I-FDA igunyaza iBiktarvy ukuthi isetshenziswe kuma-regimens e-HIV

Izindaba

Yize kungelona ikhambi le-HIV, ukuvunywa kwe-FDA kwakamuva kuzosiza abantu abane-HIV ukuthi baphile isikhathi eside. NgoFebhuwari 2018, Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) ivume ukusetshenziswa kweBiktarvy ekwelapheni ukutheleleka nge-HIV-1 kubantu abadala. Yize i-Biktarvy (noma yimuphi omunye umuthi wamanje we-HIV) ingakwazi ukwelapha i-HIV noma i-AIDS, ngokuhlangana neminye imithi ye-HIV, ingasiza abantu abane-HIV ukuthi baphile isikhathi eside futhi inciphise namathuba okuthelela abanye abantu.

I-biktarvy ingabhalwa ezigulini ezingakaze zithathe imishanguzo ye-HIV ngaphambilini. Ingaphindisela esikhundleni semithi ye-HIV yeziguli njengamanje ezisohlwini lwe-HIV. I-biktarvy akufanele iphuzwe neminye imishanguzo ye-HIV-1.

Kuyini iBiktarvy?

IBiktarvy yiphilisi eliqukethe izinto ezintathu ezisebenzayo. Eyodwa ibizwa ngokuthi i-bictegravir — isidakamizwa esisha. Isebenza ngokuvimba i-enzyme ye-HIV ebizwa nge-integrase. I-Integrase iyi-enzyme i-HIV ethembele kuyo ukuziphindaphinda futhi isabalale emzimbeni wonke, ngakho-ke ngokuvimba i-enzyme, i-bictegravir ivimbela i-HIV ukuthi ingaziphindeli futhi yehlise inani le-HIV emzimbeni. Ezinye izithako ezimbili ezisebenzayo yi-emtricitabine (eyaziwa nangokuthi Emtriva kanye ne-tenofovir alafenamide (eyaziwa nangokuthi yi-Vemlidy). Le mithi emibili, eyayivunyelwe ngaphambilini ukwelashwa nge-HIV-1, yilei-nucleoside reverse transcriptase inhibitors.Avimba i-enzyme ebizwa nge-reverse transcriptase, evimbela igciwane le-HIV ukuthi lizenzele amakhophi alo.

Yini iBiktarvy esetshenziselwa yona?

IBiktarvy, njengephilisi elilodwa eliqukethe imishanguzo emithathu, imisa i-HIV ekuphindaphindeni. Ngokumisa ukuphindaphindeka kwe-HIV, iBiktarvy inganciphisa inani legciwane emzimbeni (isilinganiso samangaki ama-virus ezinhlayiyana zemililitha egazini) emazingeni angatholakali. Iphinde inyuse inani lamaseli omzimba egazini.

Yamukelwa kanjani iBiktarvy?

Isinqumo sokwamukela iBiktarvy siza ngemuva kokuthi iGileyadi Sciences, okuyinkampani eyengamele lesi sidakamizwa, imemezele imiphumela evela ezivivinyweni ezine zokwelashwa ezinamasonto amane ezingama-484 zabantu abadala abane-HIV-1. Ucwaningo luthole ukuthi iBiktarvy iyasebenza kanye neminye imishanguzo ejwayelekile ye-HIV, yehlisa umthamo wegciwane futhi yandisa amaseli omzimba we-CD4 +.

I-Biktarvy vs. nezinye izinhlobo zemithi ye-HIV

Inkinga ejwayelekile yemithi ye-HIV ukumelana nemithi yokwelashwa. Yilapho i-HIV iba nokumelana nemithi esetshenziswayo ukunqanda igciwane ukuthi lingaziphindisi. Iziguli ocwaningweni ezelashwa nge-Biktarvy zakhonjiswa ukuthi azihlakuleli ukumelana nokwelashwa okuvela kulo muthi.

IGileyadi ixhasa ukuvivinywa okwengeziwe kwemitholampilo kweBiktarvy ukutadisha imiphumela yomuthi kwabesifazane, intsha kanye nezingane eziphila ne-HIV.

Isebenza kanjani ngokushesha iBiktarvy?

I-biktarvy yehlisa amazinga e-HIV egazini lakho iye kumanani angatholakali ngokushesha okungamaviki ayisishiyagalombili kuya kwayi-24.

Imiphumela emibi ye-Biktarvy

Njengezidakamizwa eziningi, okuqhamuka uma udla imishanguzo zilotshwe ngokusetshenziswa kweBiktarvy. Okubi kakhulu kulokhu ukukhushulwa okunamandla kwe-Hepatitis B, kanye ne-lactic acid egazini eyaziwa nangokuthi yi-lactic acidosis. Imiphumela emibi ye-Biktarvy ingafaka nezinkinga zezinso, uhudo, ikhanda, isiyezi, isicanucanu, kanye nezinguquko kumasosha omzimba. Ezinye izindlela zokwelashwa ze-HIV ezindala zingadala ukulahleka kwezinwele, kepha lokhu akuyona imiphumela emibi ebikiwe yeBiktarvy.

Ukusebenzisana kweBiktarvy

IBiktarvy nayo ingaxhumana nezinye izidakamizwa. I-biktarvy akufanele ithathwe nganoma yimiphi eminye imishanguzo ye-HIV. Buza udokotela wakho ukuthi noma imuphi omunye umuthi owuthathayo ungaxhumana neBiktarvy. Akufanele ithathwe uma okwamanje uthatha i-dofetilide noma i-rifampin. Kufanele futhi wazise umhlinzeki wakho wezokunakekelwa kwempilo uma ukhulelwe noma uhlela ukukhulelwa, noma uma usebenzisa ukulawulwa kokuzalwa kwamahomoni (njengamaphilisi, iringi yesitho sangasese sowesifazane, noma okufakelwayo).

Kubiza malini iBiktarvy?

Ngaphandle komshwalense, iBiktarvy ingabiza. Izinsuku ezingama-30 Izindleko zeBiktarvy ingu- $ 3,811.99. Nge-SingleCare, izindleko zehliselwe ku- $ 3,191.11. Umenzi, uGileyadi, unikeza ukwesekwa kwe-copay , Njengekhadi le-Biktarvy copay, elinganciphisa intengo uma uhlangabezana neziqu ezithile.