I-Jardiance vs. i-Invokana: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

Ukubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa

Uma unesifo sikashukela sohlobo 2, udokotela wakho angancoma omunye wemithi yesifo sikashukela ebizwa ngeJardiance noma i-Invokana. I-Jardiance (eyenziwe yi-Boehringer-Ingelheim) ne-Invokana (eyenziwe yi-Janssen Pharmaceuticals) yimithi emibili egunyaza igama lomkhiqizo ekhonjiswe ekwelapheni isifo sikashukela sohlobo lwe-2. Basendleleni yezidakamizwa ezibizwa ngokuthi SGLT2 (i-sodium-glucose cotransporter-2) inhibitors. Zisebenza ngokusiza izinso zisuse ushukela wegazi ngomchamo, ngaleyo ndlela zehlise ushukela wegazi.

Uyini umehluko omkhulu phakathi kweJardiance vs.Invokana?

Umehluko omkhulu phakathi kweJardiance ne-Invokana
	I-Jardiance	Invokana
Isigaba sezidakamizwa	SGLT2 inhibitor	SGLT2 inhibitor
Isimo somkhiqizo / ejwayelekile	Umkhiqizo	Umkhiqizo
Ngubani igama elijwayelekile?	I-Empagliflozin (ayikatholakali ifomu elejwayelekile)	I-Canagliflozin (ayikatholakali ifomu elejwayelekile)
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi: 10 mg, 25 mg (empagliflozin iyatholakala ne-metformin emhlanganisweni igama lomuthi elibizwa nge-Synjardy, kanye ne-linagliptin eGlyxambi)	Ithebhulethi: 100 mg, 300 mg (i-canagliflozin iyatholakala ne-metformin emhlanganisweni igama lomuthi elibizwa ngokuthi I-Invokamet)
Uyini umthamo ojwayelekile?	10 mg njalo ekuseni; ingakhuphukela ku-25 mg njalo ekuseni	100 mg njalo ekuseni; ingakhuphukela ku-300 mg njalo ekuseni
Yelashwa isikhathi esingakanani?	Iyahlukahluka	Iyahlukahluka
Ubani ovame ukusebenzisa umuthi?	Abantu abadala abane-type 2 diabetes mellitus	Abantu abadala abane-type 2 diabetes mellitus

Ufuna intengo engcono ku-Jardiance?

Bhalisela izexwayiso zentengo ye-Jardiance bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo

Imibandela ephathwe yi-Jardiance vs. Invokana

I-Jardiance (What is Jardiance?) Isetshenziswa, kanye nokudla nokuzivocavoca umzimba, ukwenza ngcono ushukela egazini kubantu abadala abanesifo sikashukela sohlobo lwe-2, nokunciphisa ingozi yokufa kwenhliziyo (i-CV) kubantu abadala abanesifo sikashukela sohlobo 2 futhi kusungulwe Isifo se-CV .

I-Invokana nayo iyasetshenziswa, ngaphezu kokudla nokuzivocavoca umzimba, ukwenza ngcono ushukela egazini kubantu abadala abanesifo sikashukela sohlobo 2. Ibuye isetshenziselwe ukunciphisa ubungozi bemicimbi emikhulu ye-CV kubantu abadala abane-type 2 diabetes mellitus kanye nesifo senhliziyo esisungulwe. Inkomba yesithathu ukwehlisa ubungozi besifo sezinso sokugcina, ukuphindaphindwa kwe-serum creatinine, ukufa kwe-CV, nokulaliswa esibhedlela ukwehluleka kwenhliziyo kubantu abadala abanesifo sikashukela sohlobo 2 kanye nephropathy yesifo sikashukela ne-albuminuria.

Asikho isidakamizwa okufanele sisetshenziselwe ukwelapha uhlobo lwesifo sikashukela sohlobo 1 noma i-ketoacidosis yesifo sikashukela.

Isimo	I-Jardiance	Invokana
Hlanganisa nokudla nokuvivinya umzimba ukuze uthuthukise ukulawulwa kwe-glycemic kubantu abadala abane-type 2 diabetes mellitus	Yebo	Yebo
Nciphisa ingozi yokufa kwenhliziyo kubantu abadala abanesifo sikashukela sohlobo 2 kanye nesifo senhliziyo esisungulwe	Yebo	Akunjalo
Nciphisa ubungozi bemicimbi emikhulu yenhliziyo nemithambo yegazi kubantu abadala abane-type 2 diabetes mellitus kanye nesifo senhliziyo esisungulwe	Akunjalo	Yebo
Nciphisa ingozi yesifo sezinso sokugcina, ukuphindaphindwa kwe-serum creatinine, ukufa kwenhliziyo, nokulaliswa esibhedlela ukwehluleka kwenhliziyo kubantu abadala abane-type 2 yesifo sikashukela kanye nephropathy yesifo sikashukela ne-albuminuria	Akunjalo	Yebo

Ngabe i-Jardiance noma i-Invokana isebenza ngempumelelo kakhulu?

Ngokulawulwa okungaboni kahle, okulawulwa yi-placebo, amasonto angama-24 funda ye-Jardiance njenge-monotherapy (esetshenziswa yodwa) ezigulini ezingama-986 zohlobo lwesifo sikashukela, ukwelashwa nge-Jardiance kuholele emazingeni aphansi e-HbA1c (isilinganiso sokulawulwa kwe-glucose ezinyangeni ezimbalwa ezedlule), i-glucose esezingeni eliphansi yokuzila, nesisindo esiphansi. Ngokuhlanganiswa nezinye izidakamizwa zesifo sikashukela noma nge-insulin, iJardiance ibe nomphumela ofanayo wokuthuthukisa izinombolo ezifana neHbA1c.

Elawulwa kabili-blind, elawulwa yi-placebo, amasonto angama-26 funda kwe-Invokana njenge-monotherapy (esetshenziswa yodwa) ezigulini ezingama-584 zohlobo lwesibili zesifo sikashukela, ukwelashwa nge-Invokana kuholele emazingeni aphansi e-HbA1c, ukuzila okuphansi kanye ne-postprandial (ngemuva kokudla) i-glucose, isisindo esiphansi, nomfutho wegazi ophansi we-systolic. NjengoJardiance, lapho ifundwa ihlangene nezinye izidakamizwa zesifo sikashukela noma i-insulin, i-Invokana nayo yaba nomphumela ofanayo wokuthuthukisa izinombolo ezifana ne-HbA1c.

Umuthi osebenza kahle kakhulu kufanele unqunywe udokotela wakho kuphela, ongabuka isithombe esigcwele sesimo (se) sakho sezempilo, umlando, neminye imithi oyiphuzayo.

Thola ikhadi lesaphulelo sekhemisi

Ukuphakama nokuqhathaniswa kwezindleko kwe-Jardiance vs. i-Invokana

Ngaphandle komshuwalense, i-Jardiance ibiza cishe u- $ 625 kanti i-Invokana ibiza cishe ama- $ 600 ngokuthengwa kwezinsuku ezingama-30. I-Jardiance kungenzeka ibe sethubeni elikhulu lokumbozwa ngumshuwalense kune-Invokana; noma kunjalo, amanani ahlukahluka kakhulu kangangokuthi kungcono ukubuza inkampani yakho yomshuwalense noma uhlelo lweMedicare Part D ukuthola eminye imininingwane. Ungagcina imali ngeSingleCare kuJardiance —umuthi otholakala kadokotela ngama- $ 434- $ 500 — no-Invokana, ukhokha isilinganiso esilinganiselwa ku- $ 450 ngesibalo esingu-30, amaphilisi angama-300mg.

	I-Jardiance	Invokana
Ngokuvamile embozwe umshwalense?	Yebo	Iyahluka kuya ngecebo
Imbozwe ngokwejwayelekile yi-Medicare Part D?	Yebo	Iyahluka kuya ngecebo
Umthamo ojwayelekile	# 30, 25 mg amaphilisi	# 30, 300 mg amaphilisi
I-Medicare copay ejwayelekile	$ 19-612	$ 25- $ 568
Izindleko ze-SingleCare	$ 434- $ 500	$ 450

Imiphumela emibi ye-Jardiance vs. Invokana

Kokubili i-Jardiance ne-Invokana, imiphumela emibi kakhulu okutheleleka ngayo ukutheleleka nge-genital mycotic, okuvela kwabesilisa nabesifazane, kepha kuvame kakhulu kwabesifazane. Ukutheleleka ngomgudu womchamo nakho kungumphumela ohlangothini ovamile wazo zombili izidakamizwa. Eminye imiphumela emibi ejwayelekile yomibili le mithi ifaka ukoma, ukwanda kokuchama, nesicanucanu.

	I-Jardiance	Invokana
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
I-DWS	Yebo	7.6-9.3% *	Yebo	4.4-5.9% *
Ukutheleleka kwe-genital mycotic	Yebo	Abesifazane: 5.4-6.4% Abesilisa: 1.6-3.1%	Yebo	Abesifazane: 10.6-11.6% Abesilisa: 3.8-4.2%
Ukutheleleka okuphezulu okuphefumulayo	Yebo	3.1-4%	Akunjalo	-
Omile	Yebo	1.5-1.7%	Yebo	2.4-2.8%
Ukwanda kokuchama	Yebo	3.2-3.4%	Yebo	4.6-5.1%
Isicanucanu	Yebo	1.1-2.3%	Yebo	2.1-2.3%

* Ububanzi ngenxa yokulinganisa okuhlukile. Umthombo: I-DailyMed (Jardiance ), I-DailyMed (i-Invokana)

Ukusebenzisana kwezidakamizwa kweJardiance kuqhathaniswa ne-Invokana

I-Invokana ihlangana nesidakamizwa senhliziyo i-Lanoxin (digoxin) kanye nezidakamizwa ezenza i-UGT (izidakamizwa ezihlanganiswa namakhemikhali athile) okubandakanya i-rifampin, i-phenytoin, i-phenobarbital, ne-ritonavir.

Kokubili i-Jardiance ne-Invokana kusebenzisana ne-diuretics efana ne-Lasix (furosemide) ne-hydrochlorothiazide, kanye ne-insulin neminye imithi yesifo sikashukela efana ne-metformin. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ukuze uthole iseluleko sezokwelapha.

Izidakamizwa	Isigaba Sezidakamizwa	I-Jardiance	Invokana
I-Rifampin Phenytoin I-Phenobarbital I-Ritonavir	Abenzi be-UGT	Akunjalo	Yebo
I-Lanoxin (digoxin)	Ama-glycosides enhliziyo	Akunjalo	Yebo
I-Lasix (furosemide) I-Hydrochlorothiazide	Izidakamizwa	Yebo	Yebo
I-Glucophage (metformin)	Imfihlo ye-insulin	Yebo	Yebo

Izixwayiso ze-Jardiance vs. i-Invokana

Ngoba bobabili iJardiance ne-Invokana bangama-SGLT2 inhibitors, babelana ngezixwayiso eziningi ezifanayo:

• Ngenxa yengozi yomfutho wegazi ophansi, iBP kufanele ibhekwe. Sebenzisa ukuqaphela okwengeziwe ezigulini ezithatha isisu, iziguli esezikhulile, iziguli ezinokukhubazeka kwezinso, kanye neziguli ezinomfutho wegazi ophansi. Ukuphela kwamanzi emzimbeni kungenzeka.
• Imibiko ye-ketoacidosis (ushukela wegazi ophakeme kakhulu; ama-ketone ane-asidi akha umchamo) enzekile ezigulini ezikuma-SGLT2 inhibitors. Lokhu kungaba kubi, noma kubulale. Izimpawu zingafaka ukoma, ukuchama njalo, isicanucanu, ubuhlungu besisu, ubuthakathaka, ukuphefumula okunephunga lezithelo, nokudideka. Funa ukwelashwa okuphuthumayo, futhi umuthi kufanele unqanyulwe. Iziguli ezisengozini enkulu ye-ketoacidosis zifaka ukwehla kwe-insulin, ukwehlisa ikhalori ngenxa yokugula noma ukuhlinzwa, ukusebenzisa kabi utshwala, nesifo se-pancreatic.
• I-SGLT2 inhibitors ingadala Izinkinga zezinso . Udokotela wakho uzohlola ukusebenza kwezinso zakho, futhi abheke izinto ezandisa ubungozi bokulimala kwezinso, njengemithi ehambisanayo nezinye izimo zezokwelapha.
• Kunobungozi obandayo bokutheleleka okukhulu kwe-urinary tract (UTI) kanye nokutheleleka nge-genital mycotic (i-vulvovaginal candidiasis kwabesifazane; i-Candida balanitis emadodeni, imvamisa abesilisa abangasokile).
• Ukusebenzisa i-insulin noma imishanguzo ethile yesifo sikashukela kungakhuphula ubungozi be-hypoglycemia (ushukela ophansi wegazi) ngenkathi uthatha i-SGLT2 inhibitor.
• Uma kwenzeka ukuzwela ngokweqile (izimpawu zokuphendula okweqile njengokuvuvukala, ukuvala umphimbo, njll), umuthi kufanele unqanyulwe futhi kufanele ufune ukunakekelwa okuphuthumayo.
• Amazinga akhuphukayo we-LDL cholesterol angenzeka; cholesterol kufanele ihlolwe.
• Kubucayi, kusongela impilo Isilonda sikaFournier (i-necrotizing fasciitis ye-perineum, ukutheleleka okuyingozi kwamagciwane) kubikiwe. Iziguli kufanele zihlolwe ngokushesha uma kwenzeka lezi zimpawu: ubuhlungu, ubumnene, ubomvu, noma ukuvuvukala esithweni sangasese noma se-perianal, umkhuhlane noma i-malaise.

I-Invokana inezinye izexwayiso ezingeziwe:

• Kunesixwayiso esibhakeleni esiza ne-Invokana, okuyisixwayiso esiqine kakhulu njengoba kudingwa yi-FDA (Food and Drug Administration), maqondana nokunqunywa izitho ezingezansi.
  • Ezivivinyweni zomtholampilo, kube nengozi eyengeziwe yokunqunywa izitho ezingezansi ezigulini ezithatha i-Invokana, ezigulini ezinesifo seCV esisunguliwe noma ezisengozini yesifo seCV. Ukunqunywa okuvame kakhulu bekukhona ezinzwaneni naphakathi kwezinyawo, yize ezinye bezibandakanya imilenze. Ezinye iziguli zazinqunywe kaningi noma zinqunywa zombili izitho zomzimba. Ngaphambi kokuqala i-Invokana, kufanele ukhulume nodokotela wakho ngezici zakho zobungozi zokunqunywa. Uma uthatha i-Invokana, kufanele ubhekwe ngeso lokhozi ukutheleleka, ubuhlungu, ukuthamba, izilonda, noma izilonda ezithweni ezingezansi, uyeke ukuthatha i-Invokana bese ufuna ukwelashwa ngokushesha uma lokhu kwenzeka.
• Kunobungozi obandayo bokuphuka kwamathambo nge-Invokana.

Akunconywa i-Jardiance noma i-Invokana ngesikhathi samathathu okukhulelwa wesibili nowesithathu. Ngenxa yengozi yemiphumela emibi kakhulu ezinso zomntwana, akunconywa ukusebenzisa noma yisiphi isidakamizwa ngesikhathi sokuncelisa.

Imibuzo ebuzwa njalo nge-Jardiance vs. i-Invokana

Yini iJardiance?

I-Jardiance, equkethe umuthi empagliflozin, ngumuthi osezigabeni zezidakamizwa owaziwa nge-SGLT2 inhibitors, osebenza ngokusiza ukususa ushukela emzimbeni ngomchamo. I-Jardiance yenziwa yi-Boehringer-Ingelheim futhi imakethwa yi-Boehringer-Ingelheim ne-Eli Lilly neNkampani.

Yini i-Invokana?

I-Invokana, equkethe umuthi i-canagliflozin, nayo ingumuthi esigabeni semithi esaziwa nge-SGLT2 inhibitors, esebenza ngokusiza ukukhipha ushukela emzimbeni ngomchamo.

Ngabe i-Jardiance vs. i-Invokana iyafana?

Ngoba basesigabeni esifanayo semithi, banokufana okuningi, kepha umehluko othile kwimiphumela emibi, umthamo, ukuxhumana kwezidakamizwa, izixwayiso, njll., Kuchazwe ngenhla.

Ngabe i-Jardiance vs. i-Invokana ingcono?

Lokho kuya ngokuthi. Zombili lezi zidakamizwa zikhombisile ukuthi ziyasebenza, njengoba kuchaziwe ngenhla. Akuzange kube nezifundo eziqhathanisa lezi zidakamizwa ezimbili ikhanda nekhanda. Udokotela wakho angakusiza unqume ukuthi i-Jardiance noma i-Invokana ikulungele yini.

Ngingayisebenzisa i-Jardiance vs. i-Invokana ngikhulelwe?

Akukho muthi onconywayo ngesikhathi samathathu okukhulelwa wesibili nowesithathu. Futhi, akunconywa ukusebenzisa noma imuphi umuthi ngesikhathi sokuncelisa ibele ngenxa yengozi yemiphumela emibi kakhulu ezinso zomntwana.

Uma usuvele uthatha i-Jardiance noma i-Invokana futhi uthola ukuthi ukhulelwe, xhumana nodokotela wakho ukuthola isiqondiso. Ukulawulwa kweglucose ngesikhathi sokukhulelwa kubaluleke kakhulu; kodwa-ke, kungenzeka ukuthi udokotela wakho azoshintsha imithi yakho ukufeza ukulawulwa kwe-glucose ngokuphepha.

Ngingayisebenzisa i-Jardiance vs. i-Invokana notshwala?

Utshwala ngesinye sezici esingaholela ku-ketoacidosis. Khuluma nodokotela wakho uma uphuza utshwala ngaphambi kokuthatha i-Jardiance noma i-Invokana.

Imuphi umuthi olingana no-Invokana?

I-Invokana ikwisigaba esifanayo semithi kodwa ayilingani ncamashi neJardiance, Farxiga (dapagliflozin), neSteglatro (ertugliflozin).

Ingabe i-Jardiance isidakamizwa esiyingozi?

Zonke izidakamizwa ziza nengozi yemiphumela emibi kanye nezexwayiso. Xhumana nodokotela wakho ukuze ubone ukuthi i-Jardiance iyisidakamizwa esiphephile nesifanele yini kuwe.

Ngabe u-Invokana uyasuswa emakethe?

Njengamanje, i-Invokana isemakethe. I-FDA yenze ngo-2017 maqondana nengozi eyengeziwe yokunqunywa izitho ezingezansi ezigulini ezinesifo senhliziyo esisunguliwe.