Main >> Izidakamizwa Vs. Umngani >> I-Trulance vs. Linzess: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Trulance vs. Linzess: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

I-Trulance vs. Linzess: Umehluko, ukufana, nokuthi yikuphi okungcono kuweIzidakamizwa Vs. Umngani

Ukubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa





I-Trulance (plecanatide) neLinzess (linaclotide) yizidakamizwa ezimbili ezingasetshenziswa ekwelapheni i-irritable bowel syndrome (IBS). Yomibili le mithi ikhuthaza ukunyakaza kwamathumbu ngokwandisa inani loketshezi emathunjini. Ezingeni lamakhemikhali, iTrulance neLinzess basebenza njengama-agonists we-guanylate cyclase-C receptors emathunjini. Lokhu-ke, kukhulisa umthwalo oketshezi, kuthambise ukwakheka kwendle, futhi kusheshise ukuhamba kokudla.



I-Trulance ne-Linzess nazo zikhonjisiwe ekwelapheni ukuqunjelwa okungapheli kwe-idiopathic (CIC). Lolu uhlobo lokuqunjelwa olungenayo imbangela eyaziwayo.

Yomibili le mithi ekhulula ukuqunjelwa idinga ukuvakashelwa ngudokotela kanye nencwadi kadokotela. ITrulance neLinzess nakho kuyaphikiswa ezinganeni ezineminyaka engaphansi kwengu-6 ubudala. Azinconywa kunoma ngubani ongaphansi kweminyaka engu-18 ubudala.

Uyini umehluko omkhulu phakathi kweTrulance neLinzess?

Yize bobabili iTrulance neLinzess besebenza ku- i-guanylate cyclase-C receptors , anamagama ahlukile ejwayelekile nezithako ezisebenzayo. I-Trulance igama lomkhiqizo le-plecanatide kanti i-Linzess igama lomkhiqizo le-linaclotide.



I-Trulance yisidakamizwa esisha ukwedlula iLinzess futhi ingathathwa ngokudla noma ngaphandle kokudla. I-Linzess ivame ukuthathwa esiswini esingenalutho imizuzu engu-30 ngaphambi kokudla kwasekuseni. Ngenkathi iTrulance itholakala njengethebhulethi yomlomo engu-3 mg, iLinzess iyatholakala njenge-capsule yomlomo ngamandla ahlukile.

Umehluko omkhulu phakathi kweTrulance neLinzess
Ukuqhuma Linzess
Isigaba Sezidakamizwa IGonanylate cyclase-C i-agonist IGonanylate cyclase-C i-agonist
Isimo somkhiqizo / ojwayelekile Ayikho inguqulo ejwayelekile etholakalayo Ayikho inguqulo ejwayelekile etholakalayo
Igama Elijwayelekile IPlecanatide Linaclotide
Ukutholakala Kwefomu Ejwayelekile Akutholakali Akutholakali
Izidakamizwa zingena ngaziphi izinhlobo? 3 mg ithebhulethi yomlomo 72, 145, 290 mcg amaphilisi omlomo
Uyini umthamo ojwayelekile? Ngokudla noma ngaphandle kokudla, kanye ngosuku. Kufanele ithathwe esiswini esingenalutho, kanye ngosuku.
Yelashwa isikhathi esingakanani? Isikhathi eside ngokuya ngemithi kadokotela wakho Isikhathi eside ngokuya ngemithi kadokotela wakho
Ubani ovame ukusebenzisa umuthi? Abantu abadala abaneminyaka engu-18 nangaphezulu Abantu abadala abaneminyaka engu-18 nangaphezulu

Ufuna intengo engcono kakhulu kuTrulance?

Bhalisela izexwayiso zentengo yeTrulance bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo



Izimo eziphathwe yiTrulance neLinzess

ILinzess neTrulance zivunyelwe ukusetshenziswa ku- ukuqunjelwa okungapheli kanye nohlobo oluvelele lokuqunjelwa kwesifo samathumbu (i-IBS-C). Ngezenzo zabo kuma-receptors emathunjini endawo, yomibili le mithi ikhuthaza uketshezi uketshezi kanye nokwanda kokudla okuya emathunjini.

Lezi imishanguzo kadokotela akuzona izidambisi. Azinikeli usizo olusheshayo ekuqunjelweni. Imiphumela ijwayele ukubonwa ngemuva kwesonto lokwelashwa ngeTrulance neLinzess. Ngokuvamile ziphephile ukusetshenziswa isikhathi eside.

I-Trulance neLinzess kwesinye isikhathi kungasetshenziswa ngaphandle kwelebuli ekwelapheni ukuqunjelwa okubangelwa i-opioid (OIC) okubangelwa yimithi efana ne-morphine. Ezinye izinkomba ezingekho ilebula zifaka phakathi i-ulcerative colitis.



Isimo Ukuqhuma Linzess
Isifo samathumbu esingathukuthele ngokuqunjelwa Yebo Yebo
Ukuqunjelwa okungapheli kwe-idiopathic Yebo Yebo
Ukuqunjelwa okubangelwa i-opioid Ngaphandle kwelebula Ngaphandle kwelebula
I-Ulcerative Colitis Ngaphandle kwelebula Ngaphandle kwelebula

Ngabe iTrulance noma iLinzess isebenza kangcono?

I-Trulance yisidakamizwa esisha uma kuqhathaniswa neLinzess. Kodwa-ke, ukusebenza kwayo yomibili le mithi kucishe kulingana.

Ukwenza ngcono imvamisa yokuhamba kwamathumbu kubonakala ekuqaleni kweviki eli-1 ngomthelela wesikhathi eside. Kanye nemvamisa eyandayo yokuhamba kwamathumbu, le mithi ibuye ithuthukise ikhwalithi yesitokisi kufaka phakathi ukuthungwa kwendle nokungaguquguquki.



Ukusebenza kweTrulance kokukodwa isilingo somtholampilo kutholakale ukuthi kwakudume kakhulu ekwelapheni ukuqunjelwa okungapheli kwe-idiopathic. Uma kuqhathaniswa ne-placebo, iTrulance nayo ikhonjiswe ukuthi iyasebenza ekwelapheni isifo samathumbu esivele sicasuke.

Njengamanje, zimbalwa izifundo eziqhathaniswayo phakathi kweLinzess neTrulance ngokusebenza kwazo kepha zombili zisebenza kakhulu kunezidakamizwa ze-placebo zokuqeda ukuqunjelwa. Eyodwa ukubuyekeza okuhlelekile ithole ukuthi iTrulance neLinzess banokusebenza okufana nokuphepha okufanayo. Kwakungekho mehluko obalulekile ekwenzekeni kwemiphumela emibi efana nohudo.



Isinqumo ngomuthi wokuzikhethela singanqunywa udokotela kuphela. Ngemuva kokuhlolwa okuphelele, udokotela uzonikeza umuthi ongcono kakhulu owenzelwe isimo somuntu jikelele.

Ufuna intengo engcono kuLinzess?

Bhalisela izexwayiso zentengo yeLinzess bese uthola ukuthi intengo ishintsha nini!



Thola izexwayiso zentengo

Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweTrulance vs. Linzess

I-Trulance yamukelwa ngo-2017 njengomuthi wegama lomkhiqizo kuphela. Okwamanje yenziwe ngabakwaSynergy Pharmaceuticals. Okwamanje ayikho inguqulo ejwayelekile etholakalayo. I-Medicare nezinhlelo eziningi zomshuwalense kungenzeka zingayifaki i-Trulance. Intengo emaphakathi yemali yeTrulance ingaba ngaphezu kwe- $ 500. Ukusebenzisa ikhadi lesaphulelo le-SingleCare kungasiza ukwehlisa izindleko ngaphansi kwama- $ 400. Ngenkathi kusengumuthi obizayo, ukusebenzisa ikhadi lesaphulelo kungalehlisa inani lapho umshuwalense ungeke ukwazi ukumboza.

ILinzess yamukelwa ngo-2012 futhi itholakala kuphela njengomuthi wegama lomkhiqizo. Njengamanye ama-agonists we-guanylate cyclase-C, i-Linzess ingabiza kakhulu ngezindleko ezijwayelekile zokuthengisa ngaphezulu kwe- $ 500. Ngenhlanhla, amanye ama-Medicare nezinhlelo zomshuwalense zingayimboza. Ngisho nomshwalense, ungakwazi ukonga okuningi ngekhadi lesaphulelo le-SingleCare elinganciphisa izindleko ziye ku- $ 400.

Ukuqhuma Linzess
Ngokuvamile embozwe umshwalense? Akunjalo Akunjalo
Imbozwe ngokujwayelekile yi-Medicare? Akunjalo Akunjalo
Umthamo ojwayelekile 3 amaphilisi mg 72, 145, 290 mcg amaphilisi
I-Medicare copay ejwayelekile $ 70- $ 474 $ 19- $ 482
Izindleko ze-SingleCare $ 389. + $ 403.38

Imiphumela emibi ejwayelekile yeTrulance vs. Linzess

Umphumela ovame kakhulu ohambisana nokusebenzisa iTrulance noma iLinzess uhudo. Ngenxa yesimo somsebenzi wabo, le mithi idala kakhulu imiphumela emibi yamathumbu. Ngokwamalebula abo ezidakamizwa e-FDA, iTrulance ingaba nemiphumela emibi ejwayelekile embalwa uma iqhathaniswa neLinzess. Umphumela oyinhloko weTrulance uhudo.

Ngaphandle kohudo, iLinzess ingadala eminye imiphumela emibi ejwayelekile njengokuqunjelwa, ukuqumba, nobuhlungu besisu.

Ezimweni ezingavamile, iTrulance neLinzess kungadala isifo sohudo esibi. Kulezi zimo, udokotela wakho uzoncoma ukumiswa ngokushesha komuthi. Ezinganeni, le mithi ingadala ukoma okukhulu. Ngakho-ke, azinconywa ezinganeni.

Ukuqhuma Linzess
Imiphumela emibi Kusebenza? Imvamisa Kusebenza? Imvamisa
Uhudo Yebo 5% Yebo amashumi amabili%
Ubuhlungu besisu Yebo <2% Yebo 7%
Ukuqhakaza Yebo <2% Yebo amaphesenti amabili
Ukuqhuma kwesisu Yebo <2% Yebo 4%
Ubuhlungu bekhanda Akunjalo - Yebo 4%

Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: I-DailyMed ( Ukuqhuma ), IDailyMed ( Linzess )

Ukusebenzisana kwezidakamizwa kweTrulance vs. Linzess

Kukhona ukuxhumana okumbalwa kwezidakamizwa neTrulance. Ngokuvamile kubhekwa njengokuphephile ukuthatha nezinye izidakamizwa. Kodwa-ke, umuthi owodwa, ikakhulukazi, unamandla okusebenzisana neTrulance. I-Idelalisib iboniswa ekwelapheni umdlavuza othile wegazi onjenge-leukemia engapheli.

I-Idelalisib, uma ithathwa ngeTrulance, ingadala isifo sohudo esibi, esisongela impilo. Kubalulekile ukuxhumana nomhlinzeki wakho wezokunakekelwa kwempilo ngokushesha uma uhlangabezana nezimpawu zalokhu kusebenzisana kwezidakamizwa.

Ngaphandle kwe-idelalisib, akukho okunye ukuxhumana kwezidakamizwa okubalulekile neTrulance. Akuphazamisi i-cytochrome P450 enzyme complex futhi ayithinti abanye abathutha amaseli.

I-Linzess, ngakolunye uhlangothi, inohlu olude lokuhlangana kwezidakamizwa okungenzeka kuqhathaniswa neTrulance. Lesi sidakamizwa sinamandla okuxhumana nemithi eminingi efana ne-levothyroxine, i-bisacodyl, i-psyllium, i-magnesium hydroxide, ne-omeprazole.

Izidakamizwa Isigaba Sezidakamizwa Ukuqhuma Linzess
I-Idealisib I-Phosphoinositide 3-kinase inhibitor Yebo Akubikiwe
I-Levothyroxine Indlala yegilo Akubikiwe Yebo
I-Bisacodyl I-laxative evuselelayo Akubikiwe Yebo
I-Psyllium I-fiber laxative Akubikiwe Yebo
Magnesium hydroxide I-saline laxative Akubikiwe Yebo
Omeprazole I-Proton pump inhibitor Akubikiwe Yebo

Lolu akulona uhlu oluphelele lokusebenzisana kwezidakamizwa. Sicela uxhumane nodokotela wakho ngaphambi kokuthatha le mithi.

Izixwayiso zeTrulance vs. Linzess

Kokubili iTrulance neLinzess kunamandla okudala imiphumela emibi, ikakhulukazi isifo sohudo kanye nokuphelelwa amandla kwamanzi.

Ezinganeni ezingaphansi kweminyaka engu-6 ubudala, le mithi inengozi yokudala ukomisa okukhulu emzimbeni. Ukuphepha nokusebenza kwabo akuzange kusungulwe kahle ezinganeni ezingaphansi kweminyaka eyi-18, yingakho bobabili iTrulance neLinzess bephikisiwe ezigulini zezingane. Ukwehla kwamanzi emzimbeni kungahle kwenzeke ngenxa yokwanda kokukhuthaza kwama-receptors e-guanylate cyclase-C akhulisa ukuhambisa kwamathumbu kanye nokukhipha uketshezi ngezinga eliphakeme kunokujwayelekile.

Labo abanokuvinjelwa kwamathumbu (ukuvinjelwa) kufanele bagweme ukuthatha iTrulance noma iLinzess. Khuluma nodokotela ukuze unqume ukuthi ngabe unokuvinjelwa kwamathumbu ngaphambi kokuthatha noma imuphi umuthi.

Uhudo ngomunye umphumela ohlangothini ovamile nobungozi obungenzeka ngokusetshenziswa kweTrulance neLinzess. Uhudo olunamandla alukwazi nje ukubangela ukuphelelwa amanzi emzimbeni kodwa futhi nokuphazamiseka kwe-electrolyte emzimbeni. Lokhu kungadinga ukwelashwa okuqhubekayo uma kungalungiswa ngendlela efanele.

UTrulance noLinzess abakaze bafundwe kwabesifazane abakhulelwe noma abancelisayo. Kufanele zisetshenziswe kuphela ngemuva kokuhlola ubungozi obungaba khona bokukhubazeka kokuzalwa.

Imibuzo ebuzwa njalo ngeTrulance vs. Linzess

Kuyini iTrulance?

I-Trulance ngumuthi kadokotela ovunyelwe ekwelapheni ukuqunjelwa-okuvame kakhulu ukucasula kwesifo samathumbu (IBS-C) kanye nokuqunjelwa okungapheli kwe-idiopathic (CIC). Kuyi-guanylate cyclase-C receptor agonist ekhulisa ukunyakaza kwamathumbu. I-Trulance iphephile ukuthi ingasetshenziswa ezigulini ezindala kuneminyaka eyi-18. Iza ngendlela yethebhulethi yomlomo enokukhululeka okubonwa kungakapheli isonto lokusetshenziswa.

Yini iLinzess?

ILinzess yisidakamizwa esidala esisebenza ngendlela efanayo neTrulance. Kuyi-guanylate cyclase-C receptor agonist eyandisa ukuhamba emathunjini futhi iqede ukuqunjelwa. Ngalesi sizathu, i-Linzess ivunyelwe i-irritable bowel syndrome-C kanye nokuqunjelwa okungapheli. Kungumuthi kadokotela otholakala ngendlela ye-capsule yomlomo.

Ngabe iTrulance neLinzess ziyefana?

Cha. Yize besesigabeni esifanayo semithi, le mithi iza ngezindlela ezahlukahlukene zokulinganisa. I-Trulance yisidakamizwa esisha esingathathwa noma ngaphandle kokudla. I-Linzess kufanele ithathwe esiswini esingenalutho imizuzu engu-30 ngaphambi kokudla kwasekuseni.

Yikuphi okungcono – iTrulance noma iLinzess?

I-Trulance neLinzess zinokusebenza okufana nokuphepha okufanayo. Kodwa-ke, iLinzess ingahle ihlotshaniswe nezigameko eziphakeme zohudo, ukuqunjelwa, negesi. Ngalesi sizathu, iTrulance ingancanyelwa kuneLinzess.

Ngingayisebenzisa iTrulance noma iLinzess ngenkathi ngikhulelwe?

Okwamanje akwaziwa ukuthi iTrulance noma iLinzess ziphephile yini ukuzithatha ngesikhathi sokukhulelwa noma sokuncelisa. Kufanele uthintane nodokotela ngaphambi kokuthatha le mithi lapho ukhulelwe noma uncelisa.

Ngingakwazi ukusebenzisa iTrulance noma iLinzess ngotshwala?

Ukusebenzisana kwezidakamizwa kweTrulance noma iLinzess notshwala akwenziwanga kahle. Kukhona kungenzeka ukuthi ukuphuza utshwala ngale mithi kungakhuphula ubungozi bezehlakalo ezimbi.

Ngabe i-Amitiza ingcono kuneLinzess?

Uma kuqhathaniswa ne-Linzess yansuku zonke, Amitiza (i-lubiprostone) idinga ukuphuzwa kabili ngosuku. I-Amitiza ingaba nemiphumela emibi ejwayelekile uma iqhathaniswa neLinzess. Ngaphezu kohudo, i-Amitiza inamandla okubanga isicanucanu, ukugaya ukudla nomlomo owomile.

Yiluphi uhlobo olujwayelekile lweLinzess?

Okwamanje ayikho inguqulo ejwayelekile yeLinzess etholakala emakethe.

Yikuphi okungcono ukuqunjelwa – iLinzess noma iTrulance?

Kokubili iTrulance neLinzess kukhonjisiwe ukuthi kungaqhathaniswa ekusebenzeni nasekuphepheni. Omunye umuthi ungakhethwa ngaphezu komunye ngokuya ngentengo nokutholakala komshuwalense. I-Trulance nayo iyisidakamizwa esisha esinemiphumela emibi embalwa ebikiwe.

Ngabe uLinzess uzokwenza wehlise isisindo?

Izinguquko zesisindo kungenzeka uma uthatha iLinzess. I-Linzess kubikwe ukuthi idale ukwehla kwesisindo noma ukuzuza kwesisindo.