Main >> Imininingwane Yezidakamizwa >> Ukusebenzisana kwezidakamizwa ze-CBD: Ingabe kuphephile ukuthatha i-CBD ngemithi kadokotela?

Ukusebenzisana kwezidakamizwa ze-CBD: Ingabe kuphephile ukuthatha i-CBD ngemithi kadokotela?

Ukusebenzisana kwezidakamizwa ze-CBD: Ingabe kuphephile ukuthatha i-CBD ngemithi kadokotela?Imininingwane Yezidakamizwa

Uma uvakashele isitolo esithengisa imikhiqizo yezempilo nobuhle muva nje, kungenzeka ukuthi uqaphele ukuthi imikhiqizo equkethe i-CBD, noma i-cannabidiol, ibonakala iyilaka lonke. Uwoyela, ushokoledi, izithasiselo, ngisho neziphuzo ezine-carbonated, zigcwalisa amashalofu — ziheha abathengi ngezinsolo zokuthi ukusebenzisa omunye wale mikhiqizo kuzokwelapha ukuqwasha, kunciphise ukukhathazeka, kunciphise ukuvuvukala noma kulaphe i-PTSD.

Nabathengi bayayithenga, ngomqondo ongokomfanekiso — umbiko wakamuva ukhombisile lokho Ukuthengiswa kwe-CBD kulindeleke ukuthi zifike ku- $ 16 billion ngonyaka ka-2026, zisuka ku- $ 1 billion ngonyaka ka-2018. Kodwa yini ngempela i-CBD, futhi iphephile yini kubantu abasebenzisa imishanguzo kadokotela? Ngaphambi kokuyisebenzisa, kubalulekile ukufunda ngokuhlangana okungenzeka kwezidakamizwa ze-CBD.



Ingabe insangu ye-CBD?

Ngenkathi i-CBD ingenye yezithako ezisebenzayo zensangu, ukusebenzisa i-CBD uqobo ngeke kukuphakamise (ingxenye eyenza lokho ibizwa nge-tetrahydrocannabinol, noma i-THC). I-CBD imane nje iyi-molecule ngaphakathi kwezinhlobonhlobo ze-hemp yesitshalo se-cannabis, futhi okungenani kunobufakazi obuthile futhi ucwaningo lokuqala okuphakamisa ukuthi ukukhishwa okwenziwe kule molekyuli kunezinzuzo ezithile zezempilo.



I-CBD kucatshangwa ukuthi isebenza kuma-receptors athile ebuchosheni bakho nakwezinye izingxenye zomzimba, ngezindlela ezingadambisa izinhlungu, noma zisize izimo ezithile zempilo, njengokuphazamiseka kwengane ekubanjweni. Kodwa-ke, njenganoma imuphi umkhiqizo wemvelo, iqiniso lokuthi livela ezitshalweni alikwenzi kungabi nobungozi ngokuzenzekelayo. Kwabanye abantu, ikakhulukazi labo abathatha imishanguzo ethile kadokotela, ukusebenzisa i-CBD kuyingozi. Inemiphumela ye-anticoagulant enganciphisa igazi; futhi yehlisa ngesizotha umfutho wegazi. Le miphumela ingaba yingozi kubantu abanezimo ezithile zezokwelapha.

ungathola i-serotonin syndrome kusuka kumthamo owodwa

Imikhiqizo engamakhambi yizidakamizwa, kusho URita Alloway, Pharm.D. , uprofesa wezocwaningo we-nephrology e-University of Cincinnati College of Medicine. Ukuthi [okuthile] kungamakhambi… akusho ukuthi ngeke kuhlanganyele nanoma imuphi umuthi owenziwe ngemithi okungenzeka ukuthi uyaphuza.



Ingabe i-CBD iyasebenzisana nemithi?

Case iphuzu: tacrolimus , umuthi wokuzivikela osetshenziselwa ukuvimbela ukwaliwa komzimba ezigulini ezifakelwe inhliziyo, isibindi noma izinso. I-CBD iphazamisa imetabolism, ngokuya kwe- ucwaningo olwenziwe nguDkt. Alloway , ogxile ekucindezelweni komzimba ngemuva kokufakelwa kabusha. Futhi ngenxa yokuthi i-tacrolimus iyisidakamizwa esincane senkomba yokwelapha (okusho ukuthi iwindi phakathi kokusebenza kahle nobuthi lincane kakhulu), lokhu kuphazamiseka kungaholela emiphumeleni emibi emitholampilo (njengezinkinga zezinso noma ukwaliwa komzimba), usho kanjalo.

Ingabe ukugxila ku-CBD okuthengiswayo kuphakeme ngokwanele ukudala lokhu kuhlangana? Ubufakazi abusho ngandlela thile. Ucwaningo lukaDkt. Alloway lubandakanya isilinganiso esiphezulu se-CBD esingeke sitholakale kumkhiqizo wokuthengisa. Kodwa-ke, kugcizelela ukuthi ukuxhumana kwezidakamizwa kukhona, kusho yena. Futhi, i-tacrolimus ihlanganiswa emzimbeni yiqembu lama-enzyme abizwa nge-cytochrome P450 futhi I-CBD iyi-inhibitor eyaziwayo yale nqubo. Kusho ukuthini lokho? Uma i-CBD ivimbela imetabolism ye-tacrolimus, isiguli singagcina sinamazinga aphezulu kakhulu we-tacrolimus emzimbeni. Ngenxa yalokhu, unxusa noma ngubani othatha i-tacrolimus ukuthi akhulume nethimba labo lokufakelwa ngaphambi kokusebenzisa i-CBD. Ungalokothi ube nethemba, noma kunjalo — ukusebenzisa amakhambi, ikakhulukazi lawo anokusebenzisana okungaba khona, ngokuvamile kubukelwa phansi odokotela ababheka abemukeli bokufakelwa (kufaka noDkt. Alloway).

Ngokuqondene nezinye izidakamizwa, kahle, eziningi azikakafundwa kuze kube manje. Kunobufakazi bokuqala bokuthi i-CBD ingaba nomphumela ofanayo nejusi lamagilebhisi, iphazamise ukuthi umzimba wakho uzisebenzisa kanjani izidakamizwa, nokukhuphula amazinga e-serum alawo mithi emzimbeni wakho. Futhi, ngobaI-cytochrome P450 inesibopho semetabolism yemithi eminingi , qhubeka ngokuqapha ngaphambi kokuxuba noma yimiphi imithi kadokotela ne-CBD, kusho uDkt. Alloway.



Kuthiwani ngezinzuzo zokwelapha ze-CBD?

Ngaphandle kwezindaba ezingezinhle neze nge-CBD yeziguli ezisebenzisa i-tacrolimus, kwabanye abantu, i-CBD empeleni iguqula impilo ngendlela enhle. Ku-2018, ngokwesibonelo, umuthi owenziwe nge-CBD u-Epidiolex owutholile Ukuvunyelwa kwe-FDA ekwelapheni i-Lennox-Gastaut syndrome ne-Dravet syndrome, izinhlobo ezimbili ezingavamile kakhulu futhi ezinzima kakhulu zesifo sokuwa.

Kepha izimangalo zokuthi izinsiza ze-CBD ekwelapheni izimo ezithile zempilo yezengqondo nezengqondo, azidluli, kusho URoger McIntyre, MD , uprofesa wezifo zengqondo nokwelashwa kwemithi eNyuvesi yaseToronto.

Akunamsebenzi njengamanje we-CBD ekulawuleni ukuphazamiseka kwengqondo engikulaphayo, njengokucindezeleka, ukuphazamiseka kwengqondo okuguquguqukayo… ukukhathazeka ne-ADHD, usho kanjalo. Asinabo nje ubufakazi obuyisekelayo.



Ngaphezu kwalokho, imishanguzo eminingi kadokotela esetshenziselwa ukuphatha lezi zimo ihlanganiswa ne-cytochrome P450, okwenza kube nokwenzeka ngokuphelele ukuthi i-CBD ingaphazamisa ukwelashwa — kunokuba ithuthukise — ukwelashwa.

UDkt McIntrye, obhalisane naye a Ucwaningo lwe-2018 lokho kuphethe ngokuthi abahlinzeki bezempilo badinga imininingwane eminingi mayelana ukuxhumana kwezidakamizwa ngemithi ye-CBD kanye ne-psychotropic, ithi imininingwane eminingi laphaya iyadida futhi iyaphikisana. Ngakho-ke, unanela isitatimende sikaDkt. Alloway sokuthi kuwukuhlakanipha ngokuphelele ukuthi iziguli zisuse ukusetshenziswa kwe-CBD nodokotela wazo ngaphambi kokukunikeza ithuba.



[Umhlinzeki] uyamazi lowo muntu futhi uyazi ukuthi yiziphi ezinye izindlela zokwelapha abangazithatha noma abangazithathi, kuchaza uDkt McIntyre. Banombono we-panoramic wemithi yesiguli, futhi bangaba [nomqondo ongcono] wokuthi ngabe isiguli sithatha omunye umuthi ongahle ube nokusebenzisana yini.