Main >> Izidakamizwa Vs. Umngani >> I-Tresiba vs. Toujeo: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Tresiba vs. Toujeo: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Izidakamizwa Vs. Umngani

UTresiba noToujeo bangama-insulins amabili ahlukene asetshenziselwa ukuphatha amazinga kashukela egazini kulabo abanesifo sikashukela. UTresiba uyi-ultra esebenza isikhathi eside i-insulin kanti uToujeo uyi-insulin esebenza isikhathi eside. Kungaba i-insulin engabekwa kubantu abadala noma ezinganeni ukuze kulawulwe ngempumelelo ushukela usuku lonke.

Uma kuqhathaniswa nama-insulins asebenza okwesikhashana, uTresiba (insulin degludec) noToujeo (insulin glargine) enzelwe ukukhipha i-insulin isikhathi eside. Ngenxa yokusebenza kwabo isikhathi eside, lawa ma-insulins angasiza ekuhlinzekeni amazinga kashukela egazini azinzile ngenkathi ehlisa ubungozi be-hypoglycemia (amazinga kashukela aphansi ayingozi). Yize kufana futhi kusebenza, uTresiba noToujeo banokuhluka okuningana.

Uyini umehluko omkhulu phakathi kukaTresiba noToujeo?

I-Tresiba igama lomkhiqizo le-insulin degludec. I-insulini esebenza isikhathi eside esebenza isikhathi eside enikezwa nsuku zonke njengomjovo ngaphansi kwesikhumba (ngaphansi kwesikhumba). I-Tresiba iyatholakala njengepeni le-FlexTouch eligcwalisiwe ngamandla we-100 units / mL nama-200 units / mL. Iphinde itholakale njenge-vial engu-10 mL yemithamo eminingi.

Ngemuva kokuphathwa kweTresiba, imiphumela yayo yokwehlisa ushukela ingahlala Amahora angu-42 noma ngaphezulu. UTresiba uqala ukusebenza kungakapheli ihora elilodwa futhi unempilo engamahhafu yamahora angama-25 ngokwesilinganiso. Kuthatha izinsuku ezintathu kuya kwezine zokusetshenziswa kwansuku zonke kweTresiba ukufinyelela amazinga angaguquki egazini (state-steady-state).

IToujeo igama lomkhiqizo le-insulin glargine. I-insulin esebenza isikhathi eside enikezwa njengomjovo ongena ngaphansi nsuku zonke. IToujeo itholakala njengepeni leSoloStar elingu-1.5 mL noma ipeni elingu-3 mL iMax SoloStar.

Imiphumela yeToujeo imvamisa ihlala phakathi Amahora angama-24 nama-36 ngemuva kokuphathwa. UToujeo uqala ukusebenza kungakapheli amahora ayisithupha ngemuva kokuyisebenzisa. Ngakho-ke, kuhamba kancane ukukhipha i-insulin kuneTresiba. Inempilo engangesiqingatha yamahora angama-19 futhi ithatha izinsuku ezinhlanu zokusetshenziswa kwansuku zonke ukufinyelela kumazinga angahambelani egazini.

Kokubili iTresiba neToujeo kungagcinwa ekamelweni lokushisa izinsuku ezingama-56 noma amasonto ayisishiyagalombili.

Umehluko omkhulu phakathi kukaTresiba noToujeo
	UTresiba	I-Toujeo
Isigaba sezidakamizwa	I-insulini I-Ultra esebenza isikhathi eside	I-insulini Osebenza isikhathi eside
Isimo somkhiqizo / ejwayelekile	Igama lomkhiqizo kuphela	Igama lomkhiqizo kuphela
Ngubani igama elijwayelekile?	I-insulini degludec	I-insulini glargine
Izidakamizwa zingena ngaziphi izinhlobo?	Isixazululo somjovo	Isixazululo somjovo
Uyini umthamo ojwayelekile?	Ukuqala komthamo kanye nomthamo wesondlo kuncike ohlotsheni lwesifo sikashukela, amazinga kashukela wamanje, nezinhloso zokwelashwa	Ukuqala komthamo kanye nomthamo wesondlo kuncike ohlotsheni lwesifo sikashukela, amazinga kashukela wamanje, nezinhloso zokwelashwa
Yelashwa isikhathi esingakanani?	Isikhathi eside sokulawulwa okuqhubekayo kwamazinga kashukela egazini	Isikhathi eside sokulawulwa okuqhubekayo kwamazinga kashukela egazini
Ubani ovame ukusebenzisa umuthi?	Abantu abadala nezingane ezineminyaka engu-1 nangaphezulu	Abantu abadala nezingane abaneminyaka engu-6 nangaphezulu

Izimo eziphathwe nguTresiba noToujeo

UTresiba noToujeo bangama-insulins wesizukulwane sesibili asetshenziselwa ukuthuthukisa ukulawula ushukela egazini kulabo abanesifo sikashukela. Kungabekwa i-insulin ukwelapha Uhlobo lwesifo sikashukela sohlobo 1 noma Uhlobo 2. Njengama-basal insulins, aphathwa kanye ngosuku ukulawulwa kwe-glucose okungaguquki usuku lonke. Abanye abantu abanesifo sikashukela bangadinga i-insulin esebenza okwesikhashana ukuze badle.

Lawa ma-insulins angasiza ukujwayelekile amazinga e-glucose ngenkathi ehlisa konke Amazinga HbA1c . I-HbA1c ichazwa ngamazinga eshukela ajwayelekile ngaphezu kwezinyanga ezimbili kuya kwezintathu.

Isimo	UTresiba	I-Toujeo
Isifo sikashukela Uhlobo 1	Yebo	Yebo
Isifo sikashukela Uhlobo 2	Yebo	Yebo

Ngabe iTresiba noma iToujeo isebenza kangcono?

I-Tresiba ne-Toujeo zingama-insulins amabili asebenzayo okwehlisa amazinga kashukela egazi nokwenza ngcono amazinga we-HbA1c. Uma kuqhathaniswa nama-insulins asebenza ngokushesha futhi enza okwesikhashana, lawa ma-insulins asetshenziswa kanye nsuku zonke ukulawula okungaguquguquki kwe-glycemic. I-insulini ephumelela kunazo zonke iyona esebenza kangcono kuwe ngokususelwa kusincomo sikadokotela wakho.

Ngokuya ngokubuyekezwa okuhlelekile okushicilelwe ngu Ukwelashwa Kwesifo Sikashukela , i-insulin degludec ne-insulin glargine ziyasebenza ngokufanayo ekuphatheni amazinga eglucose egazini . Isamba sezilingo ezi-15 zemitholampilo ezahlukahlukene eziqhathanisa ama-insulins amabili sahlolwa. Kwakungekho mehluko ophawulekayo ngokwezibalo kwikhono le-insulin lokuthuthukisa amazinga e-glucose. Kodwa-ke, i-insulin degludec yatholwa ukuthi ibangele i-hypoglycemia encane, noma amazinga kashukela aphansi ayingozi.

Ekubuyekezweni okuhlelekile okushicilelwe yi Isifo sikashukela, ukukhuluphala kanye ne-Metabolism magazine , ingqikithi yezifundo ezingama-70 ziqhathanisa imiphumela nokuphepha kwe-insulin degludec, insulin glargine, ne-insulin detemir. I-insulin detemir yi-analog esebenzayo ye-insulin eLevemir. Imiphumela ithole ukuthi womathathu ama-insulins ayefana ngokusebenza, yize i-insulin degludec idale i-hypoglycemia encane. Iziguli ezinesifo sikashukela ezithatha i-insulin detemir zithole isisindo esincane kunamanye ama-basal insulins.

Xhumana nomhlinzeki wakho wezokunakekelwa kwempilo mayelana nokwelashwa okungcono kakhulu kwe-insulin. Uhlobo olulodwa lwe-insulin lungasebenza kangcono ngokuya ngesimo sakho sonke. Eminye imishanguzo ingadingeka ukulawula ngokuphelele amazinga kashukela egazini.

Ukuhlanganiswa kanye nokuqhathaniswa kwezindleko kweTresiba vs. Toujeo

I-Tresiba imbozwe yizinhlelo eziningi zomshuwalense, kufaka phakathi iMedicare. Ngesitsha esingu-10 mL 100 unit / mL, inani lentengo eliphakathi nendawo lingafinyelela ku- $ 406.99. Ukusebenzisa ikhadi lesaphulelo kungasiza ukonga imali kuma-insulins kadokotela ngisho nangomshuwalense. Isigqebhezana se-SingleCare Tresiba singanciphisa intengo iye ku- $ 343 ngokuya ngekhemisi elibambe iqhaza.

NjengoTresiba, iToujeo imbozwe yizinhlelo eziningi zomshuwalense yize kungahle kube khona icopay. Intengo emaphakathi yemali yeToujeo ingahle isuke ku- $ 341 iye ku- $ 565 kuya ngokuthi ngabe unikezwe iToujeo Max Solostar noma iToujeo Solostar. Izindleko ezinekhadi lesaphulelo le-SingleCare ngu- $ 217 no- $ 301, ngokulandelana.

	UTresiba	I-Toujeo
Ngokuvamile embozwe umshwalense?	Yebo	Yebo
Imbozwe ngokujwayelekile yi-Medicare Part D?	Yebo	Yebo
Umthamo ojwayelekile	Isilinganiso sincike emazingeni e-glucose nezinhloso zokwelashwa	Isilinganiso sincike emazingeni e-glucose nezinhloso zokwelashwa
I-Medicare copay ejwayelekile	$ 5– $ 585	$ 13– $ 447
Izindleko ze-SingleCare	$ 343 +	$ 217- $ 301

Imiphumela emibi ejwayelekile yeTresiba vs. Toujeo

Ushukela wegazi ophansi, noma i-hypoglycemia, ungomunye wemiphumela emibi kakhulu yeTresiba neToujeo. Izimpawu ze-hypoglycemia zingaba mnene noma zibe nzima ngokuya ngempendulo yomuntu ku-insulin, ukuthi ingakanani i-insulin enikezwa, nemikhuba yokudla neyokuzivocavoca umzimba. Izimpawu ze-hypoglycemia zifaka phakathi indlala, ikhanda elikhanyayo, ukucasuka, ukudideka nokukhuphuka kokujuluka.

I-Tresiba ne-Toujeo nazo zingadala ukusabela kwendawo yokujova, njengokubomvu, ukuvuvukala, noma ukulunywa ezungeze indawo yomjovo. Kodwa-ke, le miphumela emibi ivame ukuba mncane futhi ihambe yodwa. Eminye imiphumela emibi ibandakanya izifo ezingenhla zokuphefumula noma umkhuhlane (nasopharyngitis), ukuvuvukala ezandleni noma ezinyaweni (i-edema), nokuzuza kwesisindo.

UTresiba naye kubikwe ukuthi ubanga ikhanda nokuhuda.

	UTresiba	I-Toujeo
Umphumela oseceleni	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ukuphendula kwesayithi lokujova	Yebo	4%	Yebo	*
I-Hypoglycemia	Yebo	12%	Yebo	*
Ubuhlungu bekhanda	Yebo	12%	Akunjalo	-
Ukutheleleka okuphezulu okuphefumulayo	Yebo	12%	Yebo	10%
I-Nasopharyngitis	Yebo	24%	Yebo	13%
Uhudo	Yebo	6%	Akunjalo	-
I-Edema	Yebo	1%	Yebo	*
Ukuzuza kwesisindo	Yebo	*	Yebo	*

* akubikiwe
Ukuvama akususelwa kudatha evela esivivinyweni sekhanda kuya ekhanda. Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( UTresiba ), IDailyMed ( I-Toujeo )

Ukusebenzisana kwezidakamizwa kweTresiba vs. Toujeo

Njengamanye ama-insulins, uTresiba noToujeo bangasebenzisana nemithi eminingi efanayo. Ama-antihypertensives athile, njenge-ACE inhibitors kanye nama-angiotensin II receptor blocking agents, angakhuphula ubungozi be-hypoglycemia lapho esetshenziswa neTresiba noma iToujeo. Ama-antidiabetic agents, afana ne-dulaglutide, i-glyburide, ne-pioglitazone, nawo angakhuphula ubungozi be-hypoglycemia ngeTresiba noma iToujeo.

Izidakamizwa ezinjenge-corticosteroids nezindlela zokuvimbela inzalo ngomlomo zinganciphisa ukusebenza kweTresiba noma iToujeo. Lokhu kungenxa yokuthi le mithi ingaphazamisa amandla omzimba wokusebenzisa i-glucose ngamandla. Izidakamizwa ze-antiadrenergic, njenge-beta-blockers, i-clonidine, ne-reserpine, zingazifihla izimpawu nezimpawu ze-hypoglycemia.

Ukuqapha i-glucose kungadingeka lapho iTresiba noma iToujeo isetshenziswa kanye nezinye izidakamizwa ezingathinta ukubekezelelana kwe-glucose namazinga e-insulin.

Izidakamizwa	Isigaba sezidakamizwa	UTresiba	I-Toujeo
Enalapril I-Lisinopril URamipril	Ama-ACE inhibitors	Yebo	Yebo
ILosartan Olmesartan I-Irbesartan Valsartan	Ama-ejenti wokuvimbela i-Angiotensin II	Yebo	Yebo
I-Dulaglutide Ngaphezulu I-Glyburide UPioglitazone I-Rosiglitazone	Ama-antidiabetic agents	Yebo	Yebo
I-Hydrocortisone Prednisone I-Prednisolone	Ama-Corticosteroids	Yebo	Yebo
I-Estradiol I-Ethinyl estradiol I-Drospirenone Norethindrone	Izindlela zokuvimbela inzalo ngomlomo	Yebo	Yebo
I-Atenolol I-Propranolol I-Metoprolol Clonidine IGuanethidine Hlanganisa kabusha	Ama-antiadrenergic agents	Yebo	Yebo

Thintana nochwepheshe wezokunakekelwa kwempilo mayelana nokunye ukuxhumana kwezidakamizwa okungenzeka.

Izexwayiso zikaTresiba noToujeo

I-hypoglycemia enamandla kungenzeka ngemuva kokusebenzisa ama-insulins afana neTresiba noma iToujeo. Ingozi ye-hypoglycemia enamandla ingakhuphuka kulabo abanezinkinga zezinso, noma zezinso, kanye nokukhubazeka kwe-hepatic, noma kwesibindi. Ama-insulins afana neTresiba noma i-Toujeo kufanele asetshenziswe kuphela ngemithi efanelekile nesiqondiso esivela kumhlinzeki wezokunakekelwa kwempilo. I-Hypoglycemia ingadinga ukwelashwa okuphuthumayo ngendlela yama-carbohydrate noma i-glucagon.

I-Tresiba ne-Toujeo zingadala ukusabela kwe-hypersensitivity kwabanye abantu. Uma uhlangabezana nokuqubuka okukhulu noma unenkinga yokuphefumula, funa usizo lwezokwelapha ngokushesha.

Hypokalemia, noma amazinga aphansi e-potassium , kungenzeka ngenkathi usebenzisa iTresiba noma iToujeo. I-Hypokalemia ingasongela impilo futhi ibangele izimpawu ezifana nenkinga yokuphefumula, isigqi senhliziyo esingajwayelekile (i-arrhythmia), noma ukufa.

Abanye abantu bangadinga ukugadwa ngezimpawu nezimpawu zokwehluleka kwenhliziyo uma futhi besebenzisa imishanguzo ye-thiazolidinedione. Ukusebenzisa le mithi kanye neTresiba noma iToujeo kungadala ukugcinwa koketshezi futhi kubhebhethekise ukwehluleka kwenhliziyo okucinana.

Xhumana nodokotela noma umhlinzeki wezokunakekelwa kwempilo ukuthola ezinye izixwayiso nezinyathelo zokuzivikela.

Imibuzo ebuzwa njalo ngeTresiba vs. Toujeo

Yini iTresiba?

I-Tresiba iyi-insulin esebenza isikhathi eside eyenziwe nguNovo Nordisk. Inikezwa kanye ngosuku kubantu abanesifo sikashukela sokulawula i-glucose okungaguquguquki. I-Tresiba iyatholakala ngezingqimba zemithamo eminingi noma izibaya ze-FlexTouch. Igama elijwayelekile likaTresiba yi-insulin degludec.

Yini iToujeo?

UToujeo uyi-insulin esebenza isikhathi eside eyenziwe nguSanofi-Aventis. Njenge-insulin esebenza isikhathi eside, idinga ukuphathwa kanye kuphela nsuku zonke ukulawula amazinga kashukela egazini. UToujeo uza njengepeni le-SoloStar eligcwalisiwe noma ipeni leMax SoloStar. Igama elijwayelekile likaToujeo yi-insulin glargine.

Ngabe uTresiba noToujeo bayafana?

Kokubili iTresiba neToujeo zithuthukisa amazinga kashukela egazini kanye namazinga e-HbA1c kubantu abanesifo sikashukela sohlobo 1 noma isifo sikashukela soHlobo 2. Zombili zijojowe ngaphansi kwesikhumba (ngaphansi kwesikhumba) kanye nsuku zonke. Kodwa-ke, azisona isidakamizwa esifanayo; ITresiba iqukethe i-insulin degludec ngenkathi iToujeo iqukethe i-insulin glargine. Lezi insulins zinezikhathi ezahlukahlukene zesenzo, phakathi kokunye umehluko.

Ngabe iTresiba noma iToujeo ingcono?

UTresiba unesikhathi eside esenziwayo kuneToujeo; UTresiba usebenza amahora angaphezu kwama-42 kanti uToujeo usebenza amahora angama-36. UTresiba naye uqala ukusebenza ngokushesha kuneToujeo; UTresiba uqala ukusebenza kungakapheli ihora elilodwa ngenkathi uToujeo eqala ukusebenza kungakapheli amahora ayisithupha. Noma kunjalo, womabili ama-insulins ayasebenza ekwelapheni isifo sikashukela.

Ukusebenza kahle kokwelashwa kuzoya ngomthamo we-insulin owusebenzisayo. Isilinganiso singadinga ukulungiswa uma i-insulin ingathuthukisi amazinga e-glucose ngokwanele. Isimo se-hypoglycemia singase sibe ngaphansi kulabo abathatha iTresiba uma kuqhathaniswa nalabo abathatha iToujeo.

Ngingakwazi ukusebenzisa iTresiba noma iToujeo ngenkathi ngikhulelwe?

I-Tresiba noma i-Toujeo kufanele isetshenziswe kuphela ngesikhathi sokukhulelwa uma izinzuzo zidlula izingozi. Njengamanje, azikho izifundo ezanele zokutshela ukuthi ngabe uTresiba noma uToujeo bangalimaza ingane engakazalwa. Kodwa-ke, amazinga e-glucose angalawuleki ngesikhathi sokukhulelwa (isifo sikashukela sokukhulelwa) yisimo esikhulu esingadala izinkinga uma singalashwa. Xhumana nomhlinzeki wakho wezempilo uma ukhulelwe ngaphambi kokusebenzisa iTresiba noma iToujeo.

Ngingakwazi ukusebenzisa iTresiba noma iToujeo ngotshwala?

Utshwala bungaphazamisa indlela ushukela wegazi osetshenzwa ngayo emzimbeni. Utshwala bunganciphisa ukuthi i-insulin isebenza kahle kangakanani emzimbeni. Ukusetshenziswa ngokweqile kotshwala nakho kungaholela ku-hypoglycemia, noma emazingeni kashukela aphansi ayingozi. Ukusetshenziswa kotshwala ne-hypoglycemia kungaholela ekwandeni kokudideka, ikhanda elikhanyayo, kanye nekhanda, okungadinga ukwelashwa.

Ngabe uTresiba uyefana noNovoLog?

UTresiba akafani noNovoLog. Yize bobabili bengama-insulins, basebenza ngezindlela ezingafani. UTresiba uyi-insulin esebenza okude isikhathi eside kanti uNovoLog uyi-insulin esebenza ngokushesha. INovoLog iqala ukusebenza ngokushesha okukhulu kuneTresiba, kepha imiphumela yayo ihlala amahora ambalwa kuphela. I-Tresiba iphathwa njenge-basal insulin yansuku zonke yamazinga e-glucose angaguquki usuku lonke. INovoLog inconywa njenge-insulin yesikhathi sokudla.

Yisiphi isikhathi esihle sokuthatha uTresiba?

I-Tresiba ingathathwa nganoma yisiphi isikhathi sosuku. Isibonelo, ingathathwa ekuseni noma ebusuku ngokuya ngokuncamelayo nencomo kadokotela. I-Tresiba inconyelwa ukuthi ithathwe kanye ngosuku kubantu abadala nasezinganeni. Ezinganeni, iTresiba kufanele ithathwe ngasikhathi sinye nsuku zonke.

Iyiphi i-insulin ehamba phambili?

I-insulini engcono kunazo zonke iyona esebenzela wena nesimo sakho. Izici ezahlukahlukene zidlala indima ekunqumeni i-insulin engcono kakhulu, kufaka phakathi amazinga e-glucose amanje, ezinye izimo ongase ube nazo, eminye imithi okungenzeka uyayiphuza, kanye izindleko ze-insulini . Kungadingeka futhi ama-insulins amaningi; isibonelo, i-insulin esebenza isikhathi eside ingasetshenziswa kanye nsuku zonke ngenkathi i-insulin esebenza ngokushesha ingasetshenziswa ngesikhathi sokudla njengoba kudingeka. I-Tresiba ingaba yi-insulin esebenza kahle kakhulu njengamanje ngoba inesikhathi eside kunazo zonke isenzo. Akunandaba ukuthi kusetshenziswa yiphi i-insulin, kunconywa ukuqapha i-glucose ukuthola ukuthi i-insulin enqunyiwe isebenza kahle kangakanani.