Main >> Izidakamizwa Vs. Umngani >> I-Estrace vs. Premarin: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Estrace vs. Premarin: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

Uma uhlangabezana nezimpawu zokuya esikhathini, njengokukhanya okushisayo, ukujuluka ebusuku , izinkinga zokulala, nokoma kwesitho sangasese sowesifazane, umhlinzeki wakho wezokunakekelwa kwempilo kungenzeka ukuthi ukhulume ngokwelashwa kwe-hormone noma i-estrogen therapy. Izimpawu zokunqamuka kokuya esikhathini zenzeka lapho umzimba wenza i-estrogen encane, ngakho-ke imishanguzo ebuyisela i-estrogen ingasiza ekuthuthukiseni lezi zimpawu, futhi isize nokuvimbela i-osteoporosis.

Kwabesifazane abanesibeletho, ukwelashwa kwamahomoni kufaka phakathi kokubili i-estrogen ne-progesterone. Kwabesifazane abanesibeletho, i-estrogen iyodwa inyusa ingozi yomdlavuza we-endometrium.

Abesifazane abangenaso isibeletho (abake baba ne-hysterectomy) abadingi ukuthatha i-progesterone nge-estrogen. Laba besifazane bangasebenzisa imikhiqizo ye-estrogen kuphela efana ne-Estrace noma i-Premarin.

I-Estrace ne-Premarin yimithi emibili enegama lomkhiqizo ekhonjiswe ekwelapheni izimpawu zokunqamuka kokuya esikhathini. Zombili lezi zidakamizwa zivunyelwe yi-United States Food and Drug Administration (FDA). Basesigabeni semithi ebizwa ngama-estrogens futhi baziwa nangokuthi yi-hormone replacement therapy. Zitholakala ngezindlela ezahlukahlukene, kufaka phakathi okhilimu namaphilisi. Yize zombili i-Estrace ne-Premarin ziqukethe i-estrogen, azifani ncamashi. Qhubeka ufunde ukuze ufunde kabanzi nge-Estrace ne-Premarin.

Uyini umehluko omkhulu phakathi kwe-Estrace ne-Premarin?

I-Estrace itholakala ngohlobo lomkhiqizo nolohlobo olujwayelekile futhi iqukethe isithako estradiol . I-Estrace iyatholakala njengokhilimu wesitho sangasese sowesifazane, futhi njengethebhulethi yomlomo.

I-Premarin iyatholakala njengesidakamizwa esinegama lomkhiqizo kuphela. Iqukethe ama-estrogens ahlanganisiwe, ahlanjululwe emchameni wama-mares okhulelwe (yingakho igama elithi Premarin- PREgnant MARes urINe). I-premarin iyatholakala njengokhilimu we-estrogen sowesifazane, ithebhulethi yomlomo, noma umjovo.

Umehluko omkhulu phakathi kwe-Estrace ne-Premarin
	I-Estrace	Ngaphambi kwangaphambilini
Isigaba sezidakamizwa	Ukwelashwa kwe-Estrogens / hormone	Ukwelashwa kwe-Estrogens / hormone
Isimo somkhiqizo / ejwayelekile	Umkhiqizo nokujwayelekile	Umkhiqizo
Ngubani igama elijwayelekile?	I-Estradiol	Ama-estrogens ahlanganisiwe
Izidakamizwa zingena ngaziphi izinhlobo?	Ukhilimu wesitho sangasese sowesifazane, ithebhulethi yomlomo	Ukhilimu wesitho sangasese sowesifazane, ithebhulethi yomlomo, umjovo
Uyini umthamo ojwayelekile?	I-Cream: 2 kuya ku-4 amagremu sangasese nsuku zonke amasonto ayi-1-2, bese wehlisa kancane kancane ube umthamo wesondlo ka-1 gram izikhathi eziyi-1-3 ngeviki Amathebulethi: kuyehluka	Ukhilimu: 0,5 amagremu ngokuya ngesitho sangasese sowesifazane kabili ngesonto Amathebulethi: kuyehluka
Yelashwa isikhathi esingakanani?	Iyahlukahluka	Iyahlukahluka
Ubani ovame ukusebenzisa umuthi?	Abesifazane be-Postmenopausal, ngezikhathi ezithile emadodeni ngezinkomba ezithile (bheka ngezansi)	Abesifazane be-Postmenopausal, ngezikhathi ezithile emadodeni ngezinkomba ezithile (bheka ngezansi)

Izimo eziphathwe yi-Estrace ne-Premarin

Ukhilimu we-Estrace nokhilimu we-Premarin welapha izimpawu ezilinganiselayo kuya kwezinzima ze-vagritis ne-vulvar atrophy (ukuncipha, ukomisa nokuvuvukala) ngenxa yokunqamuka kokuya esikhathini.

Kwifomu lethebhulethi, i-Estrace ne-Premarin ziphatha ezinye izimo ezahlukahlukene ezibhalwe eshadini elingezansi.

Isimo	I-Estrace	Ngaphambi kwangaphambilini
Izimpawu ezilinganiselwe kuya kwezinzima ze-vulvar / atrophy yesitho sangasese sowesifazane ngenxa yokunqamuka kokuya esikhathini	Yebo (ukhilimu)	Yebo (ukhilimu)
Ukwelashwa kwe-hypoestrogenism ngenxa ye-hypogonadism, castration, noma ukwehluleka okuyinhloko kwe-ovarian	Yebo (ithebhulethi)	Yebo (ithebhulethi)
Ukwelashwa komdlavuza webele (wokudambisa ikhanda kuphela) kwabesifazane nabesilisa abathile abanesifo se-metastatic	Yebo (ithebhulethi)	Yebo (ithebhulethi)
Ukwelashwa kwe-carcinoma esezingeni eliphakeme elincike ku-androgen le-prostate (ngokuthokomala kuphela)	Yebo (ithebhulethi)	Yebo (ithebhulethi)
Ukuvimbela i-postmenopausal osteoporosis kwabesifazane abasengozini enkulu, lapho imithi engeyona eye-estrogen ingafanele	Yebo (ithebhulethi)	Yebo (ithebhulethi)
Ukwelashwa kwe-atrophic vaginitis kanye ne-kraurosis vulvae	Ngaphandle kwelebula	Yebo (ukhilimu)
Ukwelashwa kwe-dyspareunia emaphakathi kuya kokubi (ukuya ocansini okubuhlungu) ngenxa yokunqamuka kokuya esikhathini	Ngaphandle kwelebula	Yebo (ukhilimu)
Ukwelashwa kwezimpawu ze-vasomotor ezinokulinganisela ngenxa yokunqamuka kokuya esikhathini	Yebo (ithebhulethi)	Yebo (ithebhulethi)

Ingabe i-Estrace noma i-Premarin isebenza kangcono?

Ucwaningo lukhombisa ukuthi uma uqhathanisa imikhiqizo ye-estrogen, i-estradiol (isithako e-Estrace) kanye ne-conjugated estrogens (isithako se-Premarin) zisebenza ngokulinganayo ekwelapheni izimpawu zokunqamuka kokuya esikhathini. Ukhilimu wesitho sangasese sowesifazane ziyasebenza futhi kubekezelelwe kahle.

Umhlinzeki wakho wezokunakekelwa kwezempilo anganquma ukuthi imuphi umuthi ofanele wena, ucabangela izimpawu zakho, izimo zezokwelapha, nomlando wezokwelapha.

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kwe-Estrace vs. Premarin

Amapulani kadokotela womshwalense kanye neMedicare ngokuvamile ahlanganisa i-Estrace ne-Premarin.

Umuthi ojwayelekile we-Estrace owenzelwe ithubhu kakhilimu futhi ubiza cishe u- $ 36 uma ukhokha ephaketheni, kepha ukusebenzisa isigqebhezana samahhala se-SingleCare kungaletha intengo iye ku- $ 6 nje.

Umuthi ojwayelekile webhubhu i-Premarin ubiza cishe ama- $ 250 aphume ephaketheni. Ikhadi le-SingleCare lingehlisela intengo ibe ngaphansi kwama- $ 198.

Njengoba izinhlelo ziyahlukahluka, xhumana nomhlinzeki wakho womshuwalense ngemininingwane yokumbozwa.

	I-Estrace	Ngaphambi kwangaphambilini
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokwejwayelekile yi-Medicare Part D?	Yebo	Yebo
Ubuningi	1 ithubhu	1 ithubhu
I-Medicare copay ejwayelekile	$ 1- $ 36	$ 2- $ 451
Izindleko ze-SingleCare	$ 6 +	$ 198 +

Imiphumela emibi ejwayelekile ye-Estrace vs. Premarin

Imiphumela emibi kakhulu ye-Estrace ne-Premarin cream ifaka ukusabela kwesiza sohlelo lokusebenza njengokuluma, ukukhipha, ukuphuma kwegazi lesisu nokuvuvukala. Ngokwengeziwe, kungenzeka ikhanda kanye nobuhlungu be-pelvic. Iphesenti lemiphumela emibi alifakiwe kulwazi olunqunyiwe lwe-Estrace.

Imiphumela emibi ejwayelekile ye-Estrace ne-Premarin efomini yethebhulethi ihlelekile kakhulu. Eminye yale miphumela emibi ibandakanya ubuhlungu besisu noma beqolo, ubuthakathaka, ukuvuvukala, ikhanda elibuhlungu, ukuqunjelwa, igesi, isicanucanu, ukukhuluphala, ukudana, uvalo, isiyezi, isifuba sesifuba / ubuhlungu / izinguquko, nokukhishwa kwesitho sangasese sowesifazane, ukopha noma ukutheleleka kwemvubelo.

Lolu akulona uhlu olugcwele lwemiphumela emibi. Eminye imiphumela emibi kungenzeka. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuze uxoxe ngemiphumela emibi ongayilindela, nokuthi ungayixazulula kanjani.

	Khipha ukhilimu	Ukhilimu wokuqala
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ubuhlungu bekhanda	Yebo	% akubikiwe	Yebo	3-5% *
Ubuhlungu be-pelvic	Yebo	% akubikiwe	Yebo	4%
Ukulunywa	Yebo	% akubikiwe	Yebo	1-2%
Ukukhishwa kwesitho sangasese sowesifazane	Akunjalo	-	Yebo	3-4%
Ukopha kwesitho sangasese sowesifazane	Yebo	% akubikiwe	Yebo	1-2%
Ukuvuvukala kwesitho sangasese sowesifazane	Yebo	% akubikiwe	Yebo	1-2%
Ukutheleleka kwesitho sangasese sowesifazane / ukutheleleka ngemvubelo	Yebo	% akubikiwe	Yebo	3-4%

* kuya ngemvamisa yesilinganiso
Umthombo: DailyMed ( Khipha ukhilimu ), IDailyMed ( Ukhilimu wokuqala )

Ukusebenzisana kwezidakamizwa kwe-Estrace vs. Premarin

I-Estrace noma i-Premarin ingathinteka yizidakamizwa ezithile ezihlanganiswa ne-enzyme ebizwa nge-cytochrome-p 450 3A4. Izidakamizwa ezivimbela i-enzyme zinganciphisa ukucubungula komzimba kwe-Estrace noma i-Premarin, okusho ukuthi i-Estrace noma i-Premarin ingahlala emzimbeni isikhathi eside, idale imiphumela emibi eminingi. Futhi, izidakamizwa ezenza i-enzyme zingadala ukuthi umzimba ucubungule i-Estrace noma i-Premarin ngokushesha okukhulu, kuyenze ingasebenzi kahle. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo maqondana nokuhlangana kwezidakamizwa okungenzeka.

Izidakamizwa	Isigaba sezidakamizwa	I-Estrace	Ngaphambi kwangaphambilini
I-Clarithromycin I-Erythromycin Ijusi lamagilebhisi I-Itraconazole Ketoconazole I-Ritonavir	I-CYP3A4 enzyme inhibitors	Kungenzeka	Kungenzeka
I-Carbamazepine I-Phenobarbital I-Rifampin Isibungu iSt	Ama-inducers we-CYP3A4	Kungenzeka	Kungenzeka

Izexwayiso ze-Estrace ne-Premarin

U-Estrace noPremarin bane- isexwayiso sebhokisi , okuyisixwayiso esiqine kakhulu esidingwa yi-FDA. Ngoba ukumuncwa kwesistimu kungenzeka nge-Estrace noma ukhilimu we-Premarin, izexwayiso zisebenza kukho konke ukwakheka.

I-Estrogen iyodwa:

Ukusebenzisa i-estrogen kuphela (ngaphandle kwe-progestin) kowesifazane onesibeletho kwandisa ingozi yomdlavuza we-endometrium. Ukwengeza i-progestin ekwelashweni kwe-estrogen kungehlisa ingozi yomdlavuza we-endometrium (kepha kungakhuphula ubungozi bomdlavuza webele). Abesifazane be-Postmenopausal abanegazi elingajwayelekile kufanele bahlolwe ukuze kutholakale ukuthi abanabo yini ubungozi.
Ungasebenzisi i-estrogen kuphela ukuvikela isifo senhliziyo noma ukuwohloka komqondo. I-Women’s Health Initiative (WHI) funda bathole ingozi eyengeziwe yokushaywa unhlangothi ne-DVT (i-vein thrombosis ejulile, noma ihlule legazi emlenzeni) kwabesifazane abangemva kokuya esikhathini abathathe i-estrogen yodwa (ngaphandle kweprogestin).
Ucwaningo lukhombise nengozi eyengeziwe yokuwohloka komqondo kubantu besifazane abase-postmenopausal abathathe i-estrogen yodwa.

I-Estrogen kanye ne-progestin:

Ungasebenzisi i-estrogen kanye ne-progestin ukuvikela isifo senhliziyo noma ukuwohloka komqondo. Ucwaningo lwe-WHI luthole izingozi eziphakeme ze-DVT, PE (embolism pulmonary embolism), unhlangothi, kanye ne-MI kwabesifazane be-postmenopausal abathathe i-estrogen kanye ne-progestin. Ucwaningo lukhombise nengozi enkulu yokuthola ukuwohloka komqondo kubantu besifazane abase-postmenopausal abathathe i-estrogen kanye nama-progestin.
Ucwaningo lwe-WHI luphinde lwabonisa ingozi eyandayo yomdlavuza webele ongenayo nge-estrogen kanye ne-progestin.

Ngakho-ke, ama-estrogens, noma ngabe anqunywe ngama-progestin noma ngaphandle kwawo, kufanele anqunywe kumthamo ophansi kakhulu nangesikhathi esifushane. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nobungozi obuhambisana nezinzuzo zezinhlobo ezahlukahlukene zokwelashwa okushintshwa kwamahomoni.

Udokotela wakho uzokunikeza iseluleko sezokwelapha ngokuhlolwa. Bonke abesifazane kufanele bahlolwe amabele minyaka yonke ngochwepheshe wezokunakekelwa kwempilo futhi bazihlole nyangazonke. Bonke abesifazane kufanele babe ne-mammography ngokususelwa eminyakeni yobudala, izinto ezinobungozi, nomlando.

Ezinye izixwayiso ze-Estrace ne-Premarin ziyalandela.

Ungasebenzisi i-Estrace noma i-Premarin uma une:

Ukopha okungaziwa okungaziwa
Umdlavuza webele (owaziwayo, osolwayo, noma umlando)
I-neoplasia encike ku-Estrogen (eyaziwa noma esolwayo)
I-DVT noma i-pulmonary embolism (esebenzayo noma umlando)
Ukusebenza noma umlando wesifo se-thromboembolic (isifo sohlangothi, i-MI)
Ukusabela kwangaphambilini kwe-anaphylactic ku-estrogen
Isifo sesibindi
Izinkinga ze-thrombophilic
Ukukhulelwa (okwaziwayo noma okusolwayo)

Inhlanganisela yokwelashwa kwe-hormone (i-estrogen kanye ne-progestin) ingakhuphula ubungozi bomdlavuza we-ovari.

Abesifazane be-Postmenopausal abathatha i-estrogen baba nokwanda engcupheni yesifo se-gallbladder esidinga ukuhlinzwa.

Kubantu abathatha ama-estrogens, izinkinga zokubona zenzekile. Funa ukwelashwa ngokushesha uma ulahlekelwe ukubona (ngokwengxenye noma okuphelele), ukubona kabili, ukuqhuma kwamehlo, noma i-migraine.

Ezimweni ezingavamile, ukungezwani komzimba kwenzeke. Uma unezinyosi, ukulunywa, ukuphefumula kanzima, ukuhlanza, noma ukuvuvukala kobuso, izindebe, ulimi, izandla, noma izinyawo, funa usizo lwezempilo oluphuthumayo khona manjalo. Imithi ye-Estrogen ingase ibe nzima izimpawu ze-angioedema kwabesifazane abane-angioedema yefa.

Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo ngalezi zingozi ngaphambi kokuthatha i-Estrace noma i-Premarin, ukuze ubone ukuthi umuthi uphephile yini kuwe.

Imibuzo ebuzwa njalo nge-Estrace vs. Premarin

Yini i-Estrace?

I-Estrace ngumuthi obuyisela ama-hormone oqukethe i-estradiol. Isetshenziselwa izinkomba ezahlukahlukene, imvamisa ukuthola izimpawu zokunqamuka kokuya esikhathini. I-Estrace iyatholakala njengokhilimu we-intravaginal kanye ne-tablet yomlomo.

Yini i-premarin?

I-Premarin nayo iyisidakamizwa sokufaka esikhundleni se-hormone. I-premarin iqukethe ama-estrogens ahlanganisiwe. Isetshenziselwa izinkomba eziningana, imvamisa ukuthola izimpawu zokunqamuka kokuya esikhathini. I-premarin iyatholakala njengethebhulethi yomlomo, ukhilimu we-intravaginal, kanye nomjovo.

Ingabe i-Estrace ne-Premarin ziyefana?

I-Estrace ne-Premarin ziyefana, kepha azifani ncamashi. Imininingwane engenhla iveza umehluko phakathi kwale mithi emibili.

Ngabe i-Estrace noma i-Premarin ingcono?

Yomibili le mithi iyasebenza ekwelapheni izimpawu zokunqamuka kokuya esikhathini, noma kunjalo, le mithi iza nemiphumela emibi nezingozi. Khuluma nomhlinzeki wakho wezokunakekelwa kwezempilo ukuze unqume ukuthi i-Estrace noma i-Premarin ikufanele yini.

Ngingayisebenzisa i-Estrace noma i-premarin ngenkathi ngikhulelwe?

Cha. Ayikho imithi okufanele isetshenziswe lapho ukhulelwe.

Ngingayisebenzisa i-Estrace noma i-Premarin ngotshwala?

Ukuphuza utshwala ngokuhlangana ne-Estrace noma i-Premarin can ukwandisa ingozi yakho ngomdlavuza webele. Xhumana nochwepheshe wezokunakekelwa kwezempilo ukuze uthole ukuqondiswa ngokusetshenziswa kotshwala nganoma yiziphi izimo zezokwelapha onazo.

Yini enye indlela engcono kakhulu kune-Premarin?

I-Estrace enye indlela efanayo ne-Premarin. Eminye imishanguzo equkethe i-estrogen ifaka i-Vivelle Dot Patch, iClimara Patch, noma i-estrogen yesitho sangasese sowesifazane ngesimo samaphilisi eVagifem wesitho sowesifazane sangasese (amaphilisi esitho sangasese sowesifazane asetshenziswa nomfakisicelo wesitho sangasese sowesifazane) noma i-Estring Vaginal Ring. Khuluma nomhlinzeki wakho wezokunakekelwa kwempilo ukuze ubone ukuthi ngabe le mithi ikufanele yini wena.

Ingabe i-estrogen ne-estradiol yinto efanayo?

I-Estradiol uhlobo lwe-estrogen, i-hormone yabesifazane. Yonke imikhiqizo ye-estradiol yi-estrogen. Kodwa-ke, kunezinye izinhlobo ze-estrogen kune-estradiol nje. Isibonelo, ama-estrogens ahlanganisiwe (Premarin) kungenye indlela ye-estrogen.

Ingabe i-premarin ibangela ukuwohloka komqondo?

I-Premarin (ne-Estrace) inesixwayiso esibhakelwe mayelana nokuwohloka komqondo. Isifundo seMemori se-WHI esishiwo ngenhla sathola ingozi eyengeziwe yokuthola ukuwohloka komqondo kubantu besifazane abangemva kokuya esikhathini abasebenzisa i-estrogen bodwa noma i-estrogen nge-progestin. Ngakho-ke, imininingwane yokuncoma incoma ukuthi i-estrogen, noma ngabe ithathwe yodwa noma ine-progestin, kufanele inikezwe ngomthamo ophansi kakhulu futhi ngesikhathi esifushane.

Ngabe i-Estrace inyusa amazinga e-estrogen?

I-Estrace (ne-Premarin) yandisa amazinga e-estrogen. Ngisho nasesimeni sowesifazane, kukhona ukumuncwa okuhlelekile, futhi amazinga e-estrogen ayenyuka. Umhlinzeki wakho wezokunakekelwa kwempilo anganquma ukuthi imuphi umkhiqizo ofanele kakhulu kuwe.