I-Armodafinil vs. modafinil: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Ungase ulwe nokulala ngokweqile emini uma usebenza ubusuku bonke. Kepha ngokwelashwa okufanele njenge-Armodafinil (i-Nuvigil) noma i-modafinil (i-Provigil), ungahlala uphapheme futhi uzizwe uqaphile. Le mithi ingabhalwa uma utholakale une-shift work disorder (SWD), i-narcolepsy, noma i-obstructive sleep apnea (OSA). Njengama-ejenti akhuthaza ukuvuka, i-armodafinil ne-modafinil zinemiphumela efana nokuvuselela.
Ngenkathi inqubo yabo ngqo yokusebenza ingaziwa, i-armodafinil ne-modafinil kukholakala ukuthi zisebenza ohlelweni lwezinzwa oluphakathi (CNS) futhi zikhulisa umsebenzi we-dopamine ebuchosheni. Imiphumela yabo ingahle ifane nezinye izikhuthazi ezifana ne-amphetamine (Adderall) ne-methylphenidate (Concerta). Kodwa-ke, zihlukile ngokwesakhiwo kunezinye izikhuthazi.
Kokubili i-armodafinil ne-modafinil yizidakamizwa zeSheduli IV ezinamandla aphansi okuhlukumeza nokuncika. Ziyizinto ezilawulwayo ezitholakala kuphela ngemithi kadokotela.
Uyini umehluko omkhulu phakathi kwe-armodafinil ne-modafinil?
I-Armodafinil, edayiswa ngaphansi kwegama lomkhiqizo elithi Nuvigil, iyisidakamizwa esisha uma kuqhathaniswa ne-modafinil. Kwavunywa ku-2007 njenge-R-enantiomer ye-modafinil. Ama-enantiomeri angama-molecule ayizithombe ezibukwayo zomunye nomunye — cabanga ngamagilavu angakwesokunxele nangakwesokudla. Ngale ndlela, i-armodafinil inesakhiwo samakhemikhali esihluke kancane uma kuqhathaniswa ne-modafinil.
I-Armodafinil ingaba nempilo ende ende uma iqhathaniswa ne-modafinil (igama lomkhiqizo i-Provigil). Kwezinye izimo, i-armodafinil ingathathwa njengesidakamizwa esinamandla esinemiphumela engcono yokuvuka. Yize yomibili le mithi ingaba nemiphumela emibi efanayo, eminye imiphumela emibi ingahle ivame kakhulu komunye umuthi uma uqhathanisa nomunye.
| Umehluko omkhulu phakathi kwe-armodafinil ne-modafinil | ||
|---|---|---|
| I-Armodafinil | I-Modafinil | |
| Isigaba sezidakamizwa | Isidakamizwa esifana nesikhuthazi Umenzeli okhuthaza ukuphaphama | Isidakamizwa esifana nesikhuthazi Umenzeli okhuthaza ukuphaphama |
| Isimo somkhiqizo / ejwayelekile | Izinhlobo zebrendi ne-generic ziyatholakala | Izinhlobo zebrendi ne-generic ziyatholakala |
| Ngubani igama lomkhiqizo? | UNuvigil | I-Provigil |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo | Ithebhulethi yomlomo |
| Uyini umthamo ojwayelekile? | 150 mg kanye ngosuku | 200 mg kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Isikhathi eside noma njengokuyalelwa ngudokotela | Isikhathi eside noma njengokuyalelwa ngudokotela |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nabadala abaneminyaka engu-17 nangaphezulu | Abantu abadala nabadala abaneminyaka engu-17 nangaphezulu |
Ufuna intengo engcono ku-armodafinil?
Bhalisela izexwayiso zentengo ye-armodafinil bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Izimo eziphathwe yi-armodafinil ne-modafinil
I-Armodafinil kanye ne-modafinil yimithi kadokotela evunyelwe yi-FDA ukwelapha ukulala kwasemini okuhlobene nokuhlukumezeka kwengqondo, ukuguquguquka kokuphazamiseka komsebenzi, kanye nokuphazamiseka kokuphefumula kokulala. Lezi zimo zezokwelapha zibonakaliswa yimizwa enganele yokuphumula okuholela ekulaleni ngokweqile. Zombili lezi zidakamizwa zithuthukisa ukuvuka kulabo abanenkinga yokukhathala ngokweqile nokulala usuku lonke.
I-Armodafinil ne-modafinil nazo zifundelwe izinhloso ezingekho kwelebula. Abanye izifundo khombisa ukuthi i-modafinil ingaba yindlela yokwelashwa ephumelelayo yokukhathala okwenzeka njengomphumela wokwelashwa komdlavuza nomdlavuza. Kubantu abadala abathola ngenkuthalo ukwelashwa komdlavuza, i-modafinil ingasiza ukuqeda ukukhathala ngokweqile kusuka ekhemotherapy.
Kulabo abane i-multiple sclerosis , amanani aphansi we-modafinil angasebenza ekwelapheni izimpawu zokukhathala. Kodwa-ke, imininingwane eminingi iphakamisa ukuthi i-modafinil akufanele isetshenziswe njengenketho yomugqa wokuqala walesi simo.
Okunye ukusetshenziswa kwelebula kufaka phakathi ukwelashwa kwezifo zengqondo ezifana ukudana nokunaka ukusilela-ukungasebenzi kahle (ADHD). I-Armodafinil noma i-modafinil ingahle isebenze ekwelapheni izimpawu zalezi zinkinga kepha azinconywa njengezinketho zokwelashwa zokuqala.
| Isimo | I-Armodafinil | I-Modafinil |
| Ukuxokozela | Yebo | Yebo |
| Isihibe sokuphazamiseka emsebenzini | Yebo | Yebo |
| I-apnea yokulala evimbela | Yebo | Yebo |
| Ukukhathala okuhlobene nomdlavuza | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukukhathala okuningi okuhlobene ne-sclerosis | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Izinkinga zengqondo ezifana nokudangala kanye ne-ADHD | Ngaphandle kwelebula | Ngaphandle kwelebula |
Ufuna intengo engcono kumodafinil?
Bhalisela izexwayiso zentengo ze-modafinil bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Ingabe i-armodafinil noma i-modafinil isebenza kangcono?
I-Armodafinil ne-modafinil ziyasebenza ngendlela efanayo ekwelapheni ubuthongo ezinkingeni zokulala njenge-narcolepsy, ukuvimbela ukuphefumula kokulala, kanye nesifo sokushintsha umsebenzi. Kodwa-ke, i-armodafinil ingaba nemiphumela ehlala isikhathi eside uma iqhathaniswa ne-modafinil.
Esivikini se-12 esingahleliwe, isilingo somtholampilo, i-armodafinil ne-modafinil ukulala okuthuthukisiwe ezifundweni ezisebenza ubusuku bonke. Imiphumela ithole ukuthi i-armodafinil ne-modafinil beziqhathaniswa nezikolo ezifanayo zokuphepha.
Phakathi ku ukuhlaziywa kwe-meta ngokuqhathanisa i-armodafinil ne-modafinil ye-obstructive sleep apnea, zombili lezi zidakamizwa zitholakale zisebenza ekwelapheni ubuthongo. Iziguli ezithatha noma yimiphi imiphumela emibi ebekezelelwe yizidakamizwa futhi zathola ukuvuka okuthuthukile emini.
I-Armodafinil ikhonjisiwe ukuthi iphezulu izingxube ze-plasma emzimbeni ngokuhamba kosuku. Izinga eliphakeme le-armodafinil emzimbeni lingaholela ekuvukeni okungcono uma kuqhathaniswa ne-modafinil.
Ngenkathi noma yimuphi umuthi ungasetshenziswa njengomuthi wokwelapha ukulala ngokweqile, kungcono ukubonisana nodokotela ukuze uthole iseluleko sezokwelapha. Njengamanje, azikho izifundo ezicacile ezithi enye isebenza kangcono kunenye.
Ukuhlanganiswa nokuqhathaniswa kwezindleko kwe-armodafinil vs. modafinil
I-Armodafinil ivame ukunikezwa njengethebhulethi engu-250 mg ethathwa kanye ngosuku. Itholakala kabanzi njengomuthi ojwayelekile ohlanganiswa yiMedicare nezinhlelo zomshuwalense. IGeneric Nuvigil ingabiza inani lentengo elijwayelekile elingaphezu kwe- $ 500. Le ntengo ingehliswa ngekhadi lesaphulelo le-SingleCare. Esikhundleni sokukhokha amanani aphezulu, i-armodafinil ingathengwa ngemali ephansi njenge- $ 277.
Ngokuya ngohlelo lwakho lomshuwalense, imodafinil ingambozwa. Eqinisweni, iMedicare nezinhlelo eziningi zomshuwalense zimboza i-modafinil ngezinhloso ezivunyelwe. Izindleko ezijwayelekile ze-modafinil zingabiza ngaphezulu kwe- $ 600. Emakhemisi abamba iqhaza, ungasebenzisa ikhadi lokonga le-SingleCare ukonga imali. Ukulondolozwa kwemodafinil kungaholela enanini eliphansi lama- $ 35- $ 280 kuya ngokuthi iyiphi ikhemisi oyisebenzisayo.
| I-Armodafinil | I-Modafinil | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare? | Yebo | Yebo |
| Umthamo ojwayelekile | 150 mg amaphilisi | Amaphilisi angama-200 mg |
| I-Medicare copay ejwayelekile | $ 15- $ 217 | $ 11- $ 392 |
| Izindleko ze-SingleCare | $ 277 | $ 35- $ 280 |
Imiphumela emibi ejwayelekile ye-armodafinil vs. modafinil
Imiphumela emibi kakhulu ehlotshaniswa ne-armodafinil ne-modafinil yikhanda, isicanucanu, isiyezi nokuqwasha. I-Modafinil kungenzeka ukuthi ibangele ezinye okuqhamuka uma udla imishanguzo njengokwethuka, ukuminyana kwamakhala (i-rhinitis), isifo sohudo, nobuhlungu beqolo.
Yomibili le mithi ingadala nomlomo owomile, ukuqunjelwa (i-dyspepsia) nokukhathazeka. Imiphumela emibi ehlobene nokulahleka kwesisindo nayo ingenzeka. Abanye abantu abathatha i-armodafinil noma i-modafinil bangathola ukwehla kwesifiso sokudla.
Eminye imiphumela emibi engajwayelekile kodwa emibi ifaka ukusabela okweqile njengokuqubuka nokuphefumula okuncane. Imiphumela emibi yengqondo efana nokudangala noma i-psychosis nayo iyenzeka. Funa ukwelashwa uma unale miphumela emibi.
| I-Armodafinil | I-Modafinil | |||
| Imiphumela emibi | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ubuhlungu bekhanda | Yebo | 17% | Yebo | 3. 4% |
| Isicanucanu | Yebo | 7% | Yebo | ishumi nanye% |
| Ukwesaba | Yebo | 1% | Yebo | 7% |
| Ukuqwasha | Yebo | 5% | Yebo | 5% |
| Isiyezi | Yebo | 5% | Yebo | 5% |
| Uhudo | Yebo | 4% | Yebo | 6% |
| Ukuhlungu obusemhlane | Akunjalo | - | Yebo | 6% |
| Ukuminyana emakhaleni | Akunjalo | - | Yebo | 7% |
| Ukugaya ukudla | Yebo | amaphesenti amabili | Yebo | 5% |
| Umlomo owomile | Yebo | 4% | Yebo | 4% |
| Ukukhathazeka | Yebo | 4% | Yebo | 5% |
| Ukwehla kwesifiso sokudla | Yebo | 1% | Yebo | 4% |
Lokhu kungenzeka kungabi uhlu oluphelele. Xhumana nodokotela wakho noma usokhemisi ngemiphumela engemihle engaba khona.
Umthombo: DailyMed ( armodafinil ), IDailyMed ( imvu )
Ukusebenzisana kwezidakamizwa kwe-armodafinil vs. modafinil
I-Armodafinil ne-modafinil babelana ngokusebenzisana kwezidakamizwa okufanayo. Le mithi ingasebenza njengama-inducers we-CYP3A4 enzyme kanye ne-inhibitors ye-CYP2C19 enzyme. Ngamanye amagama, zingathinta ukuthi izidakamizwa ezithile zicutshungulwa kanjani emzimbeni.
I-Armodafinil ne-modafinil kunganciphisa ukusebenza kwe-steroidal izinto zokuvimbela inzalo . Kunconywa ezinye izindlela zokuvimbela inzalo ngenkathi welashwa nge-armodafinil noma i-modafinil nangenyanga eyodwa ngemuva kokuyekiswa kwale mithi.
I-Armodafinil ne-modafinil zingakhuphula ukususwa kwe-cyclosporine emzimbeni. Uma kuthathwe ndawonye, ukusebenza kwe-cyclosporine kungancipha. Ngakolunye uhlangothi, i-armodafinil ne-modafinil zingakhuphula amazinga ezinye izidakamizwa ezaziwa ngokuthi ama-substrates e-CYP2C19. Ukwanda kwamazinga ezidakamizwa kungaholela emiphumeleni emibi.
| Izidakamizwa | Isigaba Sezidakamizwa | I-Armodafinil | I-Modafinil |
| I-Ethinyl estradiol Norethindrone | Izindlela zokuvimbela inzalo zeSteroidal | Yebo | Yebo |
| ICyclosporine | I-Immunosuppressant | Yebo | Yebo |
| Omeprazole Phenytoin I-Diazepam | Ama-substrates we-CYP2C19 | Yebo | Yebo |
Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.
Izexwayiso ze-armodafinil ne-modafinil
Kokubili i-armodafinil ne-modafinil kungadala ukuqubuka okukhulu. Le mithi kufanele iyekwe ngokushesha ezimweni zokuqubuka okukhulu. Ungathathi le mishanguzo uma unesifo sokwaliwa noma yisiphi sezithako zaso ezisebenzayo.
Ukulinganisa kwe-armodafinil noma i-modafinil kungadinga ukulungiswa ukuze kuthuthukiswe ukulala emini. Ngenkathi ulungiselela imithamo, ukulala okuqhubekayo kusengenzeka. Ngakho-ke, kubalulekile ukugwema ukushayela noma ukubamba iqhaza emisebenzini eyingozi lapho uqala ukuqala umuthi onjenge-armodafinil noma i-modafinil.
I-Armodafinil ne-modafinil kungadala izimpawu zengqondo ikakhulukazi kulabo abanomlando we i-psychosis , ukudangala, noma i-mania. Le mithi kufanele ibhekwe noma iyekwe ezimweni ezinzima zemiphumela yengqondo.
Izidakamizwa ezinjengezikhuthazi zingadala imiphumela emibi enhliziyweni nasenhlizweni yenhliziyo. Labo abane-high blood pressure bangadinga ukubhekwa lapho kuqala i-armodafinil noma i-modafinil. Xhumana nodokotela uma uzwa ubuhlungu besifuba, ukuphefumula okuncane, noma ukushaya kwenhliziyo (ukushaya kwenhliziyo okusheshayo).
Imibuzo ebuzwa njalo mayelana ne-armodafinil vs. modafinil
Yini i-armodafinil?
I-Armodafinil yaziwa futhi ngegama layo lomkhiqizo i-Nuvigil. I-Armodafinil isetshenziselwa ukwelapha ukulala ngokweqile kusuka ekuqothulweni kwe-narcolepsy nakwezinye izinkinga zokulala. Ifika ku-50 mg, 150 mg, 200 mg, naku-250 mg amaphilisi.
Yini i-modafinil?
I-Modafinil igama elejwayelekile lika-Provigil. I-Modafinil ivunyiwe yi-FDA ukwelapha ukulala emini okubangelwa ukuphazamiseka kokulala. Kungaphatha ukuvimbela ukuphefumula kokulala, ukugula , nokushintsha kokuphazamiseka komsebenzi.
Ngabe i-armodafinil ne-modafinil ziyefana?
I-Armodafinil ne-modafinil ziqukethe izithako ezifanayo kodwa azifani. I-Armodafinil iqukethe i-R-enantiomer ye-modafinil. I-Modafinil iqukethe ingxube yobuhlanga ye-R- ne-S-modafinil.
Ngabe i-armodafinil noma i-modafinil ingcono?
I-Armodafinil ne-modafinil ziyefana ngokusebenza nokuphepha. Noma kunjalo, i-armodafinil ingaba nayo amazinga aphezulu emzimbeni ngokuhamba kosuku. Imiphumela ye-armodafinil ingahlala isikhathi eside ngokuqhathaniswa ne-modafinil.
Ngingasebenzisa i-armodafinil noma i-modafinil ngenkathi ngikhulelwe?
Cha. I-Armodafinil ne-modafinil akuvamile ukuthi kunconywe ngesikhathi sokukhulelwa. Xoxa ngezinketho zakho zokwelashwa nodokotela uma ukhulelwe noma uncelisa.
Ngingasebenzisa i-armodafinil noma i-modafinil ngotshwala?
Akunconywa ukuthatha i-armodafinil noma i-modafinil ngenkathi uphuza utshwala. Ukuphuza utshwala ngenkathi usebenzisa i-armodafinil noma i-modafinil kungadala imiphumela emibi.
Ngingathatha i-armodafinil ne-modafinil ndawonye?
I-Armodafinil ne-modafinil azivame ukuthathwa ndawonye. Kokubili i-armodafinil ne-modafinil kuqukethe izithako ezifanayo ezisebenzayo. Ukuthatha i-armodafinil ne-modafinil ndawonye kungakhuphula ubungozi bemiphumela emibi.
Ngabe i-armodafinil izokhombisa ekuhlolweni kwezidakamizwa?
Cha. Ukuhlolwa kwezidakamizwa akuvamisile ukuhlola i-armodafinil. I-Armodafinil ayiqukethe amphetamine ngakho-ke izinzuzo ezingamanga ze-amphetamine azivamile.
Ungathatha i-armodafinil nsuku zonke?
I-Armodafinil isebenza kahle kakhulu uma ithathwa nsuku zonke. Kunconywa ukuthatha umthamo owodwa we-armodafinil ngasikhathi sinye nsuku zonke, imvamisa ekuseni.
