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Konke odinga ukukwazi nge-biologics ye-psoriasis

Imfundo Yezempilo

Uma ubhekene nezikhumba ezomile, ezilumazayo ezingapheli, ungadinga udokotela wesikhumba ukuthola ukuthi lokhu kuvuvukala kungukuqubuka, i-eczema, noma i-psoriasis. U-Agasti yinyanga kaZwelonke Yokuqwashisa Nge-Psoriasis, umkhankaso wokuqwashisa ngezifo zesikhumba ezithinta abantu baseMelika abangaphezu kwezigidi eziyi-8 kanye nabantu abayizigidi ezingama-125 emhlabeni jikelele, ngokusho kwe INational Psoriasis Foundation (NPF) .

Yini i-psoriasis?

Kuyinto engapheli okuzenzakalelayo isifo sesikhumba esheshisa umjikelezo wokukhula kwamaseli esikhumba, ngokusho kwe- Izikhungo Zokulawulwa Nokuvikelwa Kwezifo (CDC) . I-Psoriasis idala amabala aminyene, anamaxolo, amabala abomvu noma esiliva esikhunjeni esimhlophe, nezimagqabhagqabha ezinsomi, ezimpunga, noma ezimnyama ngokukhanyayo esikhunjeni sombala. Imvamisa ithinta izindololwane, amadolo, isikhumba sasekhanda, iqolo elingezansi, ubuso, izintende, namathe ezinyawo. Noma kunjalo, ingavela futhi kuzinzipho zeminwe, ezinzwaneni nasemlonyeni.

Uhlobo oluvame kakhulu lwalesi sifo sesikhumba-sithinta abantu abaphakathi kuka-80% no-90% abane-psoriasis-yi-plaque psoriasis, ebonakala ngamachashazi aphakeme (noma izingcwecwe) ezibuhlungu ezivame ukuqhekeka futhi zophe, ngokusho I-American Academy of Dermatology (AAD) .

I-Psoriasis kucatshangwa ukuthi ibangelwa ukuthambekela kofuzo kanye nokuqina kwesistimu yomzimba okungavamile okwenza amangqamuzana esikhumba akhule ngokushesha okukhulu, anqwabelane, futhi aholele ekuguqulweni kwesikhumba, kusho IBrendan Camp, MD, FAAD , udokotela wesikhumba oqinisekiswe ngamabhodi kabili nodokotela wesikhumba osebenza eMedical Dermatology & Cosmetic Surgery eNew York City.

Okuhlobene: Ingabe isikhumba nje esomile? Noma kungaba yi-eczema? Noma i-psoriasis?

I- AAD ithi yize lokhu kuphazamiseka kwesikhumba kungathelelani, izimbangela ezithile zingakhulisa izimpawu futhi zibangele ukuqubuka, okufana nalokhu:

Ukucindezeleka
Ukulimala kwesikhumba (isibonelo, ukusika okujulile noma ukushiswa yilanga)
Ukutheleleka
Imithi ethile kadokotela (isibonelo, i-lithium ne- umabhebhana )
Isimo sezulu (imvamisa amazinga okushisa abandayo nezimo ezomile)
Ugwayi
Utshwala

I-Psoriasis nayo ingaholela ezinhlungwini ezihlangene nezomhlane, ukuqina nokuvuvukala, isimo esibizwa nge-psoriatic arthritis, kusho UStacy Chimento, MD , udokotela wesikhumba oqinisekiswe yibhodi osebenza eRiverchase Dermatology eMiami. Ngeshwa, i-psoriasis yisimo sesikhathi eside, esingelapheki esingenalo ikhambi elaziwayo, uyachaza — kepha kunezindlela zokuyelapha.

I-Biologics ye-psoriasis

Eminyakeni eyishumi edlule, i-biologics isibe inketho yokwelashwa ethembisayo ye-plaque psoriasis. Ziyindlela ehlukile kunemithi yendabuko, njengokhilimu bezingqangi nokwelashwa okulula.

Yini i-biologics?

Izidakamizwa ze-biologic zenziwa ohlelweni oluphilayo (njengama-microorganisms, izitshalo, noma amaseli ezilwane), kanti imithi ejwayelekile iyinhlanganisela yezithako ezithile zamakhemikhali, kuchaza uDkt Chimento. Ngokuqondile, i-biologics iguqula amasosha omzimba ngendlela ephazamisa umjikelezo wezifo, ngokungafani nemithi yendabuko esebenza kuwo wonke amasosha omzimba wakho.

Isebenza kanjani i-biologics ye-psoriasis?

Uma kukhulunywa nge- ukwelashwa kwe-psoriasis , i-biologics yakhelwe ukuvimba isenzo seseli elithile lomzimba (elaziwa njenge-T-cell) noma amaprotheni ngaphakathi kwesistimu yomzimba, njenge-tumor necrosis factor-alpha (TNF-alpha), i-interleukin 17-A, noma i-interleukins 12 futhi 23.

Ku-psoriasis, ukuthumela imiyalezo ngokungajwayelekile ngamaprotheni amancane abizwa ngama-cytokines kuvuselela amangqamuzana esikhumba ukuba akhule ngokushesha, kusho uDkt Camp. I-Biologics ivimba ukuthi imilayezo ingamukelwa futhi iqeda izimpawu nezimpawu ezihambisana nayo ze-psoriasis.

Kungani usebenzisa i-biologics?

Abahlinzeki bezempilo bavame ukunquma i-biologics, uhlobo lwemithi e-systemic, ezigulini ezine-psoriasis elinganiselayo kuya kwezinzima — lezo ezihlolwa ngamaphesenti ama-3 kuya kwayi-10% (noma ngaphezulu) omzimba othintekayo yilesi sifo, kusho uDkt Chimento. Noma ngabe i-psoriasis ithinta kuphela ingxenye encane yomzimba wakho, isengathathwa njengebucayi uma ithinta impilo yakho yansuku zonke, uyaqhubeka. Udokotela futhi angaphakamisa i-biologics uma imishanguzo yendabuko (kufaka phakathi okhilimu be-topical, i-corticosteroids, i-cyclosporine, ne-retinoids) yehlulekile ukuphatha izimpawu.

Uhlala isikhathi esingakanani kuma-biologics we-psoriasis?

Ukwelashwa nge-Biologic kunikezwa ngokufakwa emthanjeni (IV) ehhovisi likadokotela noma umjovo (kungaba ukuzilimaza noma ukunikezwa ngumhlinzeki wakho wezokunakekelwa kwempilo). Njengoba i-psoriasis iyisifo esingelapheki, iziguli ngokwejwayelekile zihlala ku-biologic unomphela ukuyilawula, kusho uDkt Camp. Futhi, ukuthatha i-biologic ngokuqhubekayo kuphumelela kakhulu kunokumisa nokuyiqala ngoba lokhu kungadala ukuthi umuthi ulahlekelwe ukusebenza kwawo. Uma kwenzeka ukuthi i-biologic eyodwa ingasebenzi kahle, udokotela angahle anikeze uhlobo oluhlukile.

Ziyini izingozi ze-biologics?

Bobabili uDkt Camp noDkt Chimento baveza ukuthi ngenxa yokuthi imishanguzo ye-biologic icindezela amasosha omzimba, iziguli zingabanjwa kalula yizifo ezimbi. Ezimweni ezingavamile kakhulu, imiphumela emibi ingasongela impilo, kufaka phakathi ukutheleleka kwamagciwane njengesifo sofuba, i-pneumonia, noma i-staph kanye nezifo zefungal, kungeza uDkt Chimento. Eqinisweni, kubalulekile ukuthi kuhlolwe isifo sofuba ngaphambi kokuqala i-biologic, futhi iziguli ezithatha lesi sigaba semithi akufanele zithole imijovo ephilayo, kusho uDkt Camp.

Imithi edumile ye-biologic ye-psoriasis

Lezi ezimbalwa ze-FDA (Food and Drug Administration) ezivunyiwe ze-biologics emakethe namuhla.

Igama lomuthi	Umzila wokuphatha	Umthamo ojwayelekile	Imiphumela emibi ejwayelekile	Thola isigqebhezana
ICosentyx(secukinumab)	Ukujova	Ama-milligram angama-300 kanye ngesonto amasonto ama-4, bese kuba umjovo owodwa njalo ngenyanga. Ama-milligram ayi-150 angasebenzela ezinye iziguli.	Izimpawu ezibandayo, isifo sohudo, kanye nezifo eziphezulu zokuphefumula	Thola isigqebhezana
ISkyrizi(risankizumab-rzaa)	Ukujova	Ama-milligram angama-75. Ekuqaleni imithamo emi-2 ngaphezulu kwamasonto ama-4, bese kuthi umthamo owodwa njalo emasontweni ayi-12.	Izifo eziphezulu zokuphefumula, ikhanda, ukukhathala, ukusabela kwendawo yokujova, kanye nokutheleleka kwe-tinea	Thola isigqebhezana
Ilumya(tildrakizumab-asmn)	Ukujova	Ama-milligram ayi-100. Ekuqaleni imithamo emi-2 ngaphezulu kwamasonto ama-4, bese kuthi umthamo owodwa njalo emasontweni ayi-12.	Izifo eziphezulu zokuphefumula, ukusabela kwendawo yokujova, nohudo	Funda kabanzi
Orencia(abatacept)	Ukujova (kokubili isirinji ekhethiwe kanye ne-autoinjector) ne-IV	Ukufakwa kwe-IV: Umthamo osuselwa kwisisindo unikezwa njalo emavikini ama-2 ngemithamo emi-3, bese kuthi njalo emavikini amane ngemuva kwalokho (Abantu abadala abanesisindo esingaphansi kwama-60 kg: 500mg, 60 kg - 100 kg: 750 mg, mkhulu kune-100 mg: 1000mg) Okungaphansi kwesikhumba: I-125 mg masonto onke, noma ngaphandle kokulayisha umthamo we-IV.	Ukuphathwa yikhanda, ukutheleleka okuphezulu okuphefumulayo, umphimbo obuhlungu, nesicanucanu	Funda kabanzi

Isebenza kanjani i-biologics?

Iziguli zingalindela ukubona ukuthuthuka kungakapheli amasonto ayi-12 nemiphumela ehlala izinyanga ezimbalwa, kusho uDkt Chimento. Ngenkathi ihlukahluka kuye ngomuntu, umuntu one-psoriasis emnene angabona izimpawu zincishiswe ngokushesha njengeviki elilodwa.

Futhi imiphumela yesikhathi eside iyamangalisa. Ezigulini eziningi, ukuthatha i-biologic kube ukushintsha impilo ngoba kwasiza lapho ezinye izindlela zokwelapha zingasizanga, kusho uDkt Camp. Ezinye izindlela zokwelashwa zinganikeza ukuthethelelwa okuvela ku-psoriasis, lapho isikhumba sicacile noma sicishe sicace.

OKUSHIWO: Kunjani ngempela ukuhlala ne-psoriasis

Kubiza malini i-biologics ye-psoriasis?

Lesi sigaba semithi yokuzivikela emzimbeni siphakathi kwemithi ebiza kakhulu. Ngaphandle komshwalense, i-biologics ingabiza noma yikuphi kusuka ku- $ 10,000 kuya ku- $ 30,000 ngonyaka, kuya ngomuthi kanye nomthamo, kusho uDkt Chimento. Ngaphandle kokuthi isimo sakho sibucayi, umshuwalense wakho kungenzeka ungabandakanyi i-biologics uze uzame eyodwa noma ngaphezulu izindlela zokwelashwa, njenge-methotrexate noma i-retinoids.

Noma ngabe unayo umshwalanse we mpilo , UDkt Camp wengeza ukuthi izinkampani eziningi ezenza imithi zinikela ngosizo lwezezimali ngezinhlelo zosizo ngokuhlanganyela. I-SingleCare isebenza ngamakhemisi angaphezu kwama-35,000 ezweni lonke (kufaka phakathi i-CVS, Target, Walgreens neWalmart) futhi inikezela ngamakhuphoni amahhala wokulondolozwa okwengeziwe.