Yini iLevaquin futhi isetshenziselwani?

Imininingwane Yezidakamizwa

ILevaquin yanqanyulwa ngoDisemba 2017. Khuluma nodokotela wakho ngezinye izindlela kubandakanya i-levofloxacin ejwayelekile noma amanye ama-fluoroquinolones.

Ngabe ukufana kwezifo zesinus, i-pneumonia, izifo zezinso, ne-anthrax kufana ngani? Lapho lezi zifo zibangelwa amagciwane, zingelashwa nge-antibiotic ebizwaI-Levaquin. Amagciwane eza ngazo zonke izinhlobo nobukhulu. Baxhumana nomzimba ngezindlela ezahlukahlukene, babangela konke kusuka ekuthelelekeni okuncane kuya ezifweni ezinzima. Yingakho ama-antibiotic ahlukahlukene anjengeLevaquin ne-amoxicillin enqunywe kabanzi. Bangakwazi ukulwa namagciwane cishe kunoma iyiphi ingxenye yomzimba, kubenze babe izengezo ezifanele kunoma yiliphi ibhokisi lamathuluzi lomhlinzeki wezokunakekelwa kwempilo.

Kodwa i-Levaquin ayilona ikhambi lokwelapha eliyisimangaliso — yimithi eyinkimbinkimbi enokuxhumana okungafani neminye imiphumela emibi engaba yingozi. Kuningi ngaphansi kobuso lapha. Sebenzisa le ndatshana njenge-primer kuLevaquin, umhlahlandlela wemithi onalo lonke ulwazi olubalulekile mayelana nemisebenzi yayo, ukusetshenziswa kwayo, nemiphumela yayo.

Yini iLevaquin?

ILevaquin iyimithi elapha izifo ezahlukahlukene zamagciwane emaphashini, umgudu wokuchama, izinso, amasinusi nesikhumba. Abahlinzeki bezempilo bavame ukuyinikeza ukuthi yelaphe i-pneumonia, i-bacterial sinusitis, i-bronchitis, i-prostatitis, kanye nezifo zomgudu womchamo.

Kuyimithi elwa namagciwane enhlobonhlobo eza ngezindlela ezahlukahlukene. Abahlinzeki bezokunakekelwa kwempilo bangasebenzisa ukwakheka ngomlomo, ngemithambo, nangamehlo ukwelapha ukutheleleka ngamagciwane ezinhlobonhlobo zezitho zomzimba, ngokusho kukaJustin Friedlander, MD, udokotela wezifo zomchamo Inethiwekhi ye-Einstein Healthcare .

Isithako esisebenzayo yisidakamizwa esibizwa ngokuthi yi-levofloxacin, uhlobo lwe-antibiotic ye-fluoroquinolone. I-Levaquin inguhlobo lwegama lomkhiqizo olwenziwe inkampani engaphansi kukaJohnsen & Pharmaceuticals engaphansi kukaJohnson. Ama-Fluoroquinolones asebenza ngama-enzyme amabili ahlukene abalulekile ekuziphindaphindeni kwamagciwane, evimbela amaseli ukuthi anganda. Kodwa isebenza kuphela kuma-bacteria, hhayi amagciwane, ngakho-ke i-Levaquin ayisebenzi kumkhuhlane ovamile, umkhuhlane, noma ezinye izifo ezibangelwa amagciwane (njenge-coronavirus, noma i-COVID-19).

Yize iyi-antibiotic esebenza kahle kakhulu, iLevaquin idala imiphumela emibi engaba yingozi, ngakho ayitholakali ekhawunteni. Itholakala kuphela ngemithi kadokotela ukuze umhlinzeki wezokunakekelwa kwempilo akwazi ukuhlola izimo nezimo ezifanele zokusetshenziswa kwayo.

Yini iLevaquin esetshenziselwa yona?

Kukhona lonke ibutho lamabhaktheriya ahlukene laphaya, kanti iLevaquin iyasebenza ngokumelene namaningi awo, kufaka phakathi i- E. coli, iStaphylococcus, neStreptococcus. Eqinisweni, i-levofloxacin nezihlobo zayo eziseduze zivame ukubizwa ngokuthi yi-fluoroquinolones yokuphefumula ngenxa yokusebenza kwazo ikakhulukazi iStreptococcus pneumoniae ikakhulukazi.

Ngokuvamile, ukuphatha i-levofloxacin:

• I-bronchitis engapheli
• I-pneumonia yebhaktheriya
• Izifo zomgudu womchamo eziyinkimbinkimbi futhi eziyinkimbinkimbi
• Ukutheleleka kwezinso (njenge-pyelonephritis)
• Ukutheleleka kwendlala yesinye
• Ukutheleleka kwesikhumba
• Izifo zesinus

Kwesinye isikhathi, abahlinzeki bezokunakekelwa kwezempilo bazophinda banikeze i-levofloxacin yokutheleleka ngaphakathi esiswini, i-anthrax yangemva kokuchayeka, izinhlobo ezithile zesifo sohudo kanye nohudo oluthathelwanayo olubangelwa ukutheleleka kwe- E. coli. Futhi, kukhombisile ukuphumelela ekwelapheni izifo ezithile ezithathelwana ngocansi, ikakhulukazi i-chlamydia .

Thola ikhadi lesaphulelo le-SingleCare

Kodwa-ke, ingozi yemiphumela emibi kaLevaquin ayifanele ngezimo ezincane. Eqinisweni, i- Ukuphathwa Kwezokudla Nezidakamizwa (i-FDA) kushiwo , fama-luoroquinolones kufanele abekelwe ukusetshenziswa ezigulini… ezingenazo ezinye izindlela zokwelashwa.

Ufuna intengo engcono kakhulu kuLevaquin?

Bhalisela izexwayiso zentengo yeLevaquin bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo

Imithamo yeLevaquin

Umthamo ojwayelekile wansuku zonke weLevaquin uyatholakala kumaphilisi womlomo angama-250, 500, noma ama-750 mg. Thatha iLevaquin ngengilazi egcwele yamanzi. Umthamo ungahluka kakhulu ngokuya ngohlobo lwesimo, umzila wokuphatha, ubudala besiguli, isisindo sesiguli, neminye imithi.

Njenge-antibiotic enamandla ngokwanele, i-levofloxacin izoqala ukusebenza kungakapheli amahora ambalwa, kepha kungaba izinsuku ezimbili kuya kwezintathu ngaphambi kokuba izimpawu ziqale ukuba ngcono. Thatha inkambo ephelele yama-antibiotic njengoba kuchazwe ngumhlinzeki wezokunakekelwa kwempilo, noma ngabe uzizwa ungcono ngemuva kwezinsuku ezimbalwa.

Ngezansi kukhona amanani Kunconywa yi-FDA kubantu abadala abanomsebenzi ojwayelekile wezinso.

Ukuxilongwa	Umthamo ojwayelekile
I-pneumonia yeNosocomial	750 mg nsuku zonke izinsuku eziyi-7-14
I-pneumonia etholwe ngumphakathi	500 mg nsuku zonke izinsuku eziyi-7-14 noma i-750 mg nsuku zonke izinsuku ezingama-5 (kuya ngamagciwane)
Ukwanda kwamagciwane we-bronchitis engapheli	500 mg nsuku zonke izinsuku eziyi-7
I-bacterial sinusitis enamandla (ukutheleleka nge-sinus)	I-750 mg nsuku zonke izinsuku ezingama-5 noma i-500 mg nsuku zonke ngezinsuku eziyi-10-14
I-bacterial prostatitis engapheli (ukutheleleka kwe-prostate)	500 mg nsuku zonke izinsuku ezingama-28
I-UTI eyinkimbinkimbi	750 mg nsuku zonke izinsuku ezi-5 noma ama-250 mg nsuku zonke izinsuku eziyi-10 (kuya ngamagciwane aphansi)
I-anthrax	500 mg nsuku zonke izinsuku ezingama-60
Inhlupho	500 mg nsuku zonke izinsuku eziyi-10-14

Izexwayiso

Abesifazane abakhulelwe noma abancelisayo kufanele babonisane nabahlinzeki babo bezempilo ngaphambi kokuthatha i-Levaquin. Akuzange kube khona izifundo ezanele noma ezilawulwa kahle kwabesifazane abakhulelwe. I-Levofloxacin idlulela obisini lwebele, ngakho ukuncelisa ibele akunconywa ngenkathi welashwa ngeLevaquin. Omama abancelisayo bangacabanga ukupompa nokulahla ubisi lwebele ngenkathi belashwa ngeLevaquin kanye nezinsuku ezimbili ezingeziwe (ezilingana nezimpilo ezinhlanu) ngemuva komthamo wokugcina.

I-Levofloxacin iyatholakala ezigulini esezikhulile (ezingama-65 nangaphezulu), kepha ingahlala ohlelweni lwazo isikhathi eside ngenxa yokuncipha kwezinso. Kulezi zimo, abahlinzeki bezokunakekelwa kwempilo bavame ukwehlisa umthamo ukuze bahlaliswe. Le antibiotic ayigunyaziswanga yi-FDA ezinganeni ezineminyaka engaphansi kwengu-18 ubudala ngaphandle kwezimo ze-anthrax noma isifo esibuhlungu ngenxa yemiphumela yaso emibi futhi amandla okuthuthukisa amabhaktheriya amelana nemithi .

Ukusebenzisana kweLevaquin

Yize kwesinye isikhathi isetshenziswa ekwelashweni okuhlanganisiwe, iLevaquin akufanele ithathwe eceleni kwemithi ethile, ngoba ingadala ukuhlangana kwezidakamizwa okubi. Ungathathi iLevaquin ngasikhathi sinye no:

• Ama-Antacids, I-Carafate ( sifate ), i-cations yensimbi (njenge-iron), nama-multivitamini : Lezi zingavimbela ukumunca ipheshana le-levofloxacin emathunjini. Imikhiqizo yobisi nokunye ukudla okune-calcium eningi kungaba nomphumela ofanayo.
• I-Videx ( I-didanosine ): Lo muthi we-HIV ungavimbela nokumuncwa kwamathumbu kwe-levofloxacin.
• I-Coumadin ( warfarin ): ILevaquin ingakhuphula imiphumela ye-warfarin, inyuse ingozi yokuphuma kwegazi.
• Ama-antidiabetic agents: Ngokubambisana neLevaquin, lokhu kudala ukuguquguquka kwamazinga eglucose egazini.
• Izidakamizwa ezingezona ukuvuvukala (ama-NSAID): Ukudambisa izinhlungu okufana ne-ibuprofen noma i-aspirin kungakhuphula ubungozi bokuvuselelwa kwesistimu yezinzwa nokuquleka okuxakile.
• Theophylline : Ekubhekeni komtholampilo, lo muthi uhlanganyele namanye ama-fluoroquinolones ukukhulisa ubungozi bemiphumela yohlelo oluphakathi lwezinzwa, kufaka phakathi nokuquleka.

Lokhu ukuxhumana okuvame kakhulu, kepha lolu hlu aluhlanganisi konke. Iziguli kufanele zazise umhlinzeki wazo wezempilo ngokunquma nganoma imuphi omunye umuthi abawuthathayo.

Iyini imiphumela emibi yeLevaquin?

UJanssen ushaywe ngamacala futhi wabuye wahlolwa kakhulu ngemiphumela emibi kaLevaquin. Futhi yize kukuhle ukugcina imiphumela engemihle engqondweni, iziguli ezilandela ngokucophelela izeluleko zochwepheshe bezokunakekelwa kwezempilo futhi zibike noma yikuphi ukukhathazeka ngokushesha akufanele ziphuthelwe ukulala phezu kwazo. Imiphumela emibi kakhulu ye-Levofloxacin ifaka ikakhulukazi izitho zesisu nezomzimba, kusho uDkt. Friedlander, ngakho-ke noma ngubani oyithathayo kufanele aqaphele:

• Isicanucanu noma ukuhlanza
• Uhudo
• Ukuqunjelwa
• Ukuphathwa ikhanda
• Isiyezi
• Ukuphelelwa isifiso sokudla
• Inkinga yokulala

Akusabisi, akunjalo? Yonke le miphumela engemihle evame ukuvela kumalebula enhlobonhlobo yemithi. Kodwa, ngeshwa, lokho akusikho ukuphela. Eminyakeni embalwa edlule, uLevaquin ubelokhu engaphansi kwesibonakhulu semidiya ngenxa yokungajwayelekile kwayo, ngaphezuluimiphumela emibi kakhulu.

Imiphumela emibi kakhulu nezinkinga

Ukusetshenziswa kweLevaquin kuye kwaxhunyaniswa ne-tendinitis (ukuvuvukala kwamathambo) kanye nokulimala, ukudabuka, nokuqhekeka, imvamisa kuthenda le-Achilles, ngemuva kweqakala. Iziguli ezinomlando we-tendinitis, ukulimala, noma ezinye izinkinga zemisipha kufanele ziqaphele ikakhulukazi ngokuthatha i-Levaquin.

Kukhona nethuba lokuthi iLevaquin ingadala ukulimala kwemizwa (i-peripheral neuropathy) ezingalweni, emilenzeni, ezandleni nasezinyaweni, okukhombisa ubuhlungu, ubuthakathaka, ukushisa, ukundindizela, noma ukuba ndikindiki. Imiphumela yesistimu yezinzwa emaphakathi njengokuquleka, ikhanda elikhanyayo, ukuthuthumela, ukudideka, ukubona izinto ezingekho, nezinye izinkinga zempilo yengqondo kungenzeka futhi.

ILevaquin ingakhuthaza izinkinga zenhliziyo njengokunyuka kwenhliziyo, isigqi senhliziyo esingajwayelekile, nama-aortic aneurysms noma izinyembezi. Okokugcina kungaholela esifubeni esingalindelekile, esiswini, nasemhlane. Ngokwengeziwe, ushukela wegazi ophansi noma ophakeme kungenzeka, ngakho-ke abantu abanesifo sikashukela kufanele baqaphele ngokwengeziwe.

Abanye abantu abathatha i-Levaquin nabo bangathola ukuzwela okukhulu ekukhanyeni kwelanga, okuholele ekushisweni yilanga okukhulu, amabhamuza kanye nokuqubuka kwesikhumba ngemuva kokuchayeka okufishane ngaphandle kwesikrini selanga. Ngenkathi uthatha iLevaquin, gwema ilanga (kanye nemibhede yokushuka) uma kungenzeka. Uma uselangeni isikhathi esifushane, gqoka izinto zokuzivikela elangeni nesigqoko nezingubo ezimboza isikhumba.

Abanye bangabhekana nezinkinga zesibindi ezibonakala ngokuphuzi kwesikhumba noma abamhlophe bamehlo, umchamo omnyama, ukuhlanza, ubuhlungu besisu, nezitulo ezinombala okhanyayo.

Futhi noma ngubani onesimo esingajwayelekile myasthenia gravis bangabona isimo sabo siba sibi ngokwelashwa kweLevaquin. Ezinye zalezi zimpawu zibandakanya ubuthakathaka bemisipha, amajwabu amehlo alengayo, ubunzima bokugwinya, nokungaboni kahle noma ukubona kabili.

Ngaphezu kwakho konke lokho, iLevaquin ingadala ukungezwani komzimba okuqukethe ukuqubuka, isifuba, ukuvuvukala, ukulunywa, futhi - esimweni esibi kakhulu - i-anaphylaxis.

Imiphumela emibi, noma ngabe ivamile noma ibucayi kakhulu, ingenzeka emahoreni kuya emasontweni ngemuva kokuchayeka futhi ingahle ibe unomphela, kusho uDkt. Friedlander, ecaphuna 2016 FDA isexwayiso.

Lokho uhla oluqinile oluhle lwemiphumela emibi engaba khona, futhi kungabonakala kusabisa, kepha khumbula ukuthi lokhu akujwayelekile neze. Kuhle nje ukuwagcina engqondweni, ikakhulukazi kunoma ngubani onezimo esezikhona ezingasebenzisana nokwelashwa kweLevaquin.

Ingabe zikhona ezinye izindlela ngaphandle kweLevaquin?

ILevaquin akuyona ukuphela kwama-antibiotic e-fluoroquinolone laphaya. Eqinisweni, kunezinye izidakamizwa ezimbalwa kadokotela ezingaphatha izimo ezifanayo. Ngakho-ke, abahlinzeki bezempilo banezindlela zokwelashwa eziningi nezindlela zokuhlasela izifo ezivamile zebhaktheriya. Izindlela ezimbalwa ezisetshenziswa kakhulu zeLevaquin zifaka:

• ECyprus ( ciprofloxacin ): Lona ngomunye wemithi efaniswa kakhulu neLevaquin. Ziyizidakamizwa ezahlukahlukene, kepha njengoba zombili zingama-fluoroquinolones, zilapha izimo eziningi ezifanayo futhi ziveza imiphumela emibi efanayo (kokubili ejwayelekile futhi engathi sína). Abahlinzeki bezempilo bangasebenzisa futhi iCipro ukwelapha umkhuhlane we-typhoid nezinhlobo ezithile ze-gonorrhea.
• I-Avelox ( umagazine ): I-Avelox ingenye i-fluoroquinolone efana ncamashi neLevaquin. Yomibili le mithi ingaphatha izifo ezahlukahlukene zamagciwane. Noma kunjalo, iziguli ezithatha i-Avelox zisengozini yemiphumela emibi efanayo. I-Avelox itholakala ngendlela ejwayelekile, njenge-moxifloxacin.
• IBactrim (sulfamethoxazole / trimethoprim): I-Bactrim iyimithi elwa namagciwane esetshenziselwa ukwelapha ukutheleleka ezindlebeni, ama-UTIs, isifo sohudo, i-bronchitis engalapheki, nezinhlobo ezithile ze-pneumonia. Kodwa-ke, kuvela esigabeni esihlukile sezidakamizwa kune-Levaquin futhi akubeki engcupheni efanayo yemiphumela emibi kakhulu njengokuqhuma kwethenda noma i-aortic aneurysm. Iziguli ezinokungezwani komzimba nesulfa akufanele zithathe iBactrim.
• I-Zithromax ( azithromycin ): Leli elinye i-antibiotic elivela esigabeni esihlukile semithi, elibizwa ngokuthi ama-macrolide antibiotics. I-Zithromax (Z-Pak) ivame ukuphatha umqubuko we-strep, ukutheleleka kwezindlebe, i-bacterial conjunctivitis, i-bacterial sinusitis nezinye izifo ezibangelwa amagciwane. Kepha njengeBactrim, imiphumela yaso emibi ayinamandla kangako kuneLevaquin.
• UKeflex ( cephalexin ): I-Keflex ifana kakhulu ne-penicillin kunaleyo ye-Levaquin, kodwa inqunyelwe ezinye zezifo ezifanayo, njenge-bronchitis, i-pneumonia, ne-UTIs. I-Keflex nayo ingaphatha i-tonsillitis ne-laryngitis.
• I-levofloxacin ejwayelekile : Lo ngumuthi ofanayo noLevaquin, ngaphandle kwegama lomkhiqizo. ILevaquin ayisasebenzi, kepha i-levofloxacin ejwayelekile isatholakala ngomuthi kadokotela.

Ngabe uLevaquin unqanyuliwe?

Yebo. NgoDisemba 2017, abakwaJanssen Pharmaceuticals badonsa uLevaquin nenye i-fluoroquinolone ebizwa ngeFloxin Otic endlebeni ekhiqizwayo. UJanssen uthe kuncike esinqumweni sakhe sokuyeka iLevaquin ekutholakaleni okubanzi kwezinye izindlela, kepha-ke, kunamacala ambalwa ngenxa yemiphumela emibi kakhulu. Lawa macala aqhamuka ezigulini zakwaLevaquin ezathola omunye wemiphumela emibi ebalulwe ngenhla ngemuva kokuthatha lesi sidakamizwa, ikakhulukazi i-aortic aneurysms kanye ne-tendon ruptures. Bathi izinkampani zimaketha le mishanguzo yize kube nemiphumela yazo emibi engaba yingozi.

Ngaphambi kwalawa macala, i-FDA yayikhiphe ifayili le- isixwayiso sebhokisi elimnyama kweLevaquin, kanye neCipro, Avalox, namanye ama-fluoroquinolones, isexwayiso esikhishwe ngemiphumela emibi kakhulu. Yisixwayiso esiqine kakhulu i-FDA esizosikhipha ngaphambi kokuvimbela ngokuphelele umuthi. Izimbangi eziqondile ezifana neCipro, Avalox, namanye ama-fluoroquinolones asemakethe, kanti i-levofloxacin ejwayelekile isatholakala kalula.

Ngesikhathi sokumiswa kwayo ngo-2017, kwakukhona i-Levaquin eyanele eyayivele ikhiqiziwe futhi yathunyelwa ukugcina ngo-2020. Ngakho-ke, izinyanga ezimbalwa ezizayo kungenzeka kube ezokugcina esizibonayo ngegama lomkhiqizo Levaquin, yize izophila ngokusebenzisa izimbangi zayo eziseduze nozakwabo ojwayelekile.