IPantoprazole vs. omeprazole: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
I-Pantoprazole ne-omeprazole ngama-proton pump inhibitors (ama-PPIs) amabili asetshenziselwa ukwelapha izimo zokugaya ukudla. Zombili lezi zidakamizwa zingasetshenziselwa isifo se-reflux se-gastroesophageal (GERD), ifomu elingapheli lokushaya isilungulela, kanye ne-esophagitis erosive. Zisebenza ngokunciphisa uketshezi lwe-asidi esiswini. Ngenkathi i-pantoprazole ne-omeprazole kuyimithi efanayo, zinokuhluka okuthile.
Uyini umehluko omkhulu phakathi kwe-pantoprazole ne-omeprazole?
I-Pantoprazole (amakhuphoni e-Pantoprazole) igama elijwayelekile le-Protonix futhi okwamanje lithengwa ngomuthi kadokotela kuphela. Kuvunyelwe i-FDA ukwelapha i-GERD kubantu abadala nezingane ezineminyaka engu-5 nangaphezulu isikhathi esijwayelekile kuze kube amasonto ayi-8. IPantoprazole (imininingwane ethe xaxa yePantoprazole) inikezwa njengethebhulethi ekhishwe ukubambezeleka noma ukumiswa kuketshezi. Inganikezwa futhi njengomjovo we-intravenous (IV) esibhedlela noma emtholampilo.
I-Omeprazole (amakhuphoni e-Omeprazole) yaziwa futhi ngegama layo lomkhiqizo, i-Prilosec, futhi ingathengwa ngencwadi kadokotela noma ngaphezulu kwe-counter. Isebenza ngokufana ne-pantoprazole njenge-PPI. Kodwa-ke, futhi kuvunyelwe i-FDA ukwelapha izilonda ze-duodenal, izifo ze-helicobacter pylori (H. pylori), kanye nezilonda zesisu ngaphezu kwe-GERD kanye ne-esophagitis erosive. I-Omeprazole (imininingwane engaphezulu ye-Omeprazole) ingelapha i-GERD kubantu abadala nasezinganeni unyaka owodwa nangaphezulu. Kuza njengokumiswa kokukhishwa okubambezelekile, ithebhulethi, nokumiswa kuketshezi.
| Umehluko omkhulu phakathi kwe-pantoprazole ne-omeprazole | ||
|---|---|---|
| I-Pantoprazole | Omeprazole | |
| Isigaba sezidakamizwa | IProton pump inhibitor (PPI) | IProton pump inhibitor (PPI) |
| Isimo somkhiqizo / ejwayelekile | Uhlobo olujwayelekile luyatholakala | Uhlobo olujwayelekile luyatholakala |
| Ngubani igama elijwayelekile? Ngubani igama lomkhiqizo? | I-Pantoprazole I-Protonix | Omeprazole Prilosec |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo, ukukhishwa okubambezelekile Ukumiswa ngomlomo IV umjovo / ukumnika | Ithebhulethi yomlomo, ukukhishwa okubambezelekile I-capsule yomlomo, ukukhishwa okubambezelekile Ukumiswa ngomlomo IV umjovo / ukumnika |
| Uyini umthamo ojwayelekile? | 40 mg kanye ngosuku | 20 mg kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Kuze kube amasonto ayi-8 | 4 kuya kumaviki la-8 |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nezingane ezineminyaka engu-5 nangaphezulu | Abantu abadala nezingane unyaka owodwa nangaphezulu |
Izimo eziphathwa yi-pantoprazole ne-omeprazole
I-Pantoprazole ne-omeprazole zombili zivunyelwe i-FDA ukwelapha izimpawu zokushiswa yinhliziyo kusuka ku-GERD kanye ne-esophagitis erosive. Ama-PPI afana ne-pantoprazole ne-omeprazole anamandla kakhulu kune-antacids ejwayelekile, njenge-blockamine ye-histamine (H2). Imvamisa kunqunyelwe i- ukwelashwa kwesikhashana ingahlali ngaphezu kwamasonto ayisishiyagalombili ubude.
I-Pantoprazole ne-omeprazole nazo zingaphatha izimo ze-hypersecretory ezenza ukuthi isisu sikhiqize i-acid esiswini kakhulu. I-Zollinger-Ellison syndrome yisimo esingadala i-acid hypersecretion futhi sifake izicubu kumanyikwe noma i-duodenum (ingxenye yokuqala yamathumbu amancane).
I-Pantoprazole ne-omeprazole nazo zingasiza ekwelapheni ezinye izimo ezinjengezilonda ze-duodenal, izilonda zesisu noma isisu, nezilonda ze-peptic. Lezi zilonda zivame ukubangelwa ukutheleleka okuvela kubhaktheriya elibizwa ngeH. Pylori. Ngenkathi i-omeprazole ivunyelwe ukwelapha iH. Pylori ngokuhlangana nezinye izidakamizwa, i-pantoprazole isetshenziswa ngaphandle kwelebula lalesi sifo.
Okunye ukusetshenziswa okungekho kwelebula kuzo zombili lezi zidakamizwa kufaka phakathi isisu sikaBarrett nezilonda ezisuselwa ekusetshenzisweni kwemithi engeyona eye-steroidal anti-inflammatory (NSAIDs).
| Isimo | I-Pantoprazole | Omeprazole |
| Isifo se-Reflux se-Gastroesophageal (GERD) | Yebo | Yebo |
| Ukuqhuma kwe-Esophagitis | Yebo | Yebo |
| Isifo seZollinger-Ellison | Yebo | Yebo |
| Izimo ze-hypersecretory | Yebo | Yebo |
| Izilonda ze-duodenal | Ngaphandle kwelebula | Yebo |
| Izilonda zesisu | Ngaphandle kwelebula | Yebo |
| H. Pylori ukutheleleka | Ngaphandle kwelebula | Yebo |
| Isomlomo sikaBarrett | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukugaya ukudla | Ngaphandle kwelebula | Ngaphandle kwelebula |
| I-NSAID yenze izilonda | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Izilonda ze-Peptic | Ngaphandle kwelebula | Ngaphandle kwelebula |
Ufuna intengo enhle nge-Omeprazole?
Bhalisela izexwayiso zentengo ye-Omeprazole bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Ingabe i-pantoprazole noma i-omeprazole isebenza kangcono?
I-Pantoprazole ne-omeprazole kukhonjisiwe ukuthi iyasebenza ekwelapheni i-GERD. Phakathi ku ukuhlaziywa kwe-meta ehlanganise izifundo ezehlukene ezingama-40, imiphumela ayitholanga mehluko omkhulu ekusebenzeni phakathi kwama-PPIs. I-Pantoprazole itholakale isebenza ngokulinganayo njenge-omeprazole. Ezinye izilingo zomtholampilo ezingaboni kabili zifake namanye ama-PPIs afana ne- I-Nexium (esomeprazole) , i-lansoprazole (Prevacid), ne-rabeprazole (Aciphex).
Eyodwa funda kufakwe ekuhlaziyweni kwe-meta kutholakale ukuthi i-pantoprazole ibisebenza kangcono kune-omeprazole ekwelapheni izilonda zesisu. Imiphumela iqokelelwe ezifundweni ezi-5 ekusebenzeni okususelwa ekubuyekezweni kumazinga okuphulukisa. Ngenkathi kutholakala ukuthi i-pantoprazole isebenza kangcono, kungenzeka kube namaphutha ngokulinganisa okungalingani.
I-Pantoprazole ne-omeprazole zombili lezi zidakamizwa ziqhathaniswa nokusebenza ngempumelelo. Enye ingancanyelwa kunenye ngokuya ngesimo esiphethwe kanye nezindleko zemithi. Xhumana nodokotela ukuthola ukuthi yikuphi I-PPI ingahle ibe ngcono kwakho.
Ukuqhathaniswa kanye nezindleko kwe-pantoprazole vs. i-omeprazole
I-Pantoprazole ngumuthi ojwayelekile ovame ukumbozwa yi-Medicare nezinhlelo eziningi zomshuwalense. Izindleko ezijwayelekile zokuthengisa ze-pantoprazole cishe zingama- $ 522. Ungahle ukwazi ukonga okuningi ngesigqebhezana se-SingleCare esingaletha izindleko zehle ku- $ 28.
Thola ikhadi lesaphulelo sakwaSingleCare
I-Omeprazole ngumuthi ojwayelekile ovame ukumbozwa yi-Medicare nezinhlelo eziningi zomshuwalense. Izindleko ezijwayelekile zokuthengisa ze-omeprazole cishe zingama- $ 67.99. Ngekhuphoni le-SingleCare ungalindela ukukhokha cishe u- $ 9-20 ngama-30, 20mg capsules.
| I-Pantoprazole | Omeprazole | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare? | Yebo | Yebo |
| Umthamo ojwayelekile | 40 mg (inani lama-30) | 20 mg (inani lama-30) |
| I-Medicare copay ejwayelekile | Kuya ngecebo lakho lomshuwalense | Kuya ngecebo lakho lomshuwalense |
| Izindleko ze-SingleCare | $ 28 | $ 9-20 |
Imiphumela emibi ejwayelekile ye-pantoprazole ne-omeprazole
I-Pantoprazole ne-omeprazole kungadala imiphumela emibi enjengekhanda, isiyezi, isicanucanu nokuhlanza. Zingadala neminye imiphumela emibi yamathumbu efana nohudo, ukuqunjelwa, ubuhlungu besisu noma besisu, nokuqunjelwa noma igesi. Eminye imiphumela emibi eyabiwe ingabandakanya ubuhlungu obuhlangene, izifo ezingenhla zokuphefumula, kanye ne-asthenia noma ukungabi namandla.
I-Omeprazole nayo ingadala imiphumela emibi njengokuvuselelwa kwe-asidi, ubuhlungu beqolo nokukhwehlela. IPantoprazole ayikaze ifundwe ukukhombisa le miphumela emibi kaningi.
| I-Pantoprazole | Omeprazole | |||
| Imiphumela emibi | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ubuhlungu bekhanda | Yebo | 12.2% | Yebo | 7% |
| Isicanucanu | Yebo | 7% | Yebo | 4% |
| Uhudo | Yebo | 8.8% | Yebo | 4% |
| Ukuqunjelwa | Yebo | <2% | Yebo | amaphesenti amabili |
| Ubuhlungu besisu | Yebo | 6.2% | Yebo | 5% |
| Ukuhlanza | Yebo | 4.3% | Yebo | 3% |
| Ukuqhuma kwesisu | Yebo | 3.9% | Yebo | 3% |
| Isiyezi | Yebo | 3% | Yebo | amaphesenti amabili |
| Ubuhlungu obuhlangene | Yebo | 2.8% | Yebo | Akunjalo |
| I-Rash | Yebo | <2% | Yebo | amaphesenti amabili |
| Ukuvuselelwa kabusha kwe-acid | Akunjalo | - | Yebo | amaphesenti amabili |
| Ukutheleleka okuphezulu okuphefumulayo | Yebo | Akunjalo | Yebo | amaphesenti amabili |
| Ubuthakathaka / Ukungabi namandla | Yebo | Akunjalo | Yebo | 1% |
| Ukuhlungu obusemhlane | Akunjalo | - | Yebo | 1% |
| Khwehlela | Akunjalo | - | Yebo | 1% |
* Xhumana nodokotela noma usokhemisi ngayo yonke imiphumela engemihle engaba khona.
Umthombo: I-DailyMed (pantoprazole) , I-DailyMed (omeprazole)
Ukusebenzisana kwezidakamizwa kwe-pantoprazole kuqhathaniswa ne-omeprazole
Kokubili i-pantoprazole ne-omeprazole kungasebenzisana nezidakamizwa ezifanayo. Bobabili bangasebenzisana nemithi yezidambisigciwane efana ne-rilpivirine, i-atazanavir, ne-saquinavir. Ukuthatha le mithi ndawonye kungaguqula ukusebenza komuthi wezidambisigciwane futhi kwandise ubuthi bawo. Ukuthatha i-pantoprazole noma i-omeprazole nge-warfarin kungakhuphula ingozi yokopha. Ngakho-ke, akufanele zithathwe ndawonye. Ngenkathi i-clopidogrel ingahle ingathinteki yi-pantoprazole, kufanele igwenywe nge-omeprazole.
I-Pantoprazole ne-omeprazole zisebenzisana ne-methotrexate, umuthi we-antimetabolite, futhi ingadala ubungozi obuningi bokuba nobuthi nemiphumela engemihle.
I-Pantoprazole ne-omeprazole akufanele zithathwe ngasikhathi sinye nosawoti bensimbi nezinye izidakamizwa ezincike ku-asidi esiswini ukumunca. Eminye imishanguzo encike esiswini i-asidi ukumuncwa ifaka phakathi imishanguzo ye-chemotherapy efana ne-erlotinib ne-dasatinib nama-antifungal anjenge ketoconazole kanye ne-itraconazole.
Ngoba womabili ama-PPIs ahlanganiswe nesibindi, angahlangana nezinye izidakamizwa ezicutshungulwa ama-enzyme afanayo, kufaka phakathi i-enzyme ye-CYP2C19. Kodwa-ke, ngokusho kwe- Ilebula le-FDA , eminye yale mithi, okubandakanya i-phenytoin, i-citalopram, ne-diazepam, ayikhonjiswanga ukuthi inokuxhumana okukhulu ne-pantoprazole. Noma kunjalo, kubalulekile ukuxoxa nganoma yimiphi imithi oyiphuzayo nodokotela ngaphambi kokuthatha i-PPI.
Ama-PPI angathinta imiphumela yokuhlolwa okuthile kwelebhu. Ama-PPI aziwa ngokudala izinzuzo ezingamanga ekuhlolweni kwe-THC yomchamo.
| Izidakamizwa | Isigaba Sezidakamizwa | I-Pantoprazole | Omeprazole |
| I-Rilpivirine UNelfinavir Atazanavir I-Saquinavir I-Ritonavir | Izidambisigciwane | Yebo | Yebo |
| I-Warfarin | I-Anticoagulant | Yebo | Yebo |
| I-Clopidogrel | I-Antiplatelet | Akunjalo | Yebo |
| IMethotrexate | I-Antimetabolite | Yebo | Yebo |
| IMycophenolate mofetil Tacrolimus | Ukuzivikela komzimba | Yebo | Yebo |
| Ketoconazole I-Itraconazole Voriconazole | I-Antifungal | Yebo | Yebo |
| U-Erlotinib I-Dasatinib Nilotinib | Ukwelashwa ngamakhemikhali | Yebo | Yebo |
| Umfutho fumarate Idoyiphu yegluconate I-Sulphate eyisiyingi Umfutho succinate | Usawoti wensimbi | Yebo | Yebo |
| I-Diazepam I-Midazolam | I-Benzodiazepine | Akunjalo | Yebo |
| Phenytoin | I-antiepileptic | Akunjalo | Yebo |
| I-Clarithromycin I-Rifampin | Imithi elwa namagciwane | Yebo | Yebo |
| I-Citalopram | I-antidepressant ekhethiwe ye-serotonin reuptake inhibitor (SSRI) | Akunjalo | Yebo |
| ISt. John's Wort | Amakhambi | Yebo | Yebo |
* Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.
Izexwayiso ze-pantoprazole ne-omeprazole
I-Pantoprazole ne-omeprazole azinconywa ukuthi zisetshenziswe isikhathi eside. Ukusetshenziswa kwesikhathi eside kuhlotshaniswe ne- ingozi eyengeziwe yokuphuka kwamathambo . Uma une-osteoporosis, ungahle uthande ukuqapha noma yikuphi ukusetshenziswa kwama-PPIs.
Eminye idatha iphakamise ukuthi izidakamizwa ze-PPI zingakhuphula ubungozi bezehlakalo zenhliziyo ezifana nokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Noma kunjalo, i-FDA nezinye imibiko qinisa izinzuzo zama-PPIs ngaphezu kwale ngozi.
Ngenxa yokuthi i-pantoprazole ne-omeprazole zicutshungulwa esibindi, zingalungiswa noma zigwenywe kulabo abanokukhubazeka kwesibindi.
I-Pantoprazole ne-omeprazole zingadlulela noma zenyuse ubungozi be-systemic lupus erythematosus, isifo esingajwayelekile sokuzilimaza.
Ukwelashwa ngama-PPIs kungakhuphula ubungozi bohudo kusuka kwizifo zeClostridium difficile. Le ngozi ingase ibe phezulu kulabo abalaliswe esibhedlela isikhathi eside.
Kokubili i-pantoprazole ne-omeprazole kusigaba Sokukhulelwa C futhi kungadala ingozi enganeni engakazalwa. Xhumana nodokotela noma umhlinzeki wezempilo uma ukhulelwe noma uncelisa.
Imibuzo ebuzwa njalo nge-pantoprazole vs. Omeprazole
Yini i-pantoprazole?
I-Pantoprazole (Protonix) ngumuthi we-proton pump inhibitor (PPI) onikezwe ukwelapha i-GERD kanye ne-esophagitis erosive. Kuvame ukuthathwa njengethebhulethi yokukhishwa okulibazisekile engama-40 mg kuze kube amasonto ayi-8. Ingathathwa kubantu abadala nezingane ezineminyaka engu-5 nangaphezulu.
Yini i-omeprazole?
I-Omeprazole (Prilosec) umuthi we-PPI obekelwe ukwelapha i-GERD kanye ne-esophagitis erosive. Futhi i-FDA ivunyelwe ukutheleleka kwe-H pylori kanye nezilonda ze-duodenal noma zesisu. Kungathathwa njenge-capsule ekhishwe ukubambezeleka ekhishwe ngo-20 mg amasonto ama-4 kuye kwangama-8 kubantu abadala nezingane unyaka owodwa nangaphezulu.
Ngabe i-pantoprazole ne-omeprazole ziyefana?
I-Pantoprazole ne-omeprazole basesigabeni esifanayo semithi. Kodwa-ke, zinokusetshenziswa okuhlukile okugunyaziwe nemiphumela emibi. Ziza futhi ngemithamo ehlukene kanye nokwakhiwa.
Ingabe i-pantoprazole noma i-omeprazole ingcono?
I-Pantoprazole ne-omeprazole zombili ziyasebenza ku-GERD naku-esophagitis erosive. Umuthi owodwa we-PPI ungancanyelwa omunye ngokuya ngesimo esiphathwayo kanye nezindleko zomuthi.
Ngingayisebenzisa i-pantoprazole noma i-omeprazole ngenkathi ngikhulelwe?
I-Pantoprazole ne-omeprazole azinconywa kwabesifazane abakhulelwe ngenxa yengozi yokulimala kwengane. Kodwa-ke, kwezinye izimo, izinzuzo zingadlula ingozi. Xhumana nodokotela uma ukhulelwe.
Ngingayisebenzisa yini i-pantoprazole noma i-omeprazole ngotshwala?
Ukuphuza utshwala kungakhuphula imiphumela ethile emibi ehambisana ne-pantoprazole noma i-omeprazole. Ngenxa yokuthi ikhanda nesicanucanu kuyimiphumela emibi ejwayelekile yama-PPIs, le miphumela emibi ingaba yimbi uma ama-PPI ethathwa ngotshwala.
Ingabe i-OTC omeprazole iyefana nomuthi kadokotela?
I-omeprazole ye-Over-the-counter (OTC) iqukethe umuthi ofanayo namandla we-omeprazole kadokotela. I-OTC omeprazole ingatholakala njenge-OTC Prilosec ekunikezelweni kwezinsuku eziyi-14 kwamaphilisi angama-20 mg. Le nkambo yokwelashwa akufanele ithathwe ngaphezu kwesisodwa njalo ezinyangeni ezi-4.
Ngabe kufanele ngithathe i-Pantoprazole ne-Omeprazole ngasikhathi sinye?
I-Pantoprazole ne-omeprazole akufanele zithathwe ngasikhathi sinye. Zisebenza ngezindlela ezifanayo ngokuvala ukukhiqizwa kwesisu esiswini esiswini. Ukuzihlanganisa ndawonye kungakhuphula ubungozi bemiphumela emibi.
