Incruse Ellipta vs. Spiriva: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Ngokusho kwe- I-American Lung Association , isifo esingelapheki sokuvimbela kwamaphaphu, noma i-COPD, siyimbangela yesithathu ehamba phambili yokufa kwezifo e-U.S. Abantu abangaphezu kwezigidi eziyi-16 batholakale bene-COPD, abanezigidi ezingathinteka kakhulu kodwa abangakazazi. I-COPD yisifo esingapheli sokuvuvukala kwamaphaphu. Iziguli ezine-COPD zivame ukuzwa ubunzima bokuphefumula, ukukhwehlela, ukuphefumula, nokukhiqizwa kwamafinyila. I-COPD ifaka i-emphysema ne-bronchitis engapheli. Imithi emibili ejwayelekile esetshenziselwa ukuphatha i-COPD yimithi yokuhogela ngomlomo ebizwa nge-Incruse Ellipta noSpiriva.
I-Incruse Ellipta ne-Spiriva yomibili imishanguzo enegama lomkhiqizo ekhonjiswe ekwelashweni kwesikhathi eside kokugcinwa kwe I-COPD . Zombili lezi zidakamizwa zivunywa yi-U.S. Food and Drug Administration (FDA). Bahlukaniswa eqenjini lemithi ebizwa nge-anticholinergics. Zisebenza ngokudambisa imisipha emaphashini, okwenza ukuphefumula kube lula.
Yize i-Incruse Ellipta neSpiriva zombili zingama-anticholinergics asetshenziselwa i-COPD, awafani ncamashi. Qhubeka ufunde ngezansi ukuze ufunde kabanzi ngomuthi ngamunye.
Uyini umehluko omkhulu phakathi kwe-Incruse Ellipta noSpiriva?
I-Incruse Ellipta ne-Spiriva yimithi elwa ne-anticholinergic, etholakala ngegama lomkhiqizo kuphela. Baziwa futhi njengabaphikisi be-muscarinic abasebenza isikhathi eside (i-LAMA).
Igama lamakhemikhali le-Incruse Ellipta ngu-umeclidinium. Itholakala ngefomu le-inhaler kuphela. IGlaxoSmithKline (GSK) yenza i-Incruse Ellipta.
Igama lamakhemikhali likaSpiriva yi-tiotropium bromide. Itholakala njenge-capsule yomlomo (ye-inhalation yomlomo, engagwinywa-ebizwa nangokuthi i-powder eyomile inhaler) nenkungu yomlomo yokuhogela. I-Boehringer Ingelheim Pharmaceuticals yenza iSpiriva.
| Umehluko omkhulu phakathi kwe-Incruse Ellipta noSpiriva | ||
|---|---|---|
| Faka i-Ellipta | Spiriva | |
| Isigaba sezidakamizwa | I-Anticholinergic | I-Anticholinergic |
| Isimo somkhiqizo / ejwayelekile | Umkhiqizo | Umkhiqizo |
| Ngubani igama elijwayelekile? | Umeclidinium | I-Tiotropium bromide |
| Izidakamizwa zingena ngaziphi izinhlobo? | Faka i-Ellipta Inhaler (i-inhalation powder) | I-Spiriva Handihaler (amaphilisi we-inhalation), i-Spiriva Respimat (inkungu yokuphefumula) |
| Uyini umthamo ojwayelekile? | Ukuphefumula ngomlomo okukodwa (62.5 mcg) kanye nsuku zonke ngasikhathi sinye nsuku zonke | I-Spiriva Handihaler: Ukuhogela okomlomo kabili kokuqukethwe kwempuphu kwe-Spiriva capsule eyodwa (18 mcg) kanye ngosuku, nedivayisi ye-Handihaler (amaphilisi enzelwe ukuhogela ngomlomo kuphela; hhayi ukugwinya) I-Spiriva Respimat: 2 i-inhalations yomlomo (ye-1.25 mcg noma i-2.5 mcg) kanye ngosuku |
| Yelashwa isikhathi esingakanani? | Isikhati eside | Isikhati eside |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala | Handihaler: Abantu abadala Impendulo: Abantu abadala nezingane ezineminyaka eyisithupha nangaphezulu |
Imibandela elashwe ngu-Incruse Ellipta noSpiriva
Incruse Ellipta noSpiriva kukhonjisiwe ekwelashweni kwesifo sesifo samaphaphu esingamahlalakhona (COPD). Ngokuqondile, imininingwane yabakhiqizi beSpiriva Handihaler iphawula ukuthi isetshenziselwa ukunciphisa ukukhuphuka kweziguli zeCOPD.
ISpiriva Respimat inesinye isibonakaliso esingeziwe — ukwelashwa kokulondolozwa kwesifuba somoya ezigulini ezineminyaka engu-6 nangaphezulu.
Asikho isidakamizwa okufanele sisetshenziselwe ukuhlaselwa okunamandla.
| Isimo | Faka i-Ellipta | Spiriva |
| Ukwelashwa kwesondlo kwe-COPD | Yebo | Yebo (Handihaler ne-Respimat) |
| Ukwelashwa kokunakekelwa kwesifuba somoya ezigulini ezineminyaka eyisithupha nangaphezulu | Akunjalo | Yebo (Phendula) |
Ingabe i-Incruse Ellipta noma i-Spiriva isebenza kangcono?
Kunemininingwane emincane eqhathanisa lezi zidakamizwa ezimbili ngqo. A Isifundo samaviki ayi-12 kuqhathaniswa nokusebenza nokuphepha kuka-Incruse Ellipta noSpiriva ezigulini ezingaphezu kuka-1 000 ezine-COPD. Iphoyinti lokugcina eliyinhloko lalingumthamo ophoqelelwe wokuphefumula ngomzuzwana owodwa (obizwa nangokuthi i-FEV1) ngosuku lwama-85. Iziguli zahlolwa kusetshenziswa i-St George's Respiratory Questionnaire nokunye ukuhlola. Zombili lezi zidakamizwa zikhombise ukuthuthuka okunengqondo kwikhwalithi yempilo futhi zabekezelelwa kahle ngokuphepha. Ucwaningo luphethe ukuthi i-Incruse Ellipta isebenze kangcono kuneSpiriva.
Umhlinzeki wakho wezokunakekelwa kwempilo kuphela onganquma umuthi osebenza kakhulu kuwe. Angabheka ubunzima bezimpawu zakho nomlando wakho wezokwelapha, kanye neminye imithi oyisebenzisayo engahle isebenzisane no-Incruse Ellipta noma uSpiriva.
Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kwe-Incruse Ellipta vs. Spiriva
Izinhlelo zomshwalense kanye ne-Medicare Part D zihlanganisa kokubili i-Incruse Ellipta ne-Spiriva, kodwa inani lokumbozwa liyahluka ngohlelo.
Intengo ephuma ephaketheni le-Incruse Ellipta inhaler cishe ingama- $ 477, kepha ungasebenzisa ikhadi le-SingleCare ukwehlisa intengo ibe ngu- $ 306.
Intengo ephuma ephaketheni leSpiriva Handihaler cishe ingama- $ 634, kanti iSpiriva Respimat icishe ibe ngu- $ 600. Ukusebenzisa isigqebhezana se-SingleCare kuzokwehlisa intengo ifike ku- $ 404 ye-Handihaler noma i-Respimat.
| Faka i-Ellipta | Spiriva | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | 1 i-inhaler | I-1 Handihaler noma i-1 Respimat |
| I-Medicare copay ejwayelekile | $ 8- $ 395 | $ 3- $ 524 |
| Izindleko ze-SingleCare | $ 306 + | $ 404 + |
Imiphumela emibi ejwayelekile ye-Incruse Ellipta vs. Spiriva
Imiphumela emibi kakhulu ye-Incruse Ellipta yi-nasopharyngitis (umkhuhlane ovamile), ukutheleleka okuphezulu okuphefumulayo nokuphefumula.
Imiphumela emibi kakhulu kaSpiriva ukutheleleka okuphezulu okuphefumulayo, i-sinusitis, ubuhlungu besifuba, umlomo owomile, ukuqunjelwa, kanye nokutheleleka komgudu womchamo.
Lolu akulona uhlu oluphelele lwemiphumela emibi. Eminye imiphumela emibi kungenzeka. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola uhlu olugcwele lwemiphumela emibi ye-Incruse Ellipta noSpiriva.
| Faka i-Ellipta | Spiriva | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| I-Nasopharyngitis / pharyngitis | Yebo | 8% | Yebo | 9% |
| Ukutheleleka okuphezulu okuphefumulayo | Yebo | 5% | Yebo | 41% |
| Khwehlela | Yebo | 3% | Yebo | > 3% |
| Ubuhlungu besifuba | Akunjalo | - | Yebo | 7% |
| Umlomo owomile | Akunjalo | - | Yebo | 16% |
| Ukuqunjelwa | Akunjalo | - | Yebo | 4% |
| Ukuhlanza | Akunjalo | - | Yebo | 4% |
| Isinusitis | Yebo | Akubikiwe | Yebo | ishumi nanye% |
| I-Rash | Yebo | Akubikiwe | Yebo | 4% |
| I-Arthralgia (ubuhlungu obuhlangene) | Yebo | amaphesenti amabili | Yebo | 4.2% |
| Ukutheleleka ngomgudu womchamo | Yebo | Akubikiwe | Yebo | 7% |
Umthombo: DailyMed ( Faka i-Ellipta ), IDailyMed ( Spiriva )
Ukusebenzisana kwezidakamizwa kwe-Incruse Ellipta vs. Spiriva
Ngoba i-Incruse Ellipta ne-Spiriva yimithi yokwelapha i-anticholinergic, akufanele isetshenziswe neminye imithi ye-anticholinergic. Inhlanganisela ingadala ukwanda kwemiphumela emibi, njengokugcinwa komchamo noma i-glaucoma emincane.
Okunye ukuxhumana kwezidakamizwa kungenzeka. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola uhlu oluphelele lokuhlangana kwezidakamizwa.
| Izidakamizwa | Isigaba sezidakamizwa | Faka i-Ellipta | Spiriva |
| Ama-alkaloid eBelladonna I-Benztropine Clidinium I-Darifenacin Dicclomine I-Diphenhydramine IHyoscyamine Ipratropium I-Orphenadrine I-Oxybutynin I-Scopolamine I-Solifenacin I-Tolterodine I-Trihexyphenidyl | Ama-anticholinergics | Yebo | Yebo |
Izixwayiso ze-Incruse Ellipta noSpiriva
- Ungayisebenzisi i-Incruse Ellipta noma i-Spiriva uma une-hypersensitivity enamandla ebeleni amaprotheni noma ezinye izithako.
- I-Incruse Ellipta noma i-Spiriva ayihloselwe ukuthi isetshenziselwe ukwehla ngokushesha noma iziqephu ze-COPD ezisongela impilo. Le mithi ayifundwanga ngeziqephu ezibucayi futhi akufanele isetshenziselwe ukukhulula izimpawu ezinzima. Ungathathi imithamo eyengeziwe yokukhululeka kwezimpawu ezinzima. Umhlinzeki wakho wezokunakekelwa kwempilo kufanele akunikeze imiyalo ekuphatheni isiqephu esibucayi-uzosebenzisa i-inhaler ehlukile, esebenza okwesikhashana njenge-inhaler yokutakula.
- I-Incruse Ellipta noma i-Spiriva ingadala i-bronchospasm ephikisayo engasongela impilo (ukuwohloka kokuphefumula noma ukuphefumula), okufanele iphathwe ngokushesha nge-bronchodilator inhaler emfushane. Uma lokhu kwenzeka, yeka i-Incruse Ellipta noma i-Spiriva ngokushesha. Umhlinzeki wakho wezokunakekelwa kwempilo angakuyalela enye indlela yokwelashwa.
- Ukufaka i-Ellipta noma i-Spiriva kungadala ukusabela kwe-hypersensitivity, kufaka phakathi i-anaphylaxis, i-angioedema, ukulunywa, noma ukuqubuka. Nqamula i-Incruse Ellipta noma i-Spiriva bese uxhumane nomhlinzeki wakho wezokunakekelwa kwezempilo uma kwenzeka okunye kwalokhu kuphendula. Uma unenkinga yokuphefumula noma uhlangabezana nokuvuvukala ezindebeni zakho, olimini nasemlonyeni, funa ukwelashwa okuphuthumayo.
- Sebenzisa i-Incruse Ellipta noma i-Spiriva ngokuqapha ezigulini ezine-glaucoma emincane. Iziguli kanye nabadokotela bazo kufanele babheke izimpawu ze-glaucoma e-acute-angle glaucoma (ubuhlungu beso, umbono ophuphuthekile, ama-halos abukwayo). Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ngokushesha uma kukhona kulezi zimpawu.
- Sebenzisa i-Incruse Ellipta noma iSpiriva ngokuqapha ezigulini ezinokugcinwa komchamo. Iziguli nabadokotela kufanele bazi izimpawu zokugcina umchamo, njengokuchama kabuhlungu nobunzima bokuchama. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ngokushesha uma uhlangabezana nalezi zimpawu.
I-Spiriva kuphela:
- Gada iziguli ezinokukhubazeka kwezinso okulingene nokulingene ngemiphumela ye-anticholinergic.
- Ama-capsules enzelwe ukuhogela ngomlomo kuphela futhi akufanele agwinywe. Sebenzisa amaphilisi kuphela ngedivayisi ye-Handihaler.
Imibuzo ebuzwa njalo nge-Incruse Ellipta vs. Spiriva
Yini i-Incruse Ellipta?
Incruse Ellipta umuthi we-anticholinergic osetshenziselwa i-COPD. Kuyasiza ukukhulula amaphaphu, okwenza ukuphefumula kube lula.
Kuyini uSpiriva?
I-Spiriva nayo iyimithi elwa ne-anticholinergic esetshenziselwa i-COPD. Itholakala njenge-capsule ehogelwayo futhi njengenkungu yokuhogela.
Ngabe i-Incruse Ellipta noSpiriva bayefana?
Yomibili le mithi iyafana futhi isesigabeni esifanayo semithi. Kodwa-ke, banokunye umehluko, njengemiphumela emibi kanye nomthamo, okuchazwe ngenhla.
Ngabe i-Incruse Ellipta noma iSpiriva ingcono?
Imininingwane ekhawulelwe iyatholakala ngokuqhathanisa i-Incruse Ellipta ne-Spiriva. Ucwaningo olulodwa lukhombise ukuthi i-Incruse Ellipta isebenze kangcono, kepha yomibili le mithi kufanele iphephe ngokulinganayo. Umhlinzeki wakho wezokunakekelwa kwezempilo anganquma ukuthi imuphi umuthi ongcono kuwe.
Ngingayisebenzisa yini i-Incruse Ellipta noma iSpiriva ngenkathi ngikhulelwe?
Alukho ulwazi olwanele ngemiphumela ye-Incruse Ellipta noma iSpiriva ekukhulelweni. Xhumana ne-OB-GYN yakho ukuthola izeluleko zezokwelapha. Uma usuvele uthatha i-Incruse Ellipta noma iSpiriva bese uthola ukuthi ukhulelwe, thintana ne-OB-GYN yakho.
Ngingasebenzisa i-Incruse Ellipta noma iSpiriva ngotshwala?
Yize i-Incruse Ellipta noma iSpiriva ingahlangani notshwala, ukuphuza utshwala isikhathi eside kungakhuphula izimpawu ze-COPD futhi kunciphise amasosha akho omzimba, kubhebhethekise izimpawu zakho ze-COPD. Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ngolwazi oluthe xaxa mayelana notshwala ne-COPD.
Ingabe i-Incruse Ellipta iyi-steroid?
Cha. Incruse Ellipta akuyona i-steroid. Ihlukaniswa njengomuthi we-anticholinergic. Ixegisa imisipha esemigwaqweni yomoya ukwenza ukuphefumula kube lula.
Amanye ama-inhalers aqukethe i-corticosteroid emuncu futhi asetshenziselwa ukwelapha i-COPD. I-Advair iqukethe i-fluticasone (i-steroid) ne-salmeterol (i-beta-agonist esebenza isikhathi eside). Esinye isibonelo yiBreo Ellipta, equkethe i-fluticasone furoate (i-steroid) ne-vilanterol (i-beta-agonist esebenza isikhathi eside).
Iyiphi i-inhaler elingana ne-Spiriva?
Amanye ama-inhalers asesigabeni esifanayo seSpiriva ne-Incruse Ellipta afaka iTudorza Pressair (aclidinium) noSeebri Neohaler (glycopyrrolate).
Yini i-inhaler enhle kakhulu ye-COPD?
Lowo ngumbuzo onzima. Kuya ngezici ezimbalwa, njengobukhali nohlobo lwezimpawu, umlando wakho wezokwelapha, neminye imithi oyithathayo. Umhlinzeki wakho wezokunakekelwa kwempilo anganquma ukuthi iyiphi i-inhaler ekulungele.
Kunemithi eminingi ehogelwe emakethe. Nazi izindlela ezimbalwa zokwelashwa ezifakwa ngaphakathi ze-COPD:
I-SABA (abasebenza ngama-bronchodilator amafushane, noma ama-beta-agonists abamba iqhaza): I-Albuterol HFA, i-Proair HFA, i-Proventil HFA, i-Ventolin HFA, i-Xopenex
Ama-LABAs (i-beta2 agonists esebenza isikhathi eside): I-Brovana (arformoterol), iSerevent (salmeterol)
Ama-LAMA (abaphikisi be-muscarinic abasebenza isikhathi eside): Incruse Ellipta (umeclidinium), Seebri (glycopyrrolate), Spiriva (tiotropium) Respimat noma Handihaler, Tudorza Pressair (aclidinium)
Inhlanganisela ye-LAMA + LABA inhaler: I-Anoro Ellipta (umeclidinium / vilanterol), Bevespi Aerosphere (glycopyrrolate / formoterol), iStiolto Respimat (olodaterol / tiotropium),
I-Utibron Neohaler (indacaterol / glycopyrrolate)
I-corticosteroids emuncwe: I-Qvar RediHaler (beclomethasone), iPulmicort Flexhaler (budesonide)
Inhlanganisela ye-corticosteroid + LABA: Symbicort (budesonide / formoterol), Advair (fluticasone / salmeterol), Breo (fluticasone / vilanterol), iDulera (mometasone / formoterol)
