Main >> Izidakamizwa Vs. Umngani >> I-Estriol vs. estradiol: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Estriol vs. estradiol: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Estriol (E3) ne-estradiol (E2) yizinhlobo ezimbili ezihlukene zehomoni yabesifazane eyaziwa njenge-estrogen (kwesinye isikhathi ibizwa ngokuthi yi-estrogen). Lezi zinhlobo ze-estrogen ngamahomoni e-steroid atholakala ngokwemvelo emzimbeni. I-Estriol ne-estradiol ingasetshenziswa njenge-hormone replacement therapy (HRT) yabesifazane ngemuva kokunqamuka kokuya esikhathini.

I-Estriol ne-estradiol yizinhlobo ezimbili kwezintathu ezihlukene zamahomoni e-estrogen. Uhlobo lwesithathu lwe-estrogen yi-estrone (E1), ekhiqizwa kwabesifazane ngesikhathi sokunqamuka kokuya esikhathini kanye nabesifazane abasebasha abahlangabezana nezikhathi zabo zokuqala. I-Estrone ayijwayele ukusetshenziselwa i-HRT ngoba ithathwa njenge-estrogen ebuthakathaka.

Ama-Estrogens asebenza ngokuzibophezela ku ama-estrogen receptors (ERα noma i-ERβ) emzimbeni. Ngenkathi izindawo zabo zingaqhamuka, i-estrogen receptor alpha (ERcy) itholakala ngokuyinhloko ku-endometrium, izicubu zamabele, kanye nama-ovari. I-Estrogen receptor beta (ERβ) itholakala kwezinye izingxenye zomzimba njengobuchopho, inhliziyo, izinso, amathambo namaphaphu.

Uyini umehluko omkhulu phakathi kwe-estriol ne-estradiol?

I-Estriol (amakhuphoni e-Estriol | imininingwane ye-Estriol) kwesinye isikhathi ibizwa nge-E3 noma i-oestriol. Kuyindlela ebuthakathaka kakhulu ye-estrogen emzimbeni. Njenge-estrone, amazinga e-estriol akhula ngokwemvelo ngesikhathi sokukhulelwa. I-Estriol yi-FDA evunyelwe ukungasebenzi komchamo ezinjeni zesifazane ngemuva kokususwa kwama-ovari nesibeletho. I-Estriol ayivunyelwe yi-FDA njengomuthi kadokotela wabantu. Kodwa-ke, amanye amakhemisi ahlanganisayo angathengisa i-estriol ehlanganiswe nezinye izidakamizwa.

I-Estradiol (amakhuphoni e-Estradiol | Imininingwane ye-Estradiol), noma i-E2, inamandla kakhulu kuma-estrogens amathathu. Ezinye izinhlobo ze-estradiol zingatholakala kumaphilisi wokulawulwa kokubeletha aphansi kwabesifazane be-premenopausal. Isetshenziswa kakhulu njengethebhulethi, isichibi, noma ukhilimu wokwelashwa okushintshanisa i-estrogen. I-Estradiol ingatholakala kwimikhiqizo evunyelwe yi-FDA efana ne-Estrace, Vivelle-Dot, Vagifem, neClimara, phakathi kwabanye. I-FDA nayo ivume i-estradiol in i-hormone ephilayo ukwelashwa nge-progesterone.

Umehluko omkhulu phakathi kwe-estriol ne-estradiol
	I-Estriol	I-Estradiol
Isigaba sezidakamizwa	I-Estrogen	I-Estrogen
Isimo somkhiqizo / ejwayelekile	Okujwayelekile kuyatholakala	Okujwayelekile kuyatholakala
Ngubani igama lomkhiqizo?	I-Incurin (yezinja)	I-Estrace IVivelle-Dot I-Vagifem Climara
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi yomlomo Ukhilimu wezindaba Ukhilimu wesitho sangasese sowesifazane Ukufaka kwesitho sangasese sowesifazane	Ithebhulethi yomlomo Ijeli / ijeli Ukhilimu wesitho sangasese sowesifazane Ukufaka kwesitho sangasese sowesifazane Indandatho yesitho sangasese sowesifazane Isiqephu seTransdermal
Uyini umthamo ojwayelekile?	Kuya ngomuthi kadokotela wakho	Kuya ngomuthi kadokotela wakho
Yelashwa isikhathi esingakanani?	Isikhathi sokwelashwa siyahlukahluka ngokuya ngemiyalo kadokotela wakho	Isikhathi sokwelashwa siyahlukahluka ngokuya ngemiyalo kadokotela wakho
Ubani ovame ukusebenzisa umuthi?	Abantu abadala	Abantu abadala

Ufuna intengo engcono kakhulu ku-estriol?

Bhalisela izexwayiso zentengo ye-estriol bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo

Izimo eziphathwa yi-estriol ne-estradiol

I-Estrogen isetshenziswa kakhulu njengokwelashwa kwama-hormone kwabesifazane abathola izimpawu zokunqamuka kokuya esikhathini. Ama-Estrogens avame ukuhlanganiswa ne-progesterone noma amanye ama-hormone e-steroid abizwa ngama-progestins. I-Estradiol yi-FDA evunyelwe ukwelapha izimpawu zokunqamuka kokuya esikhathini. Lezi zimpawu zibandakanya izimpawu ze-vasomotor njengokushisa okushisayo, ukujuluka ebusuku, nokuxubha kwesikhumba. Ezinye izimpawu ze-menopausal zifaka i-atrophy yesitho sangasese sowesifazane, noma ukoma kwesitho sangasese sowesifazane, ukuvuvukala nokuncipha.

I-Estradiol nayo ingasetshenziswa esikhathini esedlule umdlavuza webele lokho kuye kwasakazeka kwezinye izitho zomzimba. Isetshenziselwa ukunciphisa ukwehla kwesifo somdlavuza (ukunakekelwa okunciphisayo). Kwabesifazane abanomdlavuza webele we-ER-positive (ER +) osetshenzisiwe, umthamo omkhulu we-estradiol ungasetshenziswa njengokwelapha. Ngokwezifundo ezivela ku- Ukuvuthwa , uma izicubu zesifuba ziveza ufuzo lwe-ESR1, umdlavuza ungaphendula kahle ekwelashweni kwe-estradiol.

Amathebulethi e-Estradiol nawo avunyelwe ukwelapha umdlavuza wesibeletho osezingeni eliphakeme oncike ku-androgen. Ngenkathi amazinga e-estrogen ingafaka isandla emdlavuzeni wendlala yesinye, i-estradiol ingasetshenziswa njengokwelashwa okunciphisayo kwamanye amadoda. Izifundo khombisa ukuthi i-estradiol iyindlela ephumelelayo yokwelapha yezinhlobo ezithile zomdlavuza wesinye.

I-Estriol ayivunyelwe yi-FDA kubantu. Kodwa-ke, kwesinye isikhathi kuhlanganiswa neminye imishanguzo yokwelashwa okubuyisela ama-hormone. Ngoba iyi-estrogen, ingasetshenziswa njengesidakamizwa esingekho kwelebula ngezimo ezihlobene ne-estrogen. Ifomu okuyiwona kuphela eligunyazwe yi-FDA le-estriol I-Incurin , elapha ukungangeni komchamo ezinjeni zesifazane ngemuva kokususwa kwamaqanda kanye nesibeletho (i-ovariohysterectomy).

Okunye ukusetshenziswa okungekho kwelebula kwe-estriol ne-estradiol kufaka ukukhululeka kwemigraines yokuya esikhathini nokuvimbela i-osteoporosis (ukulahleka kwethambo) ngemuva kokunqamuka kokuya esikhathini. I-Estrogen ibamba iqhaza elikhulu ekucineni kwamathambo. Abesifazane be-Postmenopausal abanesifo se-estrogen bangaba nenani eliphansi lamaminerali amathambo. Ukwelashwa kwe-Estrogen kungasetshenziswa futhi ekwelapheni ukucindezeleka kwangemva kokubeletha. Ngokusho kwabanye izifundo , I-transdermal estradiol ikhonjisiwe ukuthi ilusizo ekunciphiseni ukucindezeleka ngemuva kokubeletha.

Isimo	I-Estriol	I-Estradiol
Ukwelashwa kokufaka esikhundleni seHormone	Ngaphandle kwelebula	Yebo
Ukunqamuka kokuya esikhathini	Ngaphandle kwelebula	Yebo
I-atrophy yesitho sangasese sowesifazane	Ngaphandle kwelebula	Yebo
Izimpawu zeVasomotor	Ngaphandle kwelebula	Yebo
Umdlavuza webele (ukunakekelwa okunciphisayo)	Ngaphandle kwelebula	Yebo
Umdlavuza we-Prostate othuthukile (ukunakekelwa kokuncoma)	Ngaphandle kwelebula	Yebo
Ukungahambisani nomchamo (wezinja)	Yebo	Akunjalo
I-migraine yokuya esikhathini	Ngaphandle kwelebula	Ngaphandle kwelebula
I-Postmenopausal osteoporosis	Ngaphandle kwelebula	Ngaphandle kwelebula
Ukudangala kwangemva kokubeletha	Ngaphandle kwelebula	Ngaphandle kwelebula

Ingabe i-estriol noma i-estradiol isebenza kangcono?

Ezinhlotsheni ezintathu ze-estrogen, i-estradiol yiyona ifomu elinamandla kakhulu . Kuvunyelwe yi-U.S. Food and Drug Administration ukwelapha izimo ezihlobene ne-estrogen. I-Estriol ne-estrone azivunyelwe e-U.S. Kwabesifazane. Kodwa-ke, lawa ma-estrogens asengasetshenziswa kweminye imishanguzo ehlanganisiwe.

Azikho izivivinyo zekhanda ekhanda ezenziwe nge-estriol ne-estradiol. Abanye izifundo zikhombisile ukuthi i-estriol iphephile futhi iyasebenza kwizimpawu zokunqamuka kokuya esikhathini. Lapho kusetshenziswa i-topic ye-atrophy yowesifazane, i-estriol ibilokhu ikhona kubikiwe ukusebenza ngempumelelo nezinye izidakamizwa. Ngoba i-estriol ayinamandla amancane, ingaba nemiphumela emibi embalwa. Ukusebenzisa i-estriol, njengezinye izindlela zokwelapha ze-estrogen, kusengandisa ingozi yomdlavuza webele, i-endometrial hyperplasia, nomdlavuza we-endometrium.

Ukwelashwa kwe-Estradiol kungasiza njenge-HRT ngemuva kokunqamuka kokuya esikhathini. Eqinisweni, yi-estrogen ejwayelekile kakhulu enqunyelwe izimpawu zokunqamuka kokuya esikhathini. Zonke izinhlobo ze-estradiol zivunyelwe ukwelashwa kwe-hormone esikhundleni. Isiqephu se-transdermal besilokhu sikhona kukhonjisiwe ukuholela emazingeni e-estrogen azinzile okwelashwa okuhle.

Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuze uxoxe ngezinketho zakho uma ucabanga ngemithi ethinta amazinga ama-hormone. Unganconywa ezinye izinhlobo ze-estrogen njengezidakamizwa eziqukethe ama-estrogens ahlanganisiwe (isb., Premarin, Prempro).

Ufuna intengo enhle ku-estradiol?

Bhalisela izexwayiso zentengo ye-estradiol bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kwe-estriol kuqhathaniswa ne-estradiol

Njengamanje, azikho izidakamizwa ezivunyelwe i-FDA eziqukethe i-estriol yabantu. Ngakho-ke, akuvame ukumbozwa yi-Medicare nezinhlelo zomshuwalense. I-Incurin yigama lomkhiqizo le-estriol eligunyazwe izinja ezine-incontinence yokuchama. Izindleko zingahluka ngokuya ngekhemisi oyithenga kulo. Izaphulelo ze-SingleCare ze-estriol azitholakali okwamanje.

I-Estradiol iyatholakala njenge-patch ejwayelekile yesikhumba. Amagama omkhiqizo we-estradiol afaka iMinivelle, iClimara, neVivelle-Dot. Intengo yemali ye-estradiol yemali ingahluka nge-Medicare nezinhlelo zomshuwalense kepha ungathenga uhlobo olujwayelekile lwe- $ 33- $ 63 ngekhadi lesaphulelo le-SingleCare.

Thola ikhadi lesaphulelo se-SingleCare

	I-Estriol	I-Estradiol
Ngokuvamile embozwe umshwalense?	Akunjalo	Yebo
Imbozwe ngokujwayelekile yi-Medicare?	Akunjalo	Yebo
Umthamo ojwayelekile	Amaphilisi 1 mg	1 kuya ku-2 mg ngosuku
I-Medicare copay ejwayelekile	Akuhlanganisiwe	$ 0- $ 171
Izindleko ze-SingleCare	Izaphulelo ku-Estriol okwamanje azihlinzekwa nge-SingleCare	$ 33- $ 63

Imiphumela emibi ye-estriol ne-estradiol

Imiphumela emibi ejwayelekile yokwelashwa kwe-estrogen ifaka phakathi izinguquko zokuya esikhathini (izinguquko emaphethini wokopha), ukubona, ubuhlungu ngezikhathi (i-dysmenorrhea), isisa sesifuba, isicanucanu, ukugabha nokuphathwa ikhanda. Eminye imiphumela emibi yama-topical and oral estrogens ifaka ukuqunjelwa, ukuzuza kwesisindo, nokulahleka kwezinwele.

I-topical estriol noma i-estradiol ingadala imiphumela eqondile uma isetshenziswa esithweni sangasese. Imiphumela emibi ingafaka ukulunywa nokukhuphuka kwezimfihlo. Eminye imiphumela emibi kakhulu ingafaka izifo zokukhunta (candidiasis).

I-Estrogen ikhonjisiwe ukuthi iguqula noma inyusa i- ukukhiqizwa kwe-melanin , into ebhekene nombala wesikhumba. I-Estrogen ingakhuphula i-pigment futhi ifiphaze isikhumba kwezinye izimo.

Imiphumela emibi yokusetshenziswa kwe-estrogen ifaka umfutho wegazi ophakeme (umfutho wegazi ophakeme), isifo senhliziyo, amahlule egazi (i-thromboembolism), ukuwohloka kwesifuba somoya, isifo se-gallbladder, namazinga aphansi e-calcium. Eminye imiphumela emibi emibi ingafaka ukukhuliswa kwe-fibroids esibelethweni kanye nengozi eyengeziwe yomdlavuza webele nowesibeletho.

	I-Estriol	I-Estradiol
Imiphumela emibi	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Izinguquko zokuya esikhathini	Yebo	* akubikiwe	Yebo	*
Ukubona	Yebo	*	Yebo	*
I-Dysmenorrhea	Yebo	*	Yebo	*
Ubumnene besifuba	Yebo	*	Yebo	*
Isicanucanu	Yebo	*	Yebo	*
Ukuhlanza	Yebo	*	Yebo	*
Ubuhlungu bekhanda	Yebo	*	Yebo	*
Ukuzuza kwesisindo	Yebo	*	Yebo	*
Ukulahleka kwezinwele	Yebo	*	Yebo	*
Ukulunywa kwesitho sangasese sowesifazane	Yebo	*	Yebo	*
Ukuqhakaza	Yebo	*	Yebo	*
Izinguquko kumbala wesikhumba	Yebo	*	Yebo	*

Lokhu kungenzeka kungabi uhlu oluphelele. Xhumana nodokotela wakho noma wemithi ngeminye imiphumela emibi.
Umthombo: DailyMed ( I-Estriol ), IDailyMed ( I-Estradiol )

Ukusebenzisana kwezidakamizwa kwe-estriol vs. estradiol

I-Estrogen ngokuyinhloko ihlanganiswa nesibindi ngama-enzyme e-CYP3A4. Ama-CYP3A4 inhibitors, afana nama-antibiotic athile, ama-antifungal, ama-steroids, nama-anticonvulsants, angakhuphula amazinga emithi ye-estrogenic emzimbeni. Ngokulandelayo, lokhu kungandisa ubungozi bemiphumela emibi.

Ama-inducers we-CYP3A4 afana nama-antibiotic athile, ama-antifungal, nama-antivirals anganciphisa izinga le-estriol noma i-estradiol egazini. Ama-inducers e-CYP3A4 angagcina eholele ekusebenzeni okunciphisiwe ngemithi equkethe i-estrogen. (Bheka ishadi ngezibonelo)

I-Estriol ne-estradiol nazo zingasebenzisana nejusi yamagilebhisi. Ukudla ijusi lamagilebhisi nemikhiqizo equkethe i-estrogen kungakhuphula ubungozi bemiphumela emibi. Kubalulekile ukuxoxa ngomlando wakho wezokwelapha ophelele nodokotela ogxile ku-endocrinology.

Izidakamizwa	Isigaba Sezidakamizwa	I-Estriol	I-Estradiol
I-Clarithromycin I-Erythromycin Ketoconazole I-Itraconazole I-Cimetidine I-Ritonavir	I-CYP3A4 inhibitor	Yebo	Yebo
ISt. John's Wort I-Phenobarbital Phenytoin ICarbamazepine I-Rifampin I-Dexamethasone	I-CYP3A4 inducer	Yebo	Yebo

Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.

Izexwayiso ze-estriol ne-estradiol

Ukusebenzisa i-estrogen kungakhuphula ingozi yomdlavuza we-endometrium, ikakhulukazi uma kungathathwa nge-progestin. I-Estriol ne-estradiol nazo zinengozi eyengeziwe yokuhlaselwa yisifo senhliziyo (i-myocardial infarction), isifo sohlangothi, i-pulmonary embolism (i-clot yegazi emaphashini), ne-vein thrombosis ejulile (i-clot yegazi emithanjeni) kwabesifazane be-postmenopausal abaneminyaka engama-50 kuya kwengu-79 ubudala. Kubantu besifazane abafanayo, ukusetshenziswa kwe-estrogen nakho kungaholela engcupheni yokwanda komdlavuza webele, ngokusho kwe- Inhlangano Yezempilo Yabesifazane . I-Estrogen nayo ingakhuphula ubungozi bokuwohloka komqondo kwabanye besifazane abase-postmenopausal abaneminyaka engaphezu kwengama-65 ubudala.

Xhumana nodokotela uma unezinto ezinobungozi ezibandakanya umlando wezokwelapha we:

Isifo senhliziyo
Unhlangothi
Amahlule egazi
Umdlavuza (wanoma yiluphi uhlobo)
Izikhathi ezingavamile
Umfutho wegazi ophakeme
Isifo senhliziyo
Isifuba Somoya
Isifo se-gallbladder
Isifo sesibindi
Izindlala zesibeletho
I-Endometriosis
I-Hypocalcemia

Abesifazane ababhema ugwayi bangaba sengozini eyengeziwe yamahlule egazi. Imikhiqizo equkethe i-estrogen akufanele isetshenziswe kulaba besifazane.

I-Estriol, i-estradiol, nezinye izidakamizwa ezihlobene ne-estrogen zingalimaza ingane engakazalwa. Akufanele zisetshenziswe ngesikhathi sokukhulelwa noma lapho uncelisa.

Imibuzo ebuzwa njalo mayelana ne-estriol vs. estradiol

Yini i-estriol?

I-Estriol iyindlela ye-estrogen ekhiqizwa ngokwemvelo emzimbeni. I-Estriol ayivunyelwe i-FDA yokwelashwa ngokufaka i-hormone kubantu. Amanye amakhemisi ahlanganisayo angathengisa imishanguzo equkethe i-estriol esetshenziselwa izinhloso ezingekho kwelebula. I-Estriol ivunyelwe kuphela ukwelapha ukungasebenzi komchamo ezinjeni zezinsikazi.

Yini i-estradiol?

I-Estradiol iyindlela enamandla kakhulu ye-estrogen. Itholakala ezinhlotsheni eziningana ezahlukahlukene zemikhiqizo kanye nemithi ejwayelekile. Amagama omkhiqizo afaka i-Estrace, Climara, neVivelle-Dot. Ingasetshenziswa njengethebhulethi yomlomo, i-transdermal patch, noma ukhilimu wesitho sangasese sabesifazane abanezimpawu ze-postmenopausal. Ingasetshenziswa futhi njengokwelashwa okunciphisayo komdlavuza webele nowesibeletho osekugcineni.

Ingabe i-estriol ne-estradiol ziyafana?

Cha. I-Estriol ne-estradiol azifani. I-Estriol iyindlela ebuthakathaka ye-estrogen engatholwa kuphela kwimikhiqizo yokwelashwa kwamahomoni ehlanganisiwe. I-Estradiol inamandla kakhulu kune-estriol futhi i-FDA ivunyelwe ukwelashwa kwe-hormone esikhundleni.

Ngabe i-estriol noma i-estradiol ingcono?

I-Estradiol inamandla futhi isebenza kangcono kune-estriol. I-Estriol iyindlela ebuthakathaka ye-estrogen futhi ingaba nephrofayili engcono yokuphepha uma iqhathaniswa ne-estradiol. Kodwa-ke, ezinye izivivinyo zemitholampilo zingadingeka ekusebenzeni nasekuphepheni kwe-estriol.

Ngingakwazi ukusebenzisa i-estriol noma i-estradiol ngenkathi ngikhulelwe?

Cha. Ama-Estrogens afana ne-estriol ne-estradiol kufanele agwenywe ngenkathi ekhulelwe. Ukuthatha le mithi ngenkathi ukhulelwe kungaholela engozini eyengeziwe yokukhubazeka kokuzalwa. I-Estrogen akufanele iphuzwe lapho uncelisa.

Ngingakwazi ukusebenzisa i-estriol noma i-estradiol ngotshwala?

Cha. I-Estriol noma i-estradiol akufanele isetshenziswe notshwala. Ukusetshenziswa kotshwala kungakhuphula amazinga e-estrogen egazini. Ukuphuza utshwala nge-estrogen therapy kungakhuphula ingozi yomdlavuza webele.