IVascepa vs. Lovaza: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Uma unayo ama-triglycerides aphezulu , Udokotela wakho kungenzeka ukuthi ukutshele ukuthi uzame ukudla nokuzivocavoca umzimba, futhi mhlawumbe nesitatimende esifana neLipitor. Kungenzeka futhi ukuthi uzwile ngama-omega-3 fatty acids, noma izengezo zamafutha ezinhlanzi.
IVascepa neLovaza yimithi yomuthi kadokotela ebizwa ngegama le-omega-3 fatty acid elapha amazinga aphezulu e-triglyceride. Yomibili le mithi ivunywa yi-United States Food and Drug Administration (FDA). U-Amarin Pharma, Inc. wenza uVascepa, kanti uGlaxoSmithKline wenza igama lomkhiqizo weLovaza. Le mithi isebenza ngezindlela eziningi zokunciphisa ama-triglycerides. Yize yomibili le mithi ingama-omega-3 supplements, awafani ncamashi. Qhubeka ufunde ukuze ufunde kabanzi ngeVascepa neLovaza.
Yini umehluko omkhulu phakathi kukaVascepa noLovaza?
IVascepa neLovaza bahlukaniswa njengezidakamizwa ezinciphisa imithi ye-omega-3 fatty acid lipid. IVascepa okwamanje itholakala ngegama lomkhiqizo, kuyilapho iLovaza itholakala kuzo zombili izinhlobo zomkhiqizo kanye nezejenerikhi (i-omega-3-acid ethyl esters). Zombili lezi zidakamizwa zivunyelwe ukusetshenziswa kubantu abadala futhi azifundwanga ezinganeni.
IVascepa iqukethe isithako se-icosapent ethyl, noma i-ethyl ester ye-eicosapentaenoic acid (EPA). IVascepa yehlisa i-triglycerides futhi ingasiza ekuvikeleni izinkinga zenhliziyo ezigulini ezithile ezisengozini enkulu.
ILovaza iqukethe i-omega-3-acid ethyl esters, ikakhulukazi i-eicosapentaenoic acid (EPA) ne-docosahexaenoic acid (DHA). ILovaza yehlisa ama-triglycerides kepha ingakhuphula i-cholesterol ye-LDL. Ngakho-ke, umphumela wayo kwisifo senhliziyo awaziwa.
| Umehluko omkhulu phakathi kukaVascepa noLovaza | ||
|---|---|---|
| UVascepa | Lovaza | |
| Isigaba sezidakamizwa | Omega-3 okunamafutha acid lipid-ukwehlisa ejenti | Omega-3 okunamafutha acid lipid-ukwehlisa ejenti |
| Isimo somkhiqizo / ejwayelekile | Umkhiqizo | Umkhiqizo nokujwayelekile |
| Ngubani igama elijwayelekile? | I-Icosapent ethyl noma i-ethyl ester ye-eicosapentaenoic acid (EPA) | I-Omega-3-acid ethyl esters: i-eicosapentaenoic acid (EPA) ne-docosahexaenoic acid (DHA) |
| Izidakamizwa zingena ngaziphi izinhlobo? | Amaphilisi | Amaphilisi |
| Uyini umthamo ojwayelekile? | 4 amagremu ngosuku ngemithamo ehlukanisiwe (ethathwe nokudla): 2, 1 gram capsules kabili ngosuku noma 4, 0.5 gram capsules kabili ngosuku I-Swallow capsule ephelele. Musa ukuvula, ukuhlafuna, ukuncibilikisa, noma ukuchoboza. | 4 amagremu ngosuku: 4, 1 gram capsules kanye ngosuku noma 2, 1 gram capsules kabili ngosuku I-Swallow capsule ephelele. Musa ukuvula, ukuhlafuna, ukuncibilikisa, noma ukuchoboza. |
| Yelashwa isikhathi esingakanani? | Iyahlukahluka | Iyahlukahluka |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala | Abantu abadala |
Ufuna intengo engcono kakhulu kuVascepa?
Bhalisela izexwayiso zentengo yeVascepa bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Izimo ezilashwa nguVascepa noLovaza
Kokubili iVascepa neLovaza kukhonjisiwe ukuthi kusetshenziswe njengesihlanganisi sokudla ukunciphisa ama-triglycerides kubantu abadala abane-triglycerides ephezulu kakhulu (≥ 500 mg / dL).
IVascepa nayo ingasetshenziswa kanye nemithamo ephezulu kakhulu ye- ukwelashwa kwe-statin ukwehlisa ubungozi bezehlakalo zenhliziyo (isifo senhliziyo, isifo sohlangothi, i-coronary revascularization, i-angina engazinzile) kubantu abadala abane-triglycerides / 150 mg / dL abanesifo senhliziyo, noma abanesifo sikashukela mellitus nezinye izici ezimbili zobungozi benhliziyo (zenhliziyo isifo).
Umphumela kaVascepa noLovaza engcupheni yokuqaqamba kwamaphaphu ezigulini ezine-triglycerides ephezulu kakhulu awukanqunywa.
Futhi, umphumela weLovaza kwisifo senhliziyo nokufa awaziwa.
| Isimo | UVascepa | Lovaza |
| Isetshenziswe kanye ne-high-dose statin ukunciphisa izinkinga zenhliziyo kubantu abadala abane-triglycerides ≥ 150 mg / dL | Yebo | Akunjalo |
| Isetshenziswa kanye nokudla ukwehlisa amazinga we-triglyceride kubantu abadala abane-hypertriglyceridemia enamandla (≥500 mg / dL) | Yebo | Yebo |
Ngabe iVascepa noma iLovaza iphumelela kakhulu?
Phakathi ku funda ngokuqhathanisa i-omega-3 fatty acids, ababhali baphetha ngokuthi le mithi inganciphisa kakhulu ama-triglycerides ngezinga elifanayo futhi ngokuvamile ayabekezelelwa. Imithi efana neLovaza, equkethe i-DHA, ingakhuphula i-cholesterol ye-LDL, engaba yinkinga kwiziguli ezisengozini enkulu yesifo senhliziyo. IVascepa iqukethe i-EPA kuphela futhi ayithinti amazinga e-LDL.
Umhlinzeki wakho wezokunakekelwa kwempilo angakunquma umuthi osebenza kahle kakhulu kuwe. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ukuthola iseluleko sezokwelapha. Anganquma ukuthi iVascepa noma iLovaza ikufanele yini wena uma ucubungula izimo zakho zezokwelapha nomlando kanye nanoma imiphi imithi oyiphuzayo engasebenzisana noVascepa noma uLovaza.
Ufuna intengo engcono kakhulu eLovaza?
Bhalisela izexwayiso zamanani eLovaza bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Ukuqhathaniswa kanye nezindleko zeVascepa vs. Lovaza
Izinhlelo zomshuwalense kanye nezinhlelo zemithi kaMedicare zivame ukumboza uVascepa noLovaza. Uma uthatha uLovaza, ukukhetha ifomu elejwayelekile kungonga imali enkulu, kuya ngohlelo lwakho.
Intengo ephuma ephaketheni yokuhlinzekwa kwenyanga eyodwa kweVascepa icishe ibe ngama- $ 390, kepha ungasebenzisa ikhadi lamahhala le-SingleCare ukwehlisa inani libe cishe ngama- $ 332.
Ukunikezwa kwenyanga eyodwa kwe-generic Lovaza kungama- $ 100 uma ukhokha uphuma ephaketheni. Isigqebhezana samahhala se-SingleCare singehlisa intengo ibe ngaphansi kwama- $ 30.
Xhumana nohlelo lwakho lomshuwalense ngolwazi olungeziwe lokumbozwa.
| UVascepa | Lovaza | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | 120, 1 amagremu amaphilisi | 120, 1 amagremu amaphilisi |
| I-Medicare copay ejwayelekile | $ 1- $ 3 | $ 1- $ 30 |
| Izindleko ze-SingleCare | $ 332 + | $ 30 + |
Imiphumela emibi ejwayelekile yeVascepa vs. Lovaza
Imiphumela emibi evame kakhulu yeVascepa ubuhlungu bemisipha, i-peripheral edema (ukuvuvukala kwezingalo noma imilenze), ukuqunjelwa, i-gout, ne-atrial fibrillation. Eminye imiphumela emibi ingafaka isifo sohudo noma ubuhlungu besisu.
Imiphumela emibi kakhulu yeLovaza yi-belching, indigestion, kanye noguquko oluguquliwe. Eminye imiphumela emibi ingavela, njengokuqunjelwa, ukuhlanza nokuqubuka.
Lolu akulona uhlu oluphelele lwemiphumela emibi. Eminye imiphumela emibi ingavela. Xhumana nochwepheshe wezokunakekelwa kwempilo ukuthola uhlu olugcwele lwemiphumela emibi.
| UVascepa | Lovaza | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ubuhlungu bemisipha | Yebo | ≥3% | Akunjalo | - |
| I-edema yomngcele | Yebo | ≥3% | Akunjalo | - |
| Ukuqunjelwa | Yebo | ≥3% | Yebo | % akubikiwe |
| Gout | Yebo | ≥3% | Akunjalo | - |
| I-Atrial fibrillation | Yebo | ≥3% | Yebo | % akubikiwe |
| Ukubheja | Akunjalo | - | Yebo | 4% |
| Ukugaya ukudla | Akunjalo | - | Yebo | 3% |
| Ukunambitheka okushintshiwe | Akunjalo | - | Yebo | 4% |
Umthombo: DailyMed ( UVascepa ), IDailyMed ( Lovaza )
Ukusebenzisana kwezidakamizwa kweVascepa vs. Lovaza
Njengoba kuchaziwe emininingwaneni ebekelwe uVascepa noLovaza, ezinye izifundo zokwelashwa ngama-omega-3 fatty acids afana noVascepa noLovaza bakhombise isikhathi esopha kakhulu kwiziguli, kepha isikhathi besingaphezu kwemikhawulo ejwayelekile, futhi iziqephu bezingabalulekanga emtholampilo. Uma i-Vascepa noma i-Lovaza ithathwa kanye ne-anticoagulant (igazi elinciphileyo) noma umuthi we-antiplatelet, hlola isiguli ukuthi siphume igazi. Tshela umhlinzeki wakho wezokunakekelwa kwempilo ngayo yonke imithi oyiphuzayo, kufaka phakathi imishanguzo kadokotela, imishanguzo ye-counter-the-counter (OTC), kanye nezithako zokudla.
| Izidakamizwa | Isigaba sezidakamizwa | UVascepa | Lovaza |
| I-Arixtra (fondaparinux) I-Coumadin (i-warfarin) U-Eliquis I-Heparin I-Lovenox (enoxaparin) Pradaxa I-Savaysa Xarelto | Ama-anticoagulants | Yebo | Yebo |
| I-Aspirin Brilinta I-Dipyridamole I-Effient (prasugrel) I-Plavix (clopidogrel) | Ama-antiplatelet agents | Yebo | Yebo |
Izexwayiso zikaVascepa noLovaza
- Ezivivinyweni zomtholampilo ezilawulwa kabili ezingaboni, i-placebo, uVascepa noLovaza bahlotshaniswa nengozi eyengeziwe ye-atrial fibrillation noma i-atrial flutter, edinga ukulaliswa esibhedlela. Isimo siphezulu ezigulini ezinomlando we-atrial fibrillation noma i-atrial flutter.
- IVascepa neLovaza ziqukethe okunamafutha acid aqhamuka emafutheni ezinhlanzi. Akucaci ukuthi iziguli ezinokungezwani komzimba nezinhlanzi noma i-shellfish zisengozini enkulu yokungezwani neVascepa noma iLovaza. Qaphela ukuthi kungenzeka ukuthi kukhona ukusabela okweqile, futhi funa usizo lwezokwelapha ngokushesha uma kwenzeka ukusabela.
- Ekuvivinyweni komtholampilo, uVascepa noLovaza bahlotshaniswa nengozi ephezulu yokopha. Ingozi iphezulu ezigulini ezithatha ama-anticoagulants noma ama-antiplatelet drug. Bona isigaba sokusebenzisana kwezidakamizwa ukuthola eminye imininingwane.
- Ezigulini ezinenkinga yesibindi, qapha i-AST ne-ALT ngesikhathi sokwelashwa.
- ISwallow Vascepa noma iLovaza capsules ephelele. Musa ukuhlafuna noma ukuchoboza.
- ILovaza ingakhuphula amazinga e-LDL cholesterol (noma i-LDL-C) — iqaphe amazinga e-LDL ngenkathi yelashwa ngeLovaza.
Imibuzo ebuzwa njalo mayelana neVascepa vs. Lovaza
Yini uVascepa?
UVascepa ngumuthi kadokotela omega-3 fatty acid oqukethe isithako esibizwa nge-EPA (ethyl ester ye-eicosapentaenoic acid). UVascepa usiza amazinga aphansi e-triglyceride.
Yini iLovaza?
ILovaza iyi-omega-3 fatty acid kadokotela esetshenziselwa ukwehlisa i-triglycerides. ILovaza iqukethe i-eicosapentaenoic acid (EPA) ne-docosahexaenoic acid (DHA).
Ngabe uVascepa noLovaza bayafana?
Yomibili le mithi iyafana. UVascepa noLovaza bobabili bangama-omega-3 fatty acid supplements atholakalayo ngodokotela wehlise i-triglycerides. Yomibili le mithi iqukethe i-EPA; ILovaza iqukethe ne-DHA. Okunye umehluko kuchazwe ngenhla.
Ngabe uVascepa noma uLovaza ungcono?
UVascepa noLovaza bayafaniswa nokwehlisa ama-triglycerides. Zibuye zibekezeleleke kahle. Umehluko owodwa ukuthi iVascepa ayithinti amazinga e-LDL, kepha iLovaza ingakhuphula amazinga e-LDL kwezinye iziguli. Lokhu kungathinta ukuthi imuphi umuthi owukhethayo udokotela wakho, kuya ngezingcuphe zakho zesifo senhliziyo.
Ngingasebenzisa uVascepa noma uLovaza ngenkathi ngikhulelwe?
Alukho ulwazi olwanele lokuthola ukuthi ngabe iVascepa noma iLovaza ziphephile yini ngesikhathi sokukhulelwa. Xhumana nomhlinzeki wakho wezempilo uma ukhulelwe noma uhlela ukukhulelwa.
Ngingasebenzisa iVascepa noma iLovaza ngotshwala?
Imininingwane enqunyiwe yeVascepa neLovaza ayisho ukuthi iziphi iziyalezo maqondana nokusetshenziswa kotshwala. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo maqondana nokusetshenziswa kotshwala nezimo zakho zezempilo.
Ngabe iVascepa iyafana namafutha ezinhlanzi?
IVascepa iqukethe isithako esisodwa kuphela, i-EPA. Amafutha ezinhlanzi, njengeLovaza, ngokuvamile aqukethe i-EPA ne-DHA.
I-EPA yehlisa ama-triglycerides, kepha i-DHA ingakhuphula i-cholesterol ye-LDL. Njengoba iVascepa ine-EPA kuphela, yehlisa ama-triglycerides kepha ayinyusi i-cholesterol ye-LDL.
Ngabe iLovaza yehlisa malini i-triglycerides?
Ku- izifundo zokwelashwa , ILovaza yehlise ama-triglycerides ngesilinganiso esilinganiselwa ku-45%.
Ingabe iVascepa iyi-anti-inflammatory?
Indlela uVascepa asebenza ngayo ukwehlisa i-triglycerides ayiqondakali ngokuphelele kepha kungenzeka isebenze ngezindlela eziningi. Ngo-2018, i-Amarin Corporation, umkhiqizi weVascepa, ikhishwe imiphumela yokufunda ephetha ngokuthi uVascepa wehlise izimpawu zokuvuvukala ezigulini ezithile. Kodwa-ke, uVascepa akahlukanisiwe njengomuthi olwa nokuvuvukala.
