisweni kwezimpawu ze-reflux. INexium ingahle ingasebenzi ngokufanayo kuwo wonke umuntu. Uma izimpawu zingathuthuki nge-Nexium, ezinye izindlela zokwelashwa zinganconywa.