I-Zyban vs. Chantix: Umehluko, ukufana nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Izinzuzo zezempilo zokuyeka ukubhema ziningi. Umfutho wegazi ophansi nokushaya kwenhliziyo kuza cishe ngokushesha futhi ingozi yokuhlaselwa yisifo senhliziyo incipha emahoreni angama-24 nje kuphela. Ngaphezu kwalokho, i-cholesterol izothuthuka, ingozi yomdlavuza iyancipha futhi amasosha akho omzimba namathambo azoqina.
Kwesinye isikhathi udinga usizo olwengeziwe ukuyeka, futhi umuthi kadokotela ungasiza. Imithi emibili evame ukubekwa yokuyeka ukubhema ifaka iZyban (bupropion Hcl Er) neChantix. Yomibili le mithi ivunywa yi-U.S. Food and Drug Administration (FDA) futhi isetshenziselwa ukusiza iziguli ezinokuyeka ukubhema, kepha zisebenza ngezindlela ezihlukile futhi zinemiphumela engemihle eyehlukene.
Uyini umehluko omkhulu phakathi kukaZyban noChantix?
I-Zyban (bupropion Hcl Er) itholakala ngohlobo olujwayelekile, njengamathebulethi wokukhishwa okwandisiwe we-150 mg. I-Zyban ayisatholakali ngegama lomkhiqizo; ekuqaleni lenziwa nguGlaxoSmithKline. Isetshenziswa ezigulini eziyi-14 nangaphezulu; iziguli nazo kufanele zikala okungenani ama-89 lbs. IZyban iqalwa isonto elilodwa ngaphambi kosuku lokuyeka ukubhema, futhi ithathwa amasonto ayi-7-12, ngokwesilinganiso.
I-Chantix (varenicline) itholakala ngegama lomkhiqizo kuphela, njengamaphilisi angu-0.5 mg no-1 mg, futhi yenziwa yinkampani yezidakamizwa iPfizer. I-Chantix, esetshenziswa kubantu abadala kuphela, iqalwa kusasele isonto elilodwa ngaphambi kosuku lokuyeka ukubhema futhi ithathwa amasonto ayi-12; iziguli zingaqhubeka amanye amasonto ayi-12 uma umjikelezo wokuqala uphumelela.
| Umehluko omkhulu phakathi kukaZyban noChantix | ||
|---|---|---|
| I-Chantix | Zyban | |
| Isigaba sezidakamizwa | I-Aminoketone antidepressant, insiza yokuyeka ukubhema | I-nicotinic agonist, usizo lokuyeka ukubhema |
| Isimo somkhiqizo / ejwayelekile | Okujwayelekile | Umkhiqizo |
| Ngubani igama elijwayelekile? | I-Bupropion | I-Varenicline |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yokukhishwa enwetshiwe | Amathebulethi |
| Uyini umthamo ojwayelekile? | Qala isonto elilodwa ngaphambi kosuku lokuyeka ukubhema: 150 mg nsuku zonke izinsuku ezintathu, bese u-150 mg kabili ngosuku (okungenani amahora ayisishiyagalombili ngaphandle) ngemuva kwalokho | Qala isonto elilodwa ngaphambi kosuku lokuyeka ukubhema: 0.5 mg nsuku zonke izinsuku ezi-3, bese u-0.5 mg kabili ngosuku izinsuku ezingama-4, bese u-1 mg kabili nsuku zonke ngemuva kwalokho |
| Yelashwa isikhathi esingakanani? | Amasonto 7-12; kuyehluka | Amaviki ayi-12, angaqhubeka amanye amasonto ayi-12 |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nentsha eneminyaka engu-14 nangaphezulu, kumele babe ngaphezu kuka-40.5 kg | Abantu abadala abaneminyaka engu-17 nangaphezulu |
Izimo eziphathwe nguZyban noChantix
IZyban (bupropion) neChantix (varenicline) zombili zikhonjisiwe njengezisiza ekwelashweni kokuyeka ukubhema. Asikho isidakamizwa esiqukethe i-nicotine.
Zyban i-aminoketone antidepressant; indlela esebenza ngayo ekuyekeni ukubhema noma ekucindezelekeni ayaziwa kepha kuthathwa ngokuthi kuvimbela ukutholwa kwe-norepinephrine ne-dopamine. Ngokwenza njalo, izifiso ze-nicotine ziyancipha futhi izimpawu zokuhoxa ziyancipha.
Akufanele ididaniswe neWellbutrin, equkethe ne-bupropion, iZyban isetshenziselwa kuphela ukuyeka ukubhema ngenkathi ifomu le-Wellbutrin le-bupropion lisetshenziselwa iMajor Depression Disorder ne-Seasonal Affective Disorder. Le mithi emibili ayishintshi. Kodwa-ke, abanye odokotela bayayala i-Wellbutrin off-ilebula ngokuyeka ukubhema.
I-Chantix isebenza ngokuvimba ama-nicotine receptors. Ngokwenza njalo, uhlelo oluphakathi lwezinzwa ngeke lusebenze uhlelo lokuqinisa / lokuvuza oluhlotshaniswa ne-nicotine, futhi uzozizwa ungajabuli ngokwengqondo nangokomzimba ngokubhema. I-Chantix ibuye inciphise izimpawu zokuhoxa ukubhema.
| Isimo | Zyban | I-Chantix |
| Ukuyeka ukubhema | Yebo | Yebo |
Ingabe iZyban noma iChantix isebenza kangcono?
Ukuphepha nokusebenza kweZyban kwafundwa kaningana izilingo , usebenzisa uZyban kanye nokwelulekwa. Ocwaningweni lwamasonto ayisikhombisa, uZyban ukhonjiswe esebenza ngempumelelo kakhulu kune-placebo. Ezinyangeni eziyisithupha, iziguli zenze kangcono ekugcineni ukuziyeka ngemuva kokuphathwa ngoZyban. Kwesinye isifundo, ukwelashwa ngeZyban nakho kuphumelele kakhulu kune-placebo, kunciphisa isifiso sokubhema, nokunciphisa izimpawu zokuhoxa (njengokucasuka, intukuthelo nokukhathazeka).
Emtholampilo izilingo kaChantix, lesi sidakamizwa sitholakale sinciphisa isifiso sokubhema, sinciphise izimpawu zokuhoxa, futhi sisize iziguli zigcine ukungazibhemi. Ucwaningo olulodwa luqhathanisa i-Chantix ne-Zyban ne-placebo. Ucwaningo luthole ukuthi yomibili le mithi ibingcono kune-placebo, futhi yaphetha ngokuthi uChantix ubephumelela kakhulu kunoZyban.
Umuthi osebenza kahle kakhulu kufanele unqunywe udokotela wakho kuphela, kucatshangelwa isimo (izimo) sakho sezempilo, umlando, neminye imithi oyisebenzisayo engaxhumana noZyban noma iChantix.
Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweZyban vs. Chantix
Ama-generics akwa-Zyban ngokuvamile ahlanganiswa umshwalense kanye ne-Medicare Part D. Ngaphandle komshwalense, ukunikezwa kwenyanga eyodwa kwe-generic Zyban kubiza cishe ama- $ 90. Ungehlisa le ntengo uye ku- $ 50-80 ngesigqebhezana se-SingleCare ngokuya ngekhemisi langakini.
Nge-Chantix, uzoqala ngomthamo ophansi (iphakethe lenyanga yokuqala), bese uqhubeka nokugcwalisa iphakethe lenyanga eqhubekayo ngenyanga yesibili neyesithathu. I-Chantix ivame ukumbozwa umshuwalense kanye ne-Medicare Part D, ngama-copays aguquguqukayo. Ngaphandle komshwalense, iphakethe lenyanga yokuqala libiza cishe u- $ 515 kanti iphakethe lenyanga eliqhubekayo libiza cishe ama- $ 500. Unganciphisa intengo yemikhiqizo ye-Chantix ngesigqebhezana se-SingleCare.
| Zyban | I-Chantix | |
| Ngokuvamile embozwe umshwalense? | Yebo (okujwayelekile) | Ngokuvamile; ingadinga ukugunyazwa kwangaphambili kanye / noma ibe ne-copay ephezulu |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo (okujwayelekile) | Ngokuvamile; ama-copay ahluka kakhulu |
| Umthamo ojwayelekile | I-150 mg nsuku zonke izinsuku ezingama-3 bese i-150 mg kabili ngosuku | U-0.5 mg nsuku zonke izinsuku ezintathu, bese u-0.5 mg kabili ngosuku izinsuku ezingama-4, bese u-1 mg kabili ngosuku (ukuqala kwepakethe kusetshenziswa inyanga eyodwa, bese kusetshenziswa iphakethe eliqhubekayo) |
| Inkokhelo ejwayelekile yeMedicare Part D | Isilinganiso se- $ 3-64; kuyehluka | $ 25-578; kuyehluka |
| Izindleko ze-SingleCare | $ 58 | $ 400 ukuqala iphakethe, $ 452 ngokuqhubeka kwepakethe |
Imiphumela emibi ejwayelekile kaZyban noChantix
Ngaphezu kwemiphumela emibi / izixwayiso, ezichazwe ngezansi, umuthi ngamunye uza nemiphumela emibi engaba khona. I-Zyban ivame ukunikezwa kanye ne-a isichibi se-nicotine (eyaziwa nangokuthi i-nicotine replacement therapy, noma i-NRT), futhi amaphesenti emiphumela emibi angaphakama lapho iZyban isetshenziswa ngokuhlangana ne-nicotine.
Imiphumela emibi kakhulu yeZyban ukungalali, umlomo owomile, nesiyezi. Imiphumela emibi kakhulu ye-Chantix isicanucanu, ubuhlungu besisu, ikhanda elibuhlungu nokuqwasha.
Umhlahlandlela wemithi, onemininingwane egcwele mayelana nomuthi, uzokunikezwa ngomuthi omusha noma wokugcwalisa kabusha weZyban noma iChantix. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola uhlu oluphelele lwemiphumela emibi.
| Umphumela oseceleni | UZyban: kuyasebenza? | UZyban: amaphesenti | I-Chantix: iyasebenza? | I-Chantix: amaphesenti |
| Isicanucanu | Yebo | 9% | Yebo | 30% |
| Ubuhlungu besisu | Yebo | 3% | Yebo | 7% |
| Ukuqwasha / inkinga yokulala | Yebo | 40% | Yebo | 18% |
| Amaphupho angajwayelekile | Yebo | 5% | Yebo | 13% |
| Ubuhlungu bekhanda | Akunjalo | - | Yebo | ishumi nanhlanu% |
| Ukukhathala | Akuvamile | % ayinikiwe | Yebo | 7% |
| Isiyezi | Yebo | 10% | Yebo | Imvamisa:% ayinikiwe |
| Umlomo owomile | Yebo | 10% | Yebo | 6% |
Imithombo: I-DailyMed (Chantix) futhi I-DailyMed (Zyban)
Ukusebenzisana kwezidakamizwa kukaZyban vs. Chantix
UZyban unenani elibalulekile lokusebenzisana kwezidakamizwa, okuningiliziwe eshadini elingezansi. Ukuxhumana okuningi kwezidakamizwa kungenxa yama-enzyme abizwa nge-CYP2B6 ne-CYP2D6. Ezinye izibonelo yimithi yokuquleka kanye neDigoxin, umuthi wenhliziyo. Utshwala kufanele bugwenywe ngenkathi ukuZyban.
Ngokuya ngezici zomuthi, i-Chantix ayinakho ukuxhumana okuphawulekayo kwezidakamizwa. I-Chantix ayifundelwanga ukuphepha ngokuhlangana noZyban. Ngenkathi uCantix efundwa ngokuhlanganiswa ne-nicotine replacement therapy, izehlakalo zemiphumela emibi njengokucanuzela kwenhliziyo, ikhanda elibuhlungu, ukuhlanza, isiyezi, ukugaya ukudla nokukhathala, kwakuphakeme kakhulu kune-nicotine kuphela.
I-Chantix akufanele isetshenziswe ngokuhlanganiswa ne- utshwala , okungenani uze wazi ukuthi uCantix ulithinta kanjani ikhono lakho lokubekezelela utshwala. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola eminye imininingwane.
| Izidakamizwa | Isigaba sezidakamizwa | Zyban | I-Chantix |
| I-Nicotine | Ukwelashwa kokufaka esikhundleni seNicotine | Akunjalo | Yebo |
| Tegretol (carbamazepine), Neurontin (gabapentin), Lamictal (lamotrigine), Phenobarbital, Dilantin (phenytoin), Trileptal (oxcarbazepine), Topamax (topiramate), Depakote (divalproex sodium) | Imithi yokuquleka, eminye isetshenziselwa ukuphazamiseka kwengqondo okuguquguqukayo | Yebo | Akunjalo |
| I-Klonopin (clonazepam), i-Valium (diazepam), i-Ativan (i-lorazepam) | I-Benzodiazepines | Yebo | Akunjalo |
| I-plavix (clopidogrel) | I-Antiplatelet | Yebo | Akunjalo |
| Utshwala | Utshwala | Yebo | Yebo |
| I-Lanoxin (digoxin) | I-glycoside yenhliziyo | Yebo | Akunjalo |
| I-Lopressor noma i-Toprol XL (metoprolol), i-Tenormin (i-atenolol), i-Inderal (i-propranolol) | Ama-beta blockers | Yebo | Akunjalo |
| I-Risperdal (risperidone), i-Haldol (i-haloperidol) | Ama-antipsychotic | Yebo | Akunjalo |
| I-Effexor (venlafaxine), i-Pamelor (i-nortriptyline), i-Paxil (i-paroxetine), i-Prozac (i-fluoxetine), i-Zoloft (i-sertraline) | Izidambisi | Yebo | Akunjalo |
| I-Ultram (tramadol), iCodeine | Ama-painkillers | Yebo | Akunjalo |
| I-Eldepryl (selegiline), iParnate (tranylcypromine) | I-MAO Inhibitors | Yebo | Akunjalo |
Uhlu lokusebenzisana kwezidakamizwa kukaZyban lude kakhulu ukuthi lungabhalwa lapha; thintana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola eminye imininingwane.
Izexwayiso zikaZyban noChantix
Izexwayiso zikaZyban:
UZyban uza nesexwayiso sebhokisi elimnyama (isexwayiso esiqine kakhulu njengoba kudingwa yi-FDA, esibonisa ubungozi bezehlakalo ezibucayi noma ezisongela impilo) zokuzibulala. IZyban iqukethe i-bupropion, i-anti-depressant, kanye ne-anti-depressants kungandisa ubungozi bokuzibulala nokuziphatha ezigulini ezineminyaka engu-24 nangaphansi. Iziguli nabanakekeli bazo kufanele bazi nganoma yikuphi ukuguquka kwemizwelo, ukubona izinto ezingekho, ukucabanga okuphambeneyo, ukukhohlisa, umbono wokubulala, ulaka, ubutha, ukukhathazeka, ukukhathazeka nokwethuka. Noma yisiphi isiguli esithatha iZyban, noma ngabe sineminyaka emingaki, kufanele siqashwe ngeso elibukhali. Nazi ezinye izexwayiso:
- Ubungozi be-mania noma i-psychosis; ubungozi bungaba ngaphezulu kweziguli ezine-bipolar disorder.
- I-Zyban ingadala ukuquleka; ingozi ihlobene nomthamo. Umthamo akufanele weqe ama-300 mg ngosuku. Ezinye izimo zezokwelapha zingakhuphula ubungozi bokuquleka.
- I-Zyban ingadala umfutho wegazi ophakeme; qapha umfutho wegazi ngenkathi uthatha uZyban.
- Iziguli ezithile zingaba sengozini ye-glaucoma; thintana nodokotela wezifo zamehlo ukuthola eminye imininingwane.
- Ukuvela kwesikhumba okungathi sína, okungasongela impilo (iStevens-Johnson syndrome); xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ngokushesha uma uba nokuqubuka kwesikhumba.
I-Zyban kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma inzuzo engaba khona ibeka ubungozi enganeni. Ababhemayo abakhulelwe kufanele bakhuthazwe ukuthi bayeke ukubhema ngokusebenzisa izindlela zokuziphatha ngaphambi kokusebenzisa uZyban. IZyban ukufaka kwephakeji ithi ngenxa yengozi enganeni, omama abahlengikazi kufanele bayeke ukuncelisa noma bayeke uZyban. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ukuthola izeluleko.
Izexwayiso ze-chantix:
I-Chantix iza nesixwayiso esibhokisi semicimbi emibi ye-neuropsychiatric. Ukudana, ukucabanga ukuzibulala, ukuzama ukuzibulala, nokuzibulala kuqediwe kubikwe ezigulini ezithatha iChantix. Kufanele uyeke ukuthatha i-Chantix bese uthinta umhlinzeki wakho wezokunakekelwa kwempilo ngokushesha uma uhlakulela ukucasuka, ubutha, imizwa edangele, noma ushintsho ekuziphatheni noma ekucabangeni okungajwayelekile, noma uma uhlangabezana nemicabango yokuzibulala. Nazi izexwayiso eziningi ezihlotshaniswa neChantix:
- Ubungozi be-hypersensitivity noma i-angioedema, okuvuvukala ebusweni, emlonyeni, (olimini, ezindebeni nasezinsinini), emaphethelweni nasentanyeni. Misa i-Chantix futhi ufune ukunakekelwa okuphuthumayo uma lokhu kwenzeka.
- NjengoZyban, isifo seStevens-Johnson singenzeka. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ngokushesha uma uba nokuqubuka kwesikhumba.
- Ithuba elandayo lezenzakalo zenhliziyo; yazisa umhlinzeki wakho wezokunakekelwa kwempilo ngezimpawu ezintsha noma eziya ziba zimbi zesifo senhliziyo.
- Sebenzisa ukuqapha ukushayela noma ukusebenzisa imishini uze wazi ukuthi iChantix ikuthinta kanjani; ukulimala ngengozi kwenzeke ngenxa yokulala noma isiyezi.
Omama abakhulelwe qaphela imiphumela kaChantix kumbungu. NjengakuZyban, ababhemayo abakhulelwe kufanele bakhuthazwe ukuthi bayeke ukubhema ngokusebenzisa izindlela zokuziphatha. I-Chantix ukufaka kwephakeji ithi ngenxa yengozi enganeni, omama abahlengikazi kufanele bayeke ukuncelisa noma bayeke uChantix.
Iziguli kuChantix kufanele zihlolwe kakhulu.
Ngo-2016, i- Kubikwe i-FDA ukuthi ubungozi bemiphumela emibi yezempilo yengqondo evela kuZyban noChantix bungaba ngaphansi kunalokho obekucatshangwa ngaphambili nokuthi izinzuzo zokuyeka ukubhema zidlula izingozi zokusebenzisa le mithi. Akunandaba, imininingwane yezidakamizwa isenezixwayiso ezifanayo futhi iziguli kufanele ziqashwe ngeso lokhozi ngenkathi ziseZyban noma eChantix.
Imibuzo ebuzwa njalo mayelana neZyban vs. Chantix
Yini uZyban?
UZyban (bupropion) umuthi osetshenziswa njengosizo ekwelapheni ukuyeka ukubhema.
Kuyini i-Chantix?
I-Chantix (varenicline) umuthi osetshenziswa njengosizo ekwelapheni ukuyeka ukubhema.
Ngabe uZyban noChantix bayefana?
Cha. Zombili lezi zidakamizwa zisebenza ngezindlela ezahlukene ukusiza ekwelapheni ukuyeka ukubhema. Indlela ngqo kaZyban ayaziwa kodwa kuthathwa ngokuthi ihlobene ne-dopamine ne-norepinephrine. I-Chantix isebenza ngokuvimba ama-nicotine receptors, nangokuvimbela ukuqiniswa nokuvuza umuzwa ohlelweni lwezinzwa oluphakathi. Asikho isidakamizwa esiqukethe i-nicotine. Futhi zinezindleko ezahlukahlukene, ukuxhumana kwezidakamizwa, imiphumela emibi, kanye nezixwayiso, njengoba kuchaziwe ngenhla.
Ngabe iZyban noma iCantix ingcono?
Wonke umuntu usabela ngendlela ehlukile emithini ehlukahlukene. Udokotela wakho kuphela onganquma ukuthi imuphi umuthi olungele wena, kucatshangelwa umlando wakho wezokwelapha, izimo zezempilo, neminye imithi oyiphuzayo.
Ingabe ikhona enye indlela kune-Chantix?
Okwamanje ayikho enye indlela ejwayelekile kune-Chantix.
Ingabe i-Chantix iyasiza ukuyeka ukubhema?
Yebo. I-Chantix ingasiza ekunciphiseni isifiso sakho sokubhema nokusiza ngezimpawu zokuhoxa.
