ILatuda vs. Abilify: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
ILatuda (lurasidone) ne-Abilify (aripiprazole) yimithi kadokotela esetshenziselwa ukwelapha i-schizophrenia. Ischizophrenia ukuphazamiseka kwengqondo okubonakala ngezimpawu ezinjengokukhohlisa, ukubona izinto ezingekho, kanye nenkulumo noma indlela yokuziphatha engahlelekile. Ngaphezu kwe-schizophrenia, iLatuda ne-Abilify nazo zingaphatha ezinye izimo zempilo yengqondo.
Kokubili iLatuda ne-Abilify bahlukaniswa njengama-antipsychotic e-atypical, noma i-antipsychotic yesizukulwane sesibili. Basebenza ngezindlela ezifanayo ukusiza ukunciphisa izimpawu ze-schizophrenia. Ngenkathi indlela ngqo abasebenza ngayo ingaziwa, le mithi elwa ne-psychips ihlangana ne-dopamine ne-serotonin receptors ebuchosheni.
Uyini umehluko omkhulu phakathi kweLatuda ne-Abilify?
Umehluko omkhulu phakathi kweLatuda ne-Abilify ziqukethe izithako ezahlukahlukene ezisebenzayo. ILatuda iqukethe i-lurasidone futhi i-Abilify iqukethe i-aripiprazole.
ILatuda yamukelwa yi-FDA ngo-2010 ukwelapha i-schizophrenia kanye ne-bipolar depression. Iyatholakala njengethebhulethi yomlomo ngamandla we-20 mg, 40 mg, 60 mg, 80 mg, no-120 mg. ILatuda ifinyelela amazinga aphezulu emzimbeni kungakapheli ihora elilodwa kuya kwamathathu. ILatuda imvamisa iqalwa ngama-20 noma ama-40 mg ngosuku kuye ngesimo eselashwa, futhi kufanele ithathwe ngokudla ukumunca okungcono .
I-Abilify yagunyazwa yi-FDA ngo-2002 ukwelapha i-schizophrenia nezinye izimo zempilo yengqondo, njenge-bipolar disorder, i-autistic disorder, ne-Tourette's disorder. I-Abilify iyatholakala njengethebhulethi yomlomo ngamandla we-2 mg, 5 mg, 10 mg, 15 mg, 20 mg, no-30 mg. Kubuye kube njengethebhulethi ehlukaniswa ngomlomo, isisombululo somlomo, nomjovo. Hlanganisa amaphilisi omlomo afinyelela emazingeni aphezulu emzimbeni kungakapheli amahora amathathu kuya kwamahlanu ngemuva kokuphathwa, futhi angathathwa nokudla noma ngaphandle kokudla.
| Umehluko omkhulu phakathi kweLatuda ne-Abilify | ||
|---|---|---|
| ILatuda | Yenza amandla | |
| Isigaba sezidakamizwa | I-Antipsychotic | I-Antipsychotic |
| Isimo somkhiqizo / ejwayelekile | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala |
| Ngubani igama elijwayelekile? | I-Lurasidone | I-Aripiprazole |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo | Ithebhulethi yomlomo Ithebhulethi ehlakazeka ngomlomo Isixazululo somlomo I-Powder yokumiswa komjovo we-intramuscular |
| Uyini umthamo ojwayelekile? | I-Schizophrenia kubantu abadala: 40 kuya ku-160 mg ngosuku I-Schizophrenia ebusheni (iminyaka engu-13 kuya kwengu-17 ubudala): 40 kuya ku-80 mg ngosuku | I-Schizophrenia kubantu abadala: 10 kuya ku-15 mg ngosuku I-Schizophrenia ebusheni (iminyaka engu-13 kuya kwengu-17 ubudala): 2 kuya ku-10 mg ngosuku |
| Yelashwa isikhathi esingakanani? | Kuyahluka: iziguli kufanele zihlolwe kabusha ngezikhathi ezithile | Kuyahluka: iziguli kufanele zihlolwe kabusha ngezikhathi ezithile |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala, intsha kanye nezingane ezineminyaka eyi-10 nangaphezulu (kuya ngesimo eselashwa) | Abantu abadala, intsha kanye nezingane ezineminyaka engu-6 nangaphezulu (kuya ngesimo eselashwa) |
Izimo eziphathwe yiLatuda ne-Abilify
ILatuda isetshenziselwa ukwelapha i-schizophrenia kubantu abadala nasezinganeni ezineminyaka engu-13 nangaphezulu. Kuyamukelwa futhi ukwelapha iziqephu ezicindezelayo ezihambisana nesifo se-bipolar I kubantu abadala nezingane ezineminyaka eyi-10 nangaphezulu.
I-Abilify isetshenziselwa ukwelapha i-schizophrenia kubantu abadala nasezinganeni ezineminyaka engu-13 nangaphezulu. Kodwa-ke, ngokungafani neLatuda, kuvunyelwe ukwelapha iziqephu ezixubekile noma ze-manic ezihambisana ne-bipolar I disorder kubantu abadala nasezinganeni ezineminyaka eyi-10 nangaphezulu. Abilify futhi ingaphatha ukuphazamiseka kweTourette, noma I-Tourette's syndrome , nokucasuka okuhambisana nokuphazamiseka kwe-autistic. Uma unikezwa nge-anti-depressant therapy eyengeziwe, i-Abilify ingaphatha ukucindezeleka okukhulu (MDD). Ukuqeda imijovo kuvunyelwe i-FDA ekwelapheni izimpawu zokuphazamiseka okuvela ku-schizophrenia ne-bipolar mania.
| Isimo | ILatuda | Yenza amandla |
| Ischizophrenia | Yebo | Yebo |
| Ukuphazamiseka kwe-bipolar | Yebo | Yebo |
| Ukucindezeleka okukhulu | Akunjalo | Yebo |
| Isifo se-Autistic | Akunjalo | Yebo |
| Isifo sikaTourette | Akunjalo | Yebo |
Ingabe iLatuda noma i-Abilify isebenza kangcono?
ILatuda ne-Abilify yomibili iyimithi ephumelelayo yokwelapha i-schizophrenia, ebucayi ukugula ngengqondo . Ukwelashwa okuhle kakhulu kuzoncika ezintweni ezifana nesimo eselashwa, imiphumela emibi engaba khona, nezindleko.
Ukuhlaziywa okukodwa kwe-meta kuqhathanisa i-antipsychotic efana ne-lurasidone, i-olanzapine, i-quetiapine, i-risperidone ne-paliperidone. Abaphenyi bathole ukuthi i-lurasidone ibiyi ifana namanye ama-antipsychotic ekwelapheni i-schizophrenia. Kodwa-ke, i-lurasidone itholwe inesisindo esincane kanye nengozi ephansi yeminye imiphumela emibi uma iqhathaniswa namanye ama-antipsychotic atypical.
Okunye ukuhlaziywa kwemeta kusuka kufayela le- Ijenali Yomhlaba Yezebhayoloji Yezengqondo kuqhathaniswa i-lurasidone namanye ama-antipsychotic ekwelapheni ukucindezeleka kwe-bipolar. Ngaphezulu kokuhlolwa okungu-10 kwemitholampilo okuneziguli ezingaphezu kuka-6,000 okwahlolwa ekuhlaziyweni. Ama-antipsychotic, afana ne-lurasidone, i-quetiapine, i-aripiprazole, i-olanzapine, ne-ziprasidone, aqhathaniswa maqondana nokuphepha nokusebenza ngempumelelo. Ucwaningo luphethe ngokuthi i-lurasidone ingasebenza kakhulu kune-aripiprazole ne-ziprasidone, futhi ingadala ukukhuluphala kancane nokuzela kunamanye ama-antipsychotic.
Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuze uthole ukwelashwa okungcono kakhulu kuwe.
Ukuphakama nokuqhathaniswa kwezindleko kweLatuda vs. Abilify
I-FDA ivume uhlobo olujwayelekile lweLatuda. Noma kunjalo, inguqulo ejwayelekile kungenzeka noma ingatholakali okwamanje emakethe. Njengesidakamizwa esinegama lomkhiqizo, iLatuda ingabiza ngisho nangomshuwalense. Ama-Medicare nezinhlelo zomshuwalense zivame ukumboza iLatuda, noma ama-copay angahlukahluka kumasu ahlukene. Intengo yemali yeLatuda ingu- $ 1,783.52. Isigqebhezana se-SingleCare singanciphisa izindleko ziye cishe ku- $ 1,200.
I-Abilify iyatholakala njengomuthi ojwayelekile nowegama lomkhiqizo. Iningi le-Medicare nezinhlelo zomshuwalense zizobhekela i-Abilify. Uma kuqhathaniswa neLatuda, i-Abilify ingaba yindlela yokwelashwa eshibhile. Kodwa-ke, intengo yemali isengabiza cishe ku- $ 1,059.99. Ikhadi lesaphulelo le-SingleCare le-Abilify lingakwazi ukwehlisa izindleko libe ngaphansi kwe- $ 100.
| ILatuda | Yenza amandla | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Ubuningi | Amaphilisi angama-30 (40 mg) | Amaphilisi angama-30 (5 mg) |
| I-Medicare copay ejwayelekile | $ 7– $ 46 | $ 3– $ 204 |
| Izindleko ze-SingleCare | $ 1,236 + | $ 65 + |
Imiphumela emibi ejwayelekile yeLatuda vs. Abilify
Imiphumela emibi kakhulu yeLatuda ifaka ukozela, ukungahlaliseki noma isifiso sokuhambahamba (akathisia), isicanucanu nokuhlanza. Eminye imiphumela emibi yeLatuda ingafaka ukuqina kwemisipha, ukuthuthumela, nokuzuza kwesisindo.
Imiphumela emibi kakhulu ye-Abilify ifaka isicanucanu, ukuhlanza, ukuthambisa noma ukozela, isiyezi, ukuqunjelwa, ikhanda elibuhlungu, ukungaboni kahle, i-akathisia, nokuqwasha. Eminye imiphumela emibi ye-Abilify ifaka ukuqina kwemisipha nokuzuza kwesisindo.
Kokubili iLatuda ne-Abilify kungadala ushukela wegazi ophakeme namazinga e-cholesterol egazini. Imiphumela emibi kakhulu yeLatuda ne-Abilify ingafaka ukubalwa kwamaseli amhlophe aphansi, ukubanjwa, ukwehla kwengcindezi yegazi (i-orthostatic hypotension), nokunyakaza komzimba okungalawuleki (i-tardive dyskinesia).
Bona ngezansi ngeminye imiphumela emibi yeLatuda ne-Abilify.
| ILatuda | Yenza amandla | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ukozela | Yebo | 17% | Yebo | 5% |
| I-Akathisia | Yebo | 13% | Yebo | 13% |
| Isicanucanu | Yebo | 10% | Yebo | ishumi nanhlanu% |
| Ukuhlanza | Yebo | 8% | Yebo | ishumi nanye% |
| Ukugaya ukudla | Yebo | 6% | Yebo | 9% |
| Ukuqwasha | Yebo | 5% | Yebo | 18% |
| Ukukhathazeka | Yebo | 5% | Yebo | 17% |
| Isiyezi | Yebo | 5% | Yebo | 3% |
| Ukuzuza kwesisindo | Yebo | 3% | Yebo | 3% |
| Ukuhlungu obusemhlane | Yebo | 3% | Akunjalo | - |
| Ukubona okufiphele | Yebo | * | Yebo | 3% |
| Umlomo owomile | Yebo | * | Yebo | 5% |
| Ukuqunjelwa | Akunjalo | - | Yebo | ishumi nanye% |
| Ubuhlungu bekhanda | Akunjalo | - | Yebo | 10% |
| Ubuhlungu bemisipha | Akunjalo | - | Yebo | amaphesenti amabili |
* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( ILatuda ), IDailyMed ( Yenza amandla )
Ukusebenzisana kwezidakamizwa kweLatuda vs. Abilify
ILatuda ne-Abilify ngokuyinhloko zihlanganiswa nesibindi yi-enzyme ye-CYP3A4. Ukusetshenziswa kwabo kungadinga ukugwenywa, ukulungiswa, noma ukubhekwa lapho kuhlanganiswa nemithi esebenza njenge-CYP3A4 inhibitors noma i-CYP3A4 inducers. Izidakamizwa ezisebenza njenge-CYP3A4 inhibitors, njenge-ketoconazole ne-ritonavir, zingadala amazinga akhuphukile we-Latuda noma i-Abilify futhi zikhuphule ubungozi bemiphumela emibi. Izidakamizwa ezisebenza njenge-inducers ye-CYP3A4, efana ne-rifampin ne-carbamazepine, zingadala amazinga anciphile weLatuda noma i-Abilify futhi yehlise ukusebenza kwe-antipsychotic. Ukuhlanganisa i-Abilify ne-CYP2D6 inhibitors, njenge-quinidine ne-fluoxetine, kungaholela ekukhuleni kwamazinga we-Abilify nemiphumela engemihle.
Ukusetshenziswa kweLatuda ne-Abilify kungadinga ukuthi kubhekwe noma kugwenywe ngenkathi kusetshenziswa izidakamizwa ezinomfutho wegazi ophakeme noma ama-benzodiazepines. Ukuthatha le mithi elwa ne-antipsychotic ngemithi eqeda umfutho wegazi ophakeme kungakhuphula ingozi yomfutho wegazi ophansi. I-Benzodiazepines ingahlanganisa imiphumela emibi yokudambisa yeLatuda noma ye-Abilify.
| Izidakamizwa | Isigaba sezidakamizwa | ILatuda | Yenza amandla |
| Ketoconazole I-Fluconazole I-Clarithromycin I-Erythromycin I-Ritonavir Diltiazem I-Verapamil | I-CYP3A4 inhibitors | Yebo | Yebo |
| I-Rifampin Phenytoin ICarbamazepine I-Efavirenz I-Etravirine ISt. John's Wort | Ama-inducers we-CYP3A4 | Yebo | Yebo |
| I-Quinidine I-Fluoxetine I-Paroxetine | I-CYP2D6 inhibitors | Akunjalo | Yebo |
| Amlodipine I-Lisinopril ILosartan | Ama-antihypertensives | Yebo | Yebo |
| I-Alprazolam I-Diazepam I-Lorazepam | I-Benzodiazepines | Yebo | Yebo |
Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka
Izexwayiso zeLatuda ne-Abilify
Kokubili iLatuda ne-Abilify ziphethe izixwayiso zebhokisi elimnyama. Kunobungozi obandayo bokufa kanye ne-psychosis ehlobene nokuwohloka komqondo lapho imishanguzo yokulwa nemithambo yegazi ithathwa ngabantu asebekhulile. Imicabango nokuziphatha kokuzibulala kubikiwe nasezinganeni nasebasha asebenzisa iLatuda ne-Abilify. Iziguli ezisencane zingadinga ukuqashwa ngezimpawu eziya ziba zimbi noma izinguquko ekuziphatheni ngenkathi zithatha iLatuda noma i-Abilify.
Kunobungozi obandayo bokungqubuzana okuphambene ne-cerebrovascular, njengokushaywa unhlangothi nokuhlaselwa yischemic okungapheli, ezigulini esezikhulile ezine-psychosis ehlobene nokuwohloka komqondo. Ukuthatha iLatuda noma i-Abilify nakho kunengozi yoku i-neuroleptic syndrome ebulalayo (NMS), engadala izimpawu ezinjengomkhuhlane omkhulu, ukuqina kwemisipha, ukudideka, nezinguquko ekushayeni kwenhliziyo. I-NMS yisimo esibi esidinga ukwelashwa ngokushesha.
ILatuda ne-Abilify zingadala ushintsho lwe-metabolic, njengamazinga aphezulu kashukela egazini, amazinga e-cholesterol akhuphukile, nokuzuza kwesisindo. Le mithi ingadala ukubalwa kwamaseli amhlophe aphansi, ukubanjwa, nomfutho wegazi ophansi.
Thintana nomhlinzeki wezokunakekelwa kwempilo ukuthola ezinye izexwayiso nezindlela zokuqapha ngaphambi kokusebenzisa iLatuda noma i-Abilify.
Imibuzo ebuzwa njalo ngeLatuda vs. Abilify
Yini iLatuda?
I-Latuda ngumuthi we-antipsychotic we-atypical osetshenziselwa ukwelapha i-schizophrenia kanye neziqephu zokudangala ezihambisana ne-bipolar I disorder. Iyatholakala njengethebhulethi yomlomo. ILatuda ivame ukuthathwa kanye ngosuku ngokudla.
Kuyini ukuqinisa?
I-Abilify umuthi we-antipsychotic we-atypical osetshenziselwa ukwelapha i-schizophrenia kanye neziqephu ezixubekile noma ze-manic ezihambisana ne-bipolar I disorder. I-Abilify nayo ivunyelwe ukwelapha ukucindezeleka okukhulu, i-autistic disorder, ne-Tourette's disorder. Itholakala njengethebhulethi yomlomo, ithebhulethi ehlukaniswa ngomlomo, isisombululo somlomo, nomjovo. I-Abilify ivame ukuthathwa kanye ngosuku noma ngaphandle kokudla.
Ngabe iLatuda ne-Abilify ziyafana?
Kokubili iLatuda ne-Abilify zingama-antipsychotic e-atypical, noma ama-antipsychotic esizukulwane sesibili, avunyelwe ukwelashwa kwe-schizophrenia. Kodwa-ke, zivela ngezindlela ezahlukahlukene zokulinganisa futhi zinezinkomba ezihlukile ngaphandle kwe-schizophrenia. ILatuda ilapha iziqephu ezicindezelayo zokuphazamiseka kwe-bipolar I ngenkathi i-Abilify treats episodes manic of bipolar I disorder. ILatuda nayo idinga ukwenziwa ngokudla ngenkathi i-Abilify ingalawulwa ngokudla noma ngaphandle kokudla.
Ingabe iLatuda noma i-Abilify ingcono?
ILatuda ne-Abilify yomibili imishanguzo esebenzayo ye-schizophrenia nezinye izimo zempilo yengqondo. ILatuda ingahle isebenze njenge-Abilify neminye imishanguzo yokulwa ne-psychotic, futhi ingadala imiphumela emibi efana ne ukuzuza kwesisindo . Ezinye izinto kufanele zicatshangelwe lapho kukhethwa iLatuda noma i-Abilify, njengezindleko. Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuze uthole ukwelashwa okungcono kakhulu kuwe.
Ngingayisebenzisa yini iLatuda noma i-Abilify ngenkathi ngikhulelwe?
Ucwaningo lukhawulelwe ekusetshenzisweni kweLatuda ne-Abilify ngenkathi ukhulelwe. Le mithi elwa ne-antipsychotic ingadala izimpawu ze-extrapyramidal noma zokuhoxa kuma-neonates phakathi ne-trimester yesithathu. Kufanele zithathwe kuphela uma izinzuzo zidlula izingozi. Xhumana nomhlinzeki wakho wezokunakekelwa kwezempilo ukuthola iseluleko sezokwelapha ukuthola ukuthi kufanele usebenzise iLatuda noma u-Abilify ngenkathi ukhulelwe.
Ngingayisebenzisa yini iLatuda noma i-Abilify ngotshwala?
Kokubili imishanguzo yotshwala neye-antipsychotic inemiphumela edabukisayo yesistimu yezinzwa (CNS). Ukuthatha ama-antipsychotic ngotshwala kungakhuphula ubungozi bemiphumela ethile emibi, njengokulala kanye nesiyezi. Ukusetshenziswa kotshwala kufanele kukhawulelwe ngenkathi kuthatha iLatuda noma i-Abilify.
Ngabe iLatuda isisimamisi semizwa noma i-antipsychotic?
ILatuda ayisiqinisi isimo. Esikhundleni salokho, iLatuda ngumuthi olwa ne-antipsychotic ongahle unikezwe kanye ne-mood stabilizer efana ne-Lithobid (lithium) noma i-Depakene (i-valproic acid) yokwelashwa kwengcindezi ye-bipolar. Ezinye izibonelo zemithi elwa nezengqondo ifaka i-Invega (paliperidone), iSeroquel (quetiapine), iZyprexa (olanzapine), iGeodon (ziprasidone), URexulti (brexpiprazole), kanye neVraylar (cariprazine).
Ingabe kukhona okujwayelekile kweLatuda?
Uhlobo olujwayelekile lweLatuda luvunyiwe yi-FDA. Noma kunjalo, inguqulo ejwayelekile yeLatuda kungenzeka ingakatholakali emakethe. Abenzi beLatuda ejwayelekile bahlanganisa i-Accord Healthcare, iPiramal Healthcare UK Limited, kanye neSun Pharmaceutical Industries Ltd.
Kwenzekani uma ungathathi iLatuda ngokudla?
ILatuda kungenzeka ingasebenzi kahle lapho ithathwa ngaphandle kokudla. Kunconywa ukuthatha iLatuda ngokudla okungenani ama-calories angu-350 wokumuncwa okulungile. Ukumuncwa kweLatuda kwanda kabili lapho umuthi uthathwa nokudla.
