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I-Atorvastatin vs. simvastatin: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Atorvastatin vs. simvastatin: Umehluko, ukufana, nokuthi yikuphi okungcono kuweIzidakamizwa Vs. Umngani

Ukubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa





I-Atorvastatin ne-simvastatin yizidakamizwa ezimbili ezijwayele ukubekwa ezisebenza ekwelapheni i-cholesterol ephezulu. Udokotela wakho angakunikeza omunye wale mithi uma unamazinga aphezulu we-LDL (low-density lipoprotein) cholesterol, eyaziwa nangokuthi i-cholesterol embi. Ngokunciphisa amazinga e-cholesterol, i-atorvastatin noma i-simvastatin ingasiza ekwehliseni ubungozi bokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi.



Ngokuqondile, i-atorvastatin ne-simvastatin basebenza njenge-HMG-CoA reductase inhibitors. Ngokuvimba i-enzyme ye-HMG-CoA reductase, lezi izimiso ukunciphisa ukukhiqizwa kwe-cholesterol esibindi. Nge-cholesterol encane ejikeleza egazini, umzimba uyakwazi ukubuyisela kabusha i-cholesterol eyeqile futhi wehlise amazinga e-cholesterol jikelele.

I-Atorvastatin ne-simvastatin zingasebenza ngezindlela ezifanayo kepha zinomehluko othile kumthamo, ukuphathwa, kanye nemiphumela emibi engaba khona.

Uyini umehluko omkhulu phakathi kwe-atorvastatin ne-simvastatin?

I-Atorvastatin yaziwa nangegama layo lomkhiqizo, i-Lipitor, eyayigunyazwe yi-FDA ngo-1996. Phakathi kokunye ukusetshenziswa, kunqunyiwe ukunciphisa ubungozi bokuhlaselwa yisifo senhliziyo noma isifo sohlangothi kulabo abane isifo senhliziyo .



I-Atorvastatin (Yini i-Atorvastatin?) Ine-half-life ende yamahora ayi-14. Umuthi uyasebenza uma usungenile, futhi umsebenzi wawo wokwehlisa i-lipid ungahlala kuwo Amahora angama-20 kuye kwangama-30 ngemuva kokuphathwa. Kanye ne-rosuvastatin, noma i-Crestor, i-atorvastatin iyisidakamizwa esinamandla kakhulu kunamanye ama-statin afana ne-simvastatin ne-pravastatin.

I-Atorvastatin iyatholakala ku-10 mg, 20 mg, 40 mg, naku-80 mg amaphilisi. Umthamo wokuqala onconyiwe ungu-10 noma u-20 mg kanye ngosuku yize umthamo ojwayelekile ungasuka ku-10 kuye ku-80 mg kanye ngosuku. I-Atorvastatin ingathathwa nganoma yisiphi isikhathi sosuku.

ISimvastatin (Yini iSimvastatin?) Yaziwa nangegama layo lomkhiqizo, iZocor. Uma kuqhathaniswa ne-atorvastatin, i-simvastatin yisidakamizwa esidala esagunyazwa okokuqala yi-FDA ngo-1991. Njengamanye ama-statin, isetshenziselwa ukunciphisa ubungozi bokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi kulabo abanezingozi zenhliziyo nemithambo yegazi.



Ufuna intengo engcono kakhulu ku-simvastatin?

Bhalisela izexwayiso zentengo ye-simvastatin bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo

Ngokungafani ne-atorvastatin, i-simvastatin iyidrug . Okusho ukuthi, ayisebenzi kuze kube yilapho ihlanganiswa, noma icutshungulwa, esibindi. Ngemuva kokucutshungulwa, i-simvastatin iphendukela esimweni sayo esisebenzayo, i-simvastatin acid, enokuphila okuyingxenye yehora elilodwa kuya kwamabili.



ISimvastatin iyatholakala ngamandla we-5 mg, 10 mg, 20 mg, 40 mg, no-80 mg. Umthamo wokuqala onconyiwe ungu-10 noma u-20 mg kanye ngosuku, futhi umthamo ojwayelekile ungasuka ku-5 kuye ku-40 mg ngosuku. I-Simvastatin inconywa ukuthi ithathwe ebusuku.

Umehluko omkhulu phakathi kwe-atorvastatin ne-simvastatin
I-Atorvastatin Simvastatin
Isigaba sezidakamizwa I-HMG-CoA reductase inhibitor
I-Statin
I-HMG-CoA reductase inhibitor
I-Statin
Isimo somkhiqizo / ejwayelekile Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala
Ngubani igama lomkhiqizo? Lipitor Zocor
Izidakamizwa zingena ngaziphi izinhlobo? Ithebhulethi yomlomo Ithebhulethi yomlomo
Uyini umthamo ojwayelekile? 10 kuya ku-80 mg kanye ngosuku 5 kuya ku-40 mg kanye ngosuku
Yelashwa isikhathi esingakanani? Ukwelashwa nge-atorvastatin isikhathi eside ukuphatha amazinga e-cholesterol nokugcina ingozi ephansi yokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Ukwelashwa nge-simvastatin isikhathi eside ukuphatha amazinga we-cholesterol nokugcina ingozi ephansi yokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi.
Ubani ovame ukusebenzisa umuthi? Abantu abadala; izingane nentsha eneminyaka engu-10 kuya kwengu-17 ubudala ene-heterozygous family hypercholesterolemia (HeFH) Abantu abadala; izingane nentsha eneminyaka engu-10 kuya kwengu-17 ubudala ene-heterozygous family hypercholesterolemia (HeFH)

Izimo eziphathwa yi-atorvastatin ne-simvastatin

I-Atorvastatin ne-simvastatin zisetshenziselwa izinhloso ezifanayo. Bobabili baphatha amazinga aphezulu e-cholesterol (i-hypercholesterolemia), amazinga aphezulu e-lipid (i-hyperlipoproteinemia), kanye amazinga aphezulu we-triglyceride (i-hypertriglyceridemia). Ngasikhathi sinye, ama-statins angasiza ekwandiseni i-cholesterol ye-HDL, uhlobo lwe-cholesterol enhle enemiphumela yokuvikela ezifweni zenhliziyo nemithambo yegazi.



I-Atorvastatin ne-simvastatin nakho kunganciphisa ubungozi bokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi kokulandelayo:

  • Abantu abadala ngaphandle kwesifo senhliziyo (CHD) abanezici eziningi zobungozi
  • Abantu abadala abane-Type 2 diabetes ngaphandle kwe-CHD, kepha banezici eziningi eziyingozi
  • Abantu abadala abane-CHD etholakele

Izici ezinobungozi bemicimbi yenhliziyo zingafaka umfutho wegazi ophakeme (umfutho wegazi ophakeme) noshukela wegazi ophakeme (isifo sikashukela).



I-Atorvastatin ne-simvastatin kunganciphisa amazinga e-cholesterol nama-lipid kulabo abane ukuphazamiseka kwezakhi zofuzo , njenge-homozygous family hypercholesterolemia (HoFH). Lezi zimila zingaphatha izingane nentsha (iminyaka eyi-10-17 ubudala) nge-heterozygous family hypercholesterolemia (HeFH).

Ukwelashwa kwe-atherosclerosis, noma okunamafutha okufakwa ezindongeni zemithambo yegazi, ngesinye isizathu sokuthi i-atorvastatin noma i-simvastatin ingabhalwa. Ngokunciphisa uqweqwe ezindongeni zemithambo yegazi, lawa ma-statin angasiza ekunciphiseni izimpawu ezifana nobuhlungu besifuba (angina).



Isimo I-Atorvastatin Simvastatin
I-Hypercholesterolemia Yebo Yebo
Hyperlipoproteinemia Yebo Yebo
I-Hypertriglyceridemia Yebo Yebo
Ukuhlaselwa yinhliziyo nokuvinjelwa unhlangothi Yebo Yebo
I-atherosclerosis Yebo Yebo

Ingabe i-atorvastatin noma i-simvastatin isebenza kangcono?

I-Atorvastatin ne-simvastatin yomibili iyimithi esebenzayo ye-statin. Ucwaningo lukhombisile ukuthi labo abathatha imishanguzo yabo yama-statin okungenani i-90% yesikhathi ube nengozi encishisiwe engama-45% yokufa ngenxa yesifo senhliziyo, isifo sohlangothi, noma yisiphi isizathu. Ngokuvamile, ama-statins asebenza kakhulu ekwehliseni amazinga e-cholesterol futhi anciphise izehlakalo zokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi.

Azikho izivivinyo eziqinile zekhanda nekhanda eziqhathaniswa ne-atorvastatin ne-simvastatin esenziwe. Kodwa-ke, i-atorvastatin ibhekwa njengesidakamizwa esinamandla kune-simvastatin. Ku- isifundo esisodwa sokuqhathanisa sakamuva , i-atorvastatin itholakale isebenza kangcono ekwehliseni i-LDL cholesterol (LDL-C) kune-simvastatin. Lolu cwaningo luhlanganise imiphumela evela ku-50 engahleliwe, ukuhlolwa kwemitholampilo, futhi kwaqhathaniswa nezinye izidakamizwa ze-statin njenge-fluvastatin, i-pravastatin, i-rosuvastatin ne-lovastatin. IRosuvastatin ibinamandla amakhulu kakhulu okwehlisa amazinga e-LDL ocwaningweni.

Kokukodwa ukubuyekeza okuhlelekile , Kwahlaziywa izifundo ezingama-75 ezahlukahlukene eziqhathanisa imishanguzo yama-statin. Ngokwemiphumela yeqembu lokufunda, umthamo wansuku zonke we-atorvastatin 10 mg unganciphisa i-cholesterol ye-LDL ngo-30% -40% ngenkathi umthamo wansuku zonke we-simvastatin 10 mg unganciphisa i-cholesterol ye-LDL ngama-20% -30%. Kodwa-ke, imiphumela yokwelashwa yalomehluko kungenzeka ingabaluleki.

Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ukunquma ukwelashwa okungcono kakhulu kwe-statin. Ukusebenza kwama-statins kuzoya ngomlando wakho wezokwelapha nowomndeni, phakathi kwezinye izinto.

Ukuphakama nokuqhathaniswa kwezindleko kwe-atorvastatin vs. simvastatin?

I-Atorvastatin iyatholakala njengesidakamizwa esijwayelekile esivame ukuhlanganiswa njalo yiMedicare nezinye izinhlelo zomshuwalense. Inqunywe njengephilisi lansuku zonke elingakhishwa ekunikezelweni kwezinsuku ezingama-30 noma ezingama-90. Intengo emaphakathi yemali ye-atorvastatin ingafinyelela ku- $ 250. Kodwa-ke, intengo ingehliselwa ku- $ 15 ngesigqebhezana se-SingleCare atorvastatin.

ISimvastatin iyatholakala njengomuthi ojwayelekile. Njengesimiso esivame ukubekwa, i-simvastatin ivame ukumbozwa yi-Medicare nezinhlelo zomshuwalense. Intengo emaphakathi yokuthengisa ye-simvastatin icishe ibe ngu- $ 470. Kodwa-ke, ngekhadi lesaphulelo le-simvastatin, njengeSingleCare, ungalindela ukukhokha ngaphansi kuka- $ 10 ngokuthengwa kwezinsuku ezingama-30 kwamaphilisi angama-20 mg emakhemisi abambe iqhaza.

I-Atorvastatin Simvastatin
Ngokuvamile embozwe umshwalense? Yebo Yebo
Imbozwe ngokujwayelekile yi-Medicare Part D? Yebo Yebo
Umthamo ojwayelekile 10 mg kanye ngosuku (inani lama-30) 20 mg kanye ngosuku (inani lama-30)
I-Medicare copay ejwayelekile $ 0– $ 16 $ 0– $ 9
Izindleko ze-SingleCare $ 15 + $ 10 +

Thola ikhadi lesaphulelo sekhemisi

Imiphumela emibi ejwayelekile ye-atorvastatin vs. simvastatin?

Imiphumela emibi kakhulu ye-statins, efana ne-atorvastatin ne-simvastatin, ifaka izinkinga zokugaya ukudla ezifana nohudo, ukugaya ukudla, kanye nesicanucanu. Eminye imiphumela emibi ifaka isiyezi nokuvuvukala kwezandla, imilenze, noma izinyawo (i-edema). Izitatimende nazo zingadala ubuhlungu bemisipha (myalgia) noma ubuthakathaka bemisipha (myopathy).

Ingozi yobuhlungu bemisipha iyanda ngamanani aphezulu ama-statins. Kodwa-ke, uma kuqhathaniswa ne-atorvastatin, i-simvastatin ibhekwa njengengozi enkulu ye-myalgia. Abanye abantu bangaba ne- ukuthambekela kofuzo ku-myalgia kusuka ku-simvastatin. Yize wonke ama-statin enobungozi bokubangela ubuhlungu bemisipha njengomphumela wecala, i-FDA kunciphise ukusetshenziswa yamaphilisi we-simvastatin 80 mg ngenxa yengozi eyengeziwe.

Eminye imiphumela emibi ejwayelekile ingatholakala kuthebula elingezansi.

I-Atorvastatin Simvastatin
Umphumela oseceleni Kusebenza? Imvamisa Kusebenza? Imvamisa
Ubuhlungu obuhlangene Yebo 7% Yebo 0.1%
Uhudo Yebo 7% Yebo *
Ukuqunjelwa Akunjalo - Yebo amaphesenti amabili
Ukugaya ukudla Yebo 5% Yebo *
Isicanucanu Yebo 4% Yebo 6%
Ubuhlungu bemisipha Yebo 4% Yebo 4%
Ukutheleleka ngomgudu womchamo Yebo 6% Yebo 3%
I-Nasopharyngitis Yebo 8% Akunjalo -
Isiyezi Yebo * Yebo 5%
I-Edema Yebo * Yebo 3%

* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( I-Atorvastatin ), IDailyMed ( Simvastatin )

Ukusebenzisana kwezidakamizwa kwe-atorvastatin vs. simvastatin

I-Atorvastatin ne-simvastatin kucutshungulwa ikakhulukazi esibindini yi-CYP3A4 enzyme. Izidakamizwa ezivimbela, noma ezivimba le enzyme zingadala amazinga anyukayo e-atorvastatin noma i-simvastatin egazini. Uma ithathwa nge-CYP3A4 inhibitor efana ne-clarithromycin noma i-itraconazole, i-atorvastatin ingadala ubungozi obukhulayo bezinhlungu zemisipha (myalgia) noma ubuthakathaka bemisipha (myopathy). Ijusi lamagilebhisi futhi iyi-CYP3A4 inhibitor engakhuphula amazinga e-atorvastatin ne-simvastatin. Ngakolunye uhlangothi, izidakamizwa ezinjenge-rifampin ne-carbamazepine zingama-inducers we-CYP3A4 anganciphisa amazinga e-atorvastatin ne-simvastatin emzimbeni.

Ama-Protease inhibitors, afana ne-ritonavir ne-lopinavir, angadala amazinga akhuphukayo ama-statins emzimbeni. Amazinga aphezulu we-statin egazini angaholela engozini eyengeziwe yemiphumela emibi, kufaka phakathi i-myalgia. Izidakamizwa ze-fibrate ne-niacin nazo zingakhuphula ubungozi be-myalgia lapho zithathwa nge-atorvastatin noma i-simvastatin.

Ukuthatha i-atorvastatin ngezindlela zokuvimbela inzalo ngomlomo kungadala ukukhuphuka kwamazinga egazi emithini yokuvimbela inzalo.

Ukuthatha ama-statins nge-warfarin kubikwe ukuthi kubangele amazinga anyukayo we-warfarin kanye nengozi eyengeziwe yokopha. Kodwa-ke, i-atorvastatin iyi- akunakwenzeka ukuthi kuphazamise ngemiphumela ye-warfarin.

Izidakamizwa Isigaba sezidakamizwa I-Atorvastatin Simvastatin
I-Clarithromycin
I-Erythromycin
I-Itraconazole
Ketoconazole
Ijusi lamagilebhisi
I-CYP3A4 inhibitors Yebo Yebo
I-Rifampin
ICarbamazepine
Ama-inducers we-CYP3A4 Yebo Yebo
I-Ritonavir
Lopinavir
Simeprevir
I-Darunavir
Ama-Protease inhibitors Yebo Yebo
Gemfibrozil
I-Fenofibrate
Ama-Fibrates Yebo Yebo
I-Niacin I-antihyperlipidemic Yebo Yebo
I-Digoxin I-glycoside yenhliziyo Yebo Yebo
Norethindrone
I-Ethinyl estradiol
Izindlela zokuvimbela inzalo ngomlomo Yebo Akunjalo
I-Warfarin I-Anticoagulant Akunjalo Yebo

Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka.

Izexwayiso nge-atorvastatin ne-simvastatin

Kokubili i-atorvastatin ne-simvastatin kungadala izehlakalo ezimbi ezibandakanya ubuhlungu bemisipha (myalgia) noma ubuthakathaka bemisipha (myopathy). Ezimweni ezinzima, lezi zimiso zingadala ne-rhabdomyolysis, noma ukonakala okusheshayo kwemisipha yamathambo. Uhlobo olungavamile lwe-myopathy, olubizwa nge-immune-mediated necrotizing myopathy (IMNM) nalo lubikwe ngokusetshenziswa kwe-statin.

I-Atorvastatin ne-simvastatin ikakhulu kugaya umzimba esibindini. Ngakho-ke, ukusetshenziswa kwabo kungadala ukungajwayelekile ezingeni le-enzyme yesibindi. Ama-enzyme wesibindi kufanele abhekwe kulo lonke ukwelashwa kwe-statin. Abantu abanesifo sesibindi kufanele futhi babhekwe noma bagweme ama-statins ngokuphelele.

I-Atorvastatin ne-simvastatin kufanele kugwenywe kwabesifazane abakhulelwe nakomama abahlengikazi. Lezi zimiso zingaba nengozi eyengeziwe yokukhubazeka kokuzalwa.

Imibuzo ebuzwa njalo mayelana ne-atorvastatin vs. simvastatin?

Yini i-atorvastatin?

I-Atorvastatin, eyaziwa nangokuthi yi-Lipitor, ngumuthi we-statin osetshenziselwa ukwehlisa i-cholesterol futhi wehlise ubungozi bokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Ububanzi bomthamo ojwayelekile we-atorvastatin buphakathi kuka-10 kuya ku-80 mg ngosuku. I-Atorvastatin ine-half-life ende yamahora ayi-14 futhi ingathathwa nganoma yisiphi isikhathi sosuku.

Yini i-simvastatin?

ISimvastatin yaziwa nangegama layo lomkhiqizo, iZocor. Kungumuthi we-statin onganciphisa amazinga we-cholesterol, nawo ongasiza ekwehliseni ubungozi bokuhlaselwa yisifo senhliziyo nokushaywa unhlangothi. Ububanzi bomthamo ojwayelekile we-simvastatin unhlanu kuya ku-40 mg ngosuku. ISimvastatin ine-half-life emfushane uma kuqhathaniswa futhi kunconywa ukuthi ithathwe kusihlwa.

Ngabe i-atorvastatin ne-simvastatin ziyefana?

I-Atorvastatin ne-simvastatin bobabili bangabesigaba sezidakamizwa esibizwa nge-HMG-CoA reductase inhibitors, noma ama-statins. Zombili zisetshenziselwa ukwehlisa amazinga we-LDL cholesterol. Kodwa-ke, banokuhluka okuthile emandleni atholakalayo nokuthi athathwa kanjani.

Ngabe i-atorvastatin noma i-simvastatin ingcono?

I-Atorvastatin ne-simvastatin zombili izidakamizwa ezisebenzayo ze-statin zokwehlisa i-cholesterol egazini. Kodwa-ke, i-atorvastatin ibhekwa njenge-statin enamandla kakhulu. I-Atorvastatin ihlala isikhathi eside emzimbeni futhi ingathathwa ekuseni noma ebusuku. ISimvastatin inobungozi obukhulu bezinhlungu zemisipha noma ubuthakathaka kune-atorvastatin, ikakhulukazi kumanani aphezulu. Udokotela onqumayo uzonquma isitatimende esisebenza kahle kakhulu esimweni ngasinye.

Ngingayisebenzisa i-atorvastatin noma i-simvastatin ngenkathi ngikhulelwe?

I-Atorvastatin ne-simvastatin akufanele zisetshenziswe ngesikhathi sokukhulelwa. Izinga le-cholesterol lingakhula ngesikhathi sokukhulelwa futhi liyadingeka ukusekela umbungu okhulayo. Ngakho-ke, akukho nzuzo ngokuthatha lezi zimila ngesikhathi sokukhulelwa. Zingahle futhi zidale ukulimala kwengane ngesikhathi sokukhulelwa.

Ngingayisebenzisa i-atorvastatin noma i-simvastatin ngotshwala?

Ngokuvumelana ne ochwepheshe bezenhliziyo , ukuphuza utshwala ngokulinganisela ngokuvamile kuphephile ngokusetshenziswa kwe-statin. Ukuphuza ngokweqile okuholele ekutheni kube nesifo sesibindi kulapho kungavela khona izinkinga. Ama-enzyme wesibindi kufanele abhekwe kulo lonke ukwelashwa nge-statin.

Yisiphi isitatimende esinenani elincane lemiphumela emibi?

Izitatimende zivame ukuphepha ezinemiphumela engemihle emibi. Ngokwe-American Heart Association (AHA), izinzuzo zama-statins idlula ingozi engaba khona yemiphumela emibi. Kodwa-ke, izimiso ezithile, njenge i-pravastatin ne-fluvastatin , ingaba nengozi ephansi ye-myalgia kune-simvastatin ne-atorvastatin. Uma kuqhathaniswa nama-statins anikezwe ngemithamo ephansi, ama-statin aphezulu kakhulu angadala imiphumela emibi. Isibonelo, umthamo we-80 mg we-simvastatin unengozi enkulu yokubanga i-myalgia. Ngalesi sizathu, i-FDA ikhawulele le dose ye-simvastatin kuphela kubantu abathile.

Yimiphi imiphumela emibi yesikhathi eside ye-atorvastatin?

Imiphumela emibi yesikhathi eside yokwelashwa kwe-statin ingahluka ngokuya ngomuntu. Isikhati eside imiphumela emibi yezimpawu kungabandakanya ubuhlungu bemisipha, ukulimala kwesibindi, ukwanda kukashukela egazini, nezinkinga zememori. Kodwa-ke, ubungozi bemiphumela emibi yesikhathi eside buthathwa njengobuphansi lapho umuthi unikezwa futhi uphathwa kahle.

Ingabe i-atorvastatin yimbi ngezinso zakho?

Umthamo we-atorvastatin awudingi ukulungiswa kulabo abanezinkinga zezinso. Kwabanye abantu abanezinkinga ezinzima zezinso, ukusetshenziswa kwe-atorvastatin kungadinga ukuqashwa.

Ngokuvamile, i-atorvastatin ayiyona ingozi ezinso. Kodwa-ke, ukusetshenziswa kwe-atorvastatin kungaholela engcupheni eyandayo ye-rhabdomyolysis, engaholela ekuhlulekeni okukhulu kwezinso ezimweni ezinzima. Khuluma nodokotela wakho uma unomlando wezinkinga zezinso ngaphambi kokuqala kumuthi we-statin.