Main >> Izidakamizwa Vs. Umngani >> I-Metoprolol vs. atenolol: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Metoprolol vs. atenolol: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Metoprolol ne-atenolol zisetshenziswa ekwelapheni izinhlobo ezahlukahlukene zezimo ezihlobene nenhliziyo kubandakanya i-angina pectoris nomfutho wegazi ophezulu, noma umfutho wegazi ophakeme. I-Angina pectoris ibhekisa esimeni lapho uzwa khona ubuhlungu besifuba noma ukungaphatheki kahle ngenxa yenhliziyo yakho engatholi igazi elanele elicebile oksijini. Lokhu kungenzeka kakhulu ukuthi kwenzeke ngezikhathi zokuxineka kakhulu noma kokuzikhandla. Umfutho wegazi ophezulu Kusho ukuba nomfutho wegazi ophakeme lapho igazi eligeleza emithanjeni yakho lingaphansi kwengcindezi ejwayelekile.

I-Metoprolol ne-atenolol basesigabeni esifanayo semithi futhi baphatha izimo ezifanayo, kepha kukhona futhi umehluko phakathi kwale mithi, futhi sizoxoxa ngalabo lapha.

Uyini umehluko omkhulu phakathi kwe-metoprolol ne-atenolol?

I-Metoprolol isidakamizwa esinqunyelwe kuphela esibhekwa njenge-cardioselective beta-1-selective adrenergic agonist, kungenjalo ibizwa nge-beta blockers. Ama-receptors we-Beta 1 anesibopho sokukhuthaza inhliziyo okuholela ekukhuleni kwenhliziyo nokuncipha okuqinile kwemisipha yenhliziyo. Ukuvimba lawa ma-receptors, njengoba kwenza i-metoprolol, kuphumela ekushayeni kwenhliziyo kancane nasezinciphisweni ezingabi namandla kangako. I-Metoprolol isuselwa ku-cardioselective okusho ukuthi kungenzeka ithinte kuphela ama-beta 1 receptors enhliziyweni, futhi mancane amathuba okuthi ithinte ezinye izinhlobo zama-beta receptors atholakala emzimbeni wonke, njengasemoyeni wakho.

I-Metoprolol iyatholakala kumathebulethi akhishwa ngokushesha ku-25 mg, 37.5 mg, 50 mg, 75 mg, kanye namaphilisi e-100 mg. Ukukhishwa ngokushesha kwaziwa nangokuthi yi-metoprolol tartrate. Ifomu elikhishwa isikhathi eside le-metoprolol, elaziwa nge-metoprolol succinate, liyatholakala ngamandla ka-25 mg, 50 mg, 100 mg, no-200mg. Ama-capsule akhishwe isikhathi eside ayatholakala ngezikhwepha ezifanayo namaphilisi. Kukhona nesisombululo somjovo esingu-1 mg / ml kanye ne-powder yomlomo. Ingxenye yempilo ye-metoprolol tartrate cishe amahora amathathu, kanti isigamu sempilo ye-metoprolol succinate cishe amahora ayisikhombisa. Lokhu kusho ukuthi ukwakhiwa kokukhishwa okwandisiwe akudingeki ukuthi kwenziwe idosi kaningi.

I-Atenolol nayo iyisidakamizwa esinqunyelwe ukuthi sihlukaniswe njenge-cardioselective beta-1-selective adrenergic agonist. Isebenza ngendlela efanayo ne-metoprolol emzimbeni. Ingxenye yempilo ye-atenolol cishe ingamahora ayisithupha kuya kwayisikhombisa, ngakho-ke ingahlala isikhathi eside kunamanani athile we-metoprolol. I-Atenolol itholakala kuma-25 mg, 50 mg, kanye namaphilisi we-100 mg.

Umehluko omkhulu phakathi kwe-metoprolol ne-atenolol
	I-Metoprolol	I-Atenolol
Isigaba sezidakamizwa	I-Cardioselective beta-1-selective adrenergic agonist (i-beta blocker)	I-Cardioselective beta-1-selective adrenergic agonist (i-beta blocker)
Isimo somkhiqizo / ejwayelekile	I-Brand ne-generic iyatholakala	I-Brand ne-generic iyatholakala
Ngubani igama lomkhiqizo?	I-Lopressor, iToprol XL	I-Tenormin
Izidakamizwa zingena ngaziphi izinhlobo?	Amaphilisi omlomo asheshayo futhi enwetshiwe kanye namaphilisi, isixazululo somjovo, impuphu yomlomo	Amaphilisi omlomo akhululwa ngokushesha
Uyini umthamo ojwayelekile?	50 mg kabili ngosuku	50 mg kanye ngosuku
Yelashwa isikhathi esingakanani?	Isikhati eside	Isikhati eside
Ubani ovame ukusebenzisa umuthi?	Izingane kanye nabantu abadala	Izingane kanye nabantu abadala

Izimo eziphathwa yi-metoprolol ne-atenolol

I-Metoprolol ne-atenolol zombili zisetshenziswa ekwelapheni i-angina pectoris nomfutho wegazi ophezulu. Zingasetshenziswa ku-angina engapheli, ezinzile noma i-angina engazinzile. I-angina engapheli, ezinzile yenzeka ngokuqagela uma uzikhandla ngokomzimba noma ungaphansi kwengcindezi enkulu. I-angina engazinzile ayikwazi ukubikezela futhi ingavela ngisho nasekuphumuleni.

Uma isetshenziswa ekwelapheni umfutho wegazi ophakeme, i-metoprolol ne-atenolol zingasetshenziswa zodwa noma zihlanganiswe nezinye izidakamizwa ezinomfutho wegazi ophezulu. Lapho le mithi isetshenziswa ohlelweni lokwelashwa kwe-infarction esebenzayo, esolwayo, noma eqinisekisiwe ye-myocardial, noma isifo senhliziyo, ziyingxenye yomuthi wezidakamizwa eziningi ongafaka futhi i-angiotensin-converting enzyme inhibitors (ACE inhibitors) kanye nezidakamizwa. Esikhathini sesifo se-ischemic myocardial, ama-beta blockers anciphisa ukufunwa komoya-mpilo kwemisipha ye-myocardial futhi anezakhi eziphikisayo.

I-Metoprolol ne-atenolol nakho ngakunye kusetshenziswa ngaphandle kwelebula ngezinye izinkomba. Ukusetshenziswa okungekho kwelebula kusho ukusetshenziswa kwenkomba engavunyelwe yi-Food and Drug Administration (FDA). Zivame ukusetshenziselwa ukusiza ukuvimbela i-migraines nokulawula ukuthuthumela.

Lokhu kungenzeka kungabi uhlu oluphelele lokusetshenziswa okungenzeka kwale mithi. Udokotela wakho noma uchwepheshe we-cardiology kuphela onganquma ukuthi ngabe enye yalezi zidakamizwa ilungele isimo sakho.

Isimo	I-Metoprolol	I-Atenolol
I-Angina pectoris (kufaka phakathi i-angina engapheli, ezinzile ne-angina engazinzile)	Yebo	Yebo
Umfutho wegazi ophezulu	Yebo	Yebo
Ukwehluleka kwenhliziyo	Yebo	Akunjalo
I-infarction ye-myocardial	Yebo	Yebo
Ukulawulwa kwesilinganiso senhliziyo ku-fibrillation ye-atrial noma i-atrial flutter	Ngaphandle kwelebula	Ngaphandle kwelebula
Ukuthuthumela	Ngaphandle kwelebula	Ngaphandle kwelebula
I-Migraine prophylaxis	Ngaphandle kwelebula	Ngaphandle kwelebula
I-paroxysmal supraventricular tachycardia prophylaxis	Akunjalo	Ngaphandle kwelebula
Ukuhoxiswa kotshwala	Akunjalo	Ngaphandle kwelebula

Ingabe i-metoprolol noma i-atenolol isebenza kangcono?

I-Metoprolol ne-atenolol zifundwe futhi zaqhathaniswa kakhulu ngezinkomba nemiphumela eyahlukahlukene. A ukuhlaziywa kwe-meta eshicilelwe ngo-2017 yahlola ukusebenza ngokuqhathanisa kwalaba bavimba ababili be-beta kanye nepropranolol ne-oxprenolol ngokubheka imiphumela yezilingo eziningi zemitholampilo. IMetoprolol ikhombise ukwehla okuphawuleka kakhulu engcupheni yokufa kwenhliziyo nemithambo yegazi uma kuqhathaniswa ne-atenolol. IMetoprolol iphinde yabonisa ukwehla kwesimo sazo zonke izimbangela zokufa kanye nesifo senhliziyo. Lapho kuhlolwe ukwehla kwengozi yokushaywa unhlangothi, i-metoprolol yazibonakalisa iphakeme kune-atenolol futhi. Nakhu idatha lokho kuphakamisa ukuthi yomibili le mithi iyasebenza uma kuqhathaniswa ne-placebo futhi awukho umehluko ophawulekayo phakathi kwe-atenolol ne-metoprolol ngokwamandla abo okulawula umfutho wegazi (umfutho wegazi ophezulu).

I-Metoprolol kukhonjisiwe ukunciphisa i-systolic ne-diastolic blood pressure. I-Atenolol ingathinta umfutho wegazi we-systolic ngaphezu kwe-diastolic, ikakhulukazi ngezikhathi zokuzikhandla.

Ngokuya ngalolu lwazi, udokotela wakho angakhetha ukuqala nge-metoprolol kuqala lapho ekhetha i-ejenti yakho. Udokotela wakho kuphela onganquma ukuthi ukwelashwa nge-beta blocker kukufanele yini.

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kwe-metoprolol vs. atenolol

I-Metoprolol ngumuthi kadokotela ohlanganiswa yizinhlelo zombili zomshuwalense wezohwebo kanye neMedicare. Uma ukhokha ukheshi ngemithi kadokotela we-metoprolol, ungakhokha cishe ama- $ 31 ngokuhlinzekwa kwenyanga eyodwa. I-SingleCare inikeza isigqebhezana esizokuvumela ukuthi ukhokhe cishe u- $ 4 we-metoprolol.

I-Atenolol ngumuthi kadokotela ohlanganiswa yizinhlelo zombili zomshuwalense wezohwebo kanye neMedicare. Ngaphandle komshwalense, ungakhokha cishe u- $ 30 ngokuthengwa kwezinsuku ezingama-30 kwamaphilisi angama-50 mg. Ngekhadi lokonga elivela kwa-SingleCare, ungakhokha cishe ama- $ 9 ngalo muthi.

	I-Metoprolol	I-Atenolol
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokwejwayelekile yi-Medicare Part D?	Yebo	Yebo
Ubuningi	60, 50 mg amaphilisi	30, 50 mg amaphilisi
I-Medicare copay ejwayelekile	$ 0- $ 9	$ 0- $ 10
Izindleko ze-SingleCare	$ 4- $ 22	$ 9- $ 25

Imiphumela emibi ejwayelekile ye-metoprolol vs. atenolol

Ama-block blocker we-beta anjenge-metoprolol ne-atenolol anciphisa izinga inhliziyo eshaya ngalo namandla eshaya ngalo. Lokhu kuncipha kwesilinganiso senhliziyo kungaholela ku-bradycardia, noma izinga lokushaya kwenhliziyo eliphansi. Lapho inhliziyo ingashayi ngamandla, kwesinye isikhathi ukugeleza kwegazi akufinyeleli emaphethelweni ngengcindezi ebesingayithanda, okuholela emaphethelweni angahle abanda ekuthinteni.

Ukugeleza kwegazi okunamandla nokuncipha kwengcindezi yomthambo nakho kungaholela emiphumeleni emibi efana ne-postural hypotension, umuzwa onekhanda futhi onesiyezi lapho umile ngemuva kokuhlala noma ukulala phansi. Ukuphathwa yikhanda kungenzeka futhi ezigulini ezithatha i-metoprolol ne-atenolol.

Lokhu akuhloselwe ukuthi kube uhlu oluphelele lwemiphumela emibi. Sicela uxhumane nosokhemisi noma udokotela wakho ukuthola uhlu oluphelele.

	I-Metoprolol	I-Atenolol
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ukukhathala	Yebo	Akubikiwe	Yebo	0.6%
Isiyezi	Yebo	Akubikiwe	Yebo	4%
Ukucindezeleka	Yebo	Akubikiwe	Yebo	0.6%
Ubuhlungu bekhanda	Yebo	Akubikiwe	Akunjalo	n / a
Ukuphelelwa umoya	Yebo	Akubikiwe	Yebo	0.6%
I-Bradycardia	Yebo	Akubikiwe	Yebo	3%
Imikhawulo ebandayo	Yebo	Akubikiwe	Akunjalo	n / a
I-Hypotension	Yebo	Akubikiwe	Yebo	amaphesenti amabili
Ukuqhuma	Yebo	Akubikiwe	Akunjalo	n / a
Uhudo	Yebo	Akubikiwe	Yebo	amaphesenti amabili
Isicanucanu	Yebo	Akubikiwe	Yebo	4%
I-Rash	Yebo	Akubikiwe	Akunjalo	n / a

Umthombo: Metoprolol ( I-DailyMed I-Atenolol ( I-DailyMed )

Ukusebenzisana kwezidakamizwa kwe-metoprolol vs. atenolol

I-Digoxin ne-beta blockers efana ne-metoprolol ne-atenolol ngayinye ithinta ukuqina kokuphambana nokushaya kwenhliziyo. Lapho zinikezwa ndawonye, iziguli zisengozini eyengeziwe ye-bradycardia ne-hypotension. Ukushaya kwenhliziyo, umfutho wegazi, nezinye izimpawu zokukhubazeka kwenhliziyo kufanele kubhekwe njalo uma kufanele zinikezwe ndawonye.

I-Metoprolol ne-Atenolol kuhlanganiswe ne-calcium channel blocker efana ne-amlodipine kungadala ukuncipha kokungezelela kokuqina kwenhliziyo okungaba yingozi. Uma inhlanganisela idingeka, kubalulekile ukuthola izilinganiso zomsebenzi oyisisekelo futhi ube nokulandelela okungaguquguquki.

Izidambisi ezivamile ezifana ne-fluvoxamine, i-clomipramine, ne-serotonin reuptake inhibitors (SSRIs) ekhethiwe ivimbela i-enzyme (CYP2D6) ebhekele imetabolism ye-metoprolol. Uma inikezwa ngokuhambisana ne-metoprolol, le mithi ingaholela ekwandeni kwamazinga egazi le-metoprolol. Lokhu kungaholela emiphumeleni eyengeziwe nge-metoprolol ohlelweni lwezinhliziyo.

Lokhu akuhloselwe ukuthi kube luhlu olubandakanya konke ukuhlangana okungenzeka kube khona kwezidakamizwa. Kufanele uthintane nodokotela wakho wezempilo ukuthola uhlu oluphelele.

Izidakamizwa	Isigaba sezidakamizwa	I-Metoprolol	I-Atenolol
Hlanganisa kabusha Clonidine IMethyldopa	Abaphikisi be-Alpha adrenergic	Yebo	Yebo
USelegiline I-Phenelzine Isocarboxazid	I-Monoamine oxidase inhibitors (MAOIs)	Yebo	Yebo
I-Digoxin	I-Digitalis glycosides / antiarrhythmic	Yebo	Yebo
Amlodipine Nifedipine Diltiazem I-Verapamil	Ama-block block wesiteshi seCalcium	Yebo	Yebo
I-Fluvoxamine I-Clomipramine I-Desipramine	Izidambisamagciwane	Yebo	Akunjalo
I-Fluoxetine I-Paroxetine Sertraline	I-serotonin reuptake inhibitors ekhethiwe (SSRIs)	Yebo	Akunjalo
I-Hydralazine	IVasodilator	Yebo	Yebo
I-Dipyridamole	Isivimbela iplatelet	Yebo	Yebo
I-Ergotamine I-Dihydroergotamine	Ama-alkaloids atholakalayo	Yebo	Yebo

Izexwayiso ze-metoprolol ne-atenolol

Ama-beta blockers abangela ukudangala kokuqina kwenhliziyo. Kwezinye iziguli ezinezici ezithile zobungozi, lokhu kunganciphisa ukwehluleka kwenhliziyo. Uma lokhu kwenzeka, ukwehluleka kwenhliziyo kufanele kuphathwe ngokuya ngemikhombandlela yamanje.

Ama-beta blockers akufanele amiswe ngokuzumayo, ikakhulukazi ezigulini ezinesifo semithambo yenhliziyo. Ukuhlaselwa kwenhliziyo kanye ne-ventricular arrhythmias kubikiwe ezigulini eziyeka ngokungazelelwe ama-beta blocker.

Uma kungenzeka, ama-beta blocking agents kufanele agwenywe ezigulini ezinezifo ze-bronchospastic, njenge-asthma. Ukusetshenziswa okuhambisanayo kungandisa isifo se-bronchial. Uma kunesidingo sokusebenzisa i-beta blockers, kukhethwa ezenhliziyo. Akunconywa ukusetshenziswa kwama-beta blocker we-non-cardioselective, njenge-carvedilol.

I-Atenolol dosing kufanele yehliswe ezigulini ezinesifo sezinso noma ukukhubazeka kwezinso njengoba ukukhishwa komuthi kuhamba kancane.

Ukulawulwa okungahleliwe isilingo somtholampilo eshicilelwe yi-The Lancet iphakamisa ukuthi iziguli ezihlinzwa ngenkathi ziku-beta blockers (i-metoprolol ikakhulukazi) zisengozini enkulu yemiphumela emibi efana nokuhlaselwa yinhliziyo noma isifo sohlangothi. Kodwa-ke, akukhuthazwa ukumisa i-beta-blocker ukuze ihlinzwe uma isiguli sizinzile kuyo.

Kubalulekile ukwazi ukuthi kungaba nzima ukubona izimpawu ze-hypoglycemia ezigulini ezinesifo sikashukela, njenge-tachycardia, ngoba zizofihlwa yimiphumela ye-beta blocker.

Isizungu kanye ne-hypotension okubangelwa i-metoprolol ne-atenolol kungakhuphula ubungozi kanye nokuqubuka kokuwa, okungaba yingozi noma kuholele ekulimaleni kwekhanda. Ukuqapha kufanele kuthathwe kubantu abadala asebevele besengozini enkulu yokuwa.

Udokotela wakho kuphela onganquma ukuthi i-metoprolol noma i-atenolol therapy ziphephile yini kuwe.

Imibuzo ebuzwa njalo mayelana ne-metoprolol vs. atenolol

Yini i-metoprolol?

I-Metoprolol ngumuthi kadokotela ohlukaniswa njenge-cardioselective beta blocker. Isebenza ukwelapha umfutho wegazi ophakeme kanye ne-angina ngokunciphisa izinga lokushaya kwenhliziyo namandla okuncipha kwenhliziyo. Itholakala kumaphilisi omlomo akhishwa ngokushesha, amaphilisi akhishwa enwetshiwe namaphilisi, isixazululo somjovo, kanye nempuphu yomlomo.

Yini i-atenolol?

I-Atenolol iyi-beta blocker ye-cardioselective etholakala ngemithi kadokotela kuphela. Isebenza ukwelapha umfutho wegazi ophakeme kanye ne-angina ngokunciphisa izinga lokushaya kwenhliziyo namandla okuncipha kwenhliziyo. Itholakala kumaphilisi omlomo akhishwa ngokushesha.

Ingabe i-metoprolol ne-atenolol ziyefana?

I-Metoprolol ne-atenolol zingama-block blockers we-cardioselective ngamunye, futhi i-pharmacology yokuthi isebenza kanjani iyafana, kepha ayifani ncamashi. IMetoprolol inezinhlobo ezimbili ezitholakalayo, eyodwa esebenza okwesikhashana neyodwa esebenza isikhathi eside, futhi ingancishiswa kanye noma kabili nsuku zonke kuye ngokwakhiwa kwayo. I-Metoprolol nayo i-lipophilic, okusho ukuthi ijwayele ukuncibilika ezindaweni ezinamafutha amaningi (lipid). Ngalesi sizathu, ukuthatha iMetoprolol ngesidlo kuvame ukunconywa. I-Atenolol ithathwa kanye nsuku zonke futhi i-hydrophilic. I-Atenolol incibilika ezindaweni ezinamanzi amaningi, ngakho-ke idinga kuphela ukuthathwa ngengilazi yamanzi.

Ingabe i-metoprolol noma i-atenolol ingcono?

Idatha iphakamisa ukuthi le mithi emibili inemiphumela efanayo ezigulini ezinomfutho wegazi ophakeme, kepha imiphumela yesifo senhliziyo nemithambo yegazi, njengokuncipha kwesifo, ingahle ibe ne-metoprolol.

Ngingayisebenzisa i-metoprolol noma i-atenolol ngenkathi ngikhulelwe?

IMetoprolol ikuSigaba Sokukhulelwa C. Azikho izifundo ezilawulwa kahle zokuqinisekisa ukuphepha ekukhulelweni. Xhumana nodokotela mayelana nokuthatha iMetoprolol ngenkathi ukhulelwe noma uncelisa. I-Atenolol isesigabeni sokukhulelwa D. Kuphikisiwe futhi akufanele kuthathwe ngesikhathi sokukhulelwa. Xhumana nodokotela mayelana nezinyathelo okufanele uzithathe ngenkathi uhlela ukukhulelwa noma ukuncelisa.

Ngingayisebenzisa yini i-metoprolol ye-atenolol ngotshwala?

Ngenkathi kungekho ukuxhumana okuqondile kwamakhemikhali phakathi kotshwala ne-beta blocker njenge-metoprolol ne-atenolol, ukusetshenziswa kotshwala kubangela ukuthi umfutho wegazi lakho wehle. Umphumela ohlangene wezidakamizwa notshwala kungakubeka engcupheni yokuquleka noma uwe futhi uzilimaze.