ICymbalta vs. Zoloft: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
ICymbalta neLexapro yimithi emibili kadokotela esetshenziselwa ukwelapha ukucindezeleka okukhulu (MDD) nezinye izifo ezihlobene nempilo yengqondo. Ukudana, ukukhathazeka, kanye nokuphazamiseka okuhlobene nakho kuthinta izigidi zabantu baseMelika ngokusho kwe- Inhlangano Yokukhathazeka Nokucindezeleka YaseMelika .
Izinkinga zempilo yengqondo zithinta imizwa, ukukhiqiza, kanye nekhono lomuntu lokusingatha ukucindezeleka. Kwabanye, izinto ezinjengokuzivocavoca umzimba, ukuzindla, noma ukwelashwa kunganikeza ukukhululeka, kepha kwabaningi, imithi izodingeka ukufeza ukuthethelelwa kwezimpawu. Ngenkathi iCymbalta neLexapro belapha izifo eziningi ezifanayo, ziyimithi ehlukile, futhi sizoxoxa ngalowo mehluko lapha.
Uyini umehluko omkhulu phakathi kweCymbalta neZoloft?
ICymbalta (duloxetine) umuthi kadokotela okhonjisiwe ekwelapheni kokubili ukucindezeleka okukhulu nokucindezeleka okujwayelekile (GAD). ICymbalta ingeyeqembu lemithi eyaziwa ngokuthi i-serotonin-norepinephrine reuptake inhibitors ekhethiwe (SNRIs). ICymbalta ivimba ukuphinda kuthathwe kokubili i-norepinephrine ne-serotonin ku-synapse ye-neuronal kushiye i-serotonin ne-norepinephrine engaphezulu. Lawa ma-neurotransmitters atholakala kalula ukuze adlale indima enhle ekuguqukeni kwemizwa nakuthinta. Amanye ama-SNRI okungenzeka ujwayelene nawo yi-Effexor (venlafaxine) ne-Pristiq (desvenlafaxine). ICymbalta itholakala njenge-20 mg, 30 mg, ne-60 mg capsule yomlomo.
I-Zoloft (i-sertraline) nayo iyimithi kadokotela ekhonjisiwe ekwelapheni i-MDD. I-Zoloft ihlukaniswa njenge-serotonin reuptake inhibitor ekhethiwe futhi isebenza ngokuvimba ukutholwa kabusha kwe-serotonin kuphela ku-synapse ye-neuronal. Amazinga aphezulu e-serotonin atholakalayo ahlotshaniswa nokuthuthuka kwemizwelo namandla. Amanye ama-SSRI ongawajwayela afaka phakathi i-Prozac (i-fluoxetine), i-Paxil (i-paroxetine), i-Celexa (i-citalopram) ne-Lexapro (i-escitalopram).
I-Zoloft iyatholakala njengethebhulethi yomlomo ngamandla we-25 mg, 50 mg, no-100mg. Futhi iyatholakala kwisisombululo somlomo esigxile ku-20 mg / ml.
| Umehluko omkhulu phakathi kweCymbalta neZoloft | ||
|---|---|---|
| ICymbalta | Zoloft | |
| Isigaba sezidakamizwa | I-serotonin norepinephrine reuptake inhibitor ekhethiwe | I-serotonin reuptake inhibitor ekhethiwe |
| Isimo somkhiqizo / ejwayelekile | I-Brand ne-generic iyatholakala | I-Brand ne-generic iyatholakala |
| Ngubani igama elijwayelekile? | I-Duloxetine | Sertraline |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ama-capsules omlomo | Amaphilisi omlomo nesisombululo |
| Uyini umthamo ojwayelekile? | 60 mg kanye ngosuku | 50 mg kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Isikhathi eside (izinyanga kuya eminyakeni) | Isikhathi eside (izinyanga kuya eminyakeni) |
| Ubani ovame ukusebenzisa umuthi? | Intsha kanye nabantu abadala | Izingane, intsha kanye nabantu abadala |
Izimo eziphathwa yiCymbalta neZoloft
ICymbalta neZoloft zivunyelwe ngayinye ukwelapha ukucindezeleka okukhulu, kepha umuthi ngamunye unezinkomba ezihlukile. ICymbalta ivunyelwe ukwelapha ukukhathazeka kokukhathazeka okujwayelekile. ICymbalta nayo ivunyelwe ukwelapha ubuhlungu bezinzwa nobuhlungu obungapheli. Lokhu kubeka iCymbalta ngaphandle kweminye imishanguzo yokulwa nengcindezi njengoba kungukuphela kwayo evunyelwe ekuhlolweni okuhlobene nobuhlungu.
I-Zoloft ivunyelwe yi-Food and Drug Administration (FDA) ekwelapheni ukuphazamiseka kokukhathazeka komphakathi kanye ne-obsessive-compulsive disorder (OCD). Isetshenziswa ngaphandle kwelebula ekuphazamisekeni kokukhathazeka okujwayelekile nokwehlukana kokukhathazeka kokukhathazeka. Ukusetshenziswa okungekho kwelebula kukhombisa ukuthi ukusetshenziswa okuhlosiwe akuvunyelwe yi-FDA.
Leli thebula lezinkomba elenzelwe ulwazi kuphela futhi alihloselwe ukuba libe iseluleko sezokwelapha. Sicela uvakashele uchwepheshe wakho wezokunakekelwa kwezempilo ukuthola ukuthi yikuphi ukwelashwa okungcono kakhulu ngesimo sakho.
| Isimo | ICymbalta | Zoloft |
| Ukucindezeleka okukhulu | Yebo | Yebo |
| Ukukhathazeka okujwayelekile | Yebo | Ngaphandle kwelebula |
| Ubuhlungu obuhambisana ne-neuropathy yesifo sikashukela | Yebo | Akunjalo |
| Ubuhlungu obuhambisana ne-fibromyalgia | Yebo | Akunjalo |
| Ubuhlungu obungapheli bemisipha | Yebo | Akunjalo |
| Cindezela ukungahambisani nomchamo | Ngaphandle kwelebula | Akunjalo |
| Inkinga yokukhathazeka komphakathi | Akunjalo | Yebo |
| Ukuphazamiseka okubangelwa ukucindezela | Akunjalo | Yebo |
| Ukwehlukana kokukhathazeka kokukhathazeka | Akunjalo | Ngaphandle kwelebula |
| Ukuphazamiseka kwengcindezi yangemva kokubandezeleka | Akunjalo | Yebo |
| Ukuphazamiseka kovalo | Akunjalo | Ngaphandle kwelebula |
| Ukushisa okushisayo ngenxa yokunqamuka kokuya esikhathini | Akunjalo | Ngaphandle kwelebula |
| Ukuphuma ngaphambi kwesikhathi | Akunjalo | Ngaphandle kwelebula |
Ingabe iCymbalta noma iZoloft isebenza kangcono?
TO funda eshicilelwe ngo-2016 iqhathanisa ngqo iCymbalta neZoloft ekusebenzeni kwabo ekwelapheni ukucindezeleka, futhi ucwaningo lubheke izimpawu ezithile zokudangala. Sekukonke, zombili lezi zidakamizwa zakhonjiswa ukuthi ziyasebenza ekwelapheni ukucindezeleka, esinye singabi ngcono kakhulu kunomunye jikelele. Kodwa-ke, lapho kubhekwa izimpawu ezithile, umuthi ngamunye ubonakala unenzuzo ehlukile enezimpawu ezithile. Iqembu elaphathwa ngeCymbalta likhombise ukuthuthuka okuningi maqondana nokukhubazeka kwengqondo, ukudinwa komzimba kanye nokukhubazeka ngokocansi. Iqembu leZoloft likhombise ukuthuthuka okwengeziwe ezimpawu ezinjengokuxakaniseka, ukukhathazeka ne-hypochondriasis. Kokubili iCymbalta neZoloft kuyasebenza ekwelapheni ukucindezeleka, kepha lolu cwaningo lukhombisa ukuthi ababhali kufanele banake ngqo izimpawu zomuntu ezivame kakhulu lapho bekhetha ukwelashwa.
Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweCymbalta vs. Zoloft
ICymbalta isidakamizwa esikhishwe ngodokotela esivame ukumbozwa ngazo zombili izinhlelo zezidakamizwa zeMedicare. Inani elikhishwa ephaketheni leCymbalta 60 mg lingaba ngaphezu kwama- $ 300, kepha ngesigqebhezana esivela kwaSingleCare, ungathola okwejwayelekile kube ngama- $ 15 emakhemisi abambe iqhaza.
I-Zoloft nayo iyisidakamizwa esidluliselwa ngodokotela esivame ukumbozwa yizinhlelo zombili zeMedicare nezentengiso. Intengo ephuma ephaketheni yegama lomkhiqizo iZoloft ingaba ngaphezu kuka- $ 400, kepha ungasebenzisa isigqebhezana esivela kwaSingleCare ukuthola inguqulo ejwayelekile ngo- $ 10.
Thola ikhadi lesaphulelo sakwaSingleCare
| ICymbalta | Zoloft | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokwejwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | 30, 60 mg amaphilisi | 30, 50 mg amaphilisi |
| I-Medicare copay ejwayelekile | Ngaphansi kuka- $ 10 | Ngaphansi kuka- $ 10 |
| Izindleko ze-SingleCare | $ 15 + | $ 10 + |
Imiphumela emibi ejwayelekile yeCymbalta vs. Zoloft
ICymbalta neZoloft zombili ziyaziwa ukuthi zibanga ukuphazamiseka kwamathumbu njengokucanuzela kwenhliziyo, uhudo nokuqunjelwa. I-nausea ingumphumela ovelele kakhulu wezidakamizwa zombili futhi ungathinta ikhwalithi yempilo. Uma uhlangabezana nesicanucanu esinomthelela emisebenzini yakho yansuku zonke, kufanele wazise lowo omumisile.
Ukudinwa, noma ukulala ngokweqile noma ukozela, nakho kungenye yemiphumela emibi yomibili iCymbalta neZoloft. Iziguli ezithatha iCymbalta nazo zingase zizwe ikhanda nokunyuka kwengcindezi yegazi. ICymbalta, noma kunjalo, kubonakala ngathi ayithinti i-libido, kanti ukusetshenziswa kweZoloft kungasebenza.
Leli thebula alihloselwe ukuthi libe uhlu oluphelele lwemiphumela engemihle engenzeka futhi lenzelwa ulwazi kuphela. Sicela uthintane nochwepheshe wezokunakekelwa kwempilo ukuthola uhlu oluphelele.
| ICymbalta | Zoloft | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Isicanucanu | Yebo | 2. 3% | Yebo | 26% |
| Umlomo owomile | Yebo | 13% | Yebo | 14% |
| Ukujuluka | Yebo | 6% | Yebo | 7% |
| Uhudo | Yebo | 9% | Yebo | 4% |
| Ukuqunjelwa | Yebo | 9% | Yebo | 6% |
| I-Dyspepsia | Akunjalo | n / a | Yebo | 8% |
| Isiyezi | Yebo | 9% | Yebo | 12% |
| Ukozela | Yebo | 10% | Yebo | ishumi nanye% |
| Ubuhlungu bekhanda | Yebo | 14% | Akunjalo | n / a |
| Ukwanda komfutho wegazi | Yebo | amaphesenti amabili | Akunjalo | n / a |
| Ukwehla kwesifiso sokudla | Yebo | 7% | Yebo | 3% |
| Kwehlisiwe i-libido | Akunjalo | n / a | Yebo | 6% |
Umthombo: ICymbalta ( I-DailyMed I-Zoloft ( I-DailyMed )
Ukusebenzisana kwezidakamizwa kweCymbalta vs. Zoloft
ICymbalta neZoloft babelana ngokuhlangana okuvamile kwezidakamizwa, kepha kukhona okunye okucacile kumuthi ngamunye. ICymbalta inhibit CYP2D6, i-enzyme ebhekele ukwakheka kwezidakamizwa eziningi kubandakanya izidakamizwa ezihlobene ne-amphetamine. Ama-Amphetamines asetshenziswa ekwelapheni ukuphazamiseka kokushoda kokunakwa, okungenzeka nasezigulini ezinokudangala noma ukukhathazeka. Ukuvinjelwa kweCymbalta kwale enzyme kungaholela ekukhuleni kwamazinga egazi ama-amphetamine. Iziguli ezisezinhlotsheni zombili zezidakamizwa kufanele ziqashwe ngeso elibukhali.
ICymbalta neZoloft zinamandla okudala i-serotonin syndrome uma ixutshwe nezinye izidakamizwa ezinezenzo ze-serotonergic. Isifo se-Serotonin kungumphumela wamazinga aphakeme ngokungajwayelekile we-serotonin yamahhala futhi kungadala ukugula, isiyezi, nokukhuphuka kwenhliziyo. Izidakamizwa ezifana nomuthi we-migraine eletriptan noma isengezo iSt. John's Wort zingadala lokhu kuhlangana.
I-Zoloft ingadala uhlobo oluthile lwe-arrhythmia yenhliziyo eyaziwa njengesikhawu se-QTc esinde lapho ithathwa ngezigaba ezithile zemithi. Kubalulekile ukuthi uchwepheshe wakho wezokunakekelwa kwempilo nosokhemisi babe nohlu oluphelele lwemithi oyiphuzayo ukuze uhlolisise ngokufanele ukuhlangana okungaba khona.
Uhlu olulandelayo aluhloselwe ukuba luhlu oluphelele lokusebenzisana kwezidakamizwa. Udokotela wakho noma usokhemisi angakunikeza uhlu oluphelele.
| Izidakamizwa | Isigaba sezidakamizwa | ICymbalta | I-Lexapro |
| I-Almotriptan I-Eletriptan I-Oxitriptan | I-5HT Agonist / Triptans (ama-antimigraine agents) | Yebo | Yebo |
| Usawoti we-Amphetamine I-Dexmethylphenidate I-Methylphenidate | Ama-Amphetamines | Yebo | Yebo |
| I-Alosetron I-Ondansetron I-Ramosetron | Abaphikisi be-5HT3 (ama-anti-nausea agents) | Akunjalo | Yebo |
| I-Aripiprazole | I-Antipsychotic | Yebo | Yebo |
| I-Aspirin Ibuprofen I-Naproxen I-Diclofenac | Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) | Yebo | Yebo |
| Enoxaparin I-Heparin | Ama-anticoagulants | Akunjalo | Yebo |
| I-Buspirone | Ukukhathazeka ngokweqile | Yebo | Yebo |
| I-Carbamazepine | I-Anticonvulsant | Akunjalo | Yebo |
| Esomeprazole Omeprazole | I-Proton pump inhibitor | Akunjalo | Yebo |
| I-Fluconazole | I-Antifungal | Akunjalo | Yebo |
| I-Fluoxetine I-Citalopram I-Paroxetine I-Escitalopram | Ama-SSRIs | Yebo | Yebo |
| I-Hydroxychloroquine | Aminoquinolone / I-Antimalarial | Akunjalo | Yebo |
| I-Linezolid | Imithi elwa namagciwane | Yebo | Yebo |
| I-Metaxalone | Iziphumuli zemisipha | Yebo | Yebo |
| I-Pimozide | I-Antipsychotic | Akunjalo | Yebo |
| USelegiline I-Phenelzine I-Rasagiline | I-Monoamine oxidase inhibitor (MAOI) | Yebo | Yebo |
| ISt. John's Wort | Ukwengeza ngamakhambi | Yebo | Yebo |
| I-Hydrochlorothiazide I-Chlorthalidone I-Metolazone | Izidakamizwa ze-Thiazide | Akunjalo | Yebo |
| I-Tramadol | Ukudambisa izinhlungu ze-opiate | Yebo | Yebo |
| Amitriptyline I-Clomipramine I-Doxepin I-Nortriptyline | I-Tricyclic antidepressants | Yebo | Yebo |
Izexwayiso zeCymbalta neZoloft
Kubalulekile ukuqonda ukuthi iCymbalta noma iZoloft ngeke ikhiqize ukuthethelelwa ngokushesha kwezimpawu zokuphazamiseka kwengcindezi noma ukukhathazeka. Kuzothatha okungenani amasonto amabili ukuqaphela noma yiluphi ushintsho ezigulini eziningi ezithunyelwe, kuze kube amasonto amane kuya kwayisithupha ukuthola umphumela ogcwele womuthi. Ungayeki ngaphambi kwesikhathi imishanguzo yakho unenkolelo yokuthi ayisebenzi ngaphandle kokukhuluma nommeli wakho.
Iziguli ezine-MDD zingathola ukwanda kokucindezeleka noma imicabango yokuzibulala noma ngabe ziyayiphuza yini imishanguzo yokucindezela. Lezi zimo zingase zibe zimbi kuze kutholakale ukuxolelwa. Ukwelashwa kweCymbalta neZoloft kungakhuphula umbono wokuzibulala nemicabango phakathi kwentsha kanye nabantu abadala, ikakhulukazi ezigabeni zokuqala zokwelashwa. Lezi ziguli kufanele zibhekwe ngeso lokhozi uma lokhu kwelashwa kubonakala kudingekile ngokwezokwelapha. Ukushintshwa kokwelashwa kungadingeka uma izimpawu zivele kungazelelwe noma ziba zimbi kakhulu.
Kube nemibiko yokwehluleka kwesibindi, kwesinye isikhathi okubulalayo, neCymbalta. Lawa macala angabonisa ubuhlungu besisu kanye nama-enzyme aphakeme wesibindi nge-jaundice noma ngaphandle kwayo. Ukuphuza utshwala kungakhuphula le ngozi, ngakho-ke le nhlanganisela kufanele igwenywe.
I-Zoloft ingadala uhlobo oluthile lwe-arrhythmia yenhliziyo eyaziwa njengesikhawu se-QTc esinde lapho ithathwa ngezigaba ezithile zemithi. Kubalulekile ukuthi uchwepheshe wakho wezokunakekelwa kwempilo nosokhemisi babe nohlu oluphelele lwemithi oyiphuzayo ukuze uhlolisise ngokufanele ukuhlangana okungaba khona. Sicela ufune iseluleko sezokwelapha kumhlinzeki wakho wezokunakekelwa kwempilo ngaphambi kokuqala noma yiziphi izindlela zokwelapha ezintsha.
Isifo se-Serotonin kubikwe ngawo wonke ama-SSRIs nama-SNRI, kufaka phakathi iCymbalta neZoloft. Lesi yisimo esihlobene namazinga aphakeme ngokweqile we-serotonin futhi singaholela ekutheni isiguli sizizwe sikhungathekile, siba nesiyezi, futhi sikhuphuke izinga lokushaya kwenhliziyo.
Imibuzo ebuzwa njalo mayelana neCymbalta vs. Zoloft
Kuyini iCymbalta?
ICymbalta (yini iCymbalta?) Umuthi kadokotela odambisa ukucindezelwa osetshenziswa ekwelapheni ukucindezeleka okukhulu, ukukhathazeka okujwayelekile kokukhathazeka, kanye nezinhlungu ezahlukahlukene ze-neuropathic kanye ne-musculoskeletal pain. ICymbalta isekilasini lezidakamizwa ezaziwa njenge-serotonin-norepinephrine reuptake inhibitors ekhethiwe (SNRIs). ICymbalta itholakala njenge-capsule yomlomo ku-20 mg, 30 mg, naku-60 mg amandla.
Kuyini iZoloft?
I-Zoloft (yini i-Zoloft?) Imithi elwa nodokotela esetshenziswa ekwelapheni isifo esikhulu sokudangala kanye nokunye ukukhathazeka nokuphazamiseka kwengqondo. UZoloft usesigabeni semithi eyaziwa ngokuthi i-serotonin reuptake inhibitors ekhethiwe (SSRIs). I-Zoloft iyatholakala njengamaphilisi womlomo ku-25 mg, 50 mg, naku-100 mg amandla, kanye ne-concentrate yomlomo womlomo.
Ngabe iCymbalta neZoloft ziyefana?
Ngenkathi bobabili uCymbalta noZoloft belapha ukudangala kanye nokuphazamiseka okuhlukahlukene kwezempilo yengqondo, abalona uhlobo olufanayo lomuthi. ICymbalta isekilasini lezidakamizwa ezaziwa ngokuthi i-serotonin-norepinephrine reuptake inhibitors ekhethiwe (SNRIs), futhi idala ukwanda kokutholakala kwe-serotonin ne-norepinephrine. UZoloft usesigabeni semithi eyaziwa ngokuthi i-serotonin reuptake inhibitors ekhethiwe (SSRIs) futhi ibangela ukwanda kwe-serotonin etholakalayo.
Ngabe iCymbalta noma iZoloft ingcono?
ICymbalta neZoloft ziyafaniswa ngokwazi kwabo ukwelapha ukucindezeleka. ICymbalta inesibonakaliso esengeziwe sokukhathazeka okujwayelekile. Kubalulekile ukubheka izimpawu ezithile zokudangala kanye nemiphumela emibi engaba khona lapho unquma ukuthi imuphi umuthi olungele isiguli esithile.
Ngingayisebenzisa iCymbalta noma iZoloft ngenkathi ngikhulelwe?
I-FDA ibheka kokubili iCymbalta neLexapro (yini iLexapro) isigaba C sokukhulelwa, okusho ukuthi bekungekho izifundo ezanele zabantu zokunquma ukuphepha. NgeCymbalta, imiphumela engeyona eye-teratogenic iye yabonwa ezinganeni ezisanda kuzalwa kulandela ukuphathwa kweCymbalta ngenkathi ikhulelwe. Lokhu kubandakanya ukucindezeleka kokuphefumula, ubunzima bokudla, nokuthuthumela. Ngokuvamile, noma yisiphi isidakamizwa kufanele sisetshenziswe kuphela ngenzuzo kumama ngokusobala sidlula ubungozi enganeni.
Ngingasebenzisa iCymbalta noma iZoloft ngotshwala?
Iziguli kufanele zigweme ukuphuza kakhulu utshwala uma zithatha iCymbalta noma iZoloft. Utshwala bungakhuphula imiphumela enobuthi kuyo yomibili le mithi futhi bungadala ukukhubazeka okukhulu kwengqondo. NgeCymbalta ikakhulukazi, utshwala bandisa izehlakalo zokukhubazeka kwesibindi.
Yini i-anti-depressant enhle kakhulu enemiphumela emibi kakhulu?
Imithi elwa nokudangala emakethe e-United States ihlolwe ngokuphelele ukuqinisekisa ukuthi iyasebenza ekwelapheni ukucindezeleka. Ngamunye unemiphumela emibi eyenzeka ngokudlanga okuhlukile. Udokotela wakho uzocubungula izimpawu zakho zokucindezeleka kanye nemiphumela emibi ekukhathaza kakhulu lapho ukhetha ukwelashwa.
Ingabe iZoloft iyakuthinta ocansini?
Umkhiqizi ubika ukuthi iziguli ezifika ku-6% zingathola ukwehla kwe-libido, noma kwehle ukushayela i-sex, ngenkathi ithatha iCymbalta. Iziguli ezizwa lokhu kufanele zikhulume nochwepheshe wazo wezokunakekelwa kwempilo mayelana nezinye izindlela ezingenzeka.
Yikuphi okungcono: iProzac noma iZoloft?
Nakhu idatha ukuphakamisa ukuthi iZoloft ingaphakama kuneProzac (yini iProzac) ngokusebenza ngempumelelo lapho welapha ukucindezeleka. Kodwa-ke, abakwa-prescribers bazocabangela izinto eziningi lapho bekhetha ukwelashwa. Udokotela wakho kuphela onganquma ukuthi yini okungakulungela kakhulu.
