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Yini iCelebrex, futhi isetshenziselwani?

Imininingwane Yezidakamizwa

Uma uke waphathwa yikhanda elibi, ubuhlungu bamazinyo, noma amajaqamba abuhlungu okuya esikhathini, uyazi ukuthi kungaba nzima kanjani ukuthola ukukhululeka kobuhlungu. ICelebrex ngumuthi kadokotela owehlisa ubuhlungu nokuvuvukala. Ake sibheke ukuthi yini iCelebrex, imiphumela yayo emibi, ukuxhumana kwezidakamizwa, imithamo efanele, bese uyiqhathanisa nezinye izinto zokuqeda izinhlungu.

Kuyini iCelebrex?

I-Celebrex yisidakamizwa esingaqedi ukuvuvukala (i-NSAID), ikakhulukazi i-COX-2 inhibitor, elapha ubuhlungu nokuvuvukala ngokunciphisa ama-hormone abhekene nabo. Imvamisa iphatha izinhlungu nokuvuvukala okuvela ezinkingeni ezizimele zomzimba njenge-rheumatoid arthritis kanye ne-ankylosing spondylitis, kepha lezo akuzona kuphela izimo ezingasiza ekwelapheni. Ngokungafani namanye ama-NSAID, iCelebrex ayitholakali ngaphezu kwe-counter: Udokotela kufanele akunikeze. Lokhu kungenxa yokuthi ngumuthi onamandla wezinhlungu ezinzima nokuvuvukala. Ama-Cox-2 inhibitors agwema indlela enamandla okudala izilonda zesisu ngokusetshenziswa kwesikhathi eside, kanti ama-NSAID wendabuko angadala izilonda nezinye izinkinga zesisu ngokusetshenziswa kwesikhathi eside.

UCelebrex igama lomuthi wemithi ejwayelekile umagazine , ekhiqizwa yinkampani eyenza imithi iPfizer. ICelebrex ne-celecoxib zisebenza ngendlela efanayo futhi zisebenza ngokulinganayo. Umehluko phakathi kwegama lomkhiqizo nemithi ejwayelekile ukuthi amagama ezimpawu avame ukubiza kakhulu kunemithi ejwayelekile. Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kuvume zombili izinhlobo njengokunciphisa izinhlungu nokunciphisa ukuvuvukala. Akuzona izidakamizwa, futhi azisebenzi njengezidambisi zemisipha.

ICelebrex ngumuthi obizayo ngoba wawungatholakali njengomuthi ojwayelekile kuze kube ngu-2014, futhi ngenxa yokuthi nje yigama lomkhiqizo. Ngaphandle komshwalense, ukunikezwa kwenyanga kweCelebrex kubiza u- $ 360 ngokwesilinganiso. Amakhuphoni akwaCelebrex angasiza abantu ukuthi bonge imali kuCelebrex emakhemisi abamba iqhaza. I-Medicare imvamisa ayimbozi i-Celebrex, kepha iyanikeza ukumbozwa kwe-celecoxib.

Ukuphepha kukaCelebrex sekukhulunywa ngakho amashumi eminyaka, futhi ngesinye isikhathi, i-FDA icishe yayikhipha emakethe. Ngemuva kokudinga uPfizer ukuthi enze ifayili le- ukutadisha ngemuva kwemakethe , i-FDA ivumele umuthi ukuthi uhlale emakethe, kepha ilebula lokuphepha manje selinemininingwane eminingi ukukhombisa ngokunembile imiphumela emibi yeCelebrex.

Isetshenziselwani iCelebrex?

ICelebrex isetshenziselwa ukwelapha lezi zimo zezempilo ezilandelayo:

Isifo samathambo
I-osteoarthritis
Isifo samathambo sentsha
I-Ankylosing spondylitis
Ubuhlungu bokuya esikhathini
Ubuhlungu obukhulu
I-dysmenorrhea eyinhloko

Ngaphezu kokwelashwa kwalezi zimo, iCelebrex ngumuthi osebenzayo wokulwa nokuvuvukala ongasiza ekwelapheni ubuhlungu beqolo, ukuqina, ubuhlungu bamalunga, nobuhlungu bezinzwa.

Kufanele iqale ukusebenza ukunciphisa izinhlungu nokuvuvukala ngokushesha okukhulu, kepha isikhathi esithatha uCelebrex ukuqala ukusebenza sizohluka kuye ngomuntu nomuntu.

Izilinganiso zeCelebrex

Kutholakala njenge-capsule yomlomo, iCelebrex iza ngamandla ahlukene we-50 mg, 100 mg, 200 mg, no-400 mg. Thatha iCelebrex njengoba kudingekile ukulimala noma ubuhlungu bokuya esikhathini, kepha kwesinye isikhathi kudinga ukuthathwa njalo. Nayi indinganiso imithamo yeCelebrex yezimo ezehlukene zezokwelapha:

I-osteoarthritis	Isifo samathambo	Isifo samathambo sentsha	I-Ankylosing spondylitis	I-dysmenorrhea eyinhloko	Ubuhlungu bokulimala / ukuya esikhathini
I-200 mg ithathwa kanye ngosuku noma i-100 mg ithathwa kabili ngosuku	I-100-200 mg ithathwa kabili nsuku zonke	Ama-50 mg athathwa kabili nsuku zonke ngezingane ≥10 kg kuya ku- ≤25 kg noma 100 mg ethathwa kabili nsuku zonke ngezingane> 25 kg	I-200 mg ithathwa kanye ngosuku noma i-100 mg ithathwa kabili ngosuku	I-400 mg ekuqaleni, ilandelwe ngomthamo owengeziwe we-200 mg uma kudingeka ngosuku lokuqala. Ezinsukwini ezilandelayo, ama-200 mg kabili nsuku zonke njengoba kudingeka	U-200 mg uthathwa kabili ngosuku

I-Celebrex ingathathwa ekuseni noma ebusuku, noma ngaphandle kokudla, kepha ukuyithatha nokudla kunganciphisa amathuba okuba nesisu esibuhlungu. Uma unenkinga yokugwinya amaphilisi aphelele, ungazama ukuvula i-capsule bese uyixuba ngesipuni se-appleauce.

Kungcono ukugwema ukuphuza utshwala noma ukubhema ngenkathi uthatha iCelebrex. Lezi zinto zingakhuphula ubungozi bokuthola isilonda esiswini noma ukopha esiswini.

Uma uphuthelwa umthamo weCelebrex, kungcono ukuthatha umthamo owuphuthelwe ngokushesha okukhulu lapho ukhumbula. Uma ukhumbula ukuthi uphuthelwe ngumthamo futhi sekuyisikhathi sokuthi uthathe umthamo wakho wesibili wosuku, bese uthatha umthamo wakho wesibili kuphela. Lokhu kuzosiza ukuvimbela ukudlula ngokweqile ngengozi, okungadala imiphumela emibi kakhulu.

Ungayithatha kanjani iCelebrex

Lapho nje uCelebrex esengenisiwe, iqala ukusebenza ukudambisa ngokushesha izinhlungu nokuvuvukala, imvamisa ngemuva kwesilinganiso sokuqala. Abantu abaningi bazozwa ukukhululeka ezimpawu zabo ngosuku olulodwa noma ezimbili ngoba imiphumela yeCelebrex ihlala emahoreni ayi-12. Uma kungekho ukuthuthuka kwezimpawu ngemuva kokuthatha iCelebrex ye amasonto amabili kuya kwamathathu , kungaba yisikhathi sokukhuluma nodokotela wakho mayelana nokuthatha umuthi ohlukile.

Isikhathi umuntu adinga ukuba ngaso kuCelebrex sizohluka ngokuya ngamacala. Abanye abantu bangadinga ukuthatha isikhathi eside seCelebrex ngezimo ezinjengesifo samathambo, kanti abanye abantu bangadinga ukuyithatha izinsuku ezimbalwa kuphela kokuthile okufana nezikhwebu zokuya esikhathini.

Angikukhuthazi ukuthatha uCelebrex nsuku zonke isikhathi esingaphezu kwenyanga, kusho uFarzin Kabaei, MD, udokotela ohlinzayo wamathambo Ama-DOCS Spine kanye ne-Orthopedics eLos Angeles. Uma isiguli sidinga ukuyithatha izinsuku ezingama-30 noma ngaphezulu, ngincoma ukusebenza kwegazi minyaka yonke ukuhlola ukusebenza kwezinso. UDkt Kabaei ucela neziguli zakhe ukuthi zingaphuzi iphilisi elingaphezu kwesisodwa esingu-200 mg ngosuku.

Imikhawulo

I-Celebrex akuyona imithi efanelekile kuwo wonke umuntu. Okwamanje azikho izifundo ezanele nezilawulwayo zeCelebrex kwabesifazane abakhulelwe, futhi odokotela abaningi bayakugwema ukunquma iCelebrex ngesikhathi sokukhulelwa ngoba kungathinta impilo yesisu. Eminye imibiko ikhombisa ukuthi iCelebrex ingadlula isuka komama iye ezinganeni ngokuncelisa, kepha ukuthi iCelebrex izithinta kanjani izinsana akuqondakali ngokuphelele.

OKUSHIWO: Yimiphi imithi yezinhlungu ephephile ukuyithatha ngenkathi ukhulelwe?

Uma kukhulunywa ngezingane, iCelebrex iphephile ukuyithatha uma kunqunywe udokotela. Ngakolunye uhlangothi, iziguli esezikhulile zisengozini enkulu yokuthola imiphumela emibi evela kuCelebrex.

Ukusebenzisana

Ukuthatha iCelebrex ngasikhathi sinye neminye imithi ethile kungadala imiphumela emibi noma imiphumela emibi. I-Celebrex akufanele ithathwe ngasikhathi sinye nale mithi ngaphandle kokuthi ivunyelwe ngudokotela:

Ama-Corticosteroids
Izigaba ze-CYP2D6
Ama-CYP2C9 inhibitors noma ama-inducers
I-Pemetrexed
Ama-NSAID
Ama-salicylates
ICyclosporine
IMethotrexate
ILithium
I-Digoxin
Izidakamizwa
I-Aspirin
Ama-ACE inhibitors
Abavimbela i-Beta
Ama-Angiotensin receptor blockers

Ukuthatha uhlu oluphelele lwayo yonke imithi nezithasiselo ozihambisa nodokotela wakho kuzomsiza ukuthi anqume ukuthi ngabe uCelebrex uyisinqumo esingcono kakhulu kuwe yini.

Yini imiphumela emibi yeCelebrex?

Njenganoma imuphi umuthi, ukuthatha uCelebrex kuza namandla emiphumela emibi. Nayi eminye imiphumela emibi kakhulu umuntu angahlangabezana nayo ngokuthatha iCelebrex:

Ubuhlungu bomzimba
Igesi
Isicanucanu
Isisu esibuhlungu
Uhudo
Ukuvuvukala kwezandla noma izinyawo
Isiyezi
Inkinga yokulala
Ukuqunjelwa
Ukugaya ukudla
Isilungulela
Ukozela

Imiphumela emibi kakhulu

Imiphumela emibi kakhulu yeCelebrex ifaka phakathi ukulahleka kwezinwele, ukuzuza kwesisindo okungachazeki, ukusabela kwesikhumba, ukuqubuka kwesikhumba, kanye namajaqamba emilenze. Uma uthatha iCelebrex bese uqala ukuba nobunzima bokuphefumula, ukuvuvukala kobuso, intamo, umphimbo, noma isifuba, kufanele ufune usizo lwezokwelapha ngokushesha. Lezi yizimpawu zokuphendula okungezwani, okungasongela impilo.

Ngoba iCelebrex iyi-NSAID, iza nefayela le- isixwayiso sebhokisi elimnyama mayelana nezehlakalo ezinkulu zenhliziyo nemithambo yegazi. Ukuthatha iCelebrex kwandisa ingozi yokuhlaselwa yisifo senhliziyo, isifo senhliziyo, unhlangothi, amahlule egazi, nomfutho wegazi ophezulu.

Imicimbi emibi emathunjini njengokuphuma kwegazi, isilonda, nokugcwala kwesisu noma kwamathumbu nakho kungenzeka. ICelebrex ayiphazamisi ukusebenza kwamagazi egazi futhi, ngenxa yalokho, ayinciphisi ukujiya kwegazi . Iziguli esezikhulile nalabo abanomlando wangaphambili wezinkinga zenhliziyo nemithambo yegazi yibo abasengozini enkulu yokuthola le miphumela emibi yeCelebrex.

Uma uthatha uCelebrex bese uqala ukuba nobuhlungu besifuba, ukukhuluma okungahambi kahle, ukuba ndikindiki okungazelelwe noma ubuthakathaka kolunye uhlangothi lomzimba, ukuvuvukala kwemilenze, noma ubuhlungu besisu, kufanele ufune usizo oluphuthumayo lwezokwelapha khona manjalo. Lezi yizimpawu zesifo senhliziyo noma sohlangothi, ezingasongela impilo. ICelebrex ingakhuphula ubungozi bokuhlaselwa yisifo senhliziyo noma isifo sohlangothi noma ngabe awunazo izinto eziyingozi, ngakho-ke kuhlale kuwumqondo omuhle ukwazi izimpawu zabo zokuxwayisa.

Amaqembu anobungozi obukhulu bemiphumela emibi

Abantu abanezimo ezilandelayo kufanele bakhulume nabahlinzeki babo bezempilo ngaphambi kokuthatha uCelebrex, ngoba kungazenza zibe zimbi izimo zabo zezempilo noma kubangele imiphumela emibi kakhulu:

Labo abane-hypersensitivity to Celebrex noma ama-NSAID
Abantu abahlinzwe umthambo we-coronary bypass graft (CABG)
Labo abane-allergen reaction kuma-sulfonamides (sulfa)
Abantu abanomlando wesifuba somoya, i-urticaria, noma labo abaye baba nokungezwani komzimba nama-NSAID
Iziguli ezinegazi elopha esiswini noma ukopha kwamathumbu
Abantu abanezinkinga zezinso noma zenhliziyo

Ukusetshenziswa kwesikhathi eside kwama-NSAID afana neCelebrex kungahle kube nengozi eyengeziwe yokuhlaselwa yisifo senhliziyo, ukushaywa unhlangothi, ukwehluleka kwenhliziyo, ukungabi nenzalo, izinkinga zesibindi, nezinkinga zezinso. Noma ngabe I-FDA igcizelele isexwayiso sayo sokuthi ama-NSAID afana neCelebrex andisa isifo senhliziyo nobungozi bokushaywa unhlangothi, lokhu akusho ukuthi wonke umuntu kufanele agweme imishanguzo. Kwabanye abantu, izinzuzo zokuthatha iCelebrex zizodlula imiphumela emibi engaba khona. Ochwepheshe bezokwelapha bangakusiza ukuthi unqume ukuthi ukusetshenziswa kwesikhathi eside kweCelebrex kukulungele yini.

Ungayigwema kanjani imiphumela emibi

Ukugwema imiphumela emibi evela kwaCelebrex, thatha umthamo udokotela wakho akuncome wona. Ukweqa amanani noma ukuthatha imithamo eyengeziwe ngoba unezinhlungu eziningi kungadala imiphumela emibi, futhi ukweqisa ngokweqile kungasongela impilo. Uma ucabanga ukuthi ungaba nakho ukweqisa ngokweqile kuCelebrex, kufanele ushayele i-Poison Control Center ku-1-800-222-1222 futhi ufune usizo lwezokwelapha ngokushesha lapho izimpawu zokudlula ngokweqile zifaka phakathi isicanucanu, ubuhlungu besisu obunzima, ukukhathala, ukukhathala nokuhlanza okubukeka njengezizathu zekhofi.

I-Celebrex kufanele igcinwe ekamelweni lokushisa kude nelanga eliqondile, umswakama nokushisa. I-Celebrex egcinwe kahle noma ephelelwe yisikhathi ingashintsha ngamakhemikhali, ithinte ukuthi umuthi usebenza kanjani futhi idale imiphumela emibi uma ifakwa. Lahla ngokuphepha yeCelebrex uma iphelelwe yisikhathi. Bheka umhlahlandlela wemithi ukuthola eminye imininingwane yezidakamizwa zokuphepha.

Ingabe zikhona ezinye izindlela ngaphandle kweCelebrex?

Abanye abantu bangase bangakwazi ukuthatha i-Celebrex uma bengezwani nayo, uma benesimo semithi esiyimbangela esivimbela ukuyithatha, noma uma siphazamisa imithi abayiphuzayo. Izindaba ezinhle ukuthi ezinye izindlela zokwelashwa zinganciphisa ubuhlungu nokuvuvukala. Nazi ezinye izindlela ezivame kakhulu zeCelebrex:

Ezinye izindlela zeCelebrex
Igama lomuthi	Isebenzisa	Ubuhle nobubi	Ikhuphoni le-SingleCare	Ukuqhathaniswa kwemithi
I-Mobic (meloxicam)	I-osteoarthritis Isifo samathambo	I-Meloxicam ingancanyelwa kuneCelebrex ngoba kufanele ithathwe kanye ngosuku. Kodwa-ke, iCelebrexkungaba ngconoi-ankylosing spondylitis noma amajaqamba okuya esikhathini.	Thola isigqebhezana	Funda kabanzi
I-Aleve (naproxen)	I-osteoarthritis Isifo samathambo I-Ankylosing spondylitis I-tendonitis Gout Amajaqamba okuya esikhathini	Kuyatholakala ukuthenga i-OTC ngamanani aphansi, kepha udokotela kufanele anikeze imithamo ephezulu. Kodwa-ke, iNaproxen kungenzeka ukuthi ibangele izilonda zesisu kunaleyo yeCelebrex.	Thola isigqebhezana	Funda kabanzi
Ibuprofen	I-osteoarthritis Isifo samathambo Ubuhlungu obumnene kuya obulinganiselayo I-dysmenorrhea eyinhloko	I-Ibuprofen iyatholakala ukuthenga i-OTC, kepha inengozi enkulu yokubanga izilonda zesisu nezinkinga zesisu kuneCelebrex.	Thola isigqebhezana	Funda kabanzi
I-Voltaren (i-diclofenac sodium)	I-osteoarthritis Isifo samathambo I-Ankylosing spondylitis	IVoltaren ingaba ne-ingozi eyengeziweyemiphumela emibi yamathumbu nenhliziyo uma kuqhathaniswa neCelebrex.	Thola isigqebhezana	Funda kabanzi

Uma ucabanga ukumisa iCelebrex turkey ebandayo, kungcono ukukhuluma nodokotela wakho ngaphambi kwesikhathi, ikakhulukazi uma uyithatha nsuku zonke. Ukuyeka imithi ngokungazelelwe kungadala imiphumela emibi ibe mibi futhi kuholele nakwimiphumela engemihle emisha. Kungumthetho omuhle wesithupha ukufuna njalo izeluleko zezokwelapha ngaphambi kokumisa noma ukuqala noma imuphi umuthi ukuze uqiniseke ukuthi wenza okungcono kakhulu emzimbeni wakho.