Imiphumela emibi ye-Humira nokuthi ungayibalekela kanjani

Imininingwane Yezidakamizwa

Imiphumela emibi yeHumira | Imiphumela emibi ihlala isikhathi esingakanani? | Izexwayiso | Ukusebenzisana | Ungayigwema kanjani imiphumela emibi

I-Humira (i-adalimumab) —umjovo we-antibody yomuntu eyenzeka ngokwemvelo — inciphisa ukuxolelwa futhi ilawula izimpawu zezifo ezisebenzayo ezizimele. Umhlinzeki wezokunakekelwa kwempilo angabhalela uHumira isifo samathambo , i-ankylosing spondylitis, i-juvenile idiopathic arthritis , i-psoriatic arthritis, uqweqwe psoriasis , Isifo sikaCrohn , i-ulcerative colitis, uveitis, ne-hidradenitis suppurativa. Kuzo zonke lezi zimo, ukuqhuma kwenzeka lapho amasosha omzimba ehlasela ngephutha izicubu ezinempilo.

I-Humira icindezela ukuphendula komzimba ngokuvimba ikhemikhali elenziwa ngumzimba-i-tumor necrosis factor noma i-TNF-ebangela ukuvuvukala. Njengayo yonke imithi, isinqumo sokuthatha uHumira kufanele silinganise izinzuzo nezingozi zemithi, ngakho-ke kubalulekile ukuxoxa nodokotela wakho ngemiphumela emibi, ukuxhumana kwezidakamizwa, kanye nezixwayiso ezihambisana nomuthi.

OKUSHIWO: Funda kabanzi ngeHumira | Thola izaphulelo zeHumira

Imiphumela emibi ejwayelekile kaHumira

I-Humira icindezela amasosha omzimba, ngakho-ke ukutheleleka nokulimala kuyinto ejwayelekile kanye nemiphumela emibi kakhulu. Futhi, njengomjovo ongena ngaphansi kwesikhumba, uHumira ukhiqiza ukusabela kwendawo yokujova cishe 1 ezigulini ezi-5 . Imiphumela emibi kakhulu ye-Humira yile:

• Ukuphendula kwesayithi lokujova (ububomvu, ukuvuvukala, ubuhlungu, ukulunywa nokuqubuka kwesikhumba)
• Izifo eziphezulu zokuphefumula
• Ukuminyana kwesinusi
• Ubuhlungu bekhanda
• Ukuthuthukiswa kwamasosha omzimba okuzenzakalelayo
• I-Rash
• Isicanucanu
• Ubuhlungu besisu
• Umsebenzi wesibindi ongajwayelekile
• Ukutheleleka ngomgudu womchamo
• Umkhuhlane noma izimpawu ezibandayo
• Ukuhlungu obusemhlane
• Amazinga akhuphukayo amafutha egazini
• I-cholesterol ephakeme ye-serum
• Umfutho wegazi ophakeme

Ngabe uHumira ubanga ukulahleka kwezinwele noma ukuzuza kwesisindo?

Ezimweni ezingavamile kakhulu, uHumira angadala ukulahleka kwezinwele ezithile.

Ukwehla kwesisindo okungachazeki noma ukuzuza, noma kunjalo, akubangelwa ngqo nguHumira. Kodwa-ke, isithako sayo esisebenzayo sandisa ubungozi be-lymphoma, i-leukemia, neminye imidlavuza, eminingi yayo ebonakala ngokulahlekelwa isifiso sokudla kanye nokwehla kwesisindo okungazibandakanyi. Khuluma nodokotela ngokushesha uma ubona ukwehla kwesisindo, ukuncipha kwesifiso sokudla, noma ukusutha ngenani elincane lokudla ngenkathi uthatha uHumira.

Imiphumela emibi yeHumira

Ngenxa yokuthi uHumira ucindezela amasosha omzimba, iziguli zisengozini enkulu yokutheleleka okunzima ngisho nokusongela impilo nomdlavuza. Njengayo yonke imijovo yama-antibody, ukungezwani komzimba nakho kuyingozi. Imiphumela emibi kakhulu yeHumira yile

• Izifo ezibucayi noma ezisongela impilo
• Umdlavuza (i-lymphoma, i-leukemia, umdlavuza wesikhumba ongelona i-melanoma, nezinye izifo ezimbi)
• Ukusabela okweqile noma okusongela impilo
• Ukuvuselelwa kwegciwane lesifo sofuba noma i-hepatitis B
• Ukukhuphuka noma ukuqala kokuphazamiseka kwesistimu yezinzwa ezinjenge-multiple sclerosis noma i-optic neuritis
• Izinkinga zenhliziyo (i-atrial fibrillation, i-tachycardia, i-arrhythmia yenhliziyo, ubuhlungu besifuba, isifo senhliziyo)
• Ukuqina kokwehluleka kwenhliziyo okucinana
• I-Lupus-like syndrome
• Kwehliswe ukubalwa kwamaseli egazi noma i-anemia
• Ukulimala kwesibindi noma ukwehluleka
• Amatshe amatshe amade
• Isifo senkwethu
• Isifo samathambo
• Ubuthakathaka bemisipha
• Ukudideka

Kufanele uyeke ukuthatha uHumira futhi ufune usizo lwezempilo ngokushesha uma uhlangabezana nokuphendula okulandelayo lapho uthatha uHumira:

• Imfiva, ukukhathala, ukungathandi ukudla, ubuhlungu besisu, noma okunye izimpawu zokutheleleka kwesifo sokusha kwesibindi kohlobo B .
• Izindlala ezivuvukele, ukukhathala, imfiva, ukugodola, ukujuluka ebusuku, ukulahlekelwa isifiso sokudla, ukuncipha komzimba ngokungazikhetheli, izigaxa zesikhumba ezingachazeki, ukulimazeka okulula noma ukopha, noma okunye izimpawu ezivamile zomdlavuza .
• Isifuba, ukuvuvukala kobuso, ukushwabana, isikhumba esinsomi, ukuphefumula kanzima, ukwehla kwengcindezi yegazi, isiyezi, ukuquleka, noma okunye izimpawu zokuphendula okweqile noma i-anaphylaxis .
• Ukukhathala, umkhuhlane, ubuhlungu bamalunga, ukuqubuka ebusweni, izilonda zesikhumba ezibangelwa yilanga, ukuphefumula okuncane, nokunye izimpawu zesifo esifana ne-lupus .
• Ukushaya kwenhliziyo yomjaho, ukushaya kwenhliziyo, ubuhlungu besifuba, noma okunye izimpawu zokungahleleki kwenhliziyo .

Imijovo ye-Humira ingaqedwa uma ngabe kukhona yalezi zimo ezinolwazi.

Kufanele ukhulume ngokushesha nodokotela wakho ngamathuba wokuyeka uHumira uma uhlangabezana:

• Imfiva, ukukhwehlela, ukuvuvukala, amakhaza, izindlala ezivuvukele, ukungathandi ukudla, ubuhlungu besisu, noma okunye izimpawu zokutheleleka .
• Ubuthakathaka, ukukhathala, isikhumba esiphaphathekile, ukushaya kwenhliziyo okusheshayo, ukulimaza okulula noma ukopha, noma okunye izimpawu zezinkinga zegazi .
• Isikhumba esiphuzi, amehlo aphuzi, izinhlungu zangaphezulu kwesisu kwesokudla, ukuvuvukala kwesisu, ukudideka nokunye izimpawu zezinkinga ezinzima zesibindi .
• Ubuthakathaka bemisipha, ukushintsha kombono, ukuqina kwemisipha, ukuqina kwemisipha, ukugedlezela, ukuba ndikindiki, noma okunye izimpawu ze ukuphazamiseka kwesistimu yezinzwa .

I-Humira inikezwa kanye kuphela emavikini amabili, ngakho-ke odokotela neziguli banesikhathi sokucabanga kabusha ngoHumira lapho bebhekene nemiphumela emibi.

Imiphumela emibi yeHumira ihlala isikhathi esingakanani?

Imiphumela emibi ye-Humira izohluka ekuqaleni nobude. Indawo yokujova noma ukungezwani komzimba nakho kwenzeka ngaphakathi kwemizuzu yomjovo futhi kuhlala imizuzu embalwa ezinsukwini ezimbalwa. Umjovo wokuqala uyohlale wenziwa uchwepheshe wezokunakekelwa kwezempilo esimweni somtholampilo ukuqaphela ukuthi kungenzeka yini ukuthi umzimba awuphenduli. Eminye imiphumela emibi ejwayelekile enjengekhanda, ukuminyana kwesinus, isicanucanu, nomkhuhlane noma izimpawu ezibandayo nazo zifushane futhi zingelashwa ngemithi yokuthenga nokuphumula.

Kodwa-ke, imiphumela emibi kakhulu, njengezinkinga zesibindi, ukutheleleka, nezinkinga zegazi kuzothatha amasonto noma izinyanga ukukhula futhi kungaqhubeka nokuba kubi inqobo nje uma kuthathwa uHumira. Ukutheleleka okukhulu, umdlavuza, ukwehluleka kwesibindi, izinkinga zenhliziyo, kanye nama-auto-antibodies kungaba nemiphumela yesikhathi eside noma yokuphila isikhathi eside ngisho nangemva kokuba uHumira eseyekile. Ukuvakashelwa kwamahhovisi nokuhlolwa njalo kuyadingeka ukuqapha imiphumela yesikhathi eside kaHumira.

Izimo eziphikisayo nezixwayiso zeHumira

I-Humira akuyona njalo imithi efanelekile kuwo wonke umuntu. Abantu abanezifo ezithathelwanayo, ukutheleleka okucashile, ukuvezwa isifo sofuba, umlando womdlavuza, ukuhluleka kwenhliziyo yokucinana, ukuphazamiseka kwemizwa efana ne-multiple sclerosis, isifo sesibindi, noma ukungezwani komzimba nomuthi noma ezinye izithako zawo kungahle kungafaneleki ukuthatha uHumira.

Izifo ezinzima

I-Humira iqukethe isexwayiso sebhokisi elimnyama ngezifo ezimbi. I-Humira izonqanyulwa uma ukutheleleka okungathi sína, i-sepsis, noma ukutheleleka kwe-fungal okuhlasela kuqala ngenkathi kuthatha lesi sidakamizwa.

Iziguli zizodinga ukuhlolwa isifo sofuba ngaphambi nangesikhathi sokwelashwa noHumira. Noma yisiphi isiguli esivivinywa ukuthi sinesifo sofuba esivele sifike sizodinga ukwelashwa kwe-TB ngaphambi kokuthola uHumira. Umuthi uzonqanyulwa uma isiguli sithola i-TB ngesikhathi sokwelashwa.

Iziguli ezisengozini yokutheleleka nge-hepatitis B noma i-histoplasmosis nazo zizohlolwa ngaphambi kokuthola iHumira. Futhi, umuthi uzonqanyulwa uma imijovo ivuselela ukutheleleka kwesifo sokusha kwesibindi kohlobo B okufihlekile.

Izenzo ezimbi

I-Humira namanye ama-block blocker we-TNF aqukethe isexwayiso sebhokisi elimnyama lesifo esibi, ikakhulukazi i-lymphoma. Ezinye iziguli eziseHumira nakwamanye ama-block blockers we-TNF athuthukise i-hepatosplenic T-cell lymphoma (HSTCL), uhlobo lwe-lymphoma olunolaka, olungavamile futhi oluvame ukubulala. Iziguli ezelashelwe noma yimuphi umdlavuza ngaphandle komdlavuza wesikhumba ongelona i-melanoma kungenzeka zingafaneleki ukwelashwa ngeHumira noma izivimbeli ezifanayo ze-TNF. Uma isifo esibuhlungu senzeka ngesikhathi sokwelashwa, uHumira angaqedwa.

Ukuphazamiseka kwesistimu

Iziguli ezinokukhubazeka okudonsela phansi okufana ne-multiple sclerosis, i-Guillain-Barre syndrome, isifo esidambisa imiphefumulo, noma i-optic neuritis kungenzeka kungafaneleki ukwelashwa kwe-Humira. Izifo ezikhupha imishanguzo ukuthuthuka kwezinzwa okuqhubeka kancane kususe umgodla wokuvikela ozungeze amagatsha ezinzwa, kunciphise amandla abo okudlulisa amasiginali wezinzwa. I-Humira ingadala ukuqhuma kwanoma yikuphi kwalokhu kuphazamiseka, ngakho-ke ukwelashwa kweHumira kuzodinga ukuqashwa njalo kulezi ziguli.

Ukwehluleka kwenhliziyo yokubopha

I-Humira ingakhubaza ukwehluleka kwenhliziyo yokucinana, ngakho-ke iziguli ezinesifo senhliziyo esibuhlungu zizodinga ukubhekwa eduze lapho zithatha uHumira.

Ukungezwani komzimba

Iziguli ezinokungezwani komzimba nomuthi, noma iziphi izithako zawo, noma i-raber ne-latex kungenzeka zingabi yizimbangi zikaHumira. Umuthi uzonqanyulwa nganoma yisiphi isibonakaliso sempendulo ebabazekayo yokungezwani komzimba.

Ukukhulelwa

Idatha yomtholampilo iphakamisa ukuthi ubungozi obuhlobene bokukhubazeka okukhulu kokuzalwa abukho ngaphezulu kwabesifazane abaphathwa noHumira uma kuqhathaniswa nalabo abangekho. Njengeprotheni, uHumira udlula kwi-placenta aye embungwini. Ambalwa ama-antibody adlulela embungwini phakathi ne-trimester yokuqala, kepha ukudlula kwama-antibodies kuyanda kancane kuze kukhule ku-trimester yesithathu. Abesifazane abakhulelwe bangafuna ukuxoxa nodokotela babo izingozi nezinzuzo zokuthatha uHumira ngesikhathi sokukhulelwa kwabo.

Ukuncelisa ibele

I-Humira ibhekwa njengephephile ukuyithatha lapho incelisa izingane izinsana. I-Humira ayibonakali ithinta ukukhiqizwa kobisi noma ilimaze izingane ezincelisayo. I-Humira ikhona obisini lwebele kepha iphesenti elilodwa noma ngaphansi kokugxila kwayo egazini. Futhi kuyiprotheni, ngakho-ke izokwephuka ohlelweni lokugaya usana.

Ukuhlukumeza nokuncika

I-Humira ayikhiqizi ukuncika emzimbeni noma izimpawu zokuhoxa. Awekho amacala aziwayo eHumira noma okunye ukuhlukunyezwa kwe-TNF blocker.

Ukusebenzisana kukaHumira

Eminye imishanguzo ecindezela izivikeli mzimba akufanele isetshenziswe noHumira ngoba, ngokuhlangana noHumira, le mithi icindezela amasosha omzimba ngokuyingozi. I-Humira ngeke inqunywe ngokuhlanganiswa nalezi zivikeli mzimba ezilandelayo:

• I-Orencia (abatacept)
• I-Kineret (anakinra)
• I-Remicade (infliximab)
• I-Enbrel (etanercept)
• I-Cimzia (certolizumab pegol)
• I-Simponi (golimumab)

I-Humira ingahle ithuthukise imiphumela yezinye izidakamizwa ezinciphisa amasosha omzimba noma zokuzivikela ezifweni zomzimba, ikhuphule ubungozi bokutheleleka kanye nomdlavuza. Udokotela uzoqaphela lapho ebeka uHumira nge:

• I-Imuran (azathioprine)
• I-Purinethol (6-mercaptopurine)
• Cladribine
• I-Rituxan (rituximab)
• I-Xgeva (denosumab)
• I-Ocrevus (ocrelizumab)
• I-Actemra (tocilizumab)
• I-Gilenya (fingolimod)
• I-Mayzent (siponimod)
• I-Daliresp (roflumilast)

I-Humira yandisa ubuthi futhi ikhulisa imiphumela emibi yemithi ethile, kufaka phakathi okulandelayo:

• I-Arava (leflunomide)
• I-Ilaris (canakinumab)
• I-Tysabri (natalizumab)
• I-Entyvio (vedolizumab)
• I-Prograf (tacrolimus)
• U-Elidel (pimecrolimus)
• I-Arcalyst (rilonacept)

I-Humira inciphisa imiphumela yokwelashwa kweminye imithi efana ne-warfarin, imigomo kanye ne-echinacea. Yize ingekho ingozi, ithimba lezokunakekelwa kwempilo lingadinga ukuguqula le eminye imiyalo noma umthamo wayo.

Umenzi weHumira akakhombisi ukuthi utshwala kufanele bugwenywe. Ngakho-ke, kungenzeka ukuthi ukuphuza utshwala ngokulinganisela ngenkathi uthatha uHumira kuphephile. Lokhu kungenzeka kungabi yiqiniso, noma kunjalo, kwiziguli ezinezinkinga zesibindi. I-Humira ingadala izinkinga zesibindi futhi-ezimweni ezingavamile kakhulu-ukwehluleka kwesibindi, ngakho-ke thintana nodokotela mayelana nokuphuza utshwala ngenkathi uthatha uHumira.

Ungayigwema kanjani imiphumela emibi ye-Humira

Izidakamizwa eziningi zidala imiphumela emibi, ngakho-ke ayikho indlela eqinisekisiwe yokugwema imiphumela emibi lapho uthatha imishanguzo. Kodwa-ke, unganciphisa ubungozi nobukhulu bemiphumela emibi ngamathiphu ambalwa.

1. Tshela udokotela wakho ngazo zonke izimo zakho zezokwelapha nemithi

Ngenxa yengozi yemiphumela emibi kakhulu, kufanele utshele udokotela wakho mayelana:

• Ukutheleleka okusebenzayo noma okwedlule (ikakhulukazi i-hepatitis B noma isifo sofuba)
• Umlando womdlavuza, ukuphazamiseka kwesistimu yezinzwa (njenge-multiple sclerosis noma i-Guillain-Barre syndrome), noma ukwehluleka kwenhliziyo
• Uma ukhulelwe noma uncelisa ibele
• Noma imiphi imishanguzo noma izithasiselo zokudla ongase uzithathe, kufaka phakathi imishanguzo yamakhasimende
• Imishanguzo yakamuva noma ezayo
• Ubuntofontofo, ukuzwa, izinkinga zokubona, noma ubuthakathaka bemisipha
• Ukungezwani ne-Rubber noma i-latex

Lapho uthatha uHumira, yazisa udokotela wakho ngokushesha uma ugula noma ukhulelwa. Ungaqali ukuthatha noma yisiphi isidakamizwa noma isengezo sokudla kuze kube yilapho ukhuluma nodokotela wakho kuqala.

2. Gcina konke ukuqokwa kwezokwelapha okulandelwayo

Iziguli zaseHumira zizobhekwa ukugwema imiphumela emibi kakhulu. Lokhu kuzodinga ukuhlolwa kwegazi okuvamile nokuvakashelwa kwamahhovisi ukubamba izinkinga ngaphambi kokuba zibe yinkinga enkulu yezokwelapha.

3. Gwema izifo

I-Humira yenza iziguli zisengozini yokutheleleka ngezifo. Ukuzigcina uphephile, zijwayeze ukuziqhelelanisa nabantu, gqoka imaski emphakathini, gwema abantu abanezifo, hlamba izandla njalo, ugeze njalo, uphathe futhi usebenzise i-sanitizer yezandla njalo.

4. Gwema imigomo ebukhoma

Ungathola imigomo ngenkathi uthatha uHumira inqobo nje uma engeyona imigomo ebukhoma. Uma unikezwa iziguli ezithinteka ekuvikeleni amasosha omzimba, imithi yokugoma ebukhoma ayinabungozi bodwa bokudala ukutheleleka, ukutheleleka kungasakazeka kuwo wonke umzimba. Khuluma nomhlinzeki wezempilo ngaphambi kokuthatha umuthi wokugoma ngenkathi uthatha uHumira. Umkhuba omuhle kakhulu ukuthola ulwazi olusha ngokugcwele ngemithi yokugoma ngaphambi kokuqala iHumira noma yimuphi omunye umuthi ocindezela amasosha omzimba. Lapho uHumira enqanyuliwe, linda okungenani izinyanga ezimbili ngaphambi kokuthola umuthi wokugoma bukhoma.

5. Gcina uhlu lwemithi yakho yonke

Ukwehlisa ubungozi bemiphumela emibi nokuhlangana kwezidakamizwa okungenzeka kube yingozi, kuhlale kuwumqondo omuhle ukugcina uhlu lwayo yonke imithi yakho luvuselelwa ngaso sonke isikhathi. Faka noma imiphi imishanguzo ongayithengela, amavithamini, nezithako ezinamakhambi ozithatha njalo. Hlala ukhombisa lolo hlu lapho ubona udokotela wakho noma lapho ugcwalisa incwadi kadokotela.

6. Shintsha njalo isiza somjovo

Imiphumela emibi kakhulu kaHumira ukusabela kwendawo yokujova. Indlela elula yokulawula ukusabela kwendawo yokujova ukuguqula isiza somjovo ngomjovo ngamunye. I-Humira ijojowe ngendlela engaphansi kwesisodwa kanye njalo emavikini amabili esiswini noma ethangeni, ngakho-ke cabanga ukushintshanisa umjovo phakathi kwethanga ngalinye nasesiswini. Gwema ukufaka umjovo esikhunjeni esithambile, esicasukile, esibomvu, esivuvukile, esilimele noma esilumayo.

Unganciphisa futhi ukusabela kwesiza somjovo ngokususa isipontsho esigcwaliswe ngaphambili noma umjovo wepeni esiqandisini ngaphambi komjovo. IHumira ingaba sendaweni yokushisa ekamelweni kuze kube yimizuzu engama-30 ngaphambi kokujova. Qiniseka, noma kunjalo, ayivezwa ukukhanya kwelanga. Ungazami ukufudumeza umuthi nganoma iyiphi enye indlela.

7. Buza udokotela wakho ngeHumira engenazitrate

I-citric acid iyisidina esisiza ukugcina imishanguzo yokujova — ikakhulukazi amaprotheni afana neHumira — azinzile ezinyangeni ezimbalwa zokugcina. Ama-citrate buffers, noma kunjalo, avame ukudala ubuhlungu obukhulu imizuzu embalwa ngemuva komjovo. Uma ubuhlungu bomjovo weHumira bungabuthwala kakhulu, buza udokotela wakho ngeHumira engenama-citrate njengenye indlela.

Izinsiza ezihlobene nemiphumela emibi ye-Humira:

• I-Adalimumab , StatPearls
• Izinguquko zokuphendula ze-Biologic , StatPearls
• Ukweqa imikhuba emidala: ukusuka kude nezisetshenziswa ezisetshenziswa kakhulu kumakhemisi , Ukubuyekezwa Kwemithi YaseYurophu
• Humira , Epocrates
• I-Humira yabasebenzi bezempilo , AbbVie
• Umhlahlandlela wemithi kaHumira , AbbVie
• Humira enquma imininingwane , AbbVie
• I-tumor necrosis factor inhibitors , StatPearls
• I-tumor necrosis factor inhibitors: ukuqala komtholampilo , Ukuphathwa Kobuhlungu Obusebenzayo