Main >> Izidakamizwa Vs. Umngani >> I-Tramadol vs. Hydrocodone: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Tramadol vs. Hydrocodone: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

I-Tramadol ne-hydrocodone yimithi emibili esetshenziselwa ukwelapha ubuhlungu obungelula kalula nge-analgesic engeyona i-opioid. Yomibili le mithi ingelapha ubuhlungu obulinganiselayo nobunzima ngemuva kokuhlinzwa noma ezimeni ezingalapheki njengomdlavuza. Kodwa-ke, ezimweni eziningi zobuhlungu, ukwelashwa okungeyona i-opioid kuvame ukuzama kuqala.

Kokubili i-tramado l ne-hydrocodone kusebenza ngokubopha kuma-opioid receptors ukushintsha indlela umuntu aphendula ngayo ebuhlungu. Njengama-opioid kadokotela, anamandla kakhulu kune-reliever yakho yokunciphisa izinhlungu. Ngakho-ke, le mithi idinga ukuvakashelwa nodokotela ukuhlola ubuhlungu bakho.

Uyini umehluko omkhulu phakathi kweTramadol neHydrocodone?

I-Tramadol yigama elijwayelekile le-Ultram, i-Ultram ER, ne-ConZip. Kuyisidakamizwa seSheduli IV ngokusho kwe-DEA okusho ukuthi sinamandla athile okuhlukumeza. Ngenkathi ibophezela kuma-mu opioid receptors, futhi ingakhuphula nokusebenza kwamanye ama-neurotransmitter wobuchopho njenge-norepinephrine ne-serotonin.

I-Hydrocodone yigama elijwayelekile le-Zohydro ER ne-Hysingla ER. I-Hydrocodone nayo ithathwa njengethebhulethi yokuhlanganisa ne-acetaminophen ngaphansi kwamagama womkhiqizo i-Vicodin noma i-Lortab. Ngokungafani ne-tramadol, i-hydrocodone umuthi olawulwa yi-Schedule II DEA onobungozi obukhulu bokuhlukunyezwa.

Umehluko omkhulu phakathi kweTramadol neHydrocodone
	I-Tramadol	I-Hydrocodone
Isigaba sezidakamizwa	I-opioid	I-opioid
Isimo somkhiqizo / ejwayelekile	Uhlobo olujwayelekile luyatholakala	Uhlobo olujwayelekile luyatholakala
Ngubani igama elijwayelekile? Ngubani igama lomkhiqizo?	Okujwayelekile: I-Tramadol Umkhiqizo: I-Ultram, i-Ultram ER	Okujwayelekile: Hydrocodone Umkhiqizo: I-Zohydro ER, i-Hysingla ER, i-Vicodin (ehlangene ne-acetaminophen), i-Lortab (ehlangene ne-acetaminophen), i-Norco (ehlangene ne-acetaminophen)
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi yomlomo Ithebhulethi yomlomo, ukukhishwa okunwetshiwe Ama-capsules omlomo Ukumiswa ngomlomo	Ithebhulethi yomlomo Ithebhulethi yomlomo, ukukhishwa okunwetshiwe Ama-capsules omlomo Isixazululo somlomo
Uyini umthamo ojwayelekile?	I-Ultram: 50 kuya ku-100 mg njalo emahoreni ama-4 kuye kwayi-6 njengoba kudingeka I-Ultram ER: 100 mg njalo emahoreni angama-24	I-Zohydro ER: 10 mg njalo emahoreni ayi-12 IHysingla ER: 20 mg njalo emahoreni angama-24 I-Vicodin, i-Lortab, i-Norco (ehlanganiswe ne-acetaminophen): 5 kuya ku-10 mg njalo emahoreni amane kuya kwayisithupha njengoba kudingeka
Yelashwa isikhathi esingakanani?	Nsuku zonke njengoba kudingeka. Isikhathi sokwelashwa sincike emyalweni kadokotela wakho.	Nsuku zonke njengoba kudingeka. Isikhathi sokwelashwa sincike emyalweni kadokotela wakho.
Ubani ovame ukusebenzisa umuthi?	Abantu abadala abaneminyaka engu-18 nangaphezulu	Abantu abadala abaneminyaka engu-18 nangaphezulu

Izimo eziphathwa yi-Tramadol ne-Hydrocodone

I-Tramadol ne-hydrocodone zombili zikhonjisiwe ekuphathweni kobuhlungu. Imvamisa iyabekwa uma unezinhlungu ezingapheli eziphakathi nendawo, ikakhulukazi kusuka ezimeni ezinjengomdlavuza. Yomibili le mithi nayo isetshenziselwa izinhlungu ngemuva kokulimala nokuhlinzwa.

Isimo	I-Tramadol	I-Hydrocodone
Ubuhlungu obulinganiselwe kuya kabuhlungu	Yebo	Yebo
Ubuhlungu obungapheli	Yebo	Yebo
Ubuhlungu bokulimala noma ngemuva kokuhlinzwa	Yebo	Yebo
Ubuhlungu Bomdlavuza	Yebo	Yebo

Ngabe iTramadol noma iHydrocodone isebenza kangcono?

I-Tramadol ne-hydrocodone womabili lawa ma-opioid kadokotela asebenzayo wezinhlungu. Kunezifundo eziningana eziqhathanisa ukusebenza kwazo. Ngoba i-hydrocodone iyi-opiate yeSheduli II, ingahle ibhekwe njengamandla amakhulu yize iza namandla aphezulu okuhlukumeza. I-Tramadol ingaba namandla aphansi okuhlukumeza kanye nemiphumela emibi.

Kokukodwa ukutadisha okuningi , I-tramadol ene-acetaminophen yaqhathaniswa ne-hydrocodone ene-acetaminophen ezigulini ezizwa ubuhlungu obuvela eqakaleni. Cishe iziguli ezingama-400 zehlukaniswe zaba ngamaqembu amabili zithola umuthi owodwa noma omunye. Imiphumela ithole ukuthi yomibili le mishanguzo inika ukukhululeka kobuhlungu okufaniswa kungakapheli amahora amane kuqhathaniswa ne-placebo.

Kwenye isilingo somtholampilo , i-hydrocodone ene-acetaminophen yaqhathaniswa ne-tramadol ezigulini ezingama-68. Lezi ziguli bezifike emnyangweni ophuthumayo ngenxa yezinhlungu zemisipha emalungeni, emathanjeni noma emisipheni yazo. Imiphumela ithole ukuthi i-hydrocodone ene-acetaminophen inikeza ukukhululeka kobuhlungu obuningi uma kuqhathaniswa ne-tramadol ngokusekelwe ezinhlungwini zobuhlungu ezinesikali se-analog ebonakalayo (VAS).

Phakathi ku icala elimpumputhe kabili , I-hydrocodone ene-acetaminophen yaqhathaniswa ne-tramadol ezigulini eziyi-118 ezinezinhlungu ezingapheli zomdlavuza. I-Tramadol ikhombise ukukhululeka kobuhlungu ezigulini ezingama-62% uma kuqhathaniswa neziguli ezingama-56.5% ezine-hydrocodone. Kodwa-ke, ukukhululeka kobuhlungu kwakufana kuwo womabili amaqembu. I-Tramadol nayo itholwe ukuthi ikhiqiza imiphumela emibi emibi uma iqhathaniswa ne-hydrocodone.

Ukuthi unikezwe i-tramadol noma i-hydrocodone kuncike kakhulu ezingeni lobuhlungu bakho. Lapho uhlola ubuhlungu bakho, udokotela wakho uzobheka umlando wakho ophelele wezokwelapha, noma imuphi umlando wokusebenzisa kabi izidakamizwa, nanoma imiphi imithi engadala ukuhlangana kwezidakamizwa. Ngakho-ke, imithi yezinhlungu ihlukaniswe kakhulu futhi idinga ukubonisana nodokotela ukuthola ukuthi yikuphi okuzosebenza kangcono kuwe.

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kweTramadol vs.Hydrocodone

I-Tramadol iyatholakala njengomuthi ojwayelekile. Ngokuvamile imbozwa yi-Medicare nezinhlelo eziningi zomshuwalense. Izindleko ezijwayelekile zokuhlinzekwa kwamathebulethi angama-60 mg tramadol azungeze u- $ 40. Wonga okuningi ngekhuphoni le-SingleCare le-generic tramadol ekhemisi langakini.

IHydrocodone yisidakamizwa esijwayelekile esivame ukumbozwa yiMedicare nezinhlelo eziningi zomshuwalense. Izindleko ze-hydrocodone ziyahlukahluka phakathi kwezinhlelo ezahlukahlukene zomshuwalense. INorco equkethe i-hydrocodone ne-acetaminophen ingasebenza ngezindleko ezijwayelekile zama- $ 317. Ngekhuphoni le-SingleCare, ungalindela ukonga okuningi kumuthi kadokotela we-hydrocodone ene-acetaminophen.

	I-Tramadol	I-Hydrocodone
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokujwayelekile yi-Medicare?	Yebo	Yebo
Umthamo ojwayelekile	Amaphilisi angama-50 mg (ukulethwa kwama-60) Kuya ngomuthi kadokotela wakho	Amaphilisi ama-5-325 mg (ukunikezwa okungu-100) Kuya ngomuthi kadokotela wakho
I-Medicare copay ejwayelekile	$ 40	$ 317
Izindleko ze-SingleCare	$ 15	$ 18

Imiphumela emibi ejwayelekile ye-Tramadol ne-Hydrocodone

I-Tramadol ne-hydrocodone zingadala imiphumela emibi efanayo. Ngoba zombili zithinta uhlelo oluphakathi lwezinzwa (CNS), zombili zingadala isiyezi, ukulala nokukhathala. Le mithi ingadala nemiphumela emibi yamathumbu njengokuqunjelwa noma ubuhlungu besisu. I-nausea, ukuhlanza, umlomo owomile, nekhanda eminye imiphumela emibi eyabiwe.

I-Tramadol nayo ingadala isifo sohudo, ukugaya isisu nokujuluka kwabanye abantu. Ngakolunye uhlangothi, i-hydrocodone nayo ingadala uketshezi okwakhekayo (i-edema) noma ukuphazamiseka kwemisipha kwabanye abantu. Sekukonke, imiphumela emibi ejwayelekile ingaqhamuka phakathi kwale mithi emibili ngoba isekilasini elilodwa.

Eminye imiphumela emibi engajwayelekile kodwa ebucayi ye-tramadol ne-hydrocodone ingafaka ukukhathazeka, ukudangala, noma okunye ukuphazamiseka kwengqondo. Ukusabela okweqile nakho kungenzeka futhi kungabandakanya ukuqubuka, ukuqhuma, nobuhlungu besifuba.

	I-Tramadol	I-Hydrocodone
Imiphumela emibi	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ukuqunjelwa	Yebo	24-46%	Yebo	ishumi nanye%
Isiyezi	Yebo	26-33%	Yebo	3%
Isicanucanu	Yebo	24-40%	Yebo	10%
Ubuhlungu bekhanda	Yebo	18-32%	Yebo	4%
Ukozela	Yebo	16-25%	Yebo	5%
Ukuhlanza	Yebo	9-17%	Yebo	3%
Ukulunywa (Pruritus)	Yebo	8-11%	Yebo	3%
Ubuthakathaka	Yebo	6-12%	Yebo	4%
Ukujuluka	Yebo	6-9%	Akunjalo	-
Ukugaya ukudla	Yebo	5-13%	Akunjalo	-
Umlomo owomile	Yebo	5-10%	Yebo	3%
Uhudo	Yebo	5-10%	Akunjalo	-
I-Edema	Akunjalo	-	Yebo	1%
Ukutheleleka kokuphefumula	Akunjalo	-	Yebo	1%
Ukudumba kwemisipha	Akunjalo	-	Yebo	1%
Ukuhlungu obusemhlane	Akunjalo	-	Yebo	1%

* Xhumana nodokotela noma usokhemisi ngayo yonke imiphumela engemihle engaba khona.

Umthombo: I-DailyMed (iTramadol HCl) , I-DailyMed (i-Zohydro ER) .

Ukusebenzisana kwezidakamizwa kweTramadol vs.Hydrocodone

I-Tramadol ne-hydrocodone inokusebenzisana okufanayo nezinye izidakamizwa. Ngoba zihlanganiswa nesibindi, zivame ukuhlangana nezinye izidakamizwa ezithinta ama-enzyme wesibindi.

Izidakamizwa ezivimbela ama-enzyme wesibindi e-CYP3A4 kanye ne-CYP2D6 zifaka phakathi i-erythromycin, ketoconazole, ne-ritonavir engakhuphula izinga lama-opioid emzimbeni nokwandisa ubungozi bemiphumela emibi. Izidakamizwa ezakha ama-enzyme wesibindi we-CYP3A4 zifaka i-carbamazepine ne-phenytoin enganciphisa izinga lama-opioid emzimbeni futhi yehlise ukusebenza kwawo.

I-Tramadol ne-hydrocodone nazo zingasebenzisana nezinye izidakamizwa ezinemiphumela emibi ye-CNS. Lezi zinhlobo zemithi zifaka imishanguzo yokulwa nokudangala, ama-anticonvulsants, ama-benzodiazepines, ama-relaxer emisipha, nokunye okuningi. Ukuthatha ama-opioid ngama-anti-depressants akhulisa i-serotonin kungakhuphula ubungozi be-serotonin syndrome, isimo esibi esidinga ukwelashwa okuphuthumayo.

Ngokusho kwelebuli yezidakamizwa i-FDA, i-tramadol nayo ingaxhumana ne-digoxin ne-warfarin. Imibiko ithole izimo ezingavamile zobuthi be-digoxin kanye nemiphumela ye-warfarin eguqukile. Ilebuli ye-FDA ye-hydrocodone ibuye ibalule ukuthi ama-laxatives aqinile anganciphisa imiphumela ye-hydrocodone emzimbeni.

Akunconyelwa ukuphuza utshwala ngenkathi usebenzisa ama-opioid. Utshwala bungahlanganisa imiphumela emibi yama-opioid njengokuwozela nesiyezi.

Izidakamizwa	Isigaba Sezidakamizwa	I-Tramadol	I-Hydrocodone
I-Erythromycin I-Clarithromycin I-Telithromycin I-Rifampin	Imithi elwa namagciwane	Yebo	Yebo
Ketoconazole I-Itraconazole	Umenzeli we-antifungal	Yebo	Yebo
I-Ritonavir Atazanavir I-Darunavir I-Indinavir Lopinavir I-Saquinavir	I-Protease inhibitor	Yebo	Yebo
Phenytoin I-Carbamazepine	I-Anticonvulsant	Yebo	Yebo
I-Escitalopram I-Fluoxetine I-Paroxetine Sertraline I-Citalopram	I-antidepressant ekhethiwe ye-serotonin reuptake inhibitor (SSRI)	Yebo	Yebo
I-Venlafaxine I-Milnacipran I-Duloxetine I-Desvenlafaxine	ISerotonin-norepinephrine reuptake inhibitor (SSNRI) elwa nokudangala	Yebo	Yebo
I-Doxepin Amitriptyline I-Clomipramine I-Desipramine Imipramine I-Nortriptyline	I-TCA elwa nokudangala	Yebo	Yebo
I-Naratriptan I-Rizatriptan I-Sumatriptan Zolmitriptan	I-Triptan	Yebo	Yebo
I-Alprazolam Clonazepam I-Diazepam I-Lorazepam	I-Benzodiazepine	Yebo	Yebo
I-Rasagiline Isocarboxazid I-Phenelzine USelegiline I-Tranylcypromine	I-Monoamine oxidase inhibitor (MAOI)	Yebo	Yebo
ICyclobenzaprine I-Metaxalone	Ukuphumula kwemisipha	Yebo	Yebo
I-Lactulose	I-laxative enamandla	Akunjalo	Yebo
I-Digoxin	I-glycoside yenhliziyo	Yebo	Akunjalo
I-Warfarin	I-Anticoagulant	Yebo	Akunjalo

* Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.

Izexwayiso zeTramadol neHydrocodone

I-Tramadol ne-hydrocodone ziphatha isexwayiso sokulutha nokuhlukumeza uma zingasetshenziswanga njengoba kushiwo. Umlutha ungaholela ekuthembekeni ngokomzimba okungaholela ezimpawu zokuhoxa uma umuthi umisiwe nganoma yisiphi isizathu. Izimpawu zokuhoxa zingabandakanya ukukhathazeka, ukuqwasha nokuxakaniseka.

Ukuthatha okungaphezu komthamo obekiwe wama-opioid kungakhuphula ubungozi bokweqisa ngokweqile, ikhoma nokufa. Imiphumela emibi esongela impilo efana nokudangala okukhulu kokuphefumula kanye nokulala kungenziwa ngokudlula ngokweqile. Ngalesi sizathu, ama-opioid awanconywa ezinganeni ngenxa yengozi eyengeziwe ye- izinkinga zokuphefumula nokufa .

Akunconyelwa ukuphuza utshwala noma ukuthatha ezinye izidakamizwa ze-CNS ngama-opioid. Lokhu kungenxa yokuthi zandisa ubungozi bemiphumela ye-CNS efana nokudanjiswa komzimba, ukuphefumula kancane, ikhoma nokufa. Noma kudingeka idatha eningi, okusha ucwaningo iphakamisa ukuthi i-tramadol ingaba nengozi ephezulu yokufa jikelele uma kuqhathaniswa nemithi elwa nokuvuvukala.

Kokubili i-tramadol ne-hydrocodone zisesigabeni sokukhulelwa C. Ngakho-ke, azinconywa kakhulu kwabesifazane abakhulelwe noma abancelisayo ngenxa yengozi yokulimala enganeni engakazalwa. Funa iseluleko sezokwelapha uma ukhulelwe noma uhlela ukukhulelwa.

Imibuzo ebuzwa njalo ngeTramadol vs. Hydrocodone

Yini i-tramadol?

I-Tramadol ngumuthi opioid osetshenziselwa ukwelapha ubuhlungu obulinganiselayo kuya kabuhlungu. Kungumuthi weSheduli IV odinga incwadi kadokotela nokuhlolwa kobuhlungu. Itholakala kwifomu ekhishwa ngokushesha futhi enwetshiwe ngokuya ngobukhulu bezinhlungu.

Yini i-hydrocodone?

IHydrocodone ngumuthi opioid ongelapha ubuhlungu obulinganiselayo kuya kabuhlungu. Kungumuthi weSheduli II ongaba namandla aphezulu okuhlukumeza nokuncika. Itholakala ngendlela ekhishwe isikhathi eside kanye nephilisi elihlanganayo ne-acetaminophen.

Ingabe i-tramadol ne-hydrocodone ziyefana?

Yize zombili zingama-opioid, i-tramadol ne-hydrocodone azifani. Banokusetshenziswa okufanayo kuye ngobuhlungu obuzwayo. Kepha futhi zivela ngezindlela ezahlukahlukene zokulinganisa futhi zinemiphumela emibi eyehlukile nokuhlangana kwezidakamizwa.

Ngabe i-tramadol noma i-hydrocodone ingcono?

Ucwaningo lukhombisa ukuthi i-tramadol ne-hydrocodone zombili zisebenza ngokuqhathaniswa ebuhlungu. Eminye imibiko ikhombisa ukuthi i-tramadol inemiphumela emibi uma iqhathaniswa ne-hydrocodone. Kodwa-ke, olunye ucwaningo lukhombisa ukuthi i-hydrocodone inamandla kakhulu futhi ikhiqiza ukukhululeka kobuhlungu kwabanye abantu.

Ngabe i-tramadol inamandla kune-codeine?

Kokubili i-tramadol ne-codeine kungabudambisa ubuhlungu futhi bobabili babhekwa njenge-opioid ebuthakathaka. Noma kunjalo, zingahluka ngemiphumela yazo emibi nasekusebenziseni kwayo. Ngokungafani ne-tramadol, i-codeine nayo ingasetshenziswa njengesicindezeli sokukhwehlela.

Ingabe i-tramadol iyi-opiate?

Yebo. I-Tramadol iyi-opiate narcotic. Yenziwe ngokuhlanganiswa futhi isesigabeni esifanayo semithi njengamanye ama-opioid pain relievers. Njengomuthi weSheduli IV, unamandla amancane okuhlukumeza nokuncika uma kuqhathaniswa namanye ama-opioid.