Kwenzekani uma uxuba i-gabapentin notshwala?

Imininingwane Yezidakamizwa Ukuxuba

UGabapentin (I gama le-brand I-Neurontin ) ngumuthi odumile kadokotela osetshenziselwa ukwelapha ubuhlungu be-nerve kusuka kusingles noma ekubanjweni. Ngakho-ke ethandwa , eqinisweni, ukuthi ngo-2004, i-gabapentin yanikezwa izikhathi ezingaphezu kwezigidi eziyi-18 e-United States, kwathi ngo-2017, lelo nani lanyuka laba ngaphezu kwezigidi ezingama-46.

IGabapentin okwamanje ayihlukaniswa njenge- into elawulwayo . Kodwa-ke, lesi sidakamizwa sihilelekile kwabaningi ukusetshenziswa kabi kwezidakamizwa amacala, eyedwa noma ahlanganiswe nama-opioid. Umbuzo owodwa odumile obuzwa iziguli eziningi ukuthi i-gabapentin notshwala kuyahambisana yini.

Ungaphuza utshwala ngenkathi uthatha i-gabapentin?

IGabapentin notshwala akuhlangani. Kufanele ugweme ukuhlanganiswa kotshwala ne-gabapentin ngaso sonke isikhathi. Tyena owenza iNeurontin, I-Pfizer uthi, Ungaphuzi utshwala noma uthathe eminye imishanguzo eyenza ukozele noma ube nesiyezi ngenkathi uthatha iNeurontin ngaphandle kokukhuluma kuqala nomhlinzeki wakho wezokunakekelwa kwempilo. Ukuthatha i-Neurontin ngotshwala noma izidakamizwa ezidala ukulala noma isiyezi kungenza ukulala noma isiyezi sakho kube kubi kakhulu.

Kwenzekani uma uphuza utshwala ngenkathi ukwigabapentin?

IGabapentin notshwala ngamunye ngamunye kubangela ukucindezelwa kwesistimu yezinzwa eziphakathi (CNS) nokudangala kokuphefumula. Ukuhlanganisa utshwala kanye ne-gabapentin kungalimaza imiphumela noma yomibili.

Ama-CNS depressants enza umsebenzi wobuchopho kancane futhi abangele ukozela nesiyezi. Ukuhlanganisa utshwala kanye ne-gabapentin, ukucindezelwa okubili kwe-CNS kungayenza ibe yimbi le miphumela, kukwenze uzizwe ukozela kakhulu futhi ube nesiyezi, kubangele ukukhubazeka nezingozi. Kukhona nengozi eyengeziwe yokuquleka ngokusetshenziswa kotshwala ngokweqile noma ukuhoxiswa kotshwala.

Ukudangala kokuphefumula kwenzeka lapho ungatholi i-oxygen eyanele. Ukuphefumula kwakho kungancipha futhi kungajuli noma kume. Ngo-2019, I-FDA ixwayisile ukuthi i-gabapentin ingakhuphula ubungozi bokucindezeleka kokuphefumula uma kuhlangene nezici zobungozi ezinjenge:

• Ukuguga
• Izimo zokuphefumula ezifana neCOPD
• Ukusetshenziswa kwemithi (njengama-opioid) noma ukusetshenziswa kwezidakamizwa (njengotshwala) okucindezela i-CNS

Ukusetshenziswa kotshwala kanye ne-gabapentin kungaqinisa lo mphumela futhi kwandise ingozi yokudlula ngokweqile nokufa.

Ngabe i-gabapentin iyasiza yini ekuhoxisweni kwesifo sotshwala?

Ukuthembela otshwaleni kuyisimo esivamile. Iziguli ezinenkinga yokusebenzisa utshwala zisengozini yokuthuthuka ukuphuza utshwala syndrome uma beyeka ngokungazelelwe ukuphuza utshwala, yingakho abahlinzeki bezempilo bezonikeza umuthi, njenge-gabapentin noma i-benzodiazepine, futhi babone isiguli nsuku zonke kuze kuphele izimpawu zokuhoxiswa kotshwala.

Izimpawu zesifo sokuhoxiswa kotshwala zibandakanya ukuxokozela, ukuthuthumela, isicanucanu, ukujuluka, ukuhlanza, ukusangana, ukuqwasha, ukushaya kwenhliziyo okusheshayo, umfutho wegazi owandayo, nokuquleka.
Ngokuya ngobukhulu, isiguli singathola ukwelashwa kweziguli ezingalali noma iziguli. Kunoma ikuphi, isiguli kufanele sithole ukwelashwa okuqhubekayo kokuncika kotshwala.

Ngabe kukhona ama-anticonvulsants (njenge-gabapentin) angathathwa ngokuphepha ngotshwala?

Ngakho-ke, uma uthatha i-gabapentin futhi ubheke imbibe ngezimpelasonto, ungazibuza ukuthi ungashintshela yini kwenye indlela yokwelashwa futhi uphuze ngokuphepha. Ngeshwa, impendulo ithi cha. Isexwayiso se-2019 FDA mayelana ne-gabapentin sifakiwe ILyrica (pregabalin), enye i-anticonvulsant ethandwayo. Eminye imishanguzo esetshenziselwa ukulawula ukuquleka nayo akufanele ixutshwe notshwala, kufaka phakathi:

• Tegretol (carbamazepine)
• I-Lamictal (lamotrigine)
• I-Topamax (topiramate)
• I-Trokendi XR (topiramate)
• I-Trileptal (oxcarbazepine)
• I-Keppra (levetiracetam)
• I-Depakote (i-divalproex sodium)
• UDilantin (i-phenytoin)
• I-Phenobarbital
• I-Benzodiazepines (njenge I-Valium )

Imiphumela efanayo echazwe ngenhla (i-CNS nokudangala kokuphefumula) kungenzeka yenzeke.

Iyini imiphumela emibi ye-gabapentin?

Ngisho noma ungabuphuzi utshwala, i-gabapentin ingaba nemiphumela emibi. Kufanele uthintane nomhlinzeki wakho wezokunakekelwa kwezempilo ukuthola izeluleko mayelana nokuphatha. Ungahlangabezana:

• Imiphumela yamathumbu (GI): isicanucanu, ukuhlanza, ukuqunjelwa, isifo sohudo, umlomo owomile
• Imiphumela yesistimu yezinzwa: isiyezi, ukulala, ukukhathala, ukuxhumana okungakhubazekile, ukuthuthumela, ukunyakaza kwamehlo okungazibandakanyi
• Imiphumela ye-Metabolic: ukuvuvukala ezingalweni nasemilenzeni, ukuzuza kwesisindo

Ngokwengeziwe, imiphumela emibi emibi ehambisana ne-gabapentin ifaka phakathi:

• Ukudangala okwandayo
• Izinguquko kumzwelo noma ekuziphatheni
• Ingozi eyengeziwe yemicabango yokuzibulala noma yokuziphatha
• Ukushayela okungalungile
• I-Anaphylaxis

Ukwelashwa kweGabapentin akufanele kumiswe ngokungazelelwe ngenxa yengozi eyengeziwe yokuhlaselwa. Ukuyekiswa okungazelelwe kwe-gabapentin nakho kungadala ukukhathazeka, ukuqwasha, isicanucanu, ubuhlungu nokujuluka.

Futhi khumbula, uma uthatha i-gabapentin, gwema utshwala — ngokuphelele. Ukuhlanganiswa kotshwala ne-gabapentin kuyingozi. Uma unemibuzo, thintana nomhlinzeki wakho wezokunakekelwa kwempilo noma usokhemisi ukuze uthole ukuholwa.