I-Etodolac vs. ibuprofen: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Akekho ofuna ukuphila nokungahambi kahle noma ubuhlungu isikhathi eside, noma kube bonke ngalolo daba. Ngenhlanhla, imithi yokudambisa izinhlungu kanye nemithi yokudambisa izinhlungu iyatholakala esitolo sezidakamizwa esiseduze nawe. Yize zingenamandla njengokudambisa izinhlungu ze-opioid, ezidinga ukuhlolwa okujule kakhulu kwezokwelapha nemithi kadokotela, ama-NSAID afana ne-etodolac noma ibuprofen ayasebenza ekwelapheni ubuhlungu obumaphakathi kuya kokulingene.
Ngaphandle kwalokho kwaziwa njengezidakamizwa ezingezona ukuvuvukala, ama-NSAID asebenza ngokuvimba ukukhiqizwa kwama-prostaglandin. Umzimba wakho ungaphendula ezimeni ezithile zezokwelapha ngokukhiqiza ama-prostaglandin, okungamakhemikhali abangela ubuhlungu, ukuvuvukala nomkhuhlane. Ama-NSAID avimba ama-enzyme akhiqiza i-prostaglandin-i-COX-1 ne-COX-2-ukulawula ukuphendula komzimba nokunciphisa ubuhlungu.
I-Etodolac ne-ibuprofen bahlukaniswa njengama-NSAID. Noma kunjalo, banokuhluka okuthile okubalulekile.
Uyini umehluko omkhulu phakathi kwe-etodolac ne-ibuprofen?
I-Etodolac kwesinye isikhathi yaziwa ngegama layo lomkhiqizo (manje eseliyekile), iLodine. Itholakala njengomuthi ojwayelekile futhi ingatholwa kuphela ngencwadi kadokotela.
I-Etodolac ine-half-life yamahora angaba yisithupha kuya kwayisikhombisa futhi ifinyelela ukugxila okuphezulu egazini ihora elilodwa kuya kwamabili ngemuva kokuyiphuza. Imvamisa kuthathwa kabili noma kathathu nsuku zonke ngobuhlungu besifo samathambo. Kukhona nethebhulethi ekhishwa enwetshiwe ye-etodolac enengxenye ende yempilo cishe yamahora ayisishiyagalombili futhi engathathwa kanye nsuku zonke.
I-Ibuprofen yi-NSAID ejwayelekile kakhulu etholakala ngaphezu kwe-counter (OTC). Amandla aphakeme e-ibuprofen ayatholakala ngemithi kadokotela. Amagama omkhiqizo adumile we-ibuprofen afaka i-Advil, Motrin neMidol.
I-Ibuprofen ifinyelela amazinga aphezulu egazi kungakapheli ihora elilodwa kuya kwamabili ngemuva kokuyithatha. Kodwa-ke, ngokungafani ne-etodolac, ibuprofen ine-half-life emfushane ezungezile amahora amabili . Ibuprofen yamandla kadokotela iza kuthebhulethi evame ukuthathwa kathathu noma kane ngosuku. Uhlobo lwe-OTC luza kumathebulethi womlomo, ama-capsule, nokumiswa oketshezi.
| Umehluko omkhulu phakathi kwe-etodolac ne-ibuprofen | ||
|---|---|---|
| Etodolac | Ibuprofen | |
| Isigaba sezidakamizwa | Izidakamizwa ezingezona ukuvuvukala (i-NSAID) | Izidakamizwa ezingezona ukuvuvukala (i-NSAID) |
| Isimo somkhiqizo / ejwayelekile | Okujwayelekile kuyatholakala (umkhiqizo unqanyuliwe) | I-Brand ne-generic iyatholakala |
| Ngubani igama lomkhiqizo? | I-Lodine | I-Advil, iMotrin, iMidol |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ama-capsules omlomo Ithebhulethi yomlomo Ithebhulethi yomlomo, ukukhishwa okunwetshiwe | Ama-capsules omlomo Ithebhulethi yomlomo Uketshezi lomlomo Ukujova (NeoProfen) |
| Uyini umthamo ojwayelekile? | Ngobuhlungu: 200 kuya ku-400 mg njalo emahoreni ayisithupha kuya kwangu-8 njengoba kudingeka. Ungadluli umthamo ophakeme ka-1200 mg ngosuku. Kwi-osteoarthritis noma i-rheumatoid arthritis: Khipha ngokushesha ama-300 mg kabili kuya kathathu nsuku zonke noma ama-400 kuye kuma-500 mg kabili ngosuku. Ukukhishwa okunwetshiwe okungu-400 kuya ku-1000 mg kanye ngosuku. Ungadluli umthamo ophakeme ka-1200 mg ngosuku. | Ngobuhlungu: 200 kuya ku-400 mg njalo emahoreni ama-4 kuye kwayi-6 njengoba kudingeka. Ungadluli umthamo ophakeme we-1200 mg ngosuku ngaphandle kokuthi uqondiswe ngudokotela. I-osteoarthritis noma i-rheumatoid arthritis: 400 kuya ku-800 mg kathathu noma kane ngosuku. Ungadluli umthamo ophakeme ka-3200 mg ngosuku. |
| Yelashwa isikhathi esingakanani? | Isikhathi sokwelashwa sincike esimweni sempilo, ubunzima bezinhlungu, nezinye izinto. Ukwelashwa kungaba okwesikhashana noma kwesikhathi eside. | Isikhathi sokwelashwa sincike esimweni sempilo, ubunzima bezinhlungu, nezinye izinto. Ukwelashwa kungaba okwesikhashana noma kwesikhathi eside. |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nezingane ezineminyaka engu-6 nangaphezulu | Abantu abadala nezingane izinyanga eziyisithupha nangaphezulu |
Izimo eziphathwa yi-etodolac ne-ibuprofen
I-Etodolac ne-ibuprofen zifakwe ilebuli yokwelapha ubuhlungu. Zivame ukuthathwa ukwelapha ubuhlungu obumaphakathi kuya obulinganiselayo obuvela ezinkambisweni zamazinyo, migraines , noma izinhlungu zemisipha (myalgia).
I-Etodolac ne-ibuprofen ziwusizo kakhulu futhi i-FDA ivunyelwe ukwelapha ubuhlungu nokuvuvukala kusuka ku-osteoarthritis kanye nesifo samathambo. Amandla aphakeme ngokuvamile adingeka ukubhekana nobuhlungu obukhulu obuhlangene noma ubuhlungu bamathambo obuhambisana nesifo samathambo. Kwezinye izimo, izingane ezingaphezu komkhawulo weminyaka enconyiwe nazo zingaphathwa ngalawa ma-NSAID i-juvenile idiopathic arthritis .
I-over-the-counter ibuprofen ibhalwe ukuthi yelapha umkhuhlane kanye nezinkinga zokuya esikhathini (i-dysmenorrhea eyinhloko). Uhlobo olujova lwe-ibuprofen olubizwa nge-NeoProfen lusetshenziselwa ukwelapha i-patent ductus arteriosus (PDA), uhlobo lwesici senhliziyo, ezinganeni ezingakazalwa ngaphambi kwesikhathi.
| Isimo | Etodolac | Ibuprofen |
| Ubuhlungu | Yebo | Yebo |
| I-osteoarthritis | Yebo | Yebo |
| Isifo samathambo | Yebo | Yebo |
| I-juvenile idiopathic arthritis | Yebo | Yebo |
| Imfiva | Akunjalo | Yebo |
| I-dysmenorrhea eyinhloko | Akunjalo | Yebo |
| I-patent ductus arteriosus | Akunjalo | Yebo |
Ingabe i-etodolac noma ibuprofen isebenza kangcono?
Kokubili i-etodolac ne-ibuprofen ngama-NSAID asebenzayo wokudambisa izinhlungu. Zombili zivimba ama-enzyme e-cyclooxygenase (COX) ukulawula ukuvuvukala nokunciphisa izinhlungu kulabo abane-arthritis. Kodwa-ke, imiphumela ye-etodolac ihlala isikhathi eside. Ngakho-ke, abanye abantu bangakhetha i-etodolac ngokulinganisa kwayo okuvama kakhulu.
Esifundweni esingaboni kabili kuqhathanisa i-etodolac ne-ibuprofen , Iziguli eziyi-1,446 ezine-rheumatoid arthritis zinikezwe i-150 mg ye-etodolac kabili ngosuku, ama-500 mg we-etodolac kabili ngosuku, noma ama-600 mg we-ibuprofen amahlandla amane ngosuku. Yomibili imithamo ye-etodolac itholwe ifana ngokufana nomthamo we-ibuprofen. Ngokuya ngemiphumela emibi, labo abathatha i-etodolac babhekana nokugaya ukudla okuncane, ukuqubuka, nokopha esiswini kunalabo abathatha ibuprofen. Kodwa-ke, lokhu kungahle kuhlobene namanani eziguli ezidakamizwa anikezwe.
Ngenkathi kungekho okunye ukuhlolwa komtholampilo okuqhathanise ngqo i-etodolac ne-ibuprofen, izifundo ezahlukahlukene ziqhathanise amanye ama-NSAID ne-etodolac noma ibuprofen. Ukuhlaziywa okukodwa kwe-meta kuthole ukuthi i- isilinganiso esiphezulu sansuku zonke se-diclofenac iphumelela kakhulu kunemithamo ephezulu yansuku zonke ye-ibuprofen, naproxen, ne-celecoxib (kepha umthamo ophansi kakhulu we-NSAID uhlale unconywa). Okunye ukuhlaziywa kwe-meta kutholakale ukuthi ama-NSAID athile afana ne-piroxicam ne-azapropazone babe nengozi enkulu yobuthi kuyilapho i-ibuprofen yedosi ephansi inengozi encane yobuthi. Sekukonke, kungashiwo ukuthi ama-NSAID athanda ukwehluka kakhulu kwezokuphepha kunokusebenza.
Ngenxa yezinhlobo eziningi zezinketho zobuhlungu, kubalulekile ukubonisana nomhlinzeki wezokunakekelwa kwempilo ngenketho yokwelashwa engcono kakhulu. Udokotela noma umhlinzeki wezokunakekelwa kwezempilo anganikeza iseluleko esifanele sezokwelapha ngezimo ezithile zezokwelapha.
Ukuhlanganiswa nokuqhathaniswa kwezindleko kwe-etodolac vs. ibuprofen
Amaphilisi ejwayelekile e-etodolac ambozwa yi-Medicare nezinhlelo zomshuwalense. Uma unezimo zezokwelapha ezifana nesifo samathambo, izinhlelo zomshuwalense zizohlanganisa i-etodolac yezinhlungu. Izindleko ezijwayelekile zokuthengisa ze-etodolac zingahluka ngokuya ngomthamo, kepha ungakhokha cishe u- $ 50 we-etodolac ngokusebenzisa isigqebhezana se-SingleCare emakhemisi abambe iqhaza.
Njengoba i-ibuprofen itholakala ngaphezu kwe-counter, amanye amafomu angeke ahlanganiswe nezinhlelo zomshuwalense. Kodwa-ke, iningi le-Medicare Part D nezinhlelo zomshuwalense kufanele zimboze amaphilisi e-ibuprofen anamandla kadokotela ngokuya ngemithi yokwelashwa. Ngokuvamile, ibuprofen iyabiza kakhulu kune-etodolac. Sebenzisa ikhuphoni le-SingleCare le-ibuprofen uma unencwadi kadokotela evela kumhlinzeki wakho wezokunakekelwa kwempilo.
| Etodolac | Ibuprofen | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo (amaphilisi amandla kadokotela) |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | 300 mg izikhathi 2 kuya ku-3 nsuku zonke | 400 kuya ku-800 mg izikhathi ezi-3 kuya kwezingu-4 nsuku zonke |
| I-Medicare copay ejwayelekile | $ 0– $ 76 | $ 0– $ 22 |
| Izindleko ze-SingleCare | $ 40- $ 80 | $ 4– $ 24 |
Imiphumela emibi ejwayelekile ye-etodolac vs. ibuprofen
Imiphumela emibi ejwayelekile yama-NSAID, kufaka phakathi i-etodolac ne-ibuprofen, isicanucanu, ukuqunjelwa (i-dyspepsia), ukuqunjelwa, uhudo, nobuhlungu besisu noma besisu. Ngaphandle kwemiphumela emibi yamathumbu, ama-NSAID nawo angadala isizungu, ukuvuvukala ezandleni noma ezinyaweni (i-edema), ikhanda, ukuqubuka nokukhala ezindlebeni (i-tinnitus). Imiphumela eminingi emibi ye-etodolac ne-ibuprofen imnene futhi iyazihambela yodwa.
Imiphumela emibi kakhulu yama-NSAID ingabandakanya ukusabela okweqile, njengokuqhuma okukhulu noma i-anaphylaxis, kusuka kuzithako ezisebenzayo noma ezingasebenzi. Eminye imiphumela emibi ibandakanya imiphumela emibi yamathumbu njengokuphuma kwesisu kanye izilonda ezinamachaphazelo . Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo uma uthola igazi esitokisini, ekunciphiseni isisindo, noma ebuhlungu obukhulu besisu.
| Etodolac | Ibuprofen | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Isicanucanu | Yebo | 1% –10% | Yebo | 1% –3% |
| Ubuhlungu besisu | Yebo | 1% –10% | Yebo | 1% –3% |
| Ukugaya ukudla | Yebo | 1% –10% | Yebo | 1% –3% |
| Ukuqunjelwa | Yebo | 1% –10% | Yebo | 1% –3% |
| Uhudo | Yebo | 1% –10% | Yebo | 1% –3% |
| Isiyezi | Yebo | 1% –10% | Yebo | 1% –3% |
| I-Edema | Yebo | 1% –10% | Yebo | 1% –3% |
| Ubuhlungu bekhanda | Yebo | 1% –10% | Yebo | 1% –3% |
| I-Rash | Yebo | 1% –10% | Yebo | 1% –3% |
| Tinnitus | Yebo | 1% –10% | Yebo | 1% –3% |
Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( Etodolac ), IDailyMed ( Ibuprofen )
Ukusebenzisana kwezidakamizwa kwe-etodolac vs. ibuprofen
Ngoba bavimba i-enzyme ye-COX-1, edlala indima ekukhiqizeni amaplatelet namahlule egazi, ama-NSAID angaphazamisa imiphumela yabanciphisi begazi. Ama-NSAID angandisa ingozi yokuphuma kwegazi kuma-antiplatelet agents njenge-aspirin nama-anticoagulants afana ne-warfarin.
I-Etodolac ne-ibuprofen kungadala ukuthi umzimba ugcine uketshezi futhi kuthinte nokusebenza kwezinso. Ngenxa yalokhu, lawa ma-NSAID angakhuphula umfutho wegazi. Uma futhi uthatha imishanguzo yomfutho wegazi ophezulu (antihypertensive), njenge-lisinopril noma i-losartan, ingcindezi yakho yegazi ingadinga ukubhekwa ngenkathi uthatha i-NSAID.
I-Etodolac ne-ibuprofen zingathinta ukuthi i-cyclosporine, i-digoxin, noma i-methotrexate isuswa kanjani emzimbeni. Ukuthatha i-NSAID kungaholela engcupheni yokwanda kwe-cyclosporine, digoxin, noma i-methotrexate toxicity.
Thola okunye ukuxhumana kwezidakamizwa okungenzeka ngezansi.
| Izidakamizwa | Isigaba sezidakamizwa | Etodolac | Ibuprofen |
| I-Aspirin | I-Antiplatelet | Yebo | Yebo |
| I-Warfarin | I-Anticoagulant | Yebo | Yebo |
| I-Lisinopril I-Captopril URamipril | I-Angiotensin-converting enzyme (ACE) inhibitor | Yebo | Yebo |
| ILosartan Valsartan Olmesartan | I-Angiotensin receptor blocker (i-ARB) | Yebo | Yebo |
| UFurosemide I-Hydrochlorothiazide | Isisu | Yebo | Yebo |
| ILithium | Isimisi sokuqina | Yebo | Yebo |
| IMethotrexate I-Pemetrexed | I-Antimetabolite | Yebo | Yebo |
| ICyclosporine | I-Immunosuppressant | Yebo | Yebo |
| I-Digoxin | I-glycoside yenhliziyo | Yebo | Yebo |
Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka.
Izexwayiso ze-etodolac ne-ibuprofen
I-Etodolac ne-ibuprofen, njengamanye ama-NSAID, ingakhuphula ubungozi bezehlakalo ezinkulu zenhliziyo nemithambo yegazi njengokuhlaselwa yinhliziyo nokushaywa unhlangothi. Ukusetshenziswa kwe-NSAID kufanele kugwenywe noma kubhekwe kubantu abane izinkinga zenhliziyo nemithambo yegazi njengokuhluleka kwenhliziyo, isifo senhliziyo, nomfutho wegazi ophakeme.
Ukusetshenziswa kwe-etodolac noma i-ibuprofen kungaholela engcupheni eyandayo yemicimbi emibi kakhulu yamathumbu (GI), njengokuphuma kwesisu kanye nezilonda ezibelethayo. Ngaphandle kokwelashwa okufanele, ukuvuvukala, nokopha kupheshana le-GI kungabulala. Abantu abadala bangaba nengozi ephezulu yemicimbi emibi kakhulu ye-GI.
Ama-NSAID akufanele asetshenziswe ngaphambi noma ngemuva kwenqubo yenhliziyo ebizwa i-coronary artery bypass graft (CABG) ukuhlinzwa .
Labo abanezifo zezinso bangaba sengozini eyengeziwe yokuthola ezinye izinkinga zezinso ngenkathi bethatha ama-NSAID.
Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola ezinye izindlela zokuphepha ngaphambi kokuthatha i-NSAID.
Imibuzo ebuzwa njalo mayelana ne-etodolac vs. ibuprofen
Yini i-etodolac?
I-Etodolac yisidakamizwa esingaqedi ukuvuvukala (i-NSAID) esisetshenziselwa ukwelapha ubuhlungu nokuvuvukala. Kuvunyelwe i-FDA ukwelapha i-osteoarthritis ne-rheumatoid arthritis kubantu abadala. I-generic etodolac ingatholakala kuphela ngemithi kadokotela.
Kuyini ibuprofen?
I-Ibuprofen yaziwa kakhulu ngamagama ezimpawu afana no-Advil noMotrin. Itholakala ngaphezu kwe-counter ukuphatha ubuhlungu obumaphakathi kuya obulinganiselwe, umkhuhlane, kanye nokuqaqamba kokuya esikhathini. I-ibuprofen enamandla amakhulu ingatholwa ngencwadi kadokotela yokwelapha ubuhlungu nokuvuvukala kusuka ku-osteoarthritis kanye nesifo samathambo.
Ingabe i-etodolac ne-ibuprofen ziyefana?
I-Etodolac ne-ibuprofen azifani. Ngenkathi bobabili bengama-NSAID, banokuhluka kokulinganisa nokuthi asetshenziswa kanjani. I-Etodolac ngumuthi kadokotela osetshenziselwa abantu abadala abane-arthritis. I-Ibuprofen itholakala kalula njengesidakamizwa esithenga ngaphezu kwamakhompiyutha sobuhlungu nomkhuhlane omncane.
Ingabe i-etodolac noma ibuprofen ingcono?
I-NSAID engcono incike kumthamo owuthathayo nokuthi uthatha ini. Uma kuqhathaniswa ne-ibuprofen, i-etodolac ihlala isikhathi eside emzimbeni, ngakho-ke, ingathathwa izikhathi ezimbalwa usuku lonke. Noma kunjalo, kungabiza kakhulu kune-ibuprofen. Ngokuya ngesimo sakho sonke, udokotela wakho angancoma omunye komunye.
Ngingayisebenzisa i-etodolac noma ibuprofen ngenkathi ngikhulelwe?
I-Etodolac ne-ibuprofen azinconywa ngokuvamile ngesikhathi sokukhulelwa. Ukusetshenziswa kwama-NSAID ngesikhathi sokukhulelwa kuhlotshaniswa nengozi eyengeziwe yokukhubazeka kokuzalwa noma ukukhulelwa kwesisu, ikakhulukazi ngesikhathi sokukhulelwa sekwedlule isikhathi. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo uma ucabanga izinketho zokwelashwa ngenkathi ukhulelwe .
Ngingayisebenzisa i-etodolac noma ibuprofen ngotshwala?
Ukuphuza utshwala obuncane kungaba kuhle kwesinye isikhathi ngenkathi uthatha i-NSAID. Kodwa-ke, ukuphuza utshwala obuningi ngokweqile kungaholela engcupheni eyengeziwe yemiphumela emibi yamathumbu enama-NSAID. Utshwala nama-NSAID kungacasula ulwelwesi lwesisu namathumbu, okungaholela ezilondeni noma ekopha.
Ingabe i-etodolac ingumbulali wezinhlungu?
U-Etodolac ungumbulali wezinhlungu osebenzayo. Kuphumelela kakhulu ekwelapheni ubuhlungu nokuvuvukala okubangelwa yisifo samathambo. Kuyasiza futhi ekwelapheni ubuhlungu obukhulu ngemuva kwezinqubo ezithile njengokuhlinzwa kwamazinyo.
Ingabe i-etodolac inamandla kune-naproxen?
Ukusebenza kwama-NSAID kuncike kumthamo othathwe, phakathi kwezinye izinto. Zonke izinto zilingana, i-etodolac ne-naproxen ziyaqhathaniswa nokusebenza ngempumelelo. Ngokuya ngezifundo ezimpumputhe kabili, i-etodolac ne-naproxen kusebenza ngokulinganayo ekwelapheni isifo samathambo. Yomibili le mithi nayo ibekezeleleke kahle ngemiphumela emibi.
