IGlipizide vs. metformin: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
I-Glipizide ne-metformin yimithi emibili esetshenziselwa ukwelapha uhlobo lwesifo sikashukela se-Type 2. Abantu abanesifo sikashukela soHlobo 2 banenkinga nge-hormone insulin, enesibopho sokuhambisa ushukela wegazi (ushukela) kumaseli omzimba ukuze kutholakale amandla. Lapho i-insulin ingasebenzi futhi, ukumelana ne-insulin kungakhula futhi kuholele emazingeni e-glucose anyukile, angaholela kwezinye izinkinga zempilo. I-Glipizide ne-metformin zingasiza ukuphatha amazinga aphezulu e-glucose ukunciphisa ubungozi bezinkinga ezivela kusifo sikashukela.
Uma kuqhathaniswa nama-ejenti amasha, i-glipizide ne-metformin yimithi elwa namagciwane engabizi kakhulu. Zombili zisetshenziselwa ukuphathwa kwesikhathi eside kohlobo lwesifo sikashukela soHlobo 2. Noma kunokufana kwemiphumela yonke, i-glipizide ne-metformin kunokuhlukahluka okuningi, ikakhulukazi ekusebenzeni kwabo, imiphumela emibi engaba khona, nokuhlangana kwezidakamizwa.
Uyini umehluko omkhulu phakathi kwe-glipizide ne-metformin?
IGlipizide
IGlipizide igama elejwayelekile leGlucotrol. Kuyingxenye yesigaba semithi ebizwa nge-sulfonylureas, futhi isebenza nge ukuvuselela uketshezi lwe-insulin kusuka kumanyikwe. Ukwanda kwe-insulin kusiza ukwehlisa amazinga eglucose egazini emzimbeni.
IGlipizide iyatholakala njenge-5 mg noma i-10 mg tablet tablet. IGlipizide ejwayelekile nayo iza ngamathebulethi anwetshiwe anamandla we-2.5 mg, 5 mg, no-10 mg. IGlipizide ivame ukuthathwa kanye nsuku zonke ngaphambi kokudla kwasekuseni.
I-Metformin
IMetformin yigama elijwayelekile leGlucophage noma iRiomet, futhi ingelesigaba semithi esibizwa ngama-biguanides. IMetformin isebenza ukwelapha Uhlobo lwesifo sikashukela ngo ukunciphisa ukukhiqizwa kweglucose esibindini nokunciphisa ukumuncwa kweglucose emathunjini. Isebenza futhi ngokwandisa ukuzwela kwe-insulin nokwandisa ukuthathwa kweglucose ezicutshini zomzimba.
IMetformin iyatholakala njengethebhulethi yomlomo ngamandla ka-500 mg, 850 mg, no-1000 mg. Amathebulethi e-metformin akhululwa ayatholakala futhi enzelwe ukuthi athathwe kanye nsuku zonke. Imethformin ekhishwa ngokushesha ivame ukubekwa ukuthi ithathwe kabili nsuku zonke.
| Umehluko omkhulu phakathi kwe-glipizide ne-metformin | ||
|---|---|---|
| IGlipizide | I-Metformin | |
| Isigaba sezidakamizwa | Sulfonylurea | I-Biguanide |
| Isimo somkhiqizo / ejwayelekile | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala | Uhlobo lomkhiqizo nolwejwayelekile luyatholakala |
| Ngubani igama lomkhiqizo? | I-Glucotrol | I-Glucophage I-Riomet |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo | Ithebhulethi yomlomo |
| Uyini umthamo ojwayelekile? | 5 mg kanye nsuku zonke ngaphambi kokudla kwasekuseni. Isilinganiso singashintshwa ngokuya ngempendulo nesimo sempilo. Umthamo omkhulu wama-40 mg ngosuku. | I-500 mg kabili nsuku zonke noma i-850 mg kanye nsuku zonke ngokudla. Isilinganiso singashintshwa ngokuya ngempendulo nesimo sempilo. Umthamo omkhulu we-2,550 mg ngosuku. |
| Yelashwa isikhathi esingakanani? | Isikhathi eside sokuphathwa kwesifo sikashukela | Isikhathi eside sokuphathwa kwesifo sikashukela |
| Ubani ovame ukusebenzisa umuthi? | Abantu abadala abaneminyaka engu-18 nangaphezulu | Abantu abadala nezingane ezineminyaka eyi-10 nangaphezulu |
Izimo eziphathwe yi-glipizide ne-metformin
I-Glipizide ne-metformin zombili zivunyelwe i-FDA ukwelapha uhlobo lwesifo sikashukela se-Type 2. Ukulawula amazinga kashukela aphezulu kungasiza ekunciphiseni ubungozi bezinkinga ezivela kusifo sikashukela. Lezi zinkinga zingabandakanya isifo senhliziyo, isifo sezinso, isifo sesibindi, ukulimala kwamehlo nokutheleleka ngezinyawo.
I-Metformin kwesinye isikhathi isetshenziswa ngaphandle kwelebuli ukwelapha ezinye izimo, njengesifo sikashukela sokukhulelwa, noma isifo sikashukela ngesikhathi sokukhulelwa, futhi i-polycystic ovary syndrome (i-PCOS) . I-Metformin isetshenziswa futhi ngaphandle kwelebula ukwelapha ukuzuza kwesisindo okubangelwe njengomphumela oseceleni wemithi ethile elwa nokulwa nezengqondo.
Akukho cwaningo olubalulekile olwenziwe ekusetshenzisweni kwelebula okungekho kwelebuli kwe-glipizide.
| Isimo | IGlipizide | I-Metformin |
| Thayipha i-2 yesifo sikashukela | Yebo | Yebo |
| Isifo sikashukela sokukhulelwa | Akunjalo | Ngaphandle kwelebula |
| I-Polycystic ovary syndrome | Akunjalo | Ngaphandle kwelebula |
| Ukuzuza kwesisindo ngenxa yokwelashwa kwe-antipsychotic | Akunjalo | Ngaphandle kwelebula |
Ingabe i-glipizide noma i-metformin isebenza kangcono?
I-Glipizide ne-metformin yomibili iyimithi ephumelelayo yesifo sikashukela yokuthuthukisa ukulawulwa kwe-glycemic kubantu abane-Type 2 diabetes. Zingasetshenziswa njenge-monotherapy noma njengephilisi lenhlanganisela elibizwa ngeMetaglip. I-Glipizide ne-metformin zisebenza kahle kakhulu uma zisetshenziswa ngendlela efanele yokudla nokuzivocavoca umzimba.
IMetformin ihlala iyindlela yokwelashwa komugqa wokuqala wesifo sikashukela soHlobo 2, ngokwemikhombandlela evela ku I-American Diabetes Association (ADA) . Uma kuqhathaniswa nokusebenza kahle kulabo abanesifo sikashukela soHlobo 2 kanye nesifo se-coronary artery, i-metformin inciphisa ingozi yokuhlaselwa yisifo senhliziyo nokushaya uhlangothi ngaphezu kwe-glipizide. Ngokuya ngesilingo esiyimpumputhe, isilingo somtholampilo, i-metformin ikhombise okukhulu umphumela cardioprotective kune-glipizide ngemuva kweminyaka emihlanu.
Enye isilingo sokuqhathanisa ithole ukuthi i-metformin inikeze ukulawula okungcono koshukela wegazi kune-glipizide. Labo abathatha i-metformin esifundweni babenamazinga angcono okuzila i-plasma glucose kune-glipizide ngemuva kwamaviki angama-24, 36, nama-52. Labo abathatha i-metformin nabo babenokuphansi Izinga le-HbA1c kunalabo abathatha i-glipizide ngemuva kwamasonto angama-52. IMetformin idale ukwehla kwesisindo kanti i-glipizide ibangele ukuzuza kwesisindo kubahlanganyeli abaphathwayo.
Thintana nomhlinzeki wezokunakekelwa kwezempilo ngezeluleko zokwelashwa okungcono kakhulu uma unesifo sikashukela soHlobo 2. Ngokuya ngesimo sakho sempilo jikelele, amazinga kashukela egazini , kanye neminye imithi okungenzeka uyayiphuza, umuthi owodwa ungancanyelwa omunye.
Ufuna intengo engcono ku-Glipizide?
Bhalisela izexwayiso zentengo yeGlipizide bese uthola ukuthi intengo ishintsha nini!
Thola izexwayiso zentengo
Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kwe-glipizide vs. metformin
IGlipizide ngumuthi ojwayelekile we-antidiabetic ovame ukumbozwa yiMedicare nezinhlelo zomshuwalense. Ngokunikezwa okujwayelekile kwe-glipizide, i-copay ingasuka ku- $ 0 iye ku- $ 9. Intengo emaphakathi yokuthengisa ye-glipizide ingaba cishe ngama- $ 30. Isigqebhezana se-SingleCare glipizide singasiza ukwehlisa izindleko ziye ku- $ 4 kuma-pharmacy abambe iqhaza.
I-Metformin yisidakamizwa esinqunyiwe esinqunyiwe sokulwa nesifo sikashukela esimbozwe iningi le-Medicare nezinhlelo zomshuwalense. I-Medicare copay ejwayelekile ingahle isuke ku- $ 0 iye ku- $ 8, kanti intengo yokuthengisa ingaba cishe ngama- $ 25 kuye ngekhemisi oya kulo. Isigqebhezana se-metformin esivela ku-SingleCare singanciphisa intengo iye ku- $ 4.
| IGlipizide | I-Metformin | |
| Ngokuvamile embozwe umshwalense? | Yebo | Yebo |
| Imbozwe ngokujwayelekile yi-Medicare Part D? | Yebo | Yebo |
| Umthamo ojwayelekile | 5 mg kanye ngosuku (inani lamaphilisi angama-60) | 500 mg kabili ngosuku (inani lamaphilisi angama-60) |
| I-Medicare copay ejwayelekile | $ 0– $ 9 | $ 0– $ 8 |
| Izindleko ze-SingleCare | $ 4 + | $ 4 + |
Imiphumela emibi ejwayelekile ye-glipizide vs. metformin
Imiphumela emibi kakhulu ye-glipizide ifaka ushukela ophansi wegazi ( hypoglycemia ), ukuqunjelwa, uhudo, isicanucanu, nesiyezi.
Imiphumela emibi kakhulu ye-metformin ifaka uhudo, isicanucanu, ubuthakathaka (asthenia), i-hypoglycemia, nekhanda.
Imiphumela emibi ye-glipizide ifaka phakathi i-hypoglycemia enamandla kanye ne-hemolytic anemia. Imiphumela emibi ye-metformin ifaka phakathi i-lactic acidosis nokushoda kukavithamini B12. Xhumana nomhlinzeki wezokunakekelwa kwempilo ngeminye imiphumela emibi engaba khona ye-glipizide noma i-metformin.
| IGlipizide | I-Metformin | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| I-Hypoglycemia | Yebo | * | Yebo | 1% –5% |
| Ukuqunjelwa | Yebo | * | Akunjalo | - |
| Uhudo | Yebo | * | Yebo | 53% |
| Isicanucanu | Yebo | * | Yebo | 26% |
| Isiyezi | Yebo | * | Akunjalo | - |
| Ubuthakathaka | Akunjalo | - | Yebo | 9% |
| Ubuhlungu bekhanda | Yebo | * | Yebo | 6% |
* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( IGlipizide ), IDailyMed ( I-Metformin )
Ukusebenzisana kwezidakamizwa kwe-glipizide vs. metformin
I-Glipizide ne-metformin zingasebenzisana nemithi efanayo. Imithi ethile ingakhuphula imiphumela yokwehlisa ushukela egazini we-glipizide ne-metformin, engakhuphula ubungozi be-hypoglycemia. Le mithi ifaka ezinye izidakamizwa ezilwa nesifo sikashukela kanye nama-ejenti athile wokwehlisa umfutho wegazi afana ne-ACE inhibitors kanye ne-angiotensin yohlobo II receptor blockers.
Eminye imishanguzo inganciphisa ukusebenza kahle kwe-glipizide ne-metformin, okunganciphisa imiphumela yokwehlisa ushukela egazini. Le mithi ingafaka i-calcium channel blocker, i-diuretics, i-corticosteroids, i-beta blocker kanye nezindlela zokuvimbela inzalo zomlomo. Izimpawu ze-hypoglycemia zingagqunywa ngenkathi kuthatha i-beta blockers, ngakho-ke kufanele ziqashwe kubantu abathatha le mithi.
IMetformin nayo ingaxhumana ne-carbonic anhydrase inhibitors, njenge-topiramate ne-zonisamide, engakhuphula ubungozi be-lactic acidosis. Eminye imishanguzo efana ne-ranolazine ne-vandetanib ingaxhumana ne-metformin futhi iphazamise ukuqedwa kwayo ezinso. Le mithi ingakhuphula amazinga e-metformin egazini futhi inyuse ubungozi be-lactic acidosis.
| Izidakamizwa | Isigaba sezidakamizwa | IGlipizide | I-Metformin |
| I-Topiramate Zonisamide I-Acetazolamide I-Dichlorphenamide | I-Carbonic anhydrase inhibitors | Akunjalo | Yebo |
| I-Ranolazine | Ama-antianginals | Akunjalo | Yebo |
| IVandetanib | I-Tyrosine kinase inhibitors | Akunjalo | Yebo |
| I-insulini Sitagliptin I-Dulaglutide Dapagliflozin Miglitol | Ama-antidiabetic agents | Yebo | Yebo |
| I-Lisinopril Enalapril I-Captopril | Ama-ACE inhibitors | Yebo | Yebo |
| I-Candesartan I-Irbesartan ILosartan | Ama-ejenti wokuvimbela i-Angiotensin II | Yebo | Yebo |
| Amlodipine UNicardipine I-Verapamil | Ama-block block wesiteshi seCalcium | Yebo | Yebo |
| I-Hydrocortisone Prednisone I-Methylprednisolone | Ama-Corticosteroids | Yebo | Yebo |
| I-Hydrochlorothiazide I-Chlorthalidone Indapamide UFurosemide I-Bumetanide | Izidakamizwa | Yebo | Yebo |
| I-Atenolol I-Bisoprolol I-Metoprolol | Abavimbela i-Beta | Yebo | Yebo |
| Ama-estrogens ahlanganisiwe I-Ethinyl estradiol I-Levonorgestrel Norethindrone | Ama-Estrogens nezindlela zokuvimbela inzalo zomlomo | Yebo | Yebo |
Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka
Izexwayiso ze-glipizide ne-metformin
Ngenxa yemiphumela yabo yokwehlisa ushukela, i-glipizide ne-metformin zinengozi ye-hypoglycemia, noma amazinga kashukela aphansi. Ingozi ye-hypoglycemia iyanda lapho i-glipizide noma i-metformin ithathwa namanye ama-antidiabetic agents. Ukuvivinya umzimba isikhathi eside nokuphuza utshwala nakho kungakhuphula le ngozi. Izimpawu ze-hypoglycemia zifaka ukwethuka, ukujuluka, ukushaya kwenhliziyo okusheshayo nokudideka.
Abantu abathile abane-glucose 6-phosphate dehydrogenase (G6PD) yokushoda basengozini yokuthola i-hemolytic anemia ngenkathi bethatha i-glipizide. Kodwa-ke, abanye abantu abangenayo i-GP6D yokushoda bangaphinde bahlakulele i-hemolytic anemia.
Ukusetshenziswa kwe-metformin kungaholela ku-lactic acidosis ehambisana ne-metformin. Lolu hlobo lwe-lactic acidosis luvame ukuhlotshaniswa nokudlula ngokweqile kwe-metformin. Kodwa-ke, kukhona ingozi ye-lactic acidosis kubantu abanesibindi esinciphile noma imisebenzi yezinso. Izimpawu nezimpawu ze-lactic acidosis zifaka isicanucanu, umfutho ophansi wegazi, nobuhlungu besisu.
Xhumana nomhlinzeki wezokunakekelwa kwempilo ukuthola ezinye izexwayiso kanye nezinyathelo zokuzivikela ezihlobene ne-glipizide noma i-metformin.
Imibuzo ebuzwa njalo mayelana ne-glipizide vs. metformin
Yini i-glipizide?
IGlipizide ngumuthi ojwayelekile ongowesigaba semithi ebizwa ngokuthi i-sulfonylureas. Igama lomkhiqizo le-glipizide yiGlucotrol. IGlipizide isebenza ngokwandisa ukukhishwa kwe-insulin kumanyikwe kuya emazingeni kashukela egazini. Itholakala njengethebhulethi yomlomo ekhishwa ngokushesha futhi ekhishwe isikhathi eside.
Yini i-metformin?
IMetformin yaziwa nangamagama emikhiqizo ejwayelekile njengeRiomet neGlucophage. Kungokwesigaba semithi elwa nesifo sikashukela ebizwa ngama-biguanides. I-Metformin isebenza ngokwandisa ukuzwela kwe-insulin, ukunciphisa ukukhiqizwa kwe-glucose esibindini, nokunciphisa ukumuncwa emathunjini kwe-glucose. IMetformin iyatholakala njengethebhulethi yomlomo ekhishwa ngokushesha futhi ekhishwe isikhathi eside.
Ingabe i-glipizide ne-metformin ziyefana?
I-Glipizide ne-metformin azifani. I-Glipizide iyi-sulfonylurea elapha uhlobo lwesifo sikashukela kubantu abadala kanti i-metformin iyi-biguanide elapha isifo sikashukela sohlobo lwe-2 kubantu abadala kanye nezingane ezineminyaka eyi-10 nangaphezulu. I-Glipizide ne-metformin zisebenza ngezindlela ezahlukahlukene futhi zinemithamo ehlukile.
Ingabe i-glipizide noma i-metformin ingcono?
I-Glipizide ne-metformin zombili zisebenza ukwehlisa amazinga eglucose egazini kulabo abane-Type 2 diabetes. Ngokusho kwe-American Diabetes Foundation imihlahlandlela , I-metformin iyindlela yokwelapha yomugqa wokuqala yesifo sikashukela soHlobo 2. I-Glipizide ne-metformin kwesinye isikhathi kungathathwa ndawonye kwezinye izimo lapho kudingeka khona umphumela omkhulu wokwehlisa ushukela. Sekukonke, umuthi omuhle kakhulu wesifo sikashukela uncike esimweni sakho sempilo jikelele nakwimpendulo yomuthi.
Ngingasebenzisa i-glipizide noma i-metformin ngenkathi ngikhulelwe?
Uma kuqhathaniswa ne-metformin, i-glipizide ingaba namandla amakhulu okubangela ubuthi besisu. Ngokwezifundo zezilwane, i-metformin ingahle iphephe ukusetshenziswa ngesikhathi sokukhulelwa; kepha azikho izifundo eziqinisekisiwe ezenziwe ebantwini. Xhumana nomhlinzeki wezokunakekelwa kwezempilo ukuze unqume indlela engcono yokwelashwa ongayisebenzisa ngenkathi ukhulelwe.
Ngingasebenzisa i-glipizide noma i-metformin ngotshwala?
Akunconyelwe ukuphuza utshwala obuningi ngokweqile ngenkathi uthatha i-glipizide noma metformin . Ukuphuza utshwala kungadala amazinga kashukela angalindelekile futhi kwandise ubungozi be-hypoglycemia noma i-hyperglycemia. Utshwala bungabuye benyuse ubungozi be i-lactic acidosis ngenkathi uku-metformin.
Yisiphi isikhathi esihle sosuku sokuthatha i-glipizide?
Isikhathi esihle sokuthatha i-glipizide ngaphambi kokudla ukuze unciphise ubungozi be-hypoglycemia. Uma ithathwa kanye ngosuku, i-glipizide inconywa ukuthi ithathwe ngaphambi kokudla kokuqala kosuku.
Ingabe i-glipizide imbi ngezinso?
Uhlobo lwesifo sikashukela olungalawulwa lwe-2 lungaholela ezinkingeni ezifana nokulimala kwezinso. Kodwa-ke, i-glipizide ayaziwa ukuthi idale ukulimala ezinso. Ukuqedwa kwe-glipizide kungancishiswa kubantu abanokulimala kwezinso. Ukuqoqwa kwe-glipizide kungaholela engcupheni eyengeziwe yamazinga kashukela egazini aphansi.
Yisiphi isidakamizwa esiphephe kunazo zonke sohlobo 2 sikashukela?
I-Metformin ivame ukunikezwa njengokwelashwa komugqa wokuqala kohlobo lwesifo sikashukela sohlobo 2 kubantu abaningi. Lokho kungenxa yokuthi i-metformin ayibizi kakhulu, iphephile, futhi iyasebenza. Uma kuqhathaniswa namanye ama-antidiabetic agents, i-metformin ixhunywe ku- amazinga we-HbA1c aphansi noma afanayo . Ukusetshenziswa kwe-metformin kuhlotshaniswa nezehlakalo eziphansi ze-hypoglycemia kunezinye izidakamizwa ezinjenge-sulfonylureas.
