I-FDA igunyaza iTrijardy XR yohlobo 2 sikashukela

Izindaba

Izindaba ezinhle kubantu abadala abanesifo sikashukela sohlobo 2: Unenketho yokwelashwa entsha etholakalayo yokwehlisa ushukela wegazi. Ukuphathwa Kwezokudla Nezidakamizwa e-U.S. I-FDA kumemezele ukuvunywa kweTrijardy XR. Iphilisi elisha lokuhlanganiswa kathathu lihlanganisa ezintathu imithi yesifo sikashukela kumuthi kadokotela wansuku zonke:

• I-Glucophage ( metformin HCl ), i-biguanide
• Isiko (linagliptin), i-dipeptidyl peptidase-4 (DPP-4) inhibitor
• I-Jardiance (empagliflozin), i-sodium-glucose co-transporter 2 (SGLT2) inhibitor

Leli philisi akuwona neze umuthi omusha — kumane ukuphinda kufakelwe kabusha izindlela zokwelapha ezintathu ezikhona, kuphawula uDkt Marie Bellantoni, isazi se-endocrinologist esiqinisekiswe yibhodi e-The Center for Endocrinology eMercy Medical Center eBaltimore, eMaryland.

Kodwa-ke, into elula ingakhanga kakhulu.

Ngezinga lokuthi noma yini ithuthukisa ukunamathela kwesiguli emithini kuhle — amaphilisi awasebenzi uma engangeni esigulini — khona-ke lokhu kuyasiza, kusho uDkt. Bellantoni. Abanye abantu bazizwa bengakhungathekile uma bephuza amaphilisi ambalwa.

Yini iTrijardy XR?

Eminye yemithi equkethwe ku-Trijardy XR ingazwakala ijwayelekile kuwe, uma wena noma umuntu omthandayo enesifo sikashukela sohlobo 2. Kungenzeka uthathe into eyodwa noma konke lokhu ngesinye isikhathi.

I-Metformin imiswa ngokujwayelekile njengokwelashwa komugqa wokuqala kubantu abanesifo sikashukela sohlobo 2. Kuyasiza ukwehlisa amazinga kashukela ngokwehlisa ukumelana ne-insulin komzimba wakho. Iphinde inciphise inani le-glucose ekhiqizwa isibindi sakho kanye nokumunca ushukela komzimba wakho. Abanye abantu bathatha i-metformin bodwa, kepha abanye kufanele bayithathe kanye neminye imithi yesifo sikashukela.

Isiko yakhelwe ukusiza abantu abanesifo sikashukela sohlobo 2 ukuphatha amazinga kashukela egazini, kanye nokuvivinya umzimba nokudla. Kuyasiza ukwehlisa amazinga kashukela ngokwehlisa inani le-glucose ekhishwe yisibindi nokwandisa inani le-insulin ekhiqizwa amanyikwe. Kuvame ukubekelwa abantu asebevele bephuza imishanguzo yesifo sikashukela futhi benza izinguquko kwimpilo yabo kepha basadinga usizo ukufeza inhloso yabo i-A1C. (I-A1C ilinganisa isilinganiso sikashukela egazini lomuntu esikhathini esingangezinyanga ezintathu.) Iyatholakala futhi kuthebhulethi yansuku zonke.

I-Jardiance ngesinye isidakamizwa esingasiza abantu ukwehlisa amazinga kashukela egazini kanye nokudla nokuzivocavoca umzimba, kepha futhi kunganciphisa ingozi yokufa kwenhliziyo kubantu abanesifo sikashukela sohlobo 2 nesifo senhliziyo. Ithebhulethi yansuku zonke eza ngezindlela ezimbili (10 mg no-25 mg) futhi ingathathwa kanye neminye imithi eminingi, kufaka phakathi i-metformin, i-insulin, i-beta blockers, i-ACE inhibitors, nama-statins.

Imithamo ye-Trijardy XR

ITrijardy XR, emakethwa ngabakwaBoehringer Ingelheim Pharmaceuticals, Inc. no-Eli Lilly neNkampani, izotholakala ngemithamo emine:

• 5 mg empagliflozin, 2.5 mg linagliptin, 1000 mg metformin HCl enwetshiwe
• 10 mg empagliflozin, 5 mg linagliptin, 1000 mg metformin HCl enwetshiwe
• 12.5 mg empagliflozin, 2.5 mg linagliptin, 1000 mg metformin HCl enwetshiwe
• 25 mg empagliflozin, 5 mg linagliptin, 1000 mg metformin HCl enwetshiwe

Ngokusho kwabakhiqizi, iTrijardy XR yiphilisi lokuqala lokuhlanganisa kathathu ukufaka iJardiance. I-Jardiance yaqale yamukelwa yi-FDA ngo-2014, kepha ukuvunywa kwayo kwaba yanda ngasekupheleni kuka-2016 ukwamukela ukusetshenziswa kwayo ukunciphisa ubungozi bokufa kwenhliziyo.

Izixwayiso ze-Trijardy XR

I-Trijardy XR ayihloselwe abantu abanesifo sikashukela sohlobo 1 noma abantu abane-ketoacidosis yesifo sikashukela. Umenzi uxwayisa ukuthi umuthi awufundwanga kubantu abane-pancreatitis , ngakho-ke akunconywa abantu abanaleso simo. Umenzi uphinde axwayise abantu abahlakulela izimpawu ze-lactic acidosis ehlobene ne-metformin ukuyeka ukuthatha umuthi ngokushesha. Akufanele futhi isetshenziswe kulabo abanezinkinga ezinzima zezinso, isifo sezinso sokugcina, noma labo abaku-dialysis.

Enye into engaba yinkinga yemithi yokuhlanganiswa kathathu kungenzeka kube nzima kakhulu ukuthola ukuthi imuphi umuthi obhekelekayo uma uthola ukusabela okubi, kusho uDkt. Bellantoni.

Ukusetshenziswa okunengqondo kwenhlanganisela yemithi emithathu kungaba ngemuva kokuthi isiguli sikhombise ukusebenza nokubekezelela izidakamizwa ezinikezwa ngokwehlukana, uthi, lapho-ke bayakwazisa ukwehla kwenani lemithi yokugcwalisa kabusha yamakhophi okufanele bayenze.

Noma kunjalo, kuyindlela yokwelashwa entsha ethembisayo. Sikholelwa ukuthi iTrijardy XR inamandla okusiza abantu abadala abanesifo sikashukela sohlobo 2 ukuphatha kahle ukwelashwa kwabo, ikakhulukazi labo abathatha eminye imishanguzo futhi abasebenza ngezinguquko ezidingekayo zokuphila, uDkt.Mohamed Eid, usekela mongameli weClinical Development and Medical Affairs, uCardio- IMetabolism and Respiratory Medicine yeBoehringer Ingelheim Pharmaceuticals, Inc. esitatimendeni ememezela ukwamukelwa.