Imiphumela emibi ye-Topamax nokuthi ungayibalekela kanjani

Imininingwane Yezidakamizwa

Imiphumela emibi ye-Topamax | Izexwayiso | Ukusebenzisana | Ungayigwema kanjani imiphumela emibi

I-Topamax (i-topiramate) yisidakamizwa esinegama lomuthi elisebenza ngama-anticonvulsant esisebenza ebuchosheni ukuvikela ukuquleka. Kuvunyelwe i-FDA kusukela ngo-1996 ukwelashwa kwesifo sokuwa kuzingane nakubantu abadala. I-Topamax nayo ijwayele ukusetshenziselwa ukuvimbela i-migraine ikhanda kubantu abadala . Iphinde isetshenziswe ngaphandle kwelebula ku- welapha iziguli ezine-bipolar disorder (okubizwa nangokuthi ukucindezeleka komuntu) nokusiza ekwehliseni isisindo. Umuthi uvame ukunikezwa ku-25 mg kuya ku-400 mg doses.

I-Topamax iphephile ukusetshenziswa kwesikhathi eside lapho ithathwa njengoba kunqunyiwe. Kodwa-ke, imiphumela emibi eminingi ejwayelekile futhi engaba mibi kakhulu ibikwe inani elincane leziguli. Kukhona nezidakamizwa ezimbalwa ezingadala ukuhlangana okuyingozi noma zingasebenzi uma zithathwa ngokubambisana neTopamax. Nakhu konke okufanele ukwazi ngokuthatha ngokuphephile i-Topamax, kufaka phakathi ongakwenza ukuze unciphise ubungozi bokuba nemiphumela emibi kakhulu.

OKUSHIWO: Iyini i-Topamax? | Thola amakhuphoni we-Topamax

Imiphumela emibi ejwayelekile ye-Topamax

Iningi lemiphumela emibi ehlotshaniswa ne-Topamax ithathwa njengomnene ukuya kokumaphakathi. Eziningi zizonyamalala noma zinciphe njengoba ujwayela umuthi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, yazisa udokotela wakho ngokushesha ngoba zingakhombisa imiphumela emibi kakhulu. Le yimiphumela emibi kakhulu ye-Topamax, ngokusho komkhiqizi :

• Ukuphelelwa isifiso sokudla, ushintsho ekunambithekeni, ekunciphiseni isisindo, ebuhlungwini besisu, ngisho nasezincwadini
• Imiphumela emibi ye-GI (isicanucanu, isifo sohudo, ukugaya isisu)
• Ukukhathala
• I-Paresthesia (ukuzwa noma ukuthinta)
• Izinkinga zokukhuluma
• Ukungasebenzi kwengqondo (kunenkinga ngememori nokucabanga)
• Ukutheleleka okuphezulu okuphefumulayo
• Isiyezi
• Ukwesaba
• Ukusabela okuhamba kancane
• Izinguquko ezibonakalayo (ukufiphala, umbono onamafu, ukunyakaza kwamehlo okungazibandakanyi)
• Imfiva
• Ukwehla kokuzwela noma ukuba ndikindiki

Ingabe i-Topamax ikwenza ulale?

Ukuthatha i-Topamax kungakwenza wozele futhi ube nesiyezi. Kufanele ugweme ukushayela, usebenzisa imishini esindayo, noma ukwenza eminye imisebenzi edinga ukuqaphela uze wazi ukuthi lo muthi ukuthinta kanjani. Ngoba ingadala ukozela, iTopamax ivame ukuthathwa ebusuku.

Ingabe i-Topamax ibangela inkungu yobuchopho?

Iziguli zivame ukuzwa inkungu yobuchopho, noma ukwehla ukuqonda , lapho kuqala i-Topamax. Abanye babika ukungakwazi ukucubungula ngokushesha imininingwane, izinkinga zolimi, noma ukucabanga kahle. Kwabanye, lesi sibonakaliso siyasombuluka njengoba umzimba uvumelana nokulinganisa. Abanye bangadinga ukufuna ezinye izindlela ze-Topamax.

Ngabe iTopamax yenza izinwele zakho ziwe?

Ngokusho kwe- Izikhungo Zikazwelonke Zezempilo , ukulahleka kwezinwele kungumphumela ohlangothini we-topiramate, kepha umenzi weTopamax akayibhalisi njengokujwayelekile. Izinwele zivame ukukhula ngokushesha uma uyeka ukwelashwa.

Imiphumela emibi ye-Topamax

Kukhona nemiphumela emibi kakhulu okufanele uyiqaphele lapho uthatha i-Topamax. Le miphumela emibi ivame ukudinga ukulaliswa esibhedlela noma usizo lwezokwelapha, futhi ingaholela ekulimaleni unomphela noma kusongele impilo.

• I-Metabolic acidosis (ukukhathala, ukungathandi ukudla, ukushaya kwenhliziyo okungajwayelekile, inkungu yobuchopho)
• I-ammonia eyeqile egazini (lapho iTopamax ithathwa ngomuthi oqukethe i-valproic acid)
• Ukudana okusha noma okuya kuba kubi, ukukhathazeka, noma imicabango / izindlela zokuzibulala (ezenzeka ezigulini ezi-1 kweziyi-500)
• Kwehlise ukujuluka kepha kwanda ukushisa komzimba
• I-Glaucoma
• IStevens-Johnson syndrome (ukuqhuma okukhulu kwesikhumba, amabhamuza, isikhumba esihlungayo)
• Ukukhula okungamile ezinganeni
• Ukuquleka okungazelelwe kokuhoxa (uma iTopamax imiswa kungazelelwe)

Ngabe iTopamax ingashintsha ubuntu bakho?

Ama-Anticonvulsants afana neTopamax, nawo angathinta kakhulu imizwa, abe nomthelela ezifweni zengqondo ezinjengokukhathazeka, ukudangala, noma imania. I-Topamax ingaba nemiphumela emibi eminingi ye-neurocognitive ne-neuropsychiatric, kufaka phakathi leli cala le- Isifo se-dissociative esibangelwa yi-Topamax . Iziguli kufanele zazi ngoshintsho olukhulu kumzwelo noma emoyeni futhi zifune ukwelashwa uma zithola ushintsho olukhulu ebuntwini.

Ngabe iTopamax ingadala ukulahleka kwememori okungapheli?

I-Topamax ingahle ihlotshaniswe nokuwohloka komqondo futhi kufanele isetshenziswe ngokuqapha ku iziguli ezindala . Noma kunjalo, akukatholakali kahle ukuthi i-Topamax ingadala ukulahleka kwememori unomphela.

I-Topamax ne-metabolic acidosis

I-Topamax ingadala inani eliningi ngokweqile le-asidi egazini, elibizwa ngokuthi i-metabolic acidosis . Uma lokhu kwenzeka, umzimba ukhiqiza i-asidi ngokushesha okukhulu, futhi izinso azikwazi ukuhambisana nokukuhluza. Ngalesi sizathu, iziguli ezinokukhubazeka kwezinso noma isifo sezinso kufanele zibhekwe eduze lapho zithatha i-Topamax.

Ezimweni ezimbi kakhulu, i-metabolic acidosis ingaholela ekulimaleni kwezinso, ukushaqeka, noma ngisho nokufa. Lesi simo singadala namathambo athambile noma aphuke namatshe ezinso, kwehlise izinga lokukhula ezinganeni, futhi kulimaze ingane ngesikhathi sokukhulelwa. Izimpawu ezijwayelekile ze-metabolic acidosis zifaka ukuphefumula okusheshayo, umfutho ophansi wegazi, ukukhathala nokudideka, nokungabi nesifiso sokudla.

Izinkinga zeTopamax nezamehlo

I-Topamax ingadala izimo zamehlo ezinzima ezingadala ubumpumputhe. I-Acute myopia, edala ukubona eduze, ingadala ikhanda noma ifiphale ngenxa yengcindezi eyandayo esweni. Iziguli zibuye zabika izehlakalo eziningana zokuvalwa kwe-glaucoma engeli yesibili, okuthi, uma ishiywe ingalashwa, ingaholela ekulahlekelweni kombono. Iziguli ezithatha i-Topamax kufanele zifune iseluleko sezokwelapha uma zihlangabezana nobuhlungu bamehlo noma ukungaphatheki kahle.

Izexwayiso ze-Topamax

Ungathathi i-Topamax uma:

• ayizwani nayo noma yiziphi izithako ezikuyo
• uphuze utshwala kungakapheli amahora angu-6 uthathe i-Topamax
• ngibe noma ngake ngaba neyodwa yale mibandela:
  • I-glaucoma noma ezinye izinkinga zamehlo
  • Isifo sezinso
  • I-Metabolic acidosis
  • Isifo samaphaphu noma izinkinga zokuphefumula
  • Izinkinga zemood, ukudangala, imicabango yokuzibulala noma izenzo
  • Izinkinga zokukhula
  • Amathambo athambile noma aqhekekile (i-osteoporosis, i-osteomalacia)
• uhlela ukukhulelwa noma uma uncelisa

Ukuziphatha nokuzibulala

Njenge-anticonvulsant, iTopamax inethonya eliqondile ekusebenzeni kobuchopho. Mayelana 1 kwabangu-500 iziguli ezithatha imishanguzo yokulwa nesifo sokuwa njenge-Topamax zibike ukuthi zithole imicabango nokuzibulala, ikakhulukazi lapho ziqala ukwelashwa noma zishintsha amazinga ezilinganiso.

Ngenxa yalezi zinketho, iziguli kufanele zihlolwe njalo futhi zifune ukwelashwa uma ziba nokukhathazeka, ukwethuka, ukuqala noma ukukhuphuka kwengcindezi. Yize kungavamile, i-Topamax nayo ingadala ushintsho kwemizwelo noma lokuziphatha, njengobudlova noma udlame, ukukhathazeka, ukunganaki, i-mania, noma ukucasuka. Tshela uchwepheshe wezokunakekelwa kwezempilo nganoma yiluphi lolu shintsho.

I-Topamax nokukhulelwa

Uma ukhulelwe noma uhlela ukukhulelwa, kufanele wazise udokotela wakho ngokushesha okukhulu. I-Topamax yandisa ubungozi bokukhubazeka kokuzalwa ngomlomo njenge-cleft lip kanye ne-palate palate izikhathi eziyi-16 . Ukusebenzisa i-Topamax ngesikhathi sokukhulelwa nakho kungadala ukungahambi kahle kwenhliziyo, amaphaphu, ugebhezi lwamathambo njengezitho zomzimba ezingakhubazekile. Okunye ukukhubazeka kokuzalwa kungabandakanya ukuphikelela komfutho wegazi ophezulu wamaphaphu wosana olusanda kuzalwa (i-PPHN), i-spina bifida, nezinye iziphazamiso ze-neural tube, ezingasongela impilo.

Ngenxa yalokho, kuyadingeka ukuthatha izinyathelo ezithile zokuqapha ukunciphisa ubungozi balezi zinkinga ngokulawula imithamo ye-Topamax neminye imithi ngesikhathi sokukhulelwa. Ukuyekiswa ngokungazelelwe imithi efana ne-Topamax ngesikhathi sokukhulelwa akunconywa, ngakho-ke ungalungisi umthamo wakho noma uyeke ukuwuthatha ngaphandle kokukhuluma nodokotela wakho. I-Topamax kufanele isetshenziselwe kuphela ukwelapha izimo ezingasongela impilo ezigulini ezikhulelwe.

Ukusebenzisana kwe-Topamax

Kunezidakamizwa eziningi ezithengiswa ekhawunteni kanye nemithi kadokotela esebenzisana neTopamax. Imiphumela emibi yalokhu kuhlangana kwezidakamizwa isukela kokumnene kuya kokubi, inikeze eyodwa noma enye isebenze kangcono noma kancane. Buza udokotela ngaphambi kokuthatha i-Topamax uma ukule mithi elandelayo:

• Amaphilisi okuvimbela inzalo: I-Topamax inganciphisa amandla nemiphumela yokuvimbela inzalo ngomlomo noma izidakamizwa zokunqamuka kokuya esikhathini eziqukethe i-estrogen. Indlela yokuvimbela inzalo njengekhondomu noma idiyaphragm ene-spermicide indlela engcono yokuvikela ngenkathi ithatha i-Topamax.
• Izidakamizwa zokubamba: I-Tegretol (i-carbamazepine), i-Dilantin (i-phenytoin), i-Depakote (i-valproate), i-lamotrigine, ne-phenobarbital inganciphisa amazinga nemiphumela ye-Topamax emzimbeni wakho. Ukuthatha iDepakote (valproate) ngokuhlangana neTopamax kungakhuphula amazinga e-ammonia egazini lakho. Uma lokhu kwenzeka, ungaba nokudideka, ukudideka, noma ube nobunzima bokucabanga.
• I-Carbonic anhydrase inhibitorsIzidakamizwa ezifana ne-acetazolamide, i-dichlorphenamide, i-methazolamide, ne-dorzolamide zingakhuphula ubungozi bamatshe ezinso lapho zithathwa nge-Topamax.
• Imithi yokungezwani komzimba: Izidakamizwa ezithile zokungezwani komzimba ezifana ne-diphenhydramine, i-chlorpheniramine, i-hydroxyzine ingakhuphula ubungozi bemiphumela emibi njengesiyezi, ukulala noma inkinga yokugxila.
• Ukudambisa izinhlungu: Iziguli ezithatha i-Topamax zingahle zivele ukozela, isiyezi, noma kube nzima ukucabanga lapho kunqunywe ngokuhambisana nezidakamizwa ezinjenge-hydrocodone, i-oxycodone, i-morphine, noma i-hydromorphone.
• Imithi ye-bipolar: I-Topamax ingakhuphula amazinga e-lithium emzimbeni lapho ihlanganiswa.
• Izidakamizwa zikashukela: I-Glyburide noma i-pioglitazone kungenzeka ingasebenzi kahle ekulawuleni ushukela wegazi ukwelapha isifo sikashukela. Ukuthatha i-metformin nge-Topamax nakho kungaba yingozi, ikakhulukazi uma isiguli sine-metabolic acidosis.

Ungaphuza i-caffeine ne-Topamax?

I-Topamax ingakhuphula izinga lokukhishwa kwe-caffeine, elinganciphisa ukusebenza kwayo emzimbeni, kodwa ngokuvamile kuyinhlanganisela ephephile.

Yini okufanele ngiyidle ngenkathi ngithatha i-Topamax?

Ungathatha i-Topamax ngokudla noma ngaphandle kokudla. Njengoba omunye wemiphumela emibi kakhulu yokuthatha i-Topamax yi-metabolic acidosis, gwema ukudla i-ketogenic (i-carbohydrate ephansi, amaprotheni akhuphukile). Ukudla ukudla okukhuthaza i-ketosis kungakhuphula ubungozi bamatshe ezinso, okungakhuphula intela izinso zakho.

Ungayigwema kanjani imiphumela emibi ye-Topamax

Ngeminye imininingwane yezidakamizwa, funda i- Umhlahlandlela wemithi ye-Topamax ngaphambi kokuqala ukwelashwa kwakho.

1. Uma uhlangabezana nanoma yimiphi imiphumela emibi, thintana nomhlinzeki wakho wezokunakekelwa kwempilo. Ukuhlolwa kweserum okungaguquguquki ukuhlola njalo ukusebenza kwezinso nesibindi, ngokwesibonelo, nakho kunganciphisa ubungozi bezinkinga ezinzima.
2. Qaphela konke ukuxhumana kwezidakamizwa. Eminye imishanguzo efana nokuvimbela inzalo ngomlomo ayisebenzi kahle uma ithathwa nge-Topamax, kanti eminye, njengomuthi wokungezwani komzimba, ingakhuphula imiphumela emibi ye-Topamax.
3. Ungathathi i-Topamax kungakapheli amahora ayisithupha uphuze utshwala.
4. Gwema ukusebenzisa imishini esindayo, ukushayela, noma ukwenza eminye imisebenzi eyingozi uma iTopamax ikwenza wozele noma ube nesiyezi.
5. Phuza uketshezi oluningi bese wenza umzamo wokugwema ukuphelelwa amanzi emzimbeni nokuqunjelwa. Lokhu kungasiza ekwehliseni ubungozi bokwakhiwa kwamatshe ezinso, okungasiza ekuvimbeleni i-metabolic acidosis.
6. Gwema ukulandela ukudla kwe-ketogenic ukuvimbela ukukhula kwamatshe ezinso kanye ne-metabolic acidosis.
7. Funa ukunakekelwa okuphuthumayo uma ubona noma yikuphi ukuguquka okungazelelwe kwemizwa noma ukukhula kwengcindezi noma imicabango yokuzibulala.
8. Uma ungowesifazane osebenzisa izivimbeli nzalo ngomlomo, cabanga ukusebenzisa enye indlela yokuvikela yokuvimbela ukukhulelwa. Leyo enye yezindlela eziphumelela kakhulu zokugwema ubungozi bokukhubazeka okukhulu kokuzalwa okuhlobene nokuthatha i-Topamax.
9. Uma uphuthelwa umthamo, wuthathe ngokushesha lapho ukhumbula. Uma cishe sekuyisikhathi sedosi yakho elandelayo, yeqe bese uthatha umthamo ozayo. Ungathathi isamba esiphindwe kabili ukwenza isilinganiso esilahlekile.
10. Ungayeki ukuthatha i-Topamax ngokuzumayo, ngoba lokho kungadala ukuquleka, noma ngabe awukaze ube nakho esikhathini esedlule. Uma udinga ukuyeka ukuthatha i-Topamax, udokotela wakho uzokwehlisa kancane kancane umthamo wakho ukukukhipha ngokuphepha emithini.

Lapho uzobona udokotela wemiphumela emibi ye-Topamax

Imiphumela eminingi emibi ye-Topamax ingaba nzima futhi isongele impilo. Yazisa uchwepheshe wakho wezokunakekelwa kwezempilo futhi ufune usizo lwezempilo zisuka uma uqala ukuzwa noma ikuphi, ikakhulukazi lezo ezithathwa njengezibucayi.