Main >> Imfundo Yezempilo >> I-Metformin vs. metformin ER: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Metformin vs. metformin ER: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Imfundo Yezempilo

I-Metformin ngumuthi ovamise ukwenziwa osetshenziselwa ukwelapha uhlobo lwesibili sikashukela. I-ejenti elwa nesifo sikashukela engeyesigaba semithi eyaziwa ngokuthi ama-biguanides. Isebenza ngokunciphisa ukukhiqizwa kwe-glucose (ushukela wegazi) esibindi, ukunciphisa ukumuncwa kwe-glucose emathunjini, nokwandisa ukuzwela kwe-insulin. I-Metformin ithuthukisa ukuzwela kwe-insulin ngokwandisa ukuthathwa kweglucose ezicutshini zomzimba.

Uhlobo lwesifo sikashukela mellitus lutholakala lapho umzimba umelana nemiphumela ye-insulin. I-insulini iyihomoni ebalulekile ekhiqizwa amanyikwe futhi isetshenziselwe ukuhambisa i-glucose kumaseli omzimba ukuze ithole amandla. Lapho umzimba ungakwazi ukusebenzisa i-insulini kahle, kukhuphuka amazinga kashukela egazi angadala umonakalo emithanjeni yegazi nezinzwa. Ngaphandle kokwelashwa okufanele, isifo sikashukela singaholela izinkinga nokulimala kwezitho ezifana nenhliziyo nezinso.

I-Metformin iyatholakala ngefomu ekhishwa ngokushesha (i-IR) kanye nefomu lokukhishwa okweluliwe (ER). Ngenkathi zombili izinhlobo ze-metformin ziqukethe isithako esisebenzayo esifanayo, zithathwa ngezindlela ezihlukile. Futhi banokunye umehluko emiphumeleni emibi.

Uyini umehluko omkhulu phakathi kwe-metformin ne-metformin ER?

I-Metformin noma i-metformin hydrochloride igama elijwayelekile le-Glucophage. I-metformin ekhishwa ngokushesha ivame ukufakwa njenge-tablet engu-500 mg ethathwa kabili ngosuku ngokudla. Kukhona nethebhulethi engu-850 mg engathathwa kanye nsuku zonke. Umthamo omkhulu we-metformin ungama-2550 mg ngosuku ngemithamo ehlukanisiwe. I-Metformin ingaphatha uhlobo lwesibili sikashukela kubantu abadala nasezinganeni.

I-Metformin ER yaziwa nangokuthi igama lomkhiqizo iGlucophage XR. Yinguqulo ekhishwe isikhathi eside ye-metformin futhi idinga ukuthathwa kanye kuphela ngosuku ngokudla. Umthamo ophelele wansuku zonke we-metformin ER ngu-2000 mg. Ngokungafani ne-metformin ekhishwa ngokushesha, i-metformin ER ikhonjiswa kuphela kubantu abadala abanesifo sikashukela sohlobo 2. Inemiphumela emibi embalwa futhi ihlala isikhathi eside kune-metformin ejwayelekile.

OKUSHIWO: Imininingwane yeMetformin | Imininingwane ye-Metformin ER

Umehluko omkhulu phakathi kwe-metformin ne-metformin ER
	I-Metformin	I-Metformin ER
Isigaba sezidakamizwa	I-Biguanide	I-Biguanide
Isimo somkhiqizo / ejwayelekile	Uhlobo olujwayelekile luyatholakala	Uhlobo olujwayelekile luyatholakala
Ngubani igama lomkhiqizo?	I-Glucophage	IGlucophage XR, iFortamet, iGlumetza
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi yomlomo	Ithebhulethi yomlomo, ukukhishwa okunwetshiwe
Uyini umthamo ojwayelekile?	I-500 mg kabili nsuku zonke noma i-850 mg kanye nsuku zonke ngokudla	500 mg kanye nsuku zonke ngesidlo sakusihlwa
Yelashwa isikhathi esingakanani?	Isikhathi eside sokuphathwa kwesifo sikashukela	Isikhathi eside sokuphathwa kwesifo sikashukela
Ubani ovame ukusebenzisa umuthi?	Abantu abadala nezingane ezineminyaka engu-10 nangaphezulu	Abantu abadala

Izimo eziphathwa yi-metformin ne-metformin ER

Kokubili i-metformin ne-metformin ER kuvunyelwe yi-FDA ukuphatha uhlobo 2 sikashukela. Ngokusho kwe- I-American Diabetes Association (ADA) , I-metformin iyindlela yokwelashwa komugqa wokuqala wesifo sikashukela sohlobo 2. Ezigulini ezine-A1c engaphansi kuka-9% ngesikhathi sokuxilongwa, i-metformin kufanele iqalwe njenge-monotherapy nge Amazinga Wokunakekelwa Kwezokwelapha Esifo Sikashukela . I-Metformin ingasiza ekuthuthukiseni ukulawulwa kwe-glycemic futhi ekugcineni ivimbele izinkinga ezingabangelwa yisifo sikashukela.

Hhayi kuphela ukuthi i-metformin ingasetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo lwesibili, kodwa ingasetshenziselwa nezinhloso ezingekho kwelebula. Labo abane ama-prediabetes futhi i-plasma glucose yokuzila ephezulu (FPG) inganconywa i-metformin ukuvimbela ukuqala kwesifo sikashukela. I-Metformin inconywa lapho amazinga kashukela egazi engalawulwa ngokudla nokuzivocavoca umzimba kukodwa.

I-Metformin ingasetshenziswa futhi njengenketho engekho kwelebuli yokwelapha isifo sikashukela sokukhulelwa. Lolu hlobo lwesifo sikashukela lwenzeka kwabesifazane abakhulelwe abathambekele ekubeni nesifo sikashukela. Kodwa-ke, i-insulin ivame ukuzama kuqala.

IMetformin nayo ibe njalo wafunda ukwelapha i-polycystic ovary syndrome (POCS). Lesi sifo sibonakala ngokungalingani kwamahomoni ezocansi angabangela ama-cysts ama-ovari, izinguquko zomjikelezo wokuya esikhathini, izingqinamba zokukhulelwa, izinduna, kanye nokumelana ne-insulin. I-Metformin ingabekwa ukusiza ukwehlisa ukumelana ne-insulin, ukwehlisa amazinga e-testosterone, nokwenza ngcono imijikelezo yokuya esikhathini kanye nokuzala.

Ukusetshenziswa kwemithi elwa nezengqondo, njenge-olanzapine, i-risperidone, ne-clozapine, kungaholela ekutholeni isisindo. Ngokwezifundo ezithile, iMetformin ikhonjisiwe ukuthi iyasebenza ekwelapheni ukuzuza kwesisindo okubangelwa ukucindezelwa kwengqondo. Isibuyekezo esisodwa sithole ukuthi i-metformin isizile ukunciphisa inkomba yomzimba (BMI), isisindo somzimba, nokuphikiswa kwe-insulin kuqhathaniswa ne-placebo kulabo abane-antipsychotic-induced weight.

Isimo	I-Metformin	I-Metformin ER
Thayipha ukuphathwa kwesifo sikashukela se-2	Yebo	Yebo
Thayipha ukuvimbela isifo sikashukela se-2	Ngaphandle kwelebula	Ngaphandle kwelebula
Ukukhulelwa isifo sikashukela mellitus	Ngaphandle kwelebula	Ngaphandle kwelebula
I-Polycystic ovary syndrome	Ngaphandle kwelebula	Ngaphandle kwelebula
Ukuzuza kwesisindo ngenxa yokwelashwa kwe-antipsychotic	Ngaphandle kwelebula	Ngaphandle kwelebula

Ingabe i-metformin noma i-metformin ER isebenza kangcono?

Ngokusekelwe ezifundweni eziqhathanisa i-metformin ne-metformin ER yohlobo lwe-2 sikashukela mellitus, i-metformin ER itholakale ifana ne-metformin ngokusebenza. Eqinisweni, i-metformin ER ingaphakama kune-metformin ejwayelekile ngokuya ngemiphumela yayo engezansi yemiphumela emibi nokusebenziseka kalula. Labo abane-type 2 yesifo sikashukela bangase bathambekele kakhulu ekuphuzeni iphilisi le-metformin kanye ngosuku esikhundleni sephilisi yezinsuku ezimbili.

Ngokukodwa okungahleliwe, isifundo somtholampilo , i-metformin ER itholakale isebenza kangcono kune-metformin IR lapho yelapha iziguli ezinesifo sikashukela sohlobo 2. Labo abathatha i-metformin ER babhekana nokulawulwa okungcono kwe-glycemic kanye ne-lipid metabolism uma kuqhathaniswa ne-metformin IR.

Okunye okungahleliwe, icala elimpumputhe kabili ithole ukuthi i-metformin ER eyake yenziwa nsuku zonke yayisebenza ngendlela efanayo futhi iphephile ku-metformin ejwayelekile. Ngokwengeziwe, ucwaningo luye lwabona inzuzo yokuthwebula kanye ngosuku nge-metformin ER. Kokubili i-metformin ne-metformin ER kuthuthukise amazinga we-HbA1c ngaphezu kwamasonto angama-24 ezifundweni ebezingakaze zizame olunye uhlobo lokwelashwa kwesifo sikashukela.

I-metformin yokukhishwa enwetshiwe ingancanyelwa kune-metformin ekhishwa ngokushesha. Kukhonjisiwe ukuthi kunokubekezelelana okungcono yize kungabiza kakhulu kunamathebulethi akhishwa ngokushesha. Kubalulekile ukubonisana nezeluleko zezokwelapha kusuka kochwepheshe bezokunakekelwa kwezempilo lapho ukhetha indlela yokwelashwa yohlobo lwesibili sikashukela.

Ukuhlanganiswa nokuqhathaniswa kwezindleko kwe-metformin vs. metformin ER

I-Metformin inguqulo ejwayelekile yeGlucophage. I-generic metformin imbozwe yi-Medicare ingxenye D nezinhlelo eziningi zomshuwalense. Igama leBrand Glucophage lingabiza kakhulu futhi libize inani lentengo elijwayelekile elingaphezu kwe- $ 150. Lezi zindleko zingancishiswa ngokuletha ikhadi lesaphulelo le-SingleCare ekhemisi. Ikhadi le-metformin le-SingleCare lingehlisa izindleko lifike ku- $ 4 ngokunikezwa kwezinsuku ezingama-30 kwe-generic-release metformin ejwayelekile.

Cishe wonke ama-Medicare nezinhlelo zomshuwalense zizofaka i-generic metformin ER. Igama lomkhiqizo iGlucophage XR lingabiza cishe ama- $ 80 ngokuya ngekhemisi oya kulo. Ngekhadi lekhuphoni le-SingleCare, i-generic metformin ER ingathengwa ngemali ephansi njengo- $ 4 ngokunikezwa kwezinsuku ezingama-30 kwamaphilisi e-metformin ER kanye ngosuku. Noma ngomshuwalense, iSingleCare ingakwazi ukunikela ngentengo ephansi. Buza nekhemisi lakho ukubona ukuthi ungasizakala yini ngesaphulelo esingcono ngeSingleCare.

Thola ikhadi lesaphulelo se-SingleCare

	I-Metformin	I-Metformin ER
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokujwayelekile yi-Medicare?	Yebo	Yebo
Umthamo ojwayelekile	Amaphilisi angama-500 mg (inani lamaphilisi angama-60)	Amaphilisi angama-500 mg (inani lamaphilisi angama-30)
I-Medicare copay ejwayelekile	$ 0- $ 8	$ 0- $ 8
Izindleko ze-SingleCare	$ 4	$ 4

Imiphumela emibi ejwayelekile ye-metformin vs. metformin ER

IMetformin idala imiphumela emibi ethinta uhlelo lwesisu (GI). Lezi okuqhamuka uma udla imishanguzo kufaka phakathi isifo sohudo, isicanucanu, ukuhlanza, igesi (ukuqunjelwa), ukugaya isisu, nokungaphatheki kahle esiswini noma ukucasulwa yisisu. IMetformin IR nayo ibanga ukukhathala noma ukungabi namandla (asthenia) kanye nokuphathwa yikhanda.

I-Metformin ER inemiphumela emibi embalwa uma iqhathaniswa ne-metformin. Imiphumela emibi kakhulu ehlotshaniswa ne-metformin ER uhudo, isicanucanu nokuhlanza. I-Metformin ER nayo ingadala ukuqunjelwa kwabanye abantu. Yize i-metformin ER ingadala eminye imiphumela emibi ye-GI efana ne-indigestion kanye ne-flatulence, le miphumela emibi ayenzeki kaningi uma iqhathaniswa ne-metformin ejwayelekile.

Eminye imiphumela emibi engenzeka nge-metformin ne-metformin ER ifaka isizungu, ikhanda elikhanyayo, nokuphazamiseka kokunambitha. Eminye imiphumela emibi kakhulu ye-metformin ne-metformin ER ifaka ukulimala kwesibindi kanye ne-hypoglycemia (ushukela ophansi wegazi).

	I-Metformin	I-Metformin ER
Imiphumela emibi	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Uhudo	Yebo	53%	Yebo	10%
Isicanucanu noma ukuhlanza	Yebo	26%	Yebo	7%
Ukuqhuma kwesisu	Yebo	12%	Yebo	1% -5%
I-Asthenia	Yebo	9%	Akunjalo	-
Ukugaya ukudla	Yebo	7%	Yebo	1% -5%
Isisu esibuhlungu	Yebo	6%	Yebo	1% -5%
Ubuhlungu bekhanda	Yebo	6%	Yebo	1% -5%
Ukuqunjelwa	Akunjalo	-	Yebo	1% -5%
Nambitha ukuphazamiseka	Yebo	1% -5%	Yebo	1% -5%
Isiyezi / ikhanda elikhanyayo	Yebo	1% -5%	Yebo	1% -5%

Lokhu kungenzeka kungabi uhlu oluphelele. Xhumana nodokotela wakho noma usokhemisi ngemiphumela engemihle engaba khona.
Umthombo: DailyMed ( I-Metformin ), IDailyMed ( I-Metformin ER )

Ukusebenzisana kwezidakamizwa kwe-metformin vs. metformin ER

I-Metformin ne-metformin ER zingasebenzisana nemithi ehlukahlukene ehlukahlukene. Ukusebenzisana kwezidakamizwa kuvame ukuholela ekushintsheni kwe-glucose yegazi, ingozi eyengeziwe ye- i-lactic acidosis , noma ukunqwabelana kwe-metformin egazini okungakhuphula ubungozi bemiphumela emibi.

Ukuthatha i-metformin ngezidakamizwa ezibizwa nge-carbonic anhydrase inhibitors kungakhuphula ubungozi be-lactic acidosis, isimo esisongela impilo kusuka ku-lactate eningi emzimbeni. Le mithi ifaka i-topiramate ne-acetazolamide phakathi kwabanye.

Izidakamizwa ezinjenge-dolutegravir, i-cimetidine, ne-ranolazine zinganciphisa ukuvunyelwa kwe-metformin. Lokhu kungaholela emazingeni aphezulu we-metformin egazini futhi kwandise ubungozi bezehlakalo ezimbi.

Eminye imishanguzo efana ne-diuretics, i-corticosteroids, i-phenothiazines, ama-estrogens, izivimbelinzalo zomlomo, kanye nezivimbeli zesiteshi se-calcium kungaphazamisa ukulawulwa kwe-glucose. Ukuthatha noma iyiphi yale mithi nge-metformin kungahle kuholele ku-hyperglycemia (ushukela ophakeme oyingozi). Sebenzisa i-insulin noma i-sulfonylurea noma i-glinide drug ene-metformin kungadala ingozi eyengeziwe ye- hypoglycemia .

Izidakamizwa	Isigaba Sezidakamizwa	I-Metformin	I-Metformin ER
I-Topiramate I-Acetazolamide Zonisamide I-Dichlorphenamide	I-Carbonic anhydrase inhibitors	Yebo	Yebo
I-Dolutegravir I-Cimetidine IVandetanib I-Ranolazine	Izidakamizwa ezinciphisa ukususwa kwe-metformin emzimbeni	Yebo	Yebo
I-insulini	I-insulini	Yebo	Yebo
I-Glimepiride IGlipizide I-Glyburide I-Repaglinide Isigaba	Izimfihlo ze-insulin	Yebo	Yebo
I-Hydrochlorothiazide I-Chlorthalidone Indapamide UFurosemide I-Bumetanide I-Torsemide I-Ethacrynic acid	Izidakamizwa	Yebo	Yebo
I-Prednisolone Prednisone IHydrocortisone Dexamethasone Fludrocortisone	Ama-Corticosteroids	Yebo	Yebo
I-chlorpromazine I-Mesoridazine I-Prochlorperazine I-Thioridazine	Ama-phenothiazines	Yebo	Yebo
I-Levothyroxine	Imithi yegilo	Yebo	Yebo
Ama-estrogens ahlanganisiwe I-Ethinyl estradiol I-Levonorgestrel Norethindrone I-Desogestrel	Ama-Estrogens nezindlela zokuvimbela inzalo zomlomo	Yebo	Yebo
Phenytoin	I-antiepileptic	Yebo	Yebo
I-Niacin	I-Nicotinic acid	Yebo	Yebo
Ephedrine	Ukuzwelana	Yebo	Yebo
Amlodipine Diltiazem Felodipine UNicardipine Nifedipine I-Verapamil	Isivimbeli sesiteshi seCalcium	Yebo	Yebo
Isoniazid	Imithi elwa namagciwane	Yebo	Yebo

Lokhu kungenzeka kungabi uhlu oluphelele lwako konke ukuhlangana kwezidakamizwa okungenzeka. Xhumana nodokotela ngayo yonke imithi okungenzeka uyayiphuza.

Izexwayiso zemetformin vs. i-metformin ER

I-Metformin ingadala i-lactic acidosis ezimweni ezingavamile. I-Lactic acidosis yenzeka lapho kune-lactate eningi egazini. Lesi simo singadala umfutho wegazi ophansi, i-hypothermia, nokufa. Ezinye izimpawu ze-lactic acidosis zibandakanya ubuthakathaka obungavamile, isifo sohudo, ubuhlungu besisu, kanye namajaqamba. Funa usizo lwezempilo ngokushesha uma ukhombisa lezi zimpawu.

I-Metformin ingancipha uvithamini B12 amazinga emzimbeni. Ngokuhamba kwesikhathi lokhu kungaholela ekushodeni kukavithamini B12. Amavithamini B12 kufanele abhekwe njalo eminyakeni emibili kuya kwemi-3 lapho uthatha i-metformin isikhathi eside.

Yize kungavamile, i-metformin ingadala i-hypoglycemia uma ithathwa nge-insulin noma i-insulin secretagogue efana ne-glipizide noma i-repaglinide. Ezimweni ezingavamile, i-metformin ingadala i-hypoglycemia lapho ithathwa ngotshwala noma ukudla okunganele.

Imibuzo ebuzwa njalo mayelana ne-metformin vs. metformin ER

Yini i-metformin?

IMetformin ngumuthi kadokotela ovunyelwe ukwelapha uhlobo lwesifo sikashukela kubantu abadala nasezinganeni ezineminyaka eyishumi kuya phezulu. I-metformin ekhishwa ngokushesha ivame ukuthathwa kabili ngosuku ngokudla. Kubhekwa njengokwelashwa komugqa wokuqala kohlobo lwesifo sikashukela sohlobo 2 lapho kuhlanganiswe nesifanele indlela yokudla nokuvivinya umzimba .

Kuyini i-metformin ER?

I-Metformin ER iyindlela ekhishwe enwetshiwe ye-metformin. Kuyaziwa nangamagama womkhiqizo iGlucophage XR, Glumetza, noma iFortamet. I-Metformin ER ihlala isikhathi eside kune-metformin ejwayelekile futhi inemiphumela engemihle. Kunqunywa kanye nsuku zonke ngesidlo sakusihlwa.

Ingabe i-metformin ne-metformin ER ziyefana?

Cha. IMetformin ne-metformin ER azifani. IMetformin inguqulo ekhishwa ngokushesha ngenkathi i-metformin ER inguqulo ekhishwe isikhathi eside. I-Metformin ivunyelwe ukwelapha uhlobo lwesifo sikashukela kubantu abadala nasezinganeni ezineminyaka eyi-10 nangaphezulu ngenkathi i-metformin ER ivunyelwe kuphela ukwelapha uhlobo lwesifo sikashukela kubantu abadala.

Ingabe i-metformin ne-metformin ER ingcono?

I-Metformin ER ibhekwa njengenketho engcono ngoba idinga ukuthathwa kanye kuphela nsuku zonke. Iyafana noma isebenza kangcono kune-metformin futhi mancane amathuba okuthi ibangele imiphumela ethile emibi.

Ngingayisebenzisa i-metformin ne-metformin ER ngenkathi ngikhulelwe?

I-Metformin ingasetshenziswa ngesikhathi sokukhulelwa uma izinzuzo zidlula izingozi. Izifundo zezilwane khombisa ukuthi ayikho imiphumela eyingozi embungwini. Kodwa-ke, ingozi yokukhubazeka kokuzalwa ayikwazi ukukhishwa. Khuluma nodokotela ukubona ukuthi i-metformin ifanelekile ngenkathi ukhulelwe noma uncelisa.

Ngingayisebenzisa i-metformin ne-metformin ER ngotshwala?

Akunconywa ngokuvamile ukuthatha i-metformin noma i-metformin ER ngotshwala. Ukuphuza utshwala kungashintsha amazinga kashukela egazini okuholele engcupheni eyengeziwe ye-hyperglycemia noma i-hypoglycemia.