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IShingrix vs.Zostavax: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

Okwamanje kunemithi emibili yokugoma enganikezwa ukuvimbela i-herpes zoster, eyaziwa kakhulu njenge-shingles: i-Shingrix ne-Zostavax. Kunconywa umuthi wokugomela ama-shingles kubantu abadala lapho sebeneminyaka engama-50.

Iningi labantu lingenwe yigciwane le-varicella zoster uma ngabe selike laba ne-chickenpox. Ngemuva kokuxazululeka kwenkukhu, igciwane le-varicella zoster lihlala lilele emzimbeni iminyaka, uma kungenjalo ingunaphakade. Kamuva empilweni, igciwane lingaqala ukusebenza njengamabhande futhi lidale ukuqubuka okubuhlungu okuvame ukusonga ubuso noma umzimba.

Yize iShingrix neZostavax zisebenza ngezindlela ezifanayo ukuvimbela ama-shingles, kunomehluko obalulekile phakathi kwalokhu okubili.

Uyini umehluko omkhulu phakathi kweShingrix neZostavax?

I-Shingrix (Yini i-Shingrix?) Umuthi wokugoma ophindaphindiwe, osetshenzisiwe oster owagunyazwa okokuqala yi-FDA ngo-2017. Isebenzisa i-varicella-zoster glycoprotein E antigen ukukhiqiza amasosha omzimba emzimbeni. I-adjuvant, noma isithako esingeziwe, sisiza ukukhulisa ukusabela komzimba ekulweni negciwane. Ngenxa yokuthi iShingrix iwumuthi wokugoma ongasebenzi, ungasetshenziswa ezigulini ezingenamandla noma kulabo abanamasosha omzimba abuthakathaka.

I-Shingrix ilawulwa njengomjovo emisipheni (emisipheni). Inikezwa ngamanani amabili ahlukene anenkathi ye- izinyanga ezimbili kuya kweziyisithupha Iphakathi. Umthamo wesibili uyadingeka ukuqinisekisa ukusebenza kwesikhathi eside.

I-Zostavax, yamukelwa ngo-2006, umuthi wokugomela i-herpes zoster obukhoma. Ngamanye amagama, iZostavax iqukethe uhlobo olubuthakathaka lwegciwane langempela ukukhiqiza impendulo yomzimba. Ngenxa yalesi sizathu, akunconywa kulabo abangenakuzivikela. Noma kungenjalo, umuthi wokugoma ngokwawo ungadala ukutheleleka.

I-Zostavax ilawulwa njengomjovo owodwa ngaphansi kwesikhumba (ngaphansi kwesikhumba). Kufika ku inguqulo efriziwe futhi a Uhlobo oluzinzile esiqandisini . Inguqulo efriziwe kufanele igcinwe ifriziwe ngesikhathi sokuthuthwa nokugcinwa ukuze kuqinisekiswe ukusebenza kwayo ngenkathi iZostavax ezinzile esiqandisini ingagcinwa esiqandisini ize ifune ukusetshenziswa.

Umehluko omkhulu phakathi kweShingrix neZostavax
	Shingrix	Zostavax
Isigaba sezidakamizwa	Umuthi wokugoma	Umuthi wokugoma
Isimo somkhiqizo / ejwayelekile	Igama lomkhiqizo kuphela	Igama lomkhiqizo kuphela
Ngubani igama elijwayelekile?	I-Zoster Vaccine Recombinant, Isizuzile	Zoster Vaccine Live
Izidakamizwa zingena ngaziphi izinhlobo?	Ukumiswa komjovo we-intramuscular	Ukumiswa komjovo ongaphansi
Uyini umthamo ojwayelekile?	Lawula umthamo owodwa (0.5 ml) bese kuba omunye umthamo (0.5 ml) phakathi kwezinyanga ezi-2 nezingu-6 kamuva	Lawula umthamo owodwa (0.65 ml) kanye
Yelashwa isikhathi esingakanani?	Ukugoma kuqediwe ezinyangeni ezi-2 kuya kwezi-6 ngemuva kwemithamo emi-2	Ukugoma kuqeda ngemuva komthamo owodwa
Ubani ovame ukusebenzisa umuthi?	Abantu abadala abaneminyaka engama-50 nangaphezulu	Abantu abadala abaneminyaka engama-50 nangaphezulu

Izimo eziphathwe nguShingrix noZostavax

I-Shingrix ne-Zostavax yi-FDA evunyelwe ukuvimbela ama-shingles (herpes zoster). Yomibili le mithi yokugoma ikhonjisiwe ukuvimbela ama-shingles kubantu abadala abaneminyaka engama-50 nangaphezulu. I-Shingrix ne-Zostavax ayisetshenziselwa ukuvimbela ukutheleleka okuyinhloko kwe-varicella, okwaziwa nangokuthi yi-chickenpox.

I-postherpetic neuralgia iyinhlobo ejwayelekile yobuhlungu bezinzwa obuvela ngama-shingles. Ngenxa yokuthi iShingrix neZostavax zingavimbela ama-shingles, zingavimbela futhi i-postherpetic neuralgia (PHN) nezinye izinkinga ezibuhlungu ezivela kumasongo. Kodwa-ke, le mithi yokugoma ayilebuli yokwelapha i-PHN.

Isimo	Shingrix	Zostavax
Ukuvimbela i-herpes zoster (shingles)	Yebo	Yebo

Ingabe iShingrix noma iZostavax isebenza kangcono?

I-Shingrix ne-Zostavax bobabili kufakazelwe ukuthi bavikela ama-shingles. Kodwa-ke, iShingrix ngumuthi wokugoma omusha obhekwa njengosebenza kangcono kuneZostavax. I-Shingrix inconyelwa ngisho nalabo asebethole umuthi wokugoma iZostavax phambilini.

Ukuhlolwa kwemitholampilo kukhombisile ukuthi iShingrix iyi I-97% iyasebenza ekuvimbeleni ama-shingles kubantu abadala abaneminyaka engama-50 kuya kwengama-69 ubudala. I-Shingrix ibuye isebenze ekuvikeleni ama-shingles kubantu abadala asebekhulile-abadala abangaphezu kweminyaka engama-70, uShingrix unjalo Ama-91% asebenzayo .

I-Zostavax ine- Ukusebenza okungu-70% isilinganiso sokuvimbela ama-shingles kubantu abadala abaneminyaka engama-50 kuya kwengama-69 ubudala, ngokusho kweZoster Efficacy and Safety Trial (ZEST). Imiphumela evela ku Ucwaningo Lokuvimbela AmaShingles ikhombise ukuthi iZostavax ingu-51% esebenza kahle uma iqhathaniswa nezinswazi. Uma kuqhathaniswa neShingrix, ukusebenza kweZostavax kuyehla emaqenjini amadala. Ngokuya ngemiphumela ye-SPS, iZostavax isebenza ngempumelelo engama-64% kubantu abadala abaneminyaka engama-60 kuya kwengama-69 ubudala; Ama-41% asebenza kahle kubantu abadala abaneminyaka engama-70 kuya kwengama-79 ubudala; kanye ne-18% esebenzayo kubantu abadala abaneminyaka engama-80 nangaphezulu.

Umhlinzeki wakho wezokunakekelwa kwempilo cishe uzoncoma uShingrix ngaphezulu kweZostavax. I-Shingrix inconywa ikakhulukazi kwiziguli ezingenakunyakaziswa ngoba ingumuthi wokugoma ongaphili. Buza udokotela noma usokhemisi wakho ukuthi imuphi umuthi wokugomela i-shingles okulungele.

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kweShingrix vs.Zostavax

Kubantu abadala abaneminyaka engama-50 nangaphezulu, amapulani kuphela ngokutholakala kwe-Medicare Part D izomboza umuthi wokugoma weShingrix. Kodwa-ke, kungahle kube khona i-copay ngisho nokutholakala kwe-Medicare Part D. Intengo emaphakathi yemali yomthamo owodwa we-Shingrix ingu- $ 167, noma ungakwazi ukusebenzisa ikhadi lesaphulelo kadokotela ukwehlisa lezi zindleko. Buza nekhemisi langakini ukubona ukuthi ungalisebenzisa yini ikhadi le-Shingrix SingleCare.

NjengoShingrix, iZostavax imbozwe ngokuyinhloko ngamasu we-Medicare Part D noma izinhlelo ze-Medicare Advantage ngokutholakala kwe-Medicare Part D. I-copay yeZostavax enomshwalense ingahluka. Ngamanani wemali emaphakathi engu- $ 278, iZostavax ingabiza ngomshwalense noma ngaphandle kwawo. Ukusebenzisa ikhadi lesaphulelo lesidakamizwa seZostavax kungakwazi ukunciphisa le ndleko.

	Shingrix	Zostavax
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokujwayelekile yi-Medicare Part D?	Yebo	Yebo
Umthamo ojwayelekile	1 umjovo (0.5 ml) bese kuba omunye umjovo (0.5 ml) ezinyangeni ezi-2 kuye kwezi-6 kamuva	Umjovo owodwa owodwa (0.65 ml)
I-Medicare copay ejwayelekile	$ 0– $ 164	$ 0– $ 237
Izindleko ze-SingleCare	$ 155 +	Akunjalo

Imiphumela emibi ejwayelekile ye-Shingrix vs. Zostavax

Imiphumela emibi kakhulu ye-Shingrix ne-Zostavax ifaka ukusabela endaweni yomjovo. Ngemuva komjovo weShingrix noma weZostavax, ungahle uzwe ubuhlungu, ukuba bomvu, noma ukuvuvukala eduze kwesiza somjovo. Ungase futhi uzizwe ubuhlungu noma ukulunywa ezungeze indawo yomjovo.

Uma kuqhathaniswa neZostavax, uShingrix kubikwe ukuthi ubanga ukusabela okuningi kohlelo njengokuphathwa yikhanda, umkhuhlane, ubuhlungu bemisipha (myalgia) nokukhathala. Ngenkathi le miphumela emibi ingakhathaza, imvamisa imnene futhi inyamalale yodwa.

	Shingrix	Zostavax
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ububomvu endaweni yomjovo	Yebo	39%	Yebo	36%
Ubuhlungu endaweni yomjovo	Yebo	86%	Yebo	3. 4%
Ukuvuvukala endaweni yomjovo	Yebo	29%	Yebo	26%
Ukulunywa esizeni somjovo	Yebo	amaphesenti amabili	Yebo	7%
Ubuhlungu bekhanda	Yebo	Ezine. Ezinhlanu%	Yebo	1%
Imfiva	Yebo	26%	Yebo	amaphesenti amabili
Ubuhlungu bemisipha	Yebo	53%	Akunjalo	*
Ukukhathala	Yebo	51%	Akunjalo	*

* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: I-DailyMed (Shingrix) , I-DailyMed (Zostavax)

Ukusebenzisana kwezidakamizwa kweShingrix vs.Zostavax

Izidakamizwa zokuzivikela ezifana ne-cyclosporine ne-tacrolimus zinganciphisa ukusebenza kwemithi yokugoma. Ama-steroid, afana ne-prednisone, kanye ne-chemotherapy nawo angaba nemiphumela yokuzivikela emzimbeni engashintsha indlela yokugoma esebenza ngayo.

Labo abelapha imishanguzo yokuvikela ukuzivikela kufanele bagweme i-Zostavax ngokuphelele; I-Zostavax iqukethe igciwane elibukhoma, elingaholela ekutheleleni.

Imithi elwa namagciwane efana ne-acyclovir ne-famciclovir ingaphazamisa imiphumela yomuthi wokugoma we-Zostavax. IKomidi Elelulekayo Lemikhuba Yokugoma (i-ACIP) lincoma ukuthi abantu abasebenzisa imishanguzo yokuvimbela amagciwane bayeke ukuthatha imishanguzo yokulwa namagciwane Amahora angama-24 ngaphambili ukuthola umuthi wokugoma iZostavax. Ukwelashwa ngemithi elwa namagciwane akufanele kuqaliswe kabusha okungenani izinsuku eziyi-14 ngemuva kokugoma nge-Zostavax.

Izidakamizwa	Isigaba Sezidakamizwa	Shingrix	Zostavax
ICyclosporine Tacrolimus Prednisone Ukwelashwa ngamakhemikhali	Izindlela zokwelapha ze-Immunosuppressive	Yebo	Yebo
I-Acyclovir Valacyclovir Famciclovir	Ama-antiviral agents	Akunjalo	Yebo

Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka

Izexwayiso zikaShingrix noZostavax

I-Shingrix ne-Zostavax zingadala ukusabela kwe-hypersensitivity, noma i-allergen, kulabo abanezifo zokungezwani komzimba nezithako zokugoma. I-Zostavax ingadala ukusabela okweqile kulabo abanokungezwani komzimba okwaziwayo ku-gelatin noma neomycin. Ukusabela okweqile komzimba kungaholela ekuqubukeni okukhulu nenkinga yokuphefumula (i-anaphylaxis).

I-Zostavax kufanele igwenywe kulabo abathatha ama-immunosuppressive agents kanye nalabo abathinteka yizimo zezempilo ezenza buthakathaka amasosha omzimba.

Buza udokotela wakho noma usokhemisi mayelana nezinye izindlela zokuphepha ngaphambi kokuthola umuthi wokugoma i-shingles.

Imibuzo ebuzwa njalo ngeShingrix vs. Zostavax

Kuyini uShingrix?

IShingrix iyi- umuthi wokuhlanganisa izinto kabusha esetshenziselwa ukuvimbela i-herpes zoster, noma ama-shingles, kubantu abadala abaneminyaka engama-50 noma ngaphezulu. Kuvunyelwe ngo-2017, iShingrix ngumuthi wokugoma ongasebenzi ongenalo igciwane le-varicella-zoster elibukhoma. Inikezwa ngemithamo emibili enezinyanga ezimbili kuya kweziyisithupha phakathi komthamo wokuqala nomthamo wesibili. IShingrix yenziwa ngabakwaGlaxoSmithKline.

Kuyini iZostavax?

I-Zostavax iwumuthi wokugomela oster obukhoma opholile owagunyazwa yi-FDA ngo-2006. Njengomuthi wokugomela ophilayo opholile, iZostavax iqukethe inguqulo ebukhoma, ebuthaka yegciwane le-varicella-zoster. I-Zostavax ilawulwa ngomthamo owodwa kubantu abadala abaneminyaka engama-50 noma ngaphezulu. Yenziwe nguMerck.

Ngabe iShingrix neZostavax ziyefana?

Kokubili iShingrix neZostavax kunganciphisa ubungozi bokushaywa. Kodwa-ke, ziyehluka ngokusebenza, ukuphatha, kanye nemiphumela emibi. I-Shingrix ingumuthi wokugomela kabusha we-zoster futhi iZostavax ingumuthi wokugoma obukhoma. Okusho ukuthi, i-Shingrix iqukethe uhlobo olungasebenzi lwegciwane le-varicella-zoster kanti iZostavax iqukethe uhlobo lwegciwane elibukhoma, olubuthakathaka. Omunye umehluko ukuthi uShingrix ujojowe emisipheni ngenkathi iZostavax ijojowe ngaphansi kwesikhumba. Uma kuqhathaniswa ne-Zostavax, i-Shingrix iwumuthi wokugoma omusha we-shingles.

Ngabe iShingrix noma iZostavax ingcono?

I-Shingrix isebenza kangcono kune-Zostavax. I-Shingrix isebenza ngempumelelo engama-97% ekuvikeleni ama-shingles kubantu abadala abaneminyaka engama-50 kuya kwengama-69 ubudala kanti iZostavax isebenza kuphela ngama-70% ekuvikeleni ama-shingles eqenjini elifanayo. I-Shingrix ivikela njalo ama-shingles kubantu abadala asebekhulile ngenkathi ukusebenza kweZostavax kuncipha ngokukhula kweminyaka. Kodwa-ke, iShingrix inemiphumela emibi kakhulu yohlelo kuneZostavax.

Ngingayisebenzisa yini iShingrix noma iZostavax ngenkathi ngikhulelwe?

I-Centers for Disease Control and Prevention (CDC) ayincomi iShingrix noma iZostavax kwabesifazane abakhulelwe. Azikho izifundo ezanele zokunquma i- ukuphepha kukaShingrix noma I-Zostavax kwabesifazane abakhulelwe . Xhumana nodokotela wakho noma umhlinzeki wezempilo ngaphambi kokuthola umuthi wokugoma i-shingles.

Ngingasebenzisa iShingrix noma iZostavax ngotshwala?

Ukuphuza utshwala akukushintshi ukusebenza kweShingrix noma iZostavax. Ngokuvamile kuphephile ukuphuza ngokulinganisela ngemuva kokugomela umuthi wokugomela ushingles.

Umuthi wokugomela uShingrix uhlala isikhathi esingakanani?

Ukuhlolwa kwemitholampilo kubonise ukuthi uShingrix ihlala isebenza okungenani iminyaka emine ngemuva komthamo wesibili. Kuphakanyiswa ukuthi iShingrix ihlala isikhathi eside kunalokho. Noma kunjalo, kwenziwa izifundo eziningi ekusebenzeni kwesikhathi eside kweShingrix.

Isebenza isikhathi esingakanani i-Zostavax?

Ukuvikelwa kuma-shingles kuhlala kuzungezile iminyaka emihlanu ngemuva kokugoma ngeZostavax . Ngemuva kweminyaka emihlanu, ukusebenza kweZostavax kungancipha ngokuhamba kwesikhathi. I-CDC incoma ukuthola umuthi wokugoma we-shingles omusha, i-Shingrix, noma ngabe usuvele uwutholile umuthi wokugoma we-Zostavax esikhathini esedlule.

Kwenzekani uma ungatholi isibhamu sesibili seShingrix?

Ukudutshulwa kwesibili kweShingrix kubalulekile ukuqinisekisa ukuvikelwa okuphelele ngomuthi wokugoma. Kodwa-ke, awudingi ukuthi ukhathazeke uma sekudlule izinyanga ezingaphezu kweziyisithupha ngaphambi kokuthi uthole i-booster shot. Vele uqiniseke ukuthi uthola isibhamu sesibili eduze nesikhathi sesikhathi sezinyanga ezimbili kuya kweziyisithupha ngangokunokwenzeka.