I-Xiidra vs.Restasis: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

Ukubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa

I-Xiidra (i-lifitegrast) ne-Restasis (i-cyclosporine) yimithi enegama lomkhiqizo esetshenziselwa ukwelapha isifo samehlo esomile. Abantu abanesifo samehlo esomile babhekana nokushoda okungapheli komswakama emehlweni futhi kungenzeka bangakwazi ukukhipha izinyembezi ezanele zokugcoba amehlo. Lesi simo singaholela ekuhluphekeni kwamehlo nezinkinga zokufunda noma ukusebenza kwikhompyutha, phakathi kwezinye izinkinga. I-Xiidra neRestasis yimithi yokudonsa iso esetshenziswa kuwo womabili amehlo nsuku zonke.

Uyini umehluko omkhulu phakathi kweXiidra neRestasis?

Xiidra

I-Xiidra, eyaziwa nangokuthi igama layo elejwayelekile, i-lifitegrast, yenziwa yi-Shire. Kwakungu-FDA evunyelwe ngo-2016 ekilasini elisha lemithi elibizwa ngokuthi yi-lymphocyte anti-1 anti-1 (LFA-1) antagonists. Indlela ngqo esebenza ngayo ayaziwa. Kodwa-ke, kukholakala ukuthi kunciphisa ukuvuvukala nokwanda ukukhiqizwa kwezinyembezi ngokuvimba iprotheni ebizwa nge-LFA-1 ekusebenzisaneni nenye iphrotheni ebizwa nge-ICAM-1 emehlweni.

I-Xiidra yisixazululo se-5% se-topical iso esilawulwa njengethonsi elilodwa esweni ngalinye kabili ngosuku (cishe amahora ayi-12 ahlukene). Kungasiza ukukhulula ukoma esweni kungakapheli amasonto amabili, noma kungathatha amasonto ayisithupha kuya kwayishumi nambili ukuhlinzeka ukukhululeka okuphelele kwabanye abantu.

I-Restasis

I-Restasis yayigunyazwe yi-FDA ngo-1983 ukwelapha ukoma emehlweni. Yenziwe yi-Allergan futhi yaziwa ngegama layo elijwayelekile, i-cyclosporine. I-Restasis kukholakala ukuthi isebenza ngokulawula izinqubo zokuvuvukala esweni ezingathinta ukukhiqizwa kwezinyembezi.

I-Restasis iyi-emulsion yamehlo engu-0.05% efakwe emehlweni womabili kabili ngosuku noma njalo ngamahora ayi-12. Kungathatha izinyanga ezintathu ukuthola usizo ngeRestasis. Kwabanye abantu, kungathatha izinyanga eziyisithupha ukuthola usizo olwanele.

Umehluko omkhulu phakathi kweXiidra neRestasis
	Xiidra	I-Restasis
Isigaba sezidakamizwa	Umphikisi we-lymphocyte anti-1 (LFA-1) ohlobene nomsebenzi	I-Calcineurin inhibitor immunosuppressant
Isimo somkhiqizo / ejwayelekile	Ayikho inguqulo ejwayelekile etholakalayo	Ayikho inguqulo ejwayelekile etholakalayo
Ngubani igama elijwayelekile?	I-Lifitegrast	ICyclosporine
Izidakamizwa zingena ngaziphi izinhlobo?	Isixazululo se-ophthalmic	I-Ophthalmic emulsion
Uyini umthamo ojwayelekile?	Ukudonsa okukodwa esweni ngalinye kabili ngosuku noma njalo ngamahora ayi-12	Ukudonsa okukodwa esweni ngalinye kabili ngosuku noma njalo ngamahora ayi-12
Yelashwa isikhathi esingakanani?	Lo muthi usetshenziswa njengokwelashwa kwesikhathi eside	Lo muthi usetshenziswa njengokwelashwa kwesikhathi eside
Ubani ovame ukusebenzisa umuthi?	Abantu abadala nentsha eneminyaka engu-17 nangaphezulu	Abantu abadala kanye nentsha eneminyaka engu-16 nangaphezulu

Izimo eziphathwe yiXiidra neRestasis

I-Xiidra neRestasis zombili zivunyelwe ukwelapha isifo samehlo esomile, okunye okubizwa nangokuthi i-eye eye syndrome . Isifo samehlo omile singahlotshaniswa nezinye izimo zamehlo njenge-blepharitis, noma ukuvuvukala kwamajwabu amehlo, okubangelwa ukungezwani komzimba noma ezinye izinkinga. Le mithi isiza ukukhulisa ukukhiqizwa kwezinyembezi futhi inciphise ukuvuvukala ebusweni be-ocular.

Ngaphezu kokoma, i-Xiidra ne-Restasis zingasiza ekwelapheni ezinye izimpawu zesifo esomile, kufaka phakathi ukubomvu emehlweni, ukukhathala kwamehlo, ukubona okufiphele kanye nokuchachamba kwamehlo. Abanye odokotela bangancoma ukwelashwa okwengeziwe ngenkathi usebenzisa i-Xiidra noma i-Restasis, njengokucindezela okufudumele ukuthambisa iso.

Isimo	Xiidra	I-Restasis
Isifo samehlo esomile	Yebo	Yebo

Ingabe i-Xiidra noma i-Restasis isebenza kangcono?

Okwamanje azikho izivivinyo zomtholampilo eziqhathanisa ngqo ukusebenza kwe-Xiidra kuqhathaniswa ne-Restasis yezifo zamehlo ezomile. Kodwa-ke, yomibili le mithi ikhonjisiwe ukuthi iyasebenza ekuhlolweni kwemitholampilo uma iqhathaniswa ne-placebo. Umuthi osebenza kahle kakhulu yiwo okusebenzela kangcono kakhulu.

Kuzo zonke izivivinyo zomtholampilo ezingahleliwe ezine, ezinhlobonhlobo ukusebenza kahle nokuphepha kwe-lifitegrast ihlolwe ezigulini eziyi-1,181. Ekupheleni kwamasonto e-12, kube nokuthuthuka okuphawulekayo kwezimpawu kulabo abasebenzisa i-lifitegrast yesifo esomile. I-Eye Dryness Score isetshenziselwe ukuhlola ukungaphatheki kahle ngesikhathi sokwelashwa.

I-Cyclosporine, isithako esisebenzayo eRestasis, yayiyiyo wafunda ezilingweni ezine ezingahleliwe equkethe iziguli ezingaba ngu-1,200 ezinezimpawu ezomile ezinesilinganiso esilinganayo nesomile. Ngemuva kwezinyanga eziyisithupha, kwanda kakhulu ukukhiqizwa kwezinyembezi ku-15% weziguli ezelashwa nge-cyclosporine uma kuqhathaniswa no-5% weziguli ezelashwa nge-placebo.

Xhumana nomhlinzeki wezokunakekelwa kwezempilo ukuze unqume ukuthi iyiphi indlela engcono yokwelashwa ongayisebenzisa. Ungathunyelwa kuchwepheshe wokunakekelwa kweso noma udokotela ogxile ku-ophthalmology ngesimo sakho.

Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweXiidra vs.Restasis

I-Xiidra ayivame ukumbozwa yizinhlelo zomshuwalense ze-Medicare. Ayikho enye indlela ejwayelekile etholakalayo yeXiidra, ngakho-ke ingahle ibize kakhulu. Inani leCopay lingahluka kakhulu ngokuya ngohlelo lomshuwalense. Ngaphandle komshuwalense, ikhadi lesigqebhezana le-SingleCare Xiidra lingakwazi ukusiza ukwehlisa intengo yemithi cishe ku- $ 580. Ngaphandle kwalokho, intengo ejwayelekile yokuthengisa yeXiidra icishe ibe ngu- $ 730.

I-Restasis itholakala kuphela njengomuthi wegama lomkhiqizo. Kodwa-ke, iningi lamaMedicare nezinhlelo zomshuwalense zizofaka iRestasis. Ama-Copays angahluka ngokuya ngohlelo lomshuwalense. Ngaphandle komshuwalense, intengo yemali emaphakathi yeRestasis icishe ibe ngu- $ 389. Sebenzisa isigqebhezana kungasiza ukwehlisa izindleko zeRestasis. Isigqebhezana se-SingleCare Restasis siyatholakala ukuthi sisetshenziswe emakhemisi abamba iqhaza futhi sizokwehlisa izindleko zeRestasis ziye ku- $ 255.

	Xiidra	I-Restasis
Ngokuvamile embozwe umshwalense?	Akunjalo	Yebo
Imbozwe ngokujwayelekile yi-Medicare Part D?	Akunjalo	Yebo
Ubuningi	Iziqukathi ezingama-60 zokusetshenziswa okukodwa	Izitsha ezingama-60
I-Medicare copay ejwayelekile	$ 3– $ 637	$ 19– $ 652
Izindleko ze-SingleCare	$ 578 +	$ 255 +

Imiphumela emibi ejwayelekile yeXiidra vs.Restasis

Imiphumela emibi kakhulu ye-Xiidra ukucasuka nokubomvu emehlweni, ukukhishwa kwamehlo, ikhanda elibuhlungu, nokubona okufiphele. I-Xiidra nayo ingadala ukunambitheka okungavamile emlonyeni, owaziwa nangokuthi yi-dysgeusia.

Imiphumela emibi ejwayelekile yeRestasis ifaka phakathi ukushisa, ukucasuka, nokubomvu emehlweni, kanye nokungaboni kahle. I-restasis ayaziwa ukuthi ibangele ukuqonda kokunambitheka okusontekile; kodwa-ke, kungenzeka kakhulu ukuthi kune-Xiidra kubangele umuzwa ovuthayo emehlweni ngemuva kokuphathwa.

Imiphumela emibi ye-Xiidra ne-Restasis ifaka ukusabela kwe-hypersensitivity. Izimpawu nezimpawu zokuphendula kwe-hypersensitivity zifaka ukuqubuka, ukuvuvukala, ukulunywa, nokuphefumula okuncane.

	Xiidra	I-Restasis
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ukucasuka kweso	Yebo	5% –25%	Yebo	1% –5%
Umuzwa ovuthayo emehlweni	Yebo	1% –5%	Yebo	17%
Ukubomvu kwamehlo	Yebo	1% –5%	Yebo	1% –5%
Ukubona okufiphele	Yebo	5% –25%	Yebo	1% –5%
Ukuzwa kokunambitheka okungavamile	Yebo	5% –25%	Akunjalo	-
Ukukhishwa kwamehlo	Yebo	1% –5%	Yebo	1% –5%
Ukungaphatheki kahle kwamehlo noma ubuhlungu	Yebo	1% –5%	Yebo	1% –5%
Ubuhlungu bekhanda	Yebo	1% –5%	Akunjalo	-

Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( Xiidra ), IDailyMed ( I-Restasis )

Ukusebenzisana kwezidakamizwa kweXiidra kuqhathaniswa neRestasis

Akukho ukuxhumana okuphawulekayo kwezidakamizwa okubikiwe ngeXiidra noma iRestasis. Eminye imishanguzo yokulahla iso kufanele igwenywe ngenkathi usebenzisa i-Xiidra noma i-Restasis ngaphandle kokuthi iqondiswe ngumhlinzeki wezokunakekelwa kwempilo. Tshela udokotela wakho nganoma yimiphi imithi okungenzeka uyayiphuza, njengemithi kadokotela, amavithamini, kanye nezithako zemithi.

Izexwayiso zeXiidra neRestasis

Ukuthinta ichopho lesitsha, isitsha, noma ibhodlela ngqo esweni noma ezindaweni ezizungezile kufanele kugwenywe ngesikhathi sokuphathwa. Ukwenza kanjalo kungakhuphula ubungozi bokungcola, okungaholela ukutheleleka emehlweni . Ukuthinta ichopho lesitsha, isitsha, noma ibhodlela emehlweni nakho kungadala ukulimala.

Ama-lens wokuxhumana kufanele asuswe ngaphambi kokufaka i-Xiidra noma i-Restasis. Ama-lens wokuxhumana angafakwa kabusha imizuzu eyi-15 ngemuva kokusebenzisa i-Xiidra noma i-Restasis.

Iziqukathi ezisetshenziswa kanye zeXiidra kufanele zisetshenziswe ngokushesha ngemuva kokuvula. Kufanele-ke zilahlwe ngemuva kokunikeza umuthi.

Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuthola ezinye izexwayiso kanye nezinyathelo zokuzivikela ezihambisana ne-Xiidra noma i-Restasis.

Imibuzo ebuzwa njalo ngeXiidra vs. Restasis

Kuyini i-Xiidra?

I-Xiidra yisixazululo se-ophthalmic esinegama lomkhiqizo esisetshenziselwa ukwelapha isifo samehlo esomile. Ihlukaniswe njengomphikisi we-LFA-1 evimba ukuxhumana kwamaprotheni athile ukunciphisa ukuvuvukala. Igama elijwayelekile likaXiidra liyi-lifitegrast; noma kunjalo, azikho izinhlobo ezijwayelekile zeXiidra okwamanje ezitholakalayo. IXiidra ilawulwa kabili nsuku zonke ukunciphisa ukoma emehlweni. Yenziwe yiShire.

Yini iRestasis?

I-Restasis yigama lomkhiqizo wesisombululo se-cyclosporine ophthalmic, esenziwa yi-Allergan. Inikezwa kabili ngosuku ukwelapha izimpawu zokoma emehlweni. Isebenza njenge i-calcineurin inhibitor immunosuppressant ukunciphisa ukuvuvukala nokwandisa ukukhiqizwa kwezinyembezi emehlweni. Azikho izinhlobo ezijwayelekile ze-Restasis okwamanje ezitholakalayo.

Ngabe iXiidra neRestasis ziyefana?

Kokubili iXiidra neRestasis kunezinto ezilwa nokuvuvukala, kepha azifani. UXiidra umphikisi we-LFA-1 ngenkathi i-Restasis iyi-calcineurin inhibitor. Akhiqizwa yizinkampani ezahlukahlukene ezenza imithi futhi eza ngezindlela ezahlukahlukene. I-Xiidra yisisombululo se-ophthalmic esiza ngeziqukathi zokusebenzisa okukodwa. I-Restasis iyi-emulsion ye-ophthalmic eza ngezimbiza zokusetshenziswa okukodwa noma ibhodlela elingenamthamo wokulondoloza eliningi.

Ngabe iXiidra noma iRestasis ingcono?

IXiidra neRestasis zombili ziyasebenza ekwelapheni izimpawu zamehlo ezingapheli. Kodwa-ke, iXiidra ingasusa izimpawu zamehlo ezomile ngokushesha kuneRestasis. IXiidra ingaqala ukusebenza kungakapheli amasonto amabili kuyilapho iRestasis ivame ukuthatha izinyanga ezintathu ukuqala ukukhulula ukoma emehlweni.

Ngingayisebenzisa iXiidra noma iRestasis ngenkathi ngikhulelwe?

Ukusebenzisa i-Xiidra noma i-Restasis ngenkathi ukhulelwe ngokuvamile kuphephile. Njengoba iXiidra neRestasis ziphathwa emehlweni, azingeni kakhulu egazini. Ngakho-ke, ubungozi bokukhubazeka kokuzalwa ngenkathi usebenzisa i-Xiidra noma i-Restasis buphansi. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ngezeluleko zezokwelapha uma ukhulelwe noma uncelisa.

Ngingayisebenzisa iXiidra noma iRestasis ngotshwala?

IXiidra neRestasis azingenisi egazini ngamanani amakhulu. Esikhundleni salokho, le mithi isebenza emehlweni. IXiidra neRestasis aziwa ukuthi ahlangana notshwala.

Ngabe iXiidra ingaphilisa amehlo omile?

I-Xiidra isetshenziselwa ukwelapha amehlo omile ahambisana nesifo samehlo esomile noma i-blepharitis. Isetshenziswa njengokwelashwa kwesikhathi eside ukukhulula amehlo omile. Uma i-Xiidra inqanyuliwe, ukoma kwamehlo kungabuya.

Ingabe i-Xiidra iyi-steroid?

I-Xiidra akuyona i-steroid. Iqukethe isithako esisebenzayo se-lifitegrast, esisebenza njengomphikisi we-lymphocyte ohlobene nomsebenzi antigen 1 (LFA-1). Isebenza ngokuvimba iprotheni ebizwa nge-LFA-1 ekusebenzisaneni neprotheyini ebizwa nge-ICAM-1. Ukusebenzisana kwala maprotheni kudlala indima ezinhlelweni zokuvuvukala emehlweni.

Ingabe i-Xiidra inciphisa ukuvuvukala?

I-Xiidra ngumuthi osebenzayo osiza ukunciphisa ukuvuvukala nokoma emehlweni. Ingaqala ukukhulula amehlo omile kungakapheli amasonto amabili, noma kungathatha amasonto afika kwayi-12 ukunikeza ukukhululeka okuphelele. I-Xiidra iphathwa kabili nsuku zonke njengesixazululo se-ophthalmic.

Ingabe ikhona enye indlela eshibhile kuneRestasis?

Kungaba khona enye indlela eshibhile ejwayelekile yokwenza i-Restasis okwamanje ekukhiqizweni kepha kungenzeka ingatholakali okwamanje. Umhlinzeki wakho wezokunakekelwa kwempilo angancoma umkhiqizo othengiswa ngaphandle njengokuthi izinyembezi zokufakelwa ukoma ngezikhathi ezithile noma ukucasuka emehlweni. I-Restasis ngumuthi onqunyiwe okhonjiswe ukwelapha izimpawu ezingamahlalakhona zesifo samehlo esomile.