I-Wellbutrin SR vs. Wellbutrin XL: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
I-Wellbutrin SR ne-Wellbutrin XL yimithi emibili kadokotela engaphatha izimpawu zokucindezeleka. Zombili lezi zidakamizwa ziqukethe isithako esisebenzayo, i-bupropion hydrochloride. I-Wellbutrin SR ne-Wellbutrin XL ziyingxenye yesigaba semithi ebizwa nge-norepinephrine-dopamine reuptake inhibitors (NDRIs). Babizwa nangokuthi ama-aminoketone antidepressants.
I-Wellbutrin SR ne-Wellbutrin XL zinendlela yokusebenza efanayo. Basebenza ngokuvimba ukutholwa kabusha kwe-norepinephrine ne-dopamine ebuchosheni. Umsebenzi owandisiwe wala ma-neurotransmitters yilokho okusiza ekunciphiseni izimpawu zokudangala.
Uyini umehluko omkhulu phakathi kwe-Wellbutrin SR ne-Wellbutrin XL?
I-Wellbutrin SR (Amakhuphoni e-Wellbutrin SR | Imininingwane ye-Wellbutrin SR) yigama lomkhiqizo lamathebulethi akhululwa e-bupropion. Kwakuyi-FDA evunyelwe ngo-1996 ukwelashwa kwesifo esikhulu sokucindezeleka. I-Wellbutrin SR ivame ukuthathwa njenge-150 mg kabili ngosuku ngenani eliphelele lansuku zonke le-300 mg.
I-Wellbutrin XL (Amakhuphoni e-Wellbutrin XL | Imininingwane ye-Wellbutrin XL) igama lomkhiqizo lamathebulethi akhishwa nge-bupropion. Kwakuyi-FDA evunyelwe ngo-2003 ngesifo esikhulu sokucindezeleka kanye nokuphazamiseka kwonyaka. I-Wellbutrin XL ingena emzimbeni kancane. Uma kuqhathaniswa ne-bupropion ekhishwa ngokushesha futhi ekhishwa ngokuqhubekayo, ifomu le-XL likhipha umuthi isikhathi eside. Ngalesi sizathu, i-Wellbutrin XL ithathwa njengethebhulethi yansuku zonke.
| Umehluko omkhulu phakathi kwe-Wellbutrin SR ne-Wellbutrin XL | ||
|---|---|---|
| I-Wellbutrin SR | I-Wellbutrin XL | |
| Isigaba sezidakamizwa | INorepinephrine-Dopamine Reuptake Inhibitor (NDRI) I-Aminoketone antidepressant | INorepinephrine-Dopamine Reuptake Inhibitor (NDRI) I-Aminoketone antidepressant |
| Isimo somkhiqizo / ejwayelekile | Izinhlobo zebrendi ne-generic ziyatholakala | Izinhlobo zebrendi ne-generic ziyatholakala |
| Ngubani igama elijwayelekile? | I-Bupropion HCl, ukukhishwa okuqhubekayo | I-Bupropion HCl, ukukhishwa okunwetshiwe |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo, ukukhishwa okuqhubekayo | Ithebhulethi yomlomo, ukukhishwa okunwetshiwe |
| Uyini umthamo ojwayelekile? | Isilinganiso sokuqala: 150 mg ngosuku Umthamo ohlosiwe: 150 mg kabili ngosuku | Isilinganiso sokuqala: 150 mg kanye ngosuku Umthamo ohlosiwe: 300 mg kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Amaviki amathathu kuya kwayisithupha noma ngaphezulu kuye ngezimpawu | Amaviki amathathu kuya kwayisithupha noma ngaphezulu kuye ngezimpawu |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala abaneminyaka engu-18 nangaphezulu | Abantu abadala abaneminyaka engu-18 nangaphezulu |
Ufuna intengo engcono ku-Wellbutrin SR?
Bhalisela izexwayiso zentengo ye-Wellbutrin SR bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Izimo eziphathwe yi-Wellbutrin SR ne-Wellbutrin XL
Kokubili i-Wellbutrin SR ne-Wellbutrin XL kukhonjisiwe ukwelapha izimpawu zokucindezeleka okukhulu (okunye okubizwa ngokuthi yisifo sokudangala okukhulu). Kodwa-ke, i-Wellbutrin XL nayo ivunyelwe ukuvimbela ukuphazamiseka kokuphazamiseka kwesizini. Isifo sokuphazamiseka kwesizini yisifo semizwelo esithinta abanye abantu ngesikhathi sezinguquko zonyaka. Isibonelo, umuntu ovame ukungakutholi ukucindezeleka unyaka wonke angazizwa ecindezelekile phakathi nobusika. I-Wellbutrin XL ingaqalwa ngenkathi yokuwa ukuvimbela ukuguquka kwemizwelo ebusika.
I-Bupropion ingasetshenziswa ngezindlela ezingekho kwelebuli zokwelapha I-ADHD (ukunakekelwa kokushoda kwengqondo), iziqephu ezicindezelayo zokuphazamiseka kwengqondo okuguquguqukayo, kanye nokungasebenzi kahle kwezocansi okubangelwa amanye ama-anti-depressants afana ne-SSRI (i-serotonin reuptake inhibitors ekhethiwe) kanye ne-tricyclic antidepressants. Ezinye izinkomba ezingekho kwelebula zifaka i-social phobia ne-PTSD (post-traumatic stress disorder). I-Bupropion kwesinye isikhathi isetshenziswa ngokuhlangana ne-naltrexone ukwelapha ukukhuluphala nezimo ezihlobene nesisindo.
I-Bupropion ingasiza ngokuyeka ukubhema. IBupropion yokuyeka ukubhema yenziwa ngaphansi komkhiqizo ohlukile obizwa ngeZyban. IZyban neWellbutrin azinakufakwa endaweni yomunye ngenxa yokwehluka kokulinganisa.
| Isimo | I-Wellbutrin SR | I-Wellbutrin XL |
| Isifo esikhulu sokucindezeleka (MDD) | Yebo | Yebo |
| Ukuvinjelwa kwesifo se-Seasonal affective disorder (SAD) | Ngaphandle kwelebula | Yebo |
| I-ADHD | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukuphazamiseka kwe-bipolar | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukukhuluphala ngokweqile | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukungasebenzi ngokocansi | Ngaphandle kwelebula | Ngaphandle kwelebula |
| PTSD | Ngaphandle kwelebula | Ngaphandle kwelebula |
| Ukwesaba umphakathi | Ngaphandle kwelebula | Ngaphandle kwelebula |
Ingabe i-Wellbutrin SR noma i-Wellbutrin XL isebenza kangcono?
I-Wellbutrin SR ne-Wellbutrin XL zombili ziyasebenza ekwelapheni ukucindezeleka. Ukusetshenziswa kwabo nokwehluka kokulinganisa kungabamba isisindo esikhulu lapho kukhethwa phakathi kwalokhu okubili. Phakathi ku isifundo somtholampilo ngokuqhathanisa i-bupropion SR ne-bupropion XL, labo abathatha i-bupropion XL kanye-nsuku zonke babhekana namazinga aphansi okucindezeleka futhi babuyele emuva. Izilingo zomtholampilo zithole ukuthi kunokusebenziseka okungaguquguquki kanye nephilisi elenziwa nsuku zonke, ngokunokwenzeka ngenxa yokusebenziseka kalula. Labo abathatha i-bupropion SR ephindwe kabili-nsuku zonke kungenzeka babe nenkinga enkulu ukuthatha imithamo yomibili ngokungaguquguquki.
Phakathi ku ukubuyekeza okuhlelekile kwe-bupropion , ukwakhiwa kwe-XL kutholakale ukuthi kuthandwa ngaphezu kwe-placebo ukuvimbela ukuphazamiseka kokuphazamiseka kwesizini. Izilingo ezilawulwayo ngaphakathi kokubuyekezwa zikhombise ukwehla okuphawulekayo kwezimpawu zokucindezeleka kulabo abathintekayo ngesifo sokuphazamiseka sonyaka.
Zombili lezi zinhlobo ze-Wellbutrin ziwusizo ekwelapheni ezinye zezimo ezifanayo. Njengemithi kadokotela, i-Wellbutrin SR ne-Wellbutrin XL ingabekwa kuphela ngemuva kokuvakashelwa udokotela. Ngokuya ngomlando wakho wezokwelapha, ungahle unikezwe i-anti-depressant ehlukile.
Ufuna intengo engcono kakhulu ku-Wellbutrin XL?
Bhalisela izexwayiso zentengo ye-Wellbutrin XL bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Ukuqhathaniswa kanye nezindleko ze-Wellbutrin SR vs. Wellbutrin XL
I-Wellbutrin SR iyatholakala njengethebhulethi yomlomo ejwayelekile. Imvamisa imbozwa yiMedicare nezinhlelo eziningi zomshuwalense. Igama lomkhiqizo i-Wellbutrin SR ingabiza inani lentengo elingange- $ 516 ngokunikezwa kwezinsuku ezingama-60 kwamathebulethi ayi-150 mg. Uma usebenzisa ikhadi lesaphulelo le-SingleCare le-generic bupropion, izindleko zingancishiswa zibe yintengo ebiza kakhulu. Ukuthenga i-Wellbutrin SR ngekhadi lesaphulelo kunganciphisa izindleko ziye ku- $ 9 kuma-pharmacy abambe iqhaza.
Thola ikhadi lesaphulelo sakwaSingleCare
Uhlobo olujwayelekile lwe-Wellbutrin XL luvame ukumbozwa yi-Medicare nezinye izinhlelo zomshuwalense. Igama lomkhiqizo i-Wellbutrin XL ingaba nezindleko ezingaphandle kwezikhwama ezingaphezu kwe- $ 1000. Usebenzisa isigqebhezana se-generic bupropion, intengo ingama- $ 9- $ 31 kuphela. Hlola ukubona ukuthi ikhemisi lakho lamukela amakhadi e-SingleCare ngezaphulelo zemithi kadokotela.
| I-Wellbutrin SR | I-Wellbutrin XL | |
| Ngokuvamile embozwe umshwalense? | Yebo; i-generic imboziwe | Yebo; i-generic imboziwe |
| Imbozwe ngokujwayelekile yi-Medicare? | Yebo; i-generic imboziwe | Yebo; i-generic imboziwe |
| Umthamo ojwayelekile | Amaphilisi angu-150 mg (ama-60 count) | Amaphilisi angu-150 mg (ukubalwa okungu-30) |
| I-Medicare copay ejwayelekile | $ 0- $ 47 | $ 0- $ 51 |
| Izindleko ze-SingleCare | $ 9 | $ 9- $ 31 |
Imiphumela emibi ejwayelekile ye-Wellbutrin SR vs. Wellbutrin XL
Imiphumela emibi ejwayelekile ye-Wellbutrin SR ne-Wellbutrin XL ifaka ikhanda, umlomo owomile, nesicanucanu. Eminye imiphumela emibi ibandakanya i-CNS (uhlelo oluphakathi lwezinzwa) futhi ifaka isiyezi, ukuqwasha kanye nokukhathazeka.
I-Wellbutrin nayo ingadala imiphumela emibi yamathumbu njengokucasuka kwesisu nokuqunjelwa. Eminye imiphumela emibi ejwayelekile ingafaka ukushaya kwenhliziyo, ukundindizela, i-tinnitus (ukukhala ezindlebeni), ubuhlungu bemisipha nokuqubuka. Ukwehla kwesisindo nokuzuza kwesisindo kungeminye imiphumela engemihle ehlotshaniswa neWellbutrin.
Imiphumela emibi ne-Wellbutrin ayivamile futhi ivame ukuhlotshaniswa nokudlula ngokweqile. Imiphumela emibi ifaka phakathi ukusangana, i-arrhythmia (izinkinga zesigqi senhliziyo), umfutho wegazi ophansi, nokuquleka.
| I-Wellbutrin SR | I-Wellbutrin XL | |||
| Imiphumela emibi | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ubuhlungu bekhanda | Yebo | 26% | Yebo | 2. 3% |
| Umlomo owomile | Yebo | 3% | Yebo | 7% |
| Isicanucanu | Yebo | 13% | Yebo | 8% |
| Ukuqwasha | Yebo | ishumi nanye% | Yebo | 6% |
| Isiyezi | Yebo | 7% | Yebo | 5% |
| Umphimbo obuhlungu | Yebo | 3% | Yebo | amaphesenti amabili |
| Ukuqunjelwa | Yebo | 10% | Yebo | 7% |
| Ukukhathazeka | Yebo | 5% | Yebo | 3% |
| Isisu esibuhlungu | Yebo | 3% | Yebo | amaphesenti amabili |
| Tinnitus | Yebo | 6% | Yebo | amaphesenti amabili |
| Ukuthuthumela | Yebo | 6% | Yebo | 1% |
| Ukushaya kancane | Yebo | amaphesenti amabili | Yebo | amaphesenti amabili |
| Ubuhlungu bemisipha | Yebo | amaphesenti amabili | Yebo | 3% |
| Ukujuluka | Yebo | 6% | Yebo | amaphesenti amabili |
| I-Rash | Yebo | 5% | Yebo | 1% |
Lokhu kungenzeka kungabi uhlu oluphelele. Xhumana nodokotela wakho noma wemithi ngeminye imiphumela emibi.
Umthombo: DailyMed ( I-Wellbutrin SR ), IDailyMed ( I-Wellbutrin XL )
Ukusebenzisana kwezidakamizwa kwe-Wellbutrin SR ne-Wellbutrin XL
I-Bupropion icutshungulwa esibindini yi-CYP2B6 enzyme ukwakha i-metabolite esebenzayo ebizwa nge-hydroxybupropion. Izidakamizwa ezivimba (zivimbela) noma ezikhuthazayo (ezikhuthaza) le enzyme zingashintsha imiphumela ye-bupropion. Ama-CYP2B6 inhibitors angakhuphula izinga le-bupropion egazini elingakhuphula ubungozi bemiphumela emibi. Ama-inducers we-CYP2B6 angehlisa amazinga egazi e-bupropion futhi anciphise ukusebenza kwawo.
I-Bupropion nayo ingathinta i-enzyme ye-CYP2D6 futhi iguqule imiphumela yezinye izidakamizwa ezicutshungulwa yiyo. Eminye imishanguzo efana ne-monoamine oxidase inhibitors (MAOIs) ingakhuphula ubungozi bokuzwela kwe-hypersensitivity nemicimbi emibi. Izidakamizwa ezehlisa umkhawulo wokubanjwa zingakhuphula ubungozi bokuquleka kulabo abathatha i-bupropion.
| Izidakamizwa | Isigaba Sezidakamizwa | I-Wellbutrin SR | I-Wellbutrin XL |
| I-Ticlopidine I-Clopidogrel | I-CYP2B6 inhibitors | Yebo | Yebo |
| I-Ritonavir Lopinavir I-Efavirenz I-Carbamazepine Phenytoin | Ama-inducers we-CYP2B6 | Yebo | Yebo |
| I-Venlafaxine I-Nortriptyline Imipramine I-Desipramine I-Haloperidol I-Risperidone I-Thioridazine I-Metoprolol I-Propafenone | Izidakamizwa ezenziwe yi-CYP2D6 | Yebo | Yebo |
| I-Rasagiline USelegiline Isocarboxazid I-Phenelzine | I-Monoamine oxidase inhibitors (MAOIs) | Yebo | Yebo |
| ULevodopa I-Amantadine | Izidakamizwa ze-Dopaminergic | Yebo | Yebo |
| Theophylline I-Aminophylline I-Clozapine I-Baclofen | Izidakamizwa ezehlisa umkhawulo wokubamba | Yebo | Yebo |
| I-Digoxin | I-glycoside yenhliziyo | Yebo | Yebo |
Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.
Izexwayiso ze-Wellbutrin SR ne-Wellbutrin XL
I-Wellbutrin SR ne-Wellbutrin XL ingakhuphula ubungozi bokucabanga ukuzibulala nokuziphatha. Njengamanye ama-anti-depressants, le mithi kufanele ibhekwe ngokuziphatha okusha noma okubi kokuzibulala.
I-Wellbutrin SR ne-Wellbutrin XL zombili zinezingozi zokubamba, ikakhulukazi ngemithamo ephezulu. Labo abanomlando wokuphazamiseka kokuquleka kufanele babonane nodokotela ngaphambi kokuthatha iWellbutrin. Ukuthatha i-Wellbutrin kungakhuphula izehlakalo zokuquleka.
I-Wellbutrin inokunye izinyathelo zokuzivikela njengokunyuka komfutho wegazi. Ngakho-ke, kubalulekile ukubuka ukushintsha kwengcindezi yegazi. Labo abathatha imishanguzo yegazi bangadinga ukulungisa ukwelashwa kwabo nodokotela wabo.
Ukusetshenziswa kwe-bupropion kwaziwa ukuthi kubangela ukusabela kwengqondo okufana ne-mania, i-hallucinations, i-paranoia, ukukhohlisa, nokushintsha kwemizwelo. Landela udokotela uma uhlangabezana nale miphumela.
Imibuzo ebuzwa njalo nge-Wellbutrin SR vs. Wellbutrin XL
Yini i-Wellbutrin SR?
I-Wellbutrin SR iqukethe ukwakheka okuqhubekayo kokukhishwa kwe-bupropion. Kuyi-norepinephrine-dopamine reuptake inhibitor (NDRI) elinganisa ama-neurotransmitters ebuchosheni. Kunqunywe kabili ngosuku ukwelapha izimpawu zokucindezeleka.
Yini i-Wellbutrin XL?
I-Wellbutrin XL iqukethe i-bupropion ekhishwe isikhathi eside. Ikhishwa kancane emzimbeni uma iqhathaniswa ne-Wellbutrin SR. I-Wellbutrin XL ivunyelwe ukwelapha ukucindezeleka futhi ivimbele ukuphazamiseka kokuphazamiseka kwesizini. Kunqunywe kanye ngosuku.
Ingabe i-Wellbutrin SR ne-Wellbutrin XL ziyefana?
Cha. I-Wellbutrin SR ne-Wellbutrin XL akuzona izidakamizwa ezifanayo. I-Wellbutrin XL ifomu lokukhululwa elandisiwe le-bupropion elihlala isikhathi eside emzimbeni. Banokungafani kokusebenzisa kokulinganisa nokuvunyelwa.
Ngabe i-Wellbutrin SR noma i-Wellbutrin XL ingcono?
I-Wellbutrin SR ne-Wellbutrin XL zombili zisebenza ukunciphisa izimpawu zokucindezeleka. I-Wellbutrin XL ingahle ikhethwe ngokulinganisa kwayo kwansuku zonke. Kungaba ngcono futhi ekwelapheni ukudangala phakathi nezinguquko ezithile zonyaka (ukuphazamiseka kwesizini).
Ngingayisebenzisa i-Wellbutrin SR noma i-Wellbutrin XL ngenkathi ngikhulelwe?
I-Wellbutrin SR noma i-Wellbutrin XL kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma izinzuzo ezingaba khona zidlula ubungozi. Le mithi kufanele ixoxwe nomhlinzeki wezokunakekelwa kwempilo ngaphambi kokuyisebenzisa ngesikhathi sokukhulelwa noma lapho uncelisa.
Ngingayisebenzisa i-Wellbutrin SR noma i-Wellbutrin XL ngotshwala?
I-Wellbutrin SR noma i-Wellbutrin XL akufanele ithathwe ngotshwala. Ukuphuza utshwala kungaholela engozini eyengeziwe yemiphumela emibi. Utshwala kufanele bugwenywe ngale mithi.
Ingabe i-Wellbutrin iyayithinta inkumbulo?
Imemori eyehlisiwe ingumphumela ohlangothini wokuthatha i-Wellbutrin. Kodwa-ke, kungahle kungabi njengokujwayelekile njengeminye imiphumela emibi njengesiyezi, ikhanda elibuhlungu nomlomo owomile.
Kungani iWellbutrin ingenza ngizizwe ngiphezulu?
I-Wellbutrin yandisa umsebenzi we-norepinephrine ne-dopamine ebuchosheni. La ma-neurotransmitters athathwa njengamakhemikhali azizwa kahle. Lo muzwa uvame ukuvela ngemuva kokuthatha umthamo ophakeme we-bupropion.
Wenzani uWellbutrin ebuchosheni?
I-Wellbutrin ivimbela ukutholwa kabusha kwe-norepinephrine ne-dopamine. Ngenxa yalokho, lesi sidakamizwa sithuthukisa umsebenzi wala ma-neurotransmitters. I-Wellbutrin ingasetshenziselwa ukwelapha izimo zempilo yengqondo ezithintwe yilawa makhemikhali ebuchosheni.
Ingabe i-Wellbutrin ilapha ukukhathazeka?
I-Wellbutrin ayivunyelwe ukwelapha ukukhathazeka. Eqinisweni, i-Wellbutrin ingadala ukukhathazeka njengomphumela wecala. I-Wellbutrin isetshenziselwa ukwelapha izimpawu zokucindezeleka.
