Imiphumela emibi yeVyvanse nokuthi ungayibalekela kanjani

Imininingwane Yezidakamizwa

Imiphumela emibi ye-Vyvanse | Ukuphahlazeka kukaVyvanse | Ukwehla kwesisindo | Ukukhathazeka | Ukuhoxa | Imiphumela emibi ihlala isikhathi esingakanani? | Izexwayiso | Ukusebenzisana | Ungayigwema kanjani imiphumela emibi

I-Vyvanse (isithako esisebenzayo: i-lisdexamfetamine dimesylate) yisidakamizwa esinegama lomuthi elapha ukunakekelwa kokushoda kokungasebenzi ( I-ADHD ) kubantu abadala nezingane ezineminyaka engaphezu kwengu-6. Iphinde yamukelwa inkinga yokudla ngokweqile (i-BED) kubantu abadala kepha ijwayele ukusetshenziswa njenge ukwelashwa komugqa wesibili .

IVyvanse ingeyesigaba sezikhuthazi zesistimu yezinzwa ezibizwa ngama-amphetamine. Umphumela wayo oyinhloko ukusheshisa ubuchopho. Ngokungafani neminye imishanguzo evuselelayo, iVyvanse iyidrug, okusho ukuthi ayinamphumela ize ifakelwe umzimba ifomu layo elisebenzayo, dextroamphetamine . Njengayo yonke imithi evuselelayo, iVivvanse ingahle ingalungeli wonke umuntu. Imiphumela emibi, izexwayiso, kanye nokuhlangana kwezidakamizwa kudinga ukuxoxwa nodokotela ngaphambi kokuqala lo muthi.

OKUSHIWO: Funda kabanzi ngeVivvanse | Thola izaphulelo zeVyvanse

Imiphumela emibi ejwayelekile kaVyvanse

Imiphumela emibi yeVyvanse izohluka phakathi kweziguli. Izikhuthazi zinciphisa ukungasebenzi kahle, ukunganaki, nokuxhamazela ezigulini ezine-ADHD, kepha zingaba nomphumela ohlukile ezigulini kutholwe ngokungalungile ukuthi une-ADHD . Umuntu othatha iVivvanse kodwa angayidingi angaba nokukhathazeka, ukungahlaliseki, ukuphazamiseka, uvalo, ukushaya kwenhliziyo okugijimayo, noma ukujuluka okweqile.

Lapho ithathwa nge-ADHD, i- imiphumela emibi ejwayelekile kweVivvanse yilezi:

• Ukwehla kwesifiso sokudla
• Ukuphelelwa isifiso sokudla
• Ukwehla kwesisindo
• Uhudo
• Isicanucanu
• Ukuhlanza
• Ubuhlungu besisu phezulu
• Umlomo owomile
• Isiyezi
• Ukuqwasha
• Ukuthukuthela
• Ukukhathazeka

Lapho kuthathwa ukuphazamiseka kokudla ngokweqile, i- imiphumela emibi ejwayelekile kweVivvanse yilezi:

• Ukwehla kwesifiso sokudla
• Ukuqunjelwa
• Umlomo owomile
• Ukunyuka kwenhliziyo
• Ukuqwasha
• Ukukhathazeka
• Ukuzizwa jittery

Imiphumela emibi ye-Vyvanse

Yonke imishanguzo eguqula uhlelo lwezinzwa oluphakathi ingaveza imiphumela emibi futhi esongela impilo. Imiphumela emibi eminingi emibi kaVyvanse ihlobene nemiphumela yayo ekusheshiseni ubuchopho nohlelo lwezinzwa.

I- imiphumela emibi kakhulu kweVyvanse kufaka:

• Izinkinga zengqondo njengokukhathazeka, ulaka, noma imania
• Ukuphazamiseka kwemizwa njenge-tics, ukuquleka, noma isifo se-serotonin
• Izinkinga zenhliziyo njengokushaya kwenhliziyo okusheshayo, isifo senhliziyo, nokufa okungazelelwe kubantu abanezinkinga zenhliziyo
• Izinkinga zokujikeleza okufana nomfutho wegazi ophakeme, isifo sohlangothi, ukulimala komkhumbi wegazi, ukushintsha kombala wesikhumba, kanye nokwenzeka kukaRaynaud
• Ukusabela okweqile komzimba
• Ukuncika, ukusetshenziswa kabi kwezidakamizwa, kanye nezimpawu zokuhoxa uma kuyekwe ngokungazelelwe

Ukuphahlazeka kukaVyvanse

Imiphumela yedosi yasekuseni yaseVyvanse ivame ukuphela ntambama noma kusihlwa. Lapho bekwenza, ezinye iziguli zithola ukuphahlazeka kweVyvanse okubonakala ngokukhathala, ukukhathala, ukudangala, ukucasuka, ukukhathazeka, ukwethuka nokushintsha kwemizwelo. Izimpawu zokuphahlazeka kukaVyvanse ziyefana kakhulu nokuhoxa kukaVyvanse.

Ukuphahlazeka kukaVyvanse akunakugwenywa ngaso sonke isikhathi, kepha kungaphathwa ngempumelelo:

• Hlela uhlelo lwakho : Hlela imisebenzi ebaluleke kakhulu yosuku phakathi namahora lapho uVyvanse esebenza kakhulu emzimbeni. Hlela ikhefu elide ezungeze isikhathi sosuku ukuphahlazeka kukaVyvanse kwenzeka kakhulu.
• Gwema ukucindezeleka : Izimpawu zokuphahlazeka zikaVyvanse zingase zibe zimbi uma uthatha ezinye izinto ezicindezela isimiso sezinzwa esiyinhloko esifana notshwala, izidambisi, izidambisi zemisipha, ama-anticonvulsants, nezinsiza zokulala.
• Zijwayeze ukulala kahle : Ukungalali nakho kunomthelela engozini yeVyvanse. Bangu imikhuba eminingana emihle ungasebenzisa ukuqinisekisa ukulala ngokwanele ebusuku njengokuzibandakanya emisebenzini yokuphumula ngaphambi kokulala, ukulala ngasikhathi sinye njalo ebusuku, nokuqeda iziphazamiso lapho uyolala.
• Khuluma nodokotela wakho : IVivvanse akuyona eyomuntu wonke. Umhlinzeki wakho wezokunakekelwa kwempilo angaphakamisa ezinye izindlela njengokuguqula umthamo, ukushintsha uhlelo lokulinganisa, noma ukushintshela komunye umuthi.

Ukwehla kwesisindo

Imiphumela emibi emibili eveziwe kaVyvanse yehlise isifiso sokudla kanye nokwehlisa isisindo. Ngenkathi ukuncipha kwesifiso kuvame ngokufanayo kubantu abadala nezingane, ukwehlisa isisindo kungumphumela ojwayelekile kakhulu weVyvanse ezinganeni. Ezivivinyweni zokuqala zokwelashwa zikaVyvanse , cishe ingane eyodwa kwezingu-10 ethatha iVivvanse amasonto amane yehlise isisindo sayo ngokulingana nomthamo: uma kukhula umthamo, kwanda inani lesisindo elijwayelekile. Izingane eziseVyvanse nazo zibonisa ukukhula kancane kunezinye izingane.

Bangu-3% kuphela abantu abadala abathatha i-Vyvanse ye-ADHD abalahlekelwe isisindo esikhathini esifanayo samasonto amane. Kodwa-ke, lapho uVyvanse ethathwa eyinkinga yokudla ngokweqile, ukwehla kwesisindo kwaba nakho ku-4% weziguli. Izifundo zakamuva khombisa ukuthi inani elibalulekile emtholampilo labantu abanenkinga yokudla ngokweqile lilahlekelwa isisindo lapho lithatha iVivvanse ngokunciphisa ukudla kanye nenani leziqephu zokudla ngokweqile isonto ngalinye.

Ngoba ukwehlisa isifiso sokudla nokuncipha kuyimiphumela emibi yeVyvanse, abanye odokotela banikeza i-Vyvanse off-label ye ukukhuluphala okukhulu ezinganeni nasebusheni.

Ukukhathazeka

Ezifundweni ezedlule, u-5% kuya ku-6% wabantu abadala ubika ukukhathazeka njengomphumela wecala likaVyvanse. Izingane zithola ukukhathazeka njengomphumela wecala likaVyvanse kaningi. Ku- isifundo esisodwa , ukukhathazeka nokuphazamiseka kubikwe ezinganeni ezingaphansi kuka-1%.

Imvamisa, izikhuthazi ezinjengeVyvanse ziyasheshisa futhi zijabulise ubuchopho, ngakho-ke ukuphaphama, amandla, uvalo, ukungahlaliseki, ukuphazamiseka, imicabango yokujaha, nokukhathazeka yimiphumela emibi ejwayelekile. Kodwa-ke, kubantu abane-ADHD, izikhuthazi ezithile zandisa ukuqapha, ukunaka, nokulawula umfutho ngenkathi kunciphisa ukungasebenzi kahle, ukukhathazeka nokungazinzi. Lezi zivuseleli zandisa amakhemikhali athile ebuchosheni — i-dopamine ne-norepinephrine. Ngoba iziguli ezine-ADHD azikhiqizi ngokwanele lawa makhemikhali, izikhuthazi zithuthukisa ikhono lazo lokuphatha ukungasebenzi kahle nokunakwa.

I-dopamine ne-norepinephrine eningi kakhulu, ikhemikhali elifana ne-adrenaline, ikhipha ubuchopho ngokweqile futhi ibangele amandla aphezulu, ukunganaki, ukwethuka, ukudinwa, ukujabula, noma injabulo. Uma umuntu onamazinga ajwayelekile we-dopamine ne-norepinephrine ebhekene nokukhathazeka, uVyvanse cishe uzokwandisa ukukhathazeka. Imiphumela emibi efana nokukhathazeka, i-jitteriness, kanye nokungezwani kungaba yizinkomba zokuthi i-Vyvanse noma umthamo obekiwe awulungile.

Ukuhoxa

IVivvanse iyiSheduli II into elawulwayo , okusho ukuthi inamandla aphezulu okuhlukumeza nokuncika. Lapho isetshenziswa isikhathi eside, IVyvanse ingadala izimpawu zokuhoxa uma umthamo wehlisiwe noma umuthi unqanyulwe ngokuzumayo. Lezi zimpawu zifaka:

• Ukukhathala
• Ukulala ngokweqile
• Ukucindezeleka
• Ukushintsha kwemizwelo
• Ukwanda kwesifiso
• Izifiso

Izimpawu eziningi zokuhoxa kweVyvanse zixazululwa ezinsukwini ezinhlanu kuya kweziyisikhombisa. Udokotela ohlinzekayo angasebenzisa umthamo we-tapering ukuvimbela noma ukunciphisa izimpawu zokuhoxa. Kunemiphumela ethile engemihle efana ne- isifo se-serotonin noma izinkinga zenhliziyo ezizodinga ukuthi uVyvanse ayekiswe ngokushesha.

Imiphumela emibi ihlala isikhathi esingakanani?

UVyvanse uhlala esebenza emzimbeni we amahora ayisishiyagalombili kuya kwayi-14 , ngakho-ke imiphumela emibi kufanele iphele ngaleso sikhathi. Izimpawu zokuhoxa kukaVyvanse, noma kunjalo, zingahlala izinsuku eziyisikhombisa. Uma imiphumela emibi ingasuki ngemuva kokuyeka uVyvanse, khuluma nodokotela.

Ukuphikisana kwe-Vyvanse nezixwayiso

IVyvanse akuyona imithi elungele wonke umuntu. Abantu abanezimo zezempilo ezilandelayo akufanele bathathe iVyvanse:

• Ukuzwela ngokweqile kuma-amphetamine noma ezinye izithako eziseVyvanse
• Abesifazane abakhulelwe noma abancelisayo
• Isifo senhliziyo, ukukhubazeka kwenhliziyo, i-arrhythmias, noma isifo semithambo yegazi

Ezinye izixwayiso zikhona .

Abantu abathatha i-monoamine oxidase inhibitors (MAOIs), isigaba semithi efaka ezinye izinhlobo zemithi elwa nokudangala, ama-antibiotic, noma izidakamizwa ezelapha isifo sika-Parkinson, ngeke zinikezwe i-Vyvanse kuze kube ziyayeka ukuthatha ama-MAO inhibitors okungenani izinsuku eziyi-14.

Ukukhula kancane kubantwana

UVyvanse uvunyelwe yi-FDA njengokwelapha okuphephile kwe-ADHD ezinganeni ezineminyaka ephakathi kuka-6 no-17. Kodwa-ke, uVyvanse ucindezela ukukhula ezinganeni, ngakho ukuphakama nesisindo kudinga ukubhekwa ngokucophelela. Ukwelashwa kweVyvanse kungadinga ukuguqulwa uma ukucindezelwa kokukhula kuphawuleka kakhulu.

Ukukhulelwa nokuncelisa

Ayikho idatha eyanele yokuthola ukuphepha kokusetshenziswa kweVyvanse komama abakhulelwe noma abahlengikazi. I-Dextroamphetamine yeqa i-placenta futhi ikhona ku- amanani amancane obisi lwebele . Kodwa-ke, uma ubuthatha iVivvanse, ungayeki ngokungazelelwe ngaphandle kokukhuluma nomhlinzeki wakho wezokunakekelwa kwempilo.

Abadala

Ukuphepha kokusetshenziswa kukaVyvanse kubantu abaneminyaka engaphezu kwengama-65 akukaze kufundwe kahle. Uma kuthathwa njengokuvikelekile ngumsebenzi wezokunakekelwa kwempilo, abantu abadala bavame ukuqala ngomthamo ophansi weVivvanse.

Ukusebenzisana kukaVyvanse

UVyvanse unokuxhumana okubalulekile emtholampilo ngezidakamizwa ezingaphezu kuka-200 nezinye izinto. Iningi lalokhu kuxhumana akulona ubungozi, kepha abantu bangaqaphela ukuthi i-Vyvanse noma ezinye izidakamizwa azisebenzi kahle uma zithathwa ndawonye.

Ama-inhibitor e-MAO

IVivvanse akufanele ithathwe okungenani ezinsukwini eziyi-14 zokuthatha i-monoamine oxidase inhibitors (MAOIs), kufaka phakathi izinhlobo ezithile ze-antidepressants, antibiotic, kanye nemithi kaParkinson efana nale:

• I-Tranylcypromine
• I-Marplan (isocarboxazid)
• I-Nardil (COM)phenzi)
• I-Linezolid
• USelegiline
• I-Xadago (safinamide)
• Umjovo we-Methylene blue

Ngokuhlangana noVyvanse, imiphumela yale mithi ingadala umfutho wegazi oyingozi.

Izikhuthazi

IVivvanse ingathuthukisa imiphumela yezinye izikhuthazi ze-CNS, kufaka phakathi ukukhuphuka kwengcindezi yegazi nokushaya kwenhliziyo. Izikhuthazi ze-CNS zifaka:

• I-caffeine, i-cocaine, noma i-ginseng
• Eminye imithi ye-ADHD
• Ama-decongestants athile omlomo
• Isifiso sokunciphisa ukudla njenge-phendimetrazine
• Ama-ejenti wokuvuka alapha ukubola
• Ukuphuza ama-steroid
• Imithi ye-Sympathomimetic efana ne-epinephrine noma i-norepinephrine

Izicindezeli

Ngokuvamile, ukuhlanganisa izikhuthazi nezicindezeli akuvamile ukwelulekwa. Ama-amphetamine afana noVyvanse ajwayele ukwenza buthaka imiphumela yezidambisi, kepha ezinye izinhlanganisela zama-amphetamine nezidambisi zingaba yingozi. IVivvanse akufanele isetshenziswe nezicindezeli ezifana:

• Utshwala, insangu, noma ama-cannabinoids
• Imithi yokukhwehlela
• Izidakamizwa
• Izindlela
• Ama-barbiturates
• Imithi yokukhathazeka
• Izidakamizwa zezinhlungu zemizwa
• Izidakamizwa zokulwa nesicanucanu
• Ama-anticonvulsants
• Eminye imithi yesifo sikaParkinson

Ama-anti-depressants nemithi ye-serotonergic

Ngaphandle kokuthi kuthathwe njengokuvikelekile ngumhlinzeki wezokunakekelwa kwempilo, ungasebenzisi iVyvanse ngokuhlangana nanoma yisiphi esinye isidakamizwa esiguqula amazinga e-serotonin. Ama-anti-depressants, eminye imishanguzo ye-migraine, kanye nezinciphisi ezithile zokudla ezithathwa zihlangene ne-Vyvanse zandisa ubungozi be-serotonin syndrome.

Imishanguzo yegazi

Ama-amphetamine afana noVyvanse akhulisa umfutho wegazi, ngakho-ke avimba imiphumela yemithi ehlose ukwehlisa umfutho wegazi. Ukuhlanganisa ama-amphetamine nemithi yomfutho wegazi kuzodinga ukuqapha okusondele futhi nokuguqulwa kokulashwa. Ama-amphetamine nawo ayagwenywa ngokuhlanganiswa nemithi enyusa umfutho wegazi.

Ukwenza ama-ejenti asebenzayo noma alkylating

Izidakamizwa ezandisa (acidify) noma ezinciphisa (alkylate) okuqukethwe kwe-asidi esiswini noma emchameni kuzonciphisa amandla omzimba okuthola i-Vyvanse futhi kuphazamise ikhono lokuqeda i-Vyvanse. Ikakhulu, lapho uthatha iVivvanse, gwema ama-antacids, ukudla okune-acid, ama-citrate kanye ne-diuretics. Amavithamini athile kufanele futhi agwenywe.

Cela uchwepheshe wezokunakekelwa kwezempilo ukuthola uhlu oluphelele lokuhlangana kwezidakamizwa nokudla.

Ungayigwema kanjani imiphumela emibi yeVyvanse

Izikhuthazi ezinjengeVyvanse zivame ukudala imiphumela emibi. Ngoba uVyvanse usheshisa ubuchopho, akuyona into engavamile ukuhlangabezana nemiphumela emibi njengokuncipha kwesifiso sokudla, ukuqwasha, umfutho wegazi ophakeme, ukushaya kwenhliziyo okusheshayo, ukuyaluza, noma ukungahlaliseki. Ezinye iziguli zihlangabezana nokuphahlazeka kukaVyvanse okufana nokuhoxa lapho umuthi uphela ngokuhamba kosuku.

Izeluleko ezimbalwa zingasiza ukuphatha imiphumela emibi ye-Vyvanse:

• Thatha uVyvanse njengokuyalelwa. Unganyusi noma wehlise umthamo. Uma umuthi ungathi awusebenzi noma imiphumela emibi iba khona, khuluma nodokotela okuchazayo ngokushintsha umthamo noma ukushintshela kumuthi omusha. Hlala ulandela imiyalo esekuhlahleni lwemithi.
• Thatha uVyvanse ngasikhathi sinye njalo ekuseni. IVivvanse kufanele ithathwe ekuseni kakhulu. Khetha isikhathi okungenani sehora elilodwa ngaphambi kokudlikiza nokugxila bese unamathela kuleso simiso. Uma uphuthelwa umthamo, wuthathe ngokusa ekuseni. Kodwa-ke, gwema ukuthatha umthamo ntambama ukuze ugweme ukulala ngesikhathi sokulala.
• Dalula zonke izimo zakho zokwelashwa nemithi. Lokhu kuzovimbela imiphumela emibi nokuhlangana okuyingozi ukuthi kungenzeki.
• Thola enye ikhofi. Ezinye izinto ezikhuthazayo zingakhuphula ubungozi nobukhali bemiphumela emibi ye-Vyvanse, ngakho-ke umqondo omuhle ukuzigwema. Ngaphezu kwemithi ethile, izikhuthazi zifaka phakathi i-caffeine. Ungadinga ukuthola enye indlela ongithatha ngayo enkomishini yakho yansuku zonke yekhofi.
• Zijwayeze ukulala kahle. Kunzima ukulala omunye wemiphumela emibi kakhulu yeVyvanse. Isinyathelo sokuqala sokunqoba ukungalali okubangelwa yimithi ukwenza imikhuba emihle, yokuhlanzeka yokulala nsuku zonke. Gwema imidlalo ye-TV noma yevidiyo ngaphambi kokulala, qalisa inqubo yokuphumula yasebusuku, futhi ulale ngasikhathi sinye njalo ebusuku.
• Thatha iholide lemithi (uma livunywa udokotela wakho). Uma imiphumela emibi iyinkinga lapho uthatha izikhuthazi ze-ADHD, udokotela onqumayo angasikisela ukuthatha i- iholide lemithi lapho umuthi unqanyuliwe noma umthamo wehlisiwe izinsuku ezimbalwa, amasonto, noma izinyanga.

Ukuthatha iholide lemithi, noma kunjalo, akuwona wonke umuntu. Iziguli ezinezimpawu ezilinganiselwe nezimbi ze-ADHD zingadinga ukugcina uhlelo lokulinganisa olunamandla. Ukuthatha iholide lemithi yokuphazamiseka kokudla ngokweqile kuzokhulisa ingozi yokudla ngokweqile. Funa iseluleko sezokwelapha sokuqala; kungahle kube nezinye izindlela zokwelapha ezinemiphumela engemihle embalwa.

Izinsizakusebenza:

• Ukudla ngokweqile , StatPearls
• UVyvanse , Epocrates
• UVyvanse echaza imininingwane , I-FDA
• Ukubuyekezwa kwe-lisdexamfetamine dimesylate kubantu abadala abanokunakekelwa kokushoda kokungasebenzi kahle , Ijenali Yesifo Sesistimu Ephakathi
• UVyvanse wokuphazamiseka kokudla ngokweqile , Takeda
• I-Vyvanse ye-ADHD , Takeda
• I-Lisdexamfetamine ekwelapheni ukuphazamiseka kokudla ngokweqile kuya kokunzima kubantu abadala , Izifo Ne-Neuropsychiatric kanye Nokwelapha
• Ukusetshenziswa kwe-lisdexamfetamine ekwelapheni ukukhuluphala kwengane enesisindo sokukhuluphala ngokweqile nokudla ngokweqile , Izingane
• Kwehliswe ubungozi bokukhathazeka ngokwelashwa kwe-psychostimulant ezinganeni ezinenkinga yokushoda kokungasebenzi kahle , Ijenali yePsychopharmacology Yezingane Nentsha
• Ingabe zikhona izingozi zomonakalo wesikhathi eside ngenxa yokusebenzisa kabi iVyvanse? , Izikhungo Zokulutha ZaseMelika
• Ukudluliswa kwe-dexamphetamine obisini lwebele ngesikhathi sokwelashwa kokuphazamiseka kokungasebenzi kahle kwengqondo , IBritish Journal Yezemithi Yezokwelapha