I-Lorazepam vs. diazepam: Umehluko, ukufana, futhi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
ILorazepam ne-diazepam yimithi ejwayelekile esebenza ekwelapheni ukukhathazeka, phakathi kwezinye izimo zempilo yengqondo. Zombili lezi zidakamizwa zihlukaniswa njenge-benzodiazepines. Basebenza ngokwandisa umsebenzi we-GABA, noma i-gamma-aminobutyric acid, ebuchosheni. I-neurotransmitter GABA iyikhemikhali evimbela ukuvimba amasiginali wezinzwa ezithile, ikhulise imizwa, futhi ikhuthaze umuzwa wokuzola.
Kokubili i-lorazepam ne-diazepam yizidakamizwa zeSheduli IV, ngokusho kweDrug Enforcement Administration (DEA). Lokhu kusho ukuthi le mithi, njengamanye ama-benzodiazepines, inobungozi bokuncika nokuhlukunyezwa. Ngakho-ke, kufanele zisetshenziswe kuphela njengokwelashwa kwesikhashana ngaphansi kweso lomhlinzeki wezokunakekelwa kwempilo.
Funda ukuze ufunde ngeminye umehluko phakathi kwe-lorazepam ne-diazepam.
Uyini umehluko omkhulu phakathi kwe-lorazepam vs. diazepam?
Umehluko omkhulu phakathi kwe-lorazepam ne-diazepam ukuthi i-diazepam ihlala emzimbeni isikhathi eside kune-lorazepam. ILorazepam, okuyigama elijwayelekile lika-Ativan, unengxenye yempilo kuze kufike ku- Amahora angu-18 . Ngakolunye uhlangothi, i-diazepam, okuyigama elijwayelekile le-Valium, ine-half-life of up Amahora angu-48 . Ngakho-ke, i-lorazepam ithathwa njenge-benzodiazepine esebenza phakathi, futhi i-diazepam ibhekwa njenge-benzodiazepine esebenza isikhathi eside.
ILorazepam ne-diazepam nazo zenziwa umzimba, noma zicutshungulwe, emzimbeni ngokuhlukile. ILorazepam ihlanganiswa nesibindi ngenqubo eyaziwa ngokuthi i-glucuronidation . I-Diazepam ihlanganiswa nesibindi ngama-enzyme e-cytochrome. Ngenxa yalokhu, i-diazepam inamandla amaningi okuxhumana nezinye izidakamizwa kune-lorazepam.
ILorazepam itholakala kumaphilisi womlomo ojwayelekile ngamandla ka-0.5 mg, 1 mg, no-2 mg. Kubuye futhi kube yisisombululo somlomo nesisombululo somjovo. I-Ativan itholakala kumaphilisi womlomo ojwayelekile ngamandla ka-2 mg, 5 mg, no-10 mg. I-Ativan nayo ingaphathwa njengesixazululo somlomo, isixazululo somjovo, nejeli eliyi-rectal.
| Umehluko omkhulu phakathi kwe-lorazepam vs. diazepam | ||
|---|---|---|
| I-Lorazepam | I-Diazepam | |
| Isigaba sezidakamizwa | I-Benzodiazepine | I-Benzodiazepine |
| Isimo somkhiqizo / ejwayelekile | Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala | Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala |
| Ngubani igama lomkhiqizo? | I-Ativan | I-Valium |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo Isixazululo somlomo Isixazululo somjovo | Ithebhulethi yomlomo Isixazululo somlomo Isixazululo somjovo Ijeli eliphelele |
| Uyini umthamo ojwayelekile? | Ngokukhathazeka: Isilinganiso sokuqala: 2 kuya ku-3 mg ngomlomo izikhathi ezi-2 ukuya kwezi-3 ngosuku Isilinganiso sesondlo: 2 kuye ku-6 mg izikhathi ezi-2 kuya kwezi-3 ngosuku | Ngokukhathazeka: 2 kuya ku-10 mg ngomlomo izikhathi ezimbili kuya kwezi-4 ngosuku |
| Yelashwa isikhathi esingakanani? | Azikho ngaphezu kwezinyanga ezi-4 | Azikho ngaphezu kwezinyanga ezi-4 |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala nezingane ezineminyaka engu-12 nangaphezulu | Abantu abadala, izingane, nezinsana izinyanga eziyisithupha nangaphezulu |
Izimo ezilashwa yi-lorazepam vs. diazepam
I-Lorazepam ne-diazepam zisebenza njenge-anxiolytics ukunciphisa izimpawu zokukhathazeka, njengokuxineka okukhulu nobunzima bokucabanga kahle. ILorazepam ne-diazepam bobabili bavunyelwe yi-FDA ukwelapha ukukhathazeka nokukhathazeka, njengokuphazamiseka kovalo nokuhlaselwa ukwesaba.
Njengamanye ama-benzodiazepines, i-lorazepam ne-diazepam ingasetshenziselwa ukwelapha ukuphazamiseka kokuquleka, noma isithuthwane. Zingasetshenziswa futhi njengokwelashwa ngaphambi kokuhlinzwa ngenhloso yokuthambisa.
IDiazepam nayo ivunyelwe yi-FDA ukwelapha ukuhoxiswa kwesifo sotshwala nemisipha. Ngaphezu kokwelapha ukukhathazeka, i-lorazepam nayo ivunyelwe ukwelapha ukuqwasha okubangelwa ukukhathazeka. Okunye ukusetshenziswa okungekho kwelebula kungatholakala etafuleni elingezansi.
| Isimo | I-Lorazepam | I-Diazepam |
| Izinkinga zokukhathazeka | Yebo | Yebo |
| Ukuqwasha okubangelwa ukukhathazeka | Yebo | Ngaphandle kwelebula |
| Ukuphuza utshwala syndrome | Ngaphandle kwelebula | Yebo |
| Ukudumba kwemisipha | Ngaphandle kwelebula | Yebo |
| Izinkinga zokubamba | Yebo | Yebo |
| Isimo isithuthwane | Yebo | Yebo |
| Sedation noma i-premedication ngaphambi kokuhlinzwa | Yebo | Yebo |
Ingabe i-lorazepam vs. diazepam isebenza kangcono?
Uma kuqhathaniswa ne-placebo, noma ayikho imithi, womabili ama-lorazepam ne-diazepam ayasebenza ekwelapheni ukukhathazeka. I-benzodiazepine ephumelela ngokwengeziwe izoncika esimweni eselashwa, eminye imishanguzo ethathwayo, kanye nanoma ikuphi ukwelashwa okuke kwazanywa phambilini.
Izilingo zomtholampilo ezingahleliwe nezilawulwayo zikhombise kakhulu ukuthi i-lorazepam ne-diazepam ziyafana nokusebenza ekwelapheni ukukhathazeka. Impumputhe eyodwa isilingo somtholampilo ngokuqhathanisa i-lorazepam ne-diazepam ezigulini eziyi-134 ezikhathazayo ngaphezulu kwamasonto amane zithole ukuthi zombili lezi zidakamizwa zisebenza kangcono kune-placebo. Kodwa-ke, i-lorazepam itholakale isebenza kangcono ezigulini ebezinezimpawu ezimbi ekuqaleni. ISedation kubikwa ukuthi ingumphumela obaluleke kakhulu eqenjini elithatha i-lorazepam.
Phakathi ku ukuhlaziywa kwe-meta-network , i-midazolam, i-lorazepam, ne-diazepam zaqhathaniswa nokwelapha isimo se-epilepticus, ukubanjwa okunamandla isikhathi eside, ezinganeni. Imininingwane ehlanganiswe kusuka ekuhlolweni okwehlukene kwemitholampilo eyi-16 ithole ukuthi i-midazolam ne-lorazepam bebephumelela kakhulu kune-diazepam.
Lokhu kuqhathanisa kwenzelwa imininingwane ejwayelekile yolwazi. Funa iseluleko sezokwelapha kudokotela noma kumhlinzeki wezempilo ngaphambi kokusebenzisa i-benzodiazepine. Umhlinzeki wakho wezokunakekelwa kwempilo uzokwenza ukuhlolwa okuphelele kwezempilo ukuthola ukuthi isimo sakho sibucayi kangakanani futhi anqume ezinye izimo zempilo yezengqondo ezingaba khona.
Ukuphakama nokuqhathaniswa kwezindleko kwe-lorazepam vs. diazepam
IGenazepam ejwayelekile imbozwa yizinhlelo eziningi zeMedicare nezinhlelo zomshuwalense. Ngaphandle komshwalense, intengo yemali ejwayelekile ingaba ngama- $ 25 ngama-30, 0.5 mg amaphilisi. Isigqebhezana se-SingleCare se-lorazepam singaletha izindleko cishe ku- $ 9.
Njengezinye izidakamizwa ezijwayelekile, i-diazepam ivame ukumbozwa ngabakwaMedicare nezinhlelo zomshuwalense. Intengo emaphakathi yemali ye-diazepam ejwayelekile icishe ibe ngama- $ 24 ngama-30, 0.5 mg amaphilisi. Uma kuqhathaniswa ne-lorazepam, i-diazepam ingabiza kancane ngokuya ngekhemisi lakho. Ukusebenzisa isigqebhezana se-SingleCare diazepam kungehlisa izindleko kuye ku- $ 7 kuma-pharmacy abambe iqhaza.
| I-Lorazepam | I-Diazepam | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokwejwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | 2 kuya ku-6 mg izikhathi ezimbili kuya kwezingu-3 ngosuku | 2 kuya ku-10 mg ngomlomo izikhathi ezimbili kuya kwezi-4 ngosuku |
| I-Medicare copay ejwayelekile | $ 0– $ 25 | $ 0– $ 12 |
| Izindleko ze-SingleCare | $ 8 + | $ 6 + |
Imiphumela emibi ejwayelekile ye-lorazepam vs. diazepam
ILorazepam ne-diazepam, njengamanye ama-benzodiazepines, ngokuyinhloko kubangela imiphumela emibi ohlelweni lwezinzwa oluphakathi (CNS). Okuvame kakhulu imiphumela emibi ye-lorazepam , noma i-Ativan, yisidambisi, isiyezi, ubuthakathaka, nokungazinzi, noma ukulahleka kokusebenzisana. Imiphumela emibi kakhulu ye-diazepam, noma i-Valium, ukozela, ukukhathala, ubuthakathaka bemisipha, nokulahlekelwa ukuhlangana.
Eminye imiphumela emibi engaba khona ingafaka izinkinga zememori. Ukuvela kwemiphumela emibi kuvame ukuncika kumthamo wemithi ethathiwe. Imiphumela emibi kakhulu ibikwa ngemithamo ephezulu ye-benzodiazepines. Imiphumela emibi, ehlanganisa ukucindezeleka kokuphefumula, noma ukuphefumula okungajulile, ingabonisa isimo esiphuthumayo sezokwelapha.
| I-Lorazepam | I-Diazepam | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Ukuhlala | Yebo | 16% | Yebo | * |
| Ukozela | Yebo | * | Yebo | * |
| Ukukhathala | Yebo | * | Yebo | * |
| Isiyezi | Yebo | 7% | Yebo | * |
| Ubuthakathaka | Yebo | 4% | Yebo | * |
| Ukudidiyelwa okonakele | Yebo | 3% | Yebo | * |
| Izinkinga zememori | Yebo | * | Yebo | * |
* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( I-Lorazepam ), IDailyMed ( I-Diazepam )
Ukusebenzisana kwezidakamizwa ze-lorazepam vs. diazepam
ILorazepam ne-diazepam ngokuyinhloko bahlangana nezinye izidakamizwa ezithinta uhlelo lwezinzwa oluphakathi (CNS). Ukuthatha la ma-benzodiazepines ngezidakamizwa ezifana nama-opioid, ama-barbiturates, ama-antipsychotic, ama-anti-depressants, kanye nama-anticonvulsants kungaholela ekwandeni kwemiphumela ecindezela i-CNS, enjengesiyezi, ukudideka nokuzela. I-antigout drug probenecid ingathinta imetabolism ye-benzodiazepines futhi iholele emiphumeleni emibi.
Ukusetshenziswa kwe-theophylline noma i-aminophylline kungaphikisana nemiphumela yokuthambisa ye-benzodiazepines. Tshela udokotela wakho uma uthatha noma iyiphi yalezi zidakamizwa ngaphambi kokuqala i-benzodiazepine.
IDiazepam icutshungulwa ngama-enzyme athile we-P450 kanti i-lorazepam ayiyona. Eminye imishanguzo ingavimba la ma-enzyme, athinta indlela i-diazepam ecutshungulwa kahle ngayo emzimbeni. Lokhu kungaholela ekukhuleni kwemiphumela emibi ye-diazepam. Izidakamizwa ezifana ne-ketoconazole, i-cimetidine, ne-omeprazole zingasebenzisana ne-diazepam futhi ziholele ekwandeni kokuthamba.
Ama-antiacid afana ne-calcium carbonate ne-magnesium hydroxide anganciphisa ukumuncwa kwe-diazepam emzimbeni. Lo mphumela ungashintsha indlela i-diazepam esebenza kahle ngayo.
| Izidakamizwa | Isigaba sezidakamizwa | I-Lorazepam | I-Diazepam |
| I-Oxycodone I-Hydrocodone ICodeine I-Morphine | I-opioid | Yebo | Yebo |
| I-Phenobarbital IPentobarbital Isebitalbital | I-Barbiturate | Yebo | Yebo |
| I-Clozapine I-Lurasidone Olanzapine | I-Antipsychotic | Yebo | Yebo |
| I-Fluoxetine I-Fluvoxamine Amitriptyline I-Doxepin | I-anti-depressant | Yebo | Yebo |
| I-Valproate Phenytoin Clobazam | I-Anticonvulsant | Yebo | Yebo |
| I-Probenecid | Umenzeli we-antigout | Yebo | Yebo |
| Theophylline I-Aminophylline | I-Methylxanthine | Yebo | Yebo |
| Ketoconazole | Umenzeli we-antifungal | Akunjalo | Yebo |
| I-Cimetidine | Umphikisi we-H2-receptor | Akunjalo | Yebo |
| Omeprazole | I-Proton pump inhibitor | Akunjalo | Yebo |
| I-calcium carbonate Magnesium hydroxide | I-Antacid | Akunjalo | Yebo |
Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka.
Izexwayiso zelorazepam vs. diazepam
Ukusetshenziswa kwama-opioid anama-benzodiazepines kufanele kugwenywe. Uma isetshenziswa ndawonye, ama-benzodiazepines nama-opioid angakhuphula ubungozi bokucindezeleka kokuphefumula, i-coma, ngisho nokufa. Iziguli kufanele ziqashwe ngeso lokhozi lapho lezi zigaba ezimbili zemithi zihlanganiswa.
ILorazepam ne-diazepam kukhona Hlela izidakamizwa IV . Labo abanomlando owedlule wophuzo oludakayo noma ukusebenzisa kabi izidakamizwa bangaba sengozini enkulu yokuncika nokuhlukunyezwa ngama-benzodiazepines. Ukuncika kanye nokuhlukumeza kungandisa ingozi yokweqisa ngokweqile ngama-benzodiazepines. Izimpawu nezimpawu zokudlula ngokweqile kwe-benzodiazepine zifaka ukulahleka okukhulu kokuhlangana, umfutho wegazi oyingozi (i-hypotension), ukucindezeleka kokuphefumula, kanye ne-coma.
Umthamo ophansi kuphela osebenzayo we-lorazepam noma i-diazepam okufanele usetshenziswe. Xhumana nodokotela noma uchwepheshe wezempilo kwezinye izixwayiso nokuqapha okungenzeka kube khona.
Imibuzo ebuzwa njalo nge-lorazepam vs. diazepam
Yini ilorazepam?
ILorazepam yigama elijwayelekile lika-Ativan. Kuyingxenye yesigaba semithi eyaziwa ngokuthi i-benzodiazepines. ILorazepam itholakala njengethebhulethi yomlomo ngamandla ka-0.5 mg, 1 mg, no-2 mg. Inganikezwa futhi njengesixazululo somlomo noma umjovo. ILorazepam ivunyelwe ukwelapha ukukhathazeka nokuqwasha okubangelwa ukukhathazeka. Ingasetshenziswa futhi njengokwelashwa kokuphazamiseka kokuquleka noma ukunikezwa kwemithi ngaphambi kokuhlinzwa.
Yini i-diazepam?
IDiazepam yaziwa nangegama layo lomkhiqizo, iValium. Yi-benzodiazepine evunyelwe i-FDA ukwelapha ukukhathazeka, ukuhoxiswa kwesifo sotshwala, kanye ukuphazamiseka kwemisipha . Ingasetshenziselwa ukuphazamiseka kokuquleka nezinhloso zokuthambisa ngaphambi kokuhlinzwa. I-Diazepam itholakala ku-2 mg, 5 mg, naku-10 mg amaphilisi omlomo. Kubuye futhi kube yisixazululo somlomo, umjovo, nejeli ehlukanisayo.
Ngabe i-lorazepam vs. diazepam iyafana?
ILorazepam ne-diazepam womabili yi-benzodiazepines, kepha awafani. Ziza ngezindlela ezahlukahlukene futhi zinokusetshenziswa okwehlukile okuvunyelwe yi-FDA. Banemikhawulo ehlukene yeminyaka: I-Lorazepam ayinconywa ezinganeni ezingaphansi kweminyaka eyi-12 ngenkathi i-diazepam inconywa ezinganeni ezingaphansi kwezinyanga eziyisithupha.
Ngabe i-lorazepam noma i-diazepam ingcono?
ILorazepam ne-diazepam zombili izidakamizwa eziphumelelayo. IDiazepam ihlala emzimbeni isikhathi eside kune-lorazepam. Kodwa-ke, lokhu akusho ukuthi isidakamizwa esingcono. Ukusebenza kwe-benzodiazepine kuzoya ngesimo eselashwa, phakathi kwezinye izinto. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ukuze ukunqume ukwelashwa okungcono kakhulu.
Ngingasebenzisa i-lorazepam noma i-diazepam ngenkathi ngikhulelwe?
Akunconyelwa ukuthatha i-lorazepam noma i-diazepam ngenkathi ukhulelwe. Yize i-diazepam ingaphepha kancane kune-lorazepam ngesikhathi sokukhulelwa, azikho izifundo ezanele ezikhombisile ukuthi i-benzodiazepines iphephe ngokuphelele ngenkathi ikhulelwe. Xhumana nomhlinzeki wezempilo ngaphambi kokuthatha i-benzodiazepine ngesikhathi sokukhulelwa.
Ngingasebenzisa i-lorazepam noma i-diazepam ngotshwala?
Ukuhlanganisa utshwala nama-benzodiazepines akunconywa. Kokubili utshwala kanye ne-benzodiazepines kungadala imiphumela emibi ye-CNS njengokulala kanye nesiyezi. Ukuthatha lezi zinto ndawonye kungandisa ubungozi bemiphumela emibi nokudlula ngokweqile.
Ingabe i-3 mg lorazepam iningi kakhulu?
Umthamo ofanele we-lorazepam uzoncika esimweni eselashwa. Xhumana nodokotela ukuthola izeluleko zochwepheshe bezokwelapha kanye nemiyalo efanele yokuthi ungayisebenzisa kanjani le mithi. Umthamo ojwayelekile we-lorazepam ungaba kusuka ku-2 kuye ku-6 mg ngomlomo kabili kuya kathathu ngosuku.
Ngabe i-diazepam ihlala isikhathi eside kune-lorazepam?
IDiazepam ihlala isikhathi eside kune-lorazepam. Kubhekwa njenge-benzodiazepine esebenza isikhathi eside nengxenye yempilo efinyelela emahoreni angama-48. Ama-benzodiazepines asebenza isikhathi eside afaka phakathi iValium (diazepam), iLibrium (chlordiazepoxide), neDalmane (flurazepam).
Ingabe kubi ukuthatha i-Ativan nsuku zonke?
Akunconywa ngokujwayelekile ukuthatha i-Ativan (lorazepam) isikhathi eside. Azikho izifundo ezanele ezenziwe ekuphepheni nasekusebenzeni kahle kwe-Ativan ezinyangeni ezine ezedlule zokusetshenziswa. Abanye abantu bakhulisa ukuthembela nokubekezelela i-Ativan, okungathinta ukuthi isebenza kanjani ngokuhamba kwesikhathi. I-Ativan kufanele isetshenziswe kuphela njengoba kuchazwe ngumhlinzeki wezokunakekelwa kwempilo.
Ngabe ilorazepam iyashesha ukwenza?
ILorazepam iyi-benzodiazepine esebenza phakathi. Imiphumela ye-lorazepam ingazwakala ngaphakathi kwe-1 kuya emahoreni we-1.5 ngemuva kokuyithatha. Impilo yengxenye yelorazepam icishe ibe ngamahora ayi-10 kuye kwangama-20. Amanye ama-benzodiazepines asebenza phakathi ahlanganisa i-Xanax (alprazolam), iKlonopin (clonazepam), neRestoril (temazepam).
