I-Symbicort vs. Advair: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
I-Symbicort ne-Advair yimithi emibili enegama lomkhiqizo esetshenziselwa ukwelapha i-asthma kanye ne-chronic obstructive pulmonary disease (COPD). I-asthma ne-COPD yizimo ezithinta amaphaphu futhi zidale ukuvuvukala ezindleleni zomoya. Izimpawu ze-asthma ne-COPD zifaka phakathi inkinga yokuphefumula, ukushaywa umoya nokukhwehlela.
I-Symbicort ne-Advair ngama-inhalers esondlo ahlanganisa i-corticosteroid (ICS) ephefumulelwe ne-beta agonist esebenza isikhathi eside (LABA). La ma-inhaler asetshenziswa nsuku zonke ukusiza ukulawula ukuvuvukala emaphashini nokugcina imigwaqo yomoya ivulekile. Azisetshenziswa njengama-inhalers wokutakula ezimpawu ezibucayi zesifuba somoya noma i-COPD. Yize zifana, i-Symbicort ne-Advair zinomehluko othile kuzithako ezisebenzayo nomthamo onconywayo.
Uyini umehluko omkhulu phakathi kweSymbicort ne-Advair?
I-Symbicort ne-Advair iqukethe i-corticosteroid, enemiphumela elwa nokuvuvukala emaphashini. I-Symbicort iqukethe i-corticosteroid budesonide ngenkathi i-Advair iqukethe i-corticosteroid fluticasone. I-Symbicort ne-Advair nazo ziqukethe i-bronchodilator esebenza isikhathi eside, esiza ukugcina imigwaqo yomoya ivulekile; I-Symbicort iqukethe i-formoterol ngenkathi i-Advair iqukethe i-salmeterol.
I-Symbicort isetshenziswa njengokwelashwa kwesondlo kwe-COPD, futhi ingasetshenziswa ukwelapha i-asthma kubantu abaneminyaka engu-6 nangaphezulu. I-Advair isetshenziswa futhi njengokwelashwa kwesondlo kwe-COPD, futhi ingasetshenziswa ukwelapha i-asthma kubantu abaneminyaka engu-4 nangaphezulu. Umthamo ojwayelekile weSymbicort ukuphefumula kabili kabili ngosuku ngenkathi umthamo ojwayelekile we-Advair ungukuhefuzela okukabili nsuku zonke.
I-Symbicort iza njenge-inhalation aerosol enamandla we-80 / 4.5 mcg noma i-160 / 4.5 mcg ye-budesonide / formoterol. I-Advair iyatholakala njenge-inhalation aerosol ne-inhalation powder, kodwa i-aerosol ye-inhalation ivunyelwe kuphela ukwelapha i-asthma ngenkathi i-inhalation powder ingaphatha i-asthma ne-COPD. I-Advair HFA iyi-metered-dose inhaler eletha i-inhalation aerosol ngamandla we-45/21 mcg, 115/21 mcg, noma i-230/21 mcg ye-fluticasone / salmeterol. I-Advair Diskus ihambisa i-inhalation powder ngamandla we-100/50 mcg, 250/50 mcg, noma i-500/50 mcg ye-fluticasone / salmeterol.
| Umehluko omkhulu phakathi kwe-Symbicort ne-Advair | ||
|---|---|---|
| I-Symbicort | I-Advair | |
| Isigaba sezidakamizwa | I-ICS (i-corticosteroid ephefumulelwe) ne-LABA (i-agonist ye-beta2-adrenergic esebenza isikhathi eside) | I-ICS (i-corticosteroid ephefumulelwe) ne-LABA (i-agonist ye-beta2-adrenergic esebenza isikhathi eside) |
| Isimo somkhiqizo / ejwayelekile | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala |
| Ngubani igama elijwayelekile? | I-Budesonide ne-formoterol fumarate dihydrate | I-Fluticasone propionate ne-salmeterol |
| Izidakamizwa zingena ngaziphi izinhlobo? | I-inhalation aerosol (i-metered-dose inhaler) | I-inhalation aerosol (i-metered-dose inhaler) Inhalation powder (i-diskus) |
| Uyini umthamo ojwayelekile? | Ukwelashwa kwesifuba somoya ezigulini ezineminyaka engu-12 nangaphezulu: Ukuhogela okungu-2 kwe-Symbicort 80 / 4.5 noma i-160 / 4.5 kabili ngosuku Ukwelashwa kwesifuba somoya ezigulini ezineminyaka engu-6 kuya kwengaphansi kwengu-12 ubudala: Ukuhogela okungu-2 kweSymbicort 80 / 4.5 kabili ngosuku Ukwelashwa kwesondlo kwe-COPD: Ukuhogela okungu-2 kweSymbicort 160 / 4.5 kabili ngosuku | I-Advair Diskus Ukwelashwa kwesifuba somoya ezigulini ezineminyaka engu-12 nangaphezulu: 1 ukuhogela i-Advair Diskus 100/50, 250/50, noma i-500/50 kabili ngosuku Ukwelashwa kwesifuba somoya ezigulini ezineminyaka engu-4 kuya kwengu-11 ubudala: 1 ukuhogela i-Advair Diskus 100/50 kabili ngosuku Ukwelashwa kwesondlo kwe-COPD: 1 ukuhogela i-Advair Diskus 250/50 kabili ngosuku I-Advair HFA |
| Yelashwa isikhathi esingakanani? | Isikhati eside | Isikhati eside |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nezingane ezineminyaka engu-6 nangaphezulu | Abantu abadala nezingane ezineminyaka engu-4 nangaphezulu |
Izimo eziphathwe yi-Symbicort ne-Advair
I-Symbicort ne-Advair zombili zivunyelwe i-FDA ukwelapha i-asthma ne-COPD. Kodwa-ke, i-Advair Diskus ivunyelwe ukwelapha i-asthma ne-COPD ngenkathi i-Advair HFA ivunyelwe kuphela ukwelapha i-asthma. I-Symbicort ne-Advair zisetshenziswa njenge-inhalers yokwelashwa kwesondlo esetshenziswa nsuku zonke ukulawula nokuvimbela i-COPD nezimpawu zesifuba somoya, njengokuphefumula okuncane nokuphefumula.
Uma isetshenziswa isikhathi eside, le mithi ingasiza futhi ekunciphiseni ubunzima nokuvama kwe-COPD futhi ukuhlaselwa yisifuba somoya , noma ukukhushulwa. Ukuze kulawulwe ngokushesha izimpawu ezibucayi ze-COPD noma i-asthma, umhlinzeki wezokunakekelwa kwempilo uzonquma i-inhaler yokutakula efana ne-albuterol, eyaziwa nangamagama emikhiqizo efana ne-Ventolin ne-ProAir.
| Isimo | I-Symbicort | I-Advair |
| Isifuba Somoya | Yebo | Yebo |
| I-COPD | Yebo | Yebo |
Ingabe i-Symbicort noma i-Advair isebenza kangcono?
Kokubili i-Symbicort ne-Advair zingama-inhalers asebenzayo lapho zithathwa ngokungaguquguquki. Zombili ziqukethe izithako ezifanayo ezisebenzayo ezisiza ukunciphisa ukuvuvukala emaphashini futhi zivule izindlela zomoya. Khuluma nomhlinzeki wezokunakekelwa kwempilo ukuthola i-inhaler engcono kakhulu ekusebenzelayo.
Ngokuya nge- ukuhlaziywa kwe-meta , i-inhaler enakho kokubili i-corticosteroid ehogelwayo kanye ne-bronchodilator esebenza isikhathi eside isebenza kangcono ekunciphiseni ukukhushulwa kwe-COPD kune-inhaler equkethe kuphela i-bronchodilator esebenza isikhathi eside. Azikho izilingo zekhanda nekhanda eziqhathanisa ngqo izithako ezisebenzayo eSymbicort naseAdvair ezibuyekeziwe ekuhlaziyweni. Kodwa-ke, ucwaningo luthole ukuthi, ngokujwayelekile, ama-inhalers wokugcina inhlanganisela asebenza ngokufanayo.
Isilingo esisodwa somtholampilo esingahleliwe, esingaboni kabili sathola ukuthi izithako ezisebenzayo eSymbicort nase-Advair ziyanikeza ukuthuthuka okufanayo ekusebenzeni kwamaphaphu, izinsuku zokulawulwa kwesifuba somoya, kanye nekhwalithi yokuphila ehlobene nesifuba somoya. Yomibili le mithi yehlise nengozi yokulaliswa ezibhedlela noma ukuvakashelwa ngamagumbi okuphuthumayo okubangelwa ukwanda kwezimpawu zesifuba somoya. Ucwaningo lwenziwe kubantu abangaphezu kuka-2 866 abaneminyaka engu-16 kuya phezulu.
Ukuhlanganiswa nokuqhathaniswa kwezindleko ze-Symbicort vs. Advair
I-Symbicort ivame ukumbozwa yizinhlelo eziningi zeMedicare nezomshuwalense. Iyatholakala futhi njengomuthi ojwayelekile, ongabiza kakhulu kunohlobo lwegama lomkhiqizo. Intengo emaphakathi yokuthengisa ye-Symbicort icishe ibe ngama- $ 550. Ungahle ukwazi ukuthenga i-Symbicort cishe ngama- $ 250 ngohlelo lokonga noma ikhadi lesaphulelo, njengekhadi le-SingleCare.
I-Advair ibuye ihlanganiswe yiMedicare nezinhlelo zomshuwalense. Njenge-Symbicort, i-Advair iza ngendlela ejwayelekile. Uma kuqhathaniswa ne-Symbicort, intengo ejwayelekile yokuthengisa ye-Advair HFA ingaba phezulu cishe ku- $ 584. Intengo emaphakathi ye-Advair Diskus icishe ibe ngama- $ 494. Ungonga ngezindleko ze-Advair HFA noma i-Advair Diskus ngekhadi lesigqebhezana le-SingleCare emakhemisi abambe iqhaza.
| I-Symbicort | I-Advair | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Ubuningi | 1 i-inhaler | 1 i-inhaler |
| I-Medicare copay ejwayelekile | $ 19- $ 399 | $ 2- $ 425 |
| Izindleko ze-SingleCare | $ 248 + | $ 288 + |
Imiphumela emibi ejwayelekile ye-Symbicort vs. Advair
Kokubili i-Symbicort ne-Advair babelana ngemiphumela efanayo efanayo. Yomibili le mithi ingadala imiphumela emibi efana nekhanda, i-nasopharyngitis, ukutheleleka okuphezulu okuphefumulayo, i-bronchitis, kanye nokucinana kwamakhala. Eminye imiphumela engemihle ingafaka isicanucanu, ukuhlanza, ukushesha, nobuhlungu beqolo.
Ingxenye ye-steroid ye-Symbicort ne-Advair ingakhuphula ubungozi be-thrush yomlomo, noma izifo zesikhunta emlonyeni. Ngalesi sizathu, kubalulekile ukugeza umlomo ngamanzi njalo emva kokusebenzisa i-inhaler ngayinye. Idivayisi ebizwa nge-spacer nayo ingafakwa kuma-inhalers we-metered-dose ukusiza ukunciphisa ingozi ye-thrush yomlomo.
Imiphumela emibi engaba khona yemithi ye-ICS / LABA ifaka i-bronchospasm ephikisayo ne-anaphylaxis. Isizathu se-bronchospasm esiyindida asiqondakali kahle. Kodwa-ke, kungenzeka njengokuqubuka okungazelelwe kokuphefumula, ukuphefumula okuncane, nokukhwehlela ngemuva kokusebenzisa umuthi we-inhaler. I-Anaphylaxis kungenzeka ngenxa yokungezwani komzimba nanoma iziphi izithako ku-Symbicort noma ku-Advair. Funa ukunakekelwa kwezokwelapha ngokushesha uma uhlangabezana nokushaywa okukhulu, ukuvuvukala, noma ukuphefumula kanzima ngemuva kokusebenzisa i-inhaler yokuhlanganisa.
| I-Symbicort | I-Advair | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ubuhlungu bekhanda | Yebo | 7% | Yebo | 12% |
| I-Nasopharyngitis | Yebo | ishumi nanye% | Yebo | * |
| Ukutheleleka okuphezulu okuphefumulayo | Yebo | 8% | Yebo | 27% |
| I-bronchitis | Yebo | 5% | Yebo | amaphesenti amabili |
| Ukuminyana emakhaleni | Yebo | 3% | Yebo | * |
| I-thrush yomlomo | Yebo | 1% | Yebo | 1% |
| Isicanucanu | Yebo | * | Yebo | 4% |
| Ukuhlanza | Yebo | 1% | Yebo | 4% |
| Ukungahambi kahle | Yebo | * | Yebo | 5% |
| Ukuhlungu obusemhlane | Yebo | 3% | Yebo | * |
* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( I-Symbicort ), IDailyMed ( I-Advair )
Ukusebenzisana kwezidakamizwa kwe-Symbicort vs. Advair
Ukuqapha kuyelulekwa uma usebenzisa i-Symbicort noma i-Advair ngemithi eyi-CYP3A4 inhibitors, efana ne-ritonavir, ketoconazole, ne-clarithromycin. Ukuthatha i-CYP3A4 inhibitor nge-Symbicort noma i-Advair kungadala ukwanda kwamazinga egazi engxenyeni ye-corticosteroid, engaholela emiphumeleni emibi.
Usebenzisa i-monoamine oxidase inhibitors (MAOIs) noma ama-tricyclic antidepressants ane-Symbicort noma i-Advair kungandisa imiphumela yenhliziyo yengxenye ye-beta-agonist kunoma yimuphi umuthi. Ngakolunye uhlangothi, ama-beta blockers anganciphisa imiphumela ye-beta-agonist emaphashini. I-diuretics ingadala ushintsho lwe-electrocardiographic noma amazinga aphansi e-potassium (hypokalemia) uma isetshenziswa ne-Symbicort noma i-Advair.
| Izidakamizwa | Isigaba sezidakamizwa | I-Symbicort | I-Advair |
| I-Ritonavir Atazanavir Ketoconazole I-Clarithromycin I-Indinavir I-Itraconazole I-Nefazodone UNelfinavir I-Saquinavir | I-CYP3A4 inhibitors | Yebo | Yebo |
| USelegiline I-Rasagiline I-Phenelzine Isocarboxazid | I-Monoamine oxidase inhibitors (MAOIs) | Yebo | Yebo |
| Amitriptyline I-Nortriptyline | I-Tricyclic antidepressants | Yebo | Yebo |
| I-Metoprolol I-Atenolol I-Bisoprolol Nebivolol I-Propranolol | Abavimbela i-Beta | Yebo | Yebo |
| UFurosemide I-Bumetanide I-Torsemide I-Chlorthalidone | Izidakamizwa | Yebo | Yebo |
Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka.
Izexwayiso ze-Symbicort ne-Advair
Ngoba ziqukethe i-corticosteroid, iSymbicort ne-Advair kungadala ubungozi obengeziwe bokutheleleka noma ukwehla kwamaminerali amathambo. Kodwa-ke, uma kuqhathaniswa ne-systemic corticosteroids, ama-corticosteroids ahogelwayo anengozi encane yale miphumela emibi. Ukucindezelwa kwe-Adrenal kungenzeka futhi uma usebenzisa imithamo ephezulu ye-Symbicort noma i-Advair.
Ukusetshenziswa kwesikhathi eside kwe-Symbicort noma i-Advair kungakhuphula ubungozi be-glaucoma noma i-cataract. Udokotela wamehlo angadinga ukuthintwa uma izimpawu zamehlo zikhula ngokuhamba kwesikhathi ngokusebenzisa noma imuphi wale mithi.
Ukusetshenziswa kweSymbicort noma i-Advair kufanele kubhekwe ezigulini ezinenkinga yenhliziyo nemithambo yegazi, ukuphazamiseka kwesistimu yezinzwa eziphakathi, ukuphazamiseka kwemixhantela, nesifo sikashukela. Khuluma nomhlinzeki wezokunakekelwa kwempilo ukuthola ezinye izexwayiso nezinyathelo zokuqapha ngaphambi kokusebenzisa iSymbicort noma i-Advair.
Imibuzo ebuzwa njalo nge-Symbicort vs. Advair
Yini iSymbicort?
I-Symbicort ngumuthi wegama lomkhiqizo owenziwe yi-AstraZeneca. Iqukethe i-budesonide ne-formoterol, esiza ukuvimbela nokulawula izimpawu ze-asthma ne-COPD. I-Symbicort ivunyelwe ukwelapha i-asthma ezigulini ezineminyaka engu-6 nangaphezulu. Itholakala njenge-aerosol ye-inhalation esetshenziswa kabili nsuku zonke.
Kuyini i-Advair?
I-Advair ngumuthi wegama lomkhiqizo owenziwe yiGlaxoSmithKline. Iqukethe i-fluticasone ne-salmeterol. I-Advair ivunyelwe yi-FDA ukuvimbela nokulawula izimpawu ze-COPD ne-asthma. Kuvunyelwe ukwelapha i-asthma ezigulini ezineminyaka engu-4 nangaphezulu. I-Advair iyatholakala njenge-inhalation powder (i-Advair Diskus), ekwazi ukwelapha i-asthma ne-COPD, ne-inhalation aerosol (i-Advair HFA), evunyelwe ukwelapha i-asthma. Kokubili ukwakheka kusetshenziswa kabili nsuku zonke.
Ngabe i-Symbicort ne-Advair ziyefana?
I-Symbicort ne-Advair zisetshenziselwa ukwelapha i-asthma ne-COPD. Noma kunjalo, aqukethe izithako ezahlukahlukene ezisebenzayo. I-Symbicort iqukethe i-budesonide ne-formoterol ngenkathi i-Advair iqukethe i-fluticasone ne-salmeterol. I-Symbicort ingelapha i-asthma ezigulini ezineminyaka engu-6 nangaphezulu ngenkathi i-Advair ingaphatha i-asthma ezigulini ezineminyaka engu-4 nangaphezulu. I-Advair iyatholakala futhi njenge-inhalation powder noma i-aerosol ngenkathi i-Symbicort itholakala kuphela njenge-inosation aerosol.
Ingabe i-Symbicort noma i-Advair ingcono?
Kokubili i-Symbicort ne-Advair ziyasebenza ekwelapheni i-COPD nezimpawu zesifuba somoya. Ngoba yimithi yesondlo, kufanele isetshenziswe nsuku zonke ukuze isebenze kahle kakhulu. I-inhaler yesondlo enhle kakhulu kufanele inqunywe ngokubheka izinto ezinjengemiphumela emibi engaba khona, isilinganiso, nezindleko.
Ngingayisebenzisa i-Symbicort noma i-Advair ngenkathi ngikhulelwe?
Alukho ucwaningo olwanele oluphakamisa ukuthi iSymbicort noma i-Advair iphephile noma iyingozi ngesikhathi sokukhulelwa. Ngokwe-Asthma and Allergy Foundation of America (AAFA), ama-beta agonists asebenza isikhathi eside akunconyiwe njengokwelashwa komugqa wokuqala kwesifuba somoya ezigulini ezikhulelwe. Esikhundleni salokho, i-bronchodilator esebenza okwesikhashana inganconywa esikhundleni salokho. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ngezeluleko ze-COPD nezindlela zokwelashwa kwe-asthma ngenkathi ukhulelwe.
Ngingayisebenzisa i-Symbicort noma i-Advair ngotshwala?
Utshwala abaziwa ukusebenzisana ne-Symbicort noma i-Advair. Ukuphuza utshwala okungapheli kungaphazamisa amandla omzimba wokulwa nezifo, angakhula ngenxa yokonakala kwesifuba somoya noma i-COPD. Khuluma nomhlinzeki wezempilo mayelana nokuthi kuphephile yini ukuphuza utshwala ngenkathi usebenzisa iSymbicort noma i-Advair.
Yini i-inhaler elingana ne-Symbicort?
Uhlobo olujwayelekile lwe-Symbicort luyatholakala. Uhlobo olujwayelekile, oluqukethe i-budesonide ne-formoterol, lilingana ne-Symbicort. Uhlobo olujwayelekile lungaba enye indlela eshibhile kunegama lomkhiqizo i-inhaler. Ama-inhaler afanayo ne-Symbicort afaka phakathi i-Advair (fluticasone / salmeterol), iDulera (mometasone / formoterol), neBreo (fluticasone / vilanterol). Lawa ma-inhaler angasebenza ngokufanayo ne-Symbicort, kepha awathathwa njengokulingana kwe-Symbicort.
Yini i-inhaler ephephe kunazo zonke ye-COPD?
Ama-inhalers we-ICS / LABA abhekwa njengasebenza futhi aphephile ekwelapheni i-COPD. Kodwa-ke, ama-corticosteroids aphefumulelwe athwala ingozi enkulu yenyumoniya kubantu abane-COPD esezingeni eliphakeme. I-LAMA / LABA inhalers yokuhlanganiswa ibhekwa njengeyimpumelelo futhi ephephile kune-ICS / LABA inhlanganisela yama-inhalers ngenxa yalesi sizathu. I-LAMA / LABA inhalers inhalers ifaka phakathi i-Anoro (umeclidinium / vilanterol), iStiolto (tiotropium / olodaterol), neBevepi (glycopyrrolate / formoterol).
