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I-Humalog vs. Novolog: Umehluko, ukufana, futhi okungcono kuwe

Izidakamizwa Vs. Umngani

Izigidi zabantu baseMelika abanesifo sikashukela zisebenzisa i-insulini njalo, noma ngabe ingeyesifo sikashukela sohlobo 1, isifo sikashukela sohlobo 2, noma isifo sikashukela sokukhulelwa. Ama-insulins afana neHumalog neNovolog ayadingeka ukulawula amazinga kashukela egazini kulabo abanesifo sikashukela. Kepha uyini umehluko phakathi kwale mikhiqizo ye-insulin?

I-Humalog neNovolog yizifo ezivimbela ukusebenza ngokushesha ezisebenza ngokushesha futhi zihlala isikhathi esifushane uma ziqhathaniswa nezinye i-insulins. Zinganikezwa ngaphambi kokudla ukulawula amazinga kashukela egazini noma ngokuqhubekayo usuku lonke ngepompo ye-insulin. I-insulin isebenza ngokwandisa ukuthathwa kukashukela kumaseli omzimba ukuze kutholakale amandla. Ushukela (i-glucose) ubalulekile ekukhiqizweni kwamandla nasemisebenzini yomzimba iyonke.

I-Humalog neNovolog zingasebenza ngezindlela ezifanayo. Kepha azishintsheki. Okusho ukuthi, enye ayinakushintshwa enye. Lokhu kungenxa yokuthi banokuhluka okuthile ngendlela enqunywe futhi esetshenziswa ngayo.

Uyini umehluko omkhulu phakathi kweHumalog neNovolog?

I-Humalog iyi-analog esebenza nge-insulin esheshayo eyamukelwa yi-FDA ngo-1996. Iyafana ne-insulin yomuntu enesakhiwo samakhemikhali esifanayo. I-Humalog, eyaziwa nangokuthi igama layo elijwayelekile i-insulin lispro, iyatholakala njengesisombululo somjovo ngaphansi kwesikhumba (ngaphansi kwesikhumba).

I-Humalog insulin iza nezitsha ezingama-10 mL nezingu-3 mL zemithamo eminingi kanye ne-3 mL cartridges namapeni agcwaliswe ngaphambili (Humalog KwikPen, Humalog Tempo Pen, Humalog Junior KwikPen). Konke ukwakheka kweHumalog kuqukethe amayunithi ayi-100 / mL (U-100) we-insulin ngaphandle kweHumalog KwikPen, nayo eza ngenguqulo engu-200 units / mL (U-200).

INovolog iyi-analog esheshayo esebenza njenge-insulin eyaziwa ngegama layo elijwayelekile elithi insulin aspart. Ifana ngokwamakhemikhali ne-insulin ejwayelekile yomuntu ngaphandle kokuthi ine-aspartic acid esikhundleni se-proline amino acid engxenyeni yesakhiwo sayo se-DNA. INovolog yayigunyazwe yi-FDA ngo-2000.

NjengoHumalog, iNovolog iyatholakala njenge-10 mL multi-dose vial yeziguli noma abahlinzeki bokuzenzela isipontsho sabo. INovolog ibuye iza ne-3 mL cartridge (PenFill cartridges) namapeni agcwaliswe ngaphambili (i-Novolog FlexPen, i-Novolog FlexTouch). Lezi zakhiwo ziqukethe amayunithi ayi-100 / mL we-insulin aspart.

Umehluko omkhulu phakathi kweHumalog neNovolog
	I-Humalog	I-Novolog
Isigaba sezidakamizwa	I-insulini	I-insulini
Isimo somkhiqizo / ejwayelekile	Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala	Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala
Ngubani igama elijwayelekile?	Umjovo we-insulin lispro	Umjovo we-insulin aspart
Izidakamizwa zingena ngaziphi izinhlobo?	Isixazululo somjovo ongaphansi	Isixazululo somjovo ongaphansi
Uyini umthamo ojwayelekile?	Imithamo ye-insulini iyahlukahluka kakhulu futhi kufanele inqunywe ngokuya ngesimo somuntu, ukudla, kanye nendlela yokuphila. I-insulin esebenza ngokushesha ivame ukunikezwa izikhathi ezi-2 kuye kwezingu-4 nsuku zonke ngaphambi noma ngemuva kokudla ebangeni lomthamo we-0.5 kuya ku-1 iyunithi / kg / ngosuku.
Yelashwa isikhathi esingakanani?	Isifo sikashukela yisifo esiqhubekayo esivame ukudinga ukugcinwa impilo yonke nge-insulin.
Ubani ovame ukusebenzisa umuthi?	Abantu abadala abane-Type 2 diabetes Abantu abadala nezingane ezineminyaka emithathu kuya phezulu abanesifo sikashukela soHlobo 1	Abantu abadala abane-Type 2 diabetes Abantu abadala nezingane ezineminyaka engu-2 nangaphezulu abane-Type 1 diabetes

Izimo eziphathwe yi-Humalog ne-Novolog

Kokubili iHumalog neNovolog yizinhlobo zamagama e-insulin evame ukubekwa ukulawula ushukela wegazi kubantu abanesifo sikashukela. Lawa ma-insulins asebenza ngokushesha avunyelwe ukwelapha labo abane-Type 1 noma Type 2 diabetes.

I-Humalog neNovolog zisetshenziswa ngaphandle kwelebuli ukwelapha isifo sikashukela sokukhulelwa, noma isifo sikashukela esenzeka kwabesifazane abakhulelwe. Abesifazane abanezici ezinobungozi besifo sikashukela banamathuba amaningi okuzwa isifo sikashukela sokukhulelwa ngesikhathi sokukhulelwa. Ama-insulin afana noHumalog noNovolog nawo asetshenziselwa ukwelapha i-ketoacidosis yesifo sikashukela, inkinga enkulu engavela amazinga aphezulu we-ketone kulabo abanesifo sikashukela soHlobo 1 — futhi, kuyaqabukela benesifo sikashukela soHlobo 2.

Isimo	I-Humalog	I-Novolog
Thayipha isifo sikashukela sokuqala	Yebo	Yebo
Thayipha 2 sikashukela	Yebo	Yebo
Isifo sikashukela sokukhulelwa	Ngaphandle kwelebula	Ngaphandle kwelebula
I-ketoacidosis yesifo sikashukela	Ngaphandle kwelebula	Ngaphandle kwelebula

Ingabe i-Humalog noma i-Novolog isebenza kangcono?

I-Humalog neNovolog inikezela ngemiphumela esebenza ngokushesha lapho iphathwa kahle. I-insulin kufanele inikezwe njengomjovo endaweni yesisu, emathangeni, ezingalweni ezingaphezulu, noma ezinqeni. Kokubili iHumalog neNovolog kusebenza ngokulinganayo ekwehliseni amazinga kashukela egazini.

Yize womabili ama-insulins esebenza ngokushesha, iNovolog isebenza ngokushesha kancane kuneHumalog. INovolog ingajovwa ngaphakathi kwemizuzu emihlanu kuya kwengu-10 ngaphambi kokudla isidlo kanti i-Humalog kufanele ijovwe kungakapheli imizuzu eyi-15 ngaphambi kokudla.

Uma kuqhathaniswa nezinye izinhlobo ze-insulin, ama-insulins asebenza ngokushesha angaba izinketho ezingcono uma esetshenziselwa ukulawula i-glucose ngaphambi noma ngemuva kokudla. Ku-meta-analysis kusuka ku- Ukwelashwa Kwesifo Sikashukela , abacwaningi bathola ukuthi i-insulin esebenza ngokushesha yayisebenza kangcono njenge-insulin yesikhathi sokudla sohlobo 1 sikashukela uma iqhathaniswa ne-insulin ejwayelekile. Ama-insulins asebenza ngokushesha atholakala nokuthi athuthukile Amazinga HbA1c ngempumelelo kakhulu kubantu abanesifo sikashukela sohlobo 1.

Ukuthi unikezwe i-Humalog, i-Novolog, noma olunye uhlobo lwe-insulin kuzoya ngesimo sakho sonke. Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuthola i-insulin engcono kakhulu kuwe.

Ukuhlanganisa nokuqhathanisa izindleko kweHumalog vs.Novolog

I-Humalog neNovolog iyatholakala ngama-brand nama-generic form. Ezinye, kepha hhayi zonke izinhlelo zeMedicare Part D ezizomboza i-insulin ngaphandle kwalapho ziphathwa ngepompo ye-insulin. Lapho i-insulin idinga ukwenziwa ngepompo ye-insulin, iMedicare Part B ingakhokhela izindleko zayo. Hlola amafomula ohlelo lwakho lomshuwalense ukuze ubone ukuthi yini ehlanganisiwe nokuthi izindleko zakho ezingaphandle kwephakethe zingaba yini.

Noma uhlelo lwakho lomshuwalense lumboza i-insulin, ungakwazi ukusindisa okuningi ngekhadi le-SingleCare. Intengo yeHumalog ejwayelekile ingafika ku- $ 300. Ngekhuphoni le-SingleCare, cishe kungama- $ 145. Ngokufanayo, isigqebhezana seNovolog singanciphisa intengo isuka ku- $ 300 iye cishe ku- $ 150 nge-10 ml vial. Gcina engqondweni, amanani entengo e-insulin ayahluka phakathi kwezigubhu namakhadibhodi.

	I-Humalog	I-Novolog
Ngokuvamile embozwe umshwalense?	Kungambozwa; kuya ngohlelo lomshuwalense	Kungambozwa; kuya ngohlelo lomshuwalense
Imbozwe ngokujwayelekile yi-Medicare?	Kungambozwa; kuya ngohlelo lomshuwalense	Kungambozwa; kuya ngohlelo lomshuwalense
Umthamo ojwayelekile	I-10 mL vial (isilinganiso siyahluka)	I-10 mL vial (isilinganiso siyahluka)
I-Medicare copay ejwayelekile	$ 318	$ 335
Izindleko ze-SingleCare	$ 140- $ 150	$ 146- $ 155

Imiphumela emibi ejwayelekile yeHumalog vs.Novolog

Imiphumela emibi kakhulu ye-Humalog ifaka phakathi ikhanda, isicanucanu, isifo sohudo, ubuhlungu besisu (ubuhlungu besisu), umphimbo obuhlungu (pharyngitis), ikhala eligijimayo (i-rhinitis), nobuthakathaka bemisipha (asthenia).

Imiphumela emibi ejwayelekile yeNovolog ifaka phakathi ikhanda, isicanucanu, isifo sohudo, ubuhlungu besisu, i-rhinitis, ubuhlungu besifuba nokuphazamiseka kwezinzwa.

Eminye imiphumela emibi ye-insulin ingabandakanya ubuhlungu bendawo, ukushisa, ukulunywa noma ukucasuka okuzungeze indawo yomjovo. Imiphumela emibi eminingi imnene. Kodwa-ke, ukusabela okweqile kokungezwani komzimba kungenzeka kulabo abazwela izithako ze-insulin.

	I-Humalog	I-Novolog
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ubuhlungu bekhanda	Yebo	24%	Yebo	12%
Isicanucanu	Yebo	5%	Yebo	7%
Uhudo	Yebo	7%	Yebo	5%
Isisu esibuhlungu	Yebo	6%	Yebo	5%
Umphimbo obuhlungu	Yebo	27%	Akunjalo	Akunjalo
Iphunga eligijimayo	Yebo	amashumi amabili%	Yebo	5%
Ubuthakathaka bemisipha	Yebo	6%	Akunjalo	Akunjalo
Ubuhlungu besifuba	Akunjalo	Akunjalo	Yebo	5%
Ukuphazamiseka kwemizwa	Akunjalo	Akunjalo	Yebo	9%

Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( I-Humalog ), IDailyMed ( I-Novolog )

Ukusebenzisana kwezidakamizwa kweHumalog vs.Novolog

I-Humalog neNovolog insulin ingaxhumana nezidakamizwa ezahlukahlukene ezahlukahlukene. Ama-antidiabetic agents, afana ne-glipizide noma i-glyburide, kwesinye isikhathi asetshenziswa kanye ne-insulin ukusiza ukulawula amazinga kashukela egazini. Kodwa-ke, ukusebenzisa le mithi nge-insulin futhi kungakhuphula ubungozi bamazinga kashukela egazini ayingozi, noma i-hypoglycemia.

Ama-Corticosteroids afana ne-prednisone noma i-dexamethasone angakhuphula amazinga e-glucose egazini. Ngakho-ke, ukuthatha le mithi kunganciphisa imiphumela ye-insulin. Ukuthatha izidakamizwa ezinjenge-antipsychotic noma i-diuretics nakho kunganciphisa imiphumela ye-insulin futhi kukhuphule ukumelana ne-insulin. Imithamo ye-insulin ingadinga ukulungiswa lapho uthatha le minye imithi.

Ama-beta blockers ingaguqula imiphumela ye-insulin. Ngokwengeziwe, ama-beta-blockers angazifihla izimpawu ze-hypoglycemia ezinokwenzeka ngemuva kokuthatha umthamo ongalungile we-insulin. Lokhu kungadala isimo esiyingozi esidinga ukugadwa.

Tshela udokotela wakho nganoma yimiphi imishanguzo oyiphuzayo ukuvimbela ukuthi kungenzeka ukuhlangana kwezidakamizwa.

Izidakamizwa	Isigaba sezidakamizwa	I-Humalog	I-Novolog
IGlipizide I-Glyburide Isigaba I-Repaglinide	Ama-antidiabetic agents	Yebo	Yebo
Prednisone I-Prednisolone I-Dexamethasone	Ama-Corticosteroids	Yebo	Yebo
I-Clozapine Olanzapine	Ama-antipsychotic e-Atypical	Yebo	Yebo
I-Hydrochlorothiazide I-Chlorthalidone	Izidakamizwa	Yebo	Yebo
I-Propranolol UNadolol I-Labetalol	Ama-beta blockers	Yebo	Yebo

* Xhumana nochwepheshe wezokunakekelwa kwempilo ngokunye ukusebenzisana kwezidakamizwa.

Izexwayiso ze-Humalog ne-Novolog

Kukhona njalo ubungozi be-hypoglycemia lapho usebenzisa ama-insulins afana neHumalog noma iNovolog. Izimpawu zikashukela wegazi ophansi zingafaka isicanucanu, indlala, ukudideka nobuthakathaka. Ngalesi sizathu, kunconywa ukuphatha amaphilisi e-glucose ukusiza ukulwa nalesi simo esingahle sisonge impilo. Ukwelashwa kweminye imithi kufanele kuhlanganiswe ngokucophelela ukuqinisekisa ukuthi inani elifanele le-insulin linikezwa.

Kufanele ugweme ukusebenzisa i-Humalog noma i-Novolog uma unokuzwela okwaziwayo kwesinye sezithako zawo ezisebenzayo. Ukusabela kwe-Hypersensitivity kungabandakanya ukuqhuma okukhulu noma inkinga yokuphefumula (anaphylaxis).

Amasirinji, amapeni agcwaliswe ngaphambili, namakhadibhodi akufanele kwabelwane ngawo nabanye abantu abanesifo sikashukela. Ukusebenzisa i-insulin yomunye umuntu kungakubeka engcupheni enkulu yokuthola i-HIV.

Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo ukuthola ezinye izindlela okufanele uzithathe ngenkathi usebenzisa i-insulin.

Imibuzo ebuzwa njalo nge-Humalog vs. Novolog

Yini iHumalog?

I-Humalog iyi-analog esebenza ngokushesha esetshenziswa ukulawula ushukela egazini kulabo abanesifo sikashukela. Kuvunyelwe i-FDA ukwelapha uhlobo lwesifo sikashukela sohlobo 2 kubantu abadala kanye nohlobo 1 sikashukela kubantu abadala nezingane ezineminyaka emithathu kuya phezulu. I-Humalog igama lomkhiqizo le-insulin lispro.

Yini i-Novolog?

INovolog iyi-analog esebenza ngokushesha ye-insulin engalawula amazinga kashukela egazini kubantu abanesifo sikashukela. Kuvunyelwe i-FDA ukwelapha Uhlobo lwesifo sikashukela kubantu abadala kanye nohlobo 1 sikashukela kubantu abadala nasezinganeni ezineminyaka emi-2 nangaphezulu. INovolog igama lomkhiqizo le-insulin aspart.

Ngabe iHumalog neNovolog ziyefana?

Cha, iHumalog neNovolog azifani. Banokwakheka okuhluke kancane, imikhawulo yeminyaka, nezindleko ezihambisana nokusetshenziswa kwabo.

Ngabe iHumalog noma iNovolog ingcono?

I-Humalog neNovolog zombili ziyasebenza ekwehliseni i-glucose yegazi. Kodwa-ke, iNovolog isebenza ngokushesha kancane kuneHumalog. Uma kuqhathaniswa nama-insulins asebenza isikhathi eside njengeLantus (insulin glargine), ama-insulins asebenza ngokushesha afaneleka kakhulu ukulawula amazinga kashukela egazini ngaphambi nangemva kokudla. Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuthola i-insulin engcono kakhulu ngesimo sakho.

Ngingayisebenzisa i-Humalog noma i-Novolog ngenkathi ngikhulelwe?

Ngokusho kwe- I-American Diabetes Association , i-insulin iyindlela yokuqala yokwelapha ukulawula isifo sikashukela ngenkathi ukhulelwe. Akutholakalanga ukuwela i-placenta. Ngakho-ke, kuthathwa njengokuphephile ukusetshenziswa ngesikhathi sokukhulelwa.

Ngingasebenzisa i-Humalog noma i-Novolog ngotshwala?

Utshwala kufanele bugwenywe ngenkathi usebenzisa i-insulin. Lokhu kungenxa yokuthi utshwala bungakhuphula ushukela wegazi wehlise imiphumela ye-insulin futhi okungadala i-hypoglycemia .

Uyini umehluko phakathi kwe-insulin lispro ne-insulin aspart?

I-insulini lispro ne-insulin aspart yizinhlobo ezimbili ezijwayelekile ze-insulin esebenza ngokushesha. Kodwa-ke, ahlukile ngokwamakhemikhali anezinyathelo zesenzo ezihluke kancane. I-insulin lispro isebenza kungakapheli imizuzu eyi-15 kanti i-insulin aspart isebenza ngaphakathi kwemizuzu emihlanu kuya kweyishumi. I-insulini eyodwa nayo ingabiza kakhulu kunenye kuye ngohlelo lwakho lomshuwalense.

Iyiphi i-insulin engaqhathaniswa neNovoLog?

INovolog ifana namanye ama-insulins asebenza ngokushesha njenge-Humalog (insulin lispro) ne-Apidra (insulin glulisine). Ngenxa yokushesha kwazo ezenzweni, i-Novolog, Humalog, ne-Apidra zivame ukusetshenziswa njengama-insulins esikhathi sokudla. Kuthatha imizuzu engaphansi kwengama-20 ukuqala ukusebenza nokuhlala isikhathi esiphelele cishe samahora amane.