I-Tamiflu vs. Xofluza: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe
Izidakamizwa Vs. UmnganiUkubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa
Uma kufika isikhathi senkathi yomkhuhlane, kungcono ukuthi uzilungiselele lapho wazi ukuthi yiziphi izinketho zakho zokwelashwa. Ngaphandle kokuthola i- umkhuhlane udutshulwa minyaka yonke , Kunconywa kakhulu, kunemithi etholakalayo uma kwenzeka wehla ne- umkhuhlane . Le mithi ingasiza ekwehliseni ubunzima nobude bezimpawu zomkhuhlane ezinjengekhanda, umkhuhlane, ukukhathala, nobuhlungu bemisipha noma obuhlangene.
Ukwelashwa kwemikhuhlane emibili evunyelwe yi-FDA yiTamiflu (oseltamivir) neXofluza (baloxavir marboxil). Yize yomibili le mithi ingalapha umkhuhlane, kodwa isebenza ngezindlela ezahlukene futhi iba nemiphumela engemihle eyehlukene. Funda ukuze uthole ukuthi le mithi iqhathanisa kanjani.
Uyini umehluko omkhulu phakathi kukaTamiflu noXofluza?
UTamiflu igama lomkhiqizo le-oseltamivir, elavunywa ngo-1999. Lisebenza njenge-neuraminidase inhibitor (NAI) eyeka ukukhishwa kwegciwane lomkhuhlane kumaseli athelelekile. Ngokwenza lokhu, kunciphisa ukusabalala kwegciwane emzimbeni wonke. I-Tamiflu ivame ukunikezwa kabili nsuku zonke izinsuku ezinhlanulapho welapha umkhuhlane. Ingasetshenziselwa ukuvimbela umkhuhlane (prophylaxis).
Xofluza igama lomkhiqizo we-baloxavir marboxil, elisanda kuvunywa ngo-2018. Lo muthi omusha usebenza njenge-i-polymerase acidic (PA)i-endonuclease inhibitor evimba igciwane lomkhuhlane ukuthi lingazenzeli amakhophi alo. Ngale ndlela, iXofluza isebenza ngokuhlukile uma iqhathaniswa neminye imishanguzo efana neTamiflu (oseltamivir) ne-Relenza (zanamivir). Isidakamizwa sidinga kuphela ukuthathwa kanye njengomthamo owodwa ukwelapha noma ukuvimbela umkhuhlane.
| Umehluko omkhulu phakathi kukaTamiflu vs. Xofluza | ||
|---|---|---|
| UTamiflu | Xofluza | |
| Isigaba sezidakamizwa | Amagciwane Isithinteli se-Neuraminidase | Amagciwane I-Polymerase acidic (PA) endonuclease inhibitor |
| Isimo somkhiqizo / ejwayelekile | Uhlobo olujwayelekile luyatholakala | Uhlobo olujwayelekile alutholakali okwamanje |
| Ngubani igama elijwayelekile? | Oseltamiviri-phosphate | I-Baloxavir marboxil |
| Izidakamizwa zingena ngaziphi izinhlobo? | Ithebhulethi yomlomo Powder ukumiswa ngomlomo | Ithebhulethi yomlomo |
| Uyini umthamo ojwayelekile? | Ukwelashwa komkhuhlane: Iminyaka engu-13 nangaphezulu: 75 mg kabili ngosuku izinsuku ezi-5 Uneminyaka engu-1 kuye kwengu-12 ubudala: Isilinganiso sincike esisindweni, kabili ngosuku izinsuku ezi-5 Amaviki ama-2 kuze kube ngaphansi konyaka owodwa ubudala: 3 mg / kg kabili ngosuku izinsuku ezi-5 Ukuvimbela umkhuhlane: Iminyaka engu-13 nangaphezulu: 75 mg kanye ngosuku okungenani izinsuku eziyi-10 Uneminyaka engu-1 kuye kwengu-12 ubudala: Isilinganiso sincike esisindweni, kanye nsuku zonke izinsuku eziyi-10 | Ukwelapha noma ukuvimbela umkhuhlane: Iminyaka eyi-12 nangaphezulu enesisindo somzimba esingu-90 kuye ku-180 lbs (40 kuya ku-80 kg): Amaphilisi amabili ama-20 mg athathwe ndawonye njengomthamo owodwa weminyaka engama-40 mg ayi-12 nangaphezulu enesisindo somzimba okungenani esingu-175 lbs (80 kg): Amaphilisi amabili ama-40 mg athathwe ndawonye njengomthamo owodwa we-80 mg |
| Yelashwa isikhathi esingakanani? | Ukwelashwa: Izinsuku ezi-5 Ukuvimbela: Izinsuku eziyi-10 * Ukwelashwa okuvimbela ukuqubuka komphakathi kungahlala kuze kube amasonto ayisithupha | Ukwelashwa noma ukuvimbela: Usuku olungu-1 ngomthamo owodwa |
| Ubani ovame ukusebenzisa umuthi? | Ukwelashwa: Amasonto amabili ubudala nangaphezulu Ukuvimbela: Unyaka ongu-1 nangaphezulu | Ukwelashwa noma ukuvimbela: Uneminyaka engu-12 ubudala nangaphezulu |
Izimo ezilashwa nguTamiflu noXofluza
Kokubili iTamiflu neXofluza kusetshenziswa njengezindlela zokwelapha umkhuhlane .Zisebenza kahle kakhulu uma zinikezwa ekuqaleni kwesibonakaliso sokuqala kwezimpawu nangaphambi kokuba izimpawu zibe nokuhlangabezana namahora angaphezu kwama-48. Kokubili iTamiflu neXofluza nakho kungavimbela umkhuhlane kulabo abebesondelene kakhulu nomuntu onegciwane. Le mithi ingaba wusizo ikakhulukazi kubantu abasengozini enkulu yokuba nezinkinga zomkhuhlane, njengalezo ezihlala endaweni enesifo segciwane noma labo abanamasosha omzimba abuthaka ngenxa yezimo zezempilo ezingaphansi.
Sebenzisa ithebula elilandelayo ukuqhathanisa ukusetshenziswa kwezokwelapha okugunyaziwe nokusetshenziswa okungekho kwelebula kukaTamiflu noXofluza.
| UTamiflu | Xofluza | |
| Ukwelashwa kwe-Influenza A / H1N1 | Yebo | Yebo |
| Ukwelashwa komkhuhlane i-A / H3N2 | Yebo | Yebo |
| Ukwelashwa komkhuhlane B | Yebo | Yebo |
| Umkhuhlane A / H1N1, umkhuhlane A / H3N2, kanye nomkhuhlane B wokuvikela | Yebo | Yebo |
Ngabe iTamiflu noma iXofluza isebenza ngempumelelo kakhulu?
Kokubili i-Tamiflu ne-Xofluza ziyasebenza ekunciphiseni izimpawu ngokushesha kunokuthi ubungathatha i-placebo noma ungasebenzisi lutho. Ngokuya kokuhlolwa komtholampilo, iTamiflu neXofluza zitholwe zinciphisa izimpawu ngokushesha uma kuqhathaniswa ne-placebo. Phakathi ku ukubuyekezwa kwemitholampilo ,uma kuqhathaniswa ne-placebo, iTamiflu itholwe ukunciphisa isikhathi sokwenza ngcono izimpawu ngosuku olulodwa kuya kwezimbili. Etsheni-capstone-1 icala yeXofluza, uma kuqhathaniswa ne-placebo, iXofluza yayinesikhathi esifushane sokukhululeka kwezimpawu (umehluko wamahora angama-26.5).
Lapho uTamiflu noXofluza beqhathaniswa kwenye icala ,
I-Xofluza ibonakale isebenza kangcono kuneTamiflu ngesikhathi esifushane sokuthuthukisa izimpawu: amahora angama-73 noXofluza uma kuqhathaniswa namahora angama-81 noTamiflu. I-Xofluza iphinde ifinyeze isikhathi sokuchithwa kwegciwane, noma ukuthathelana, kube ngamahora angama-48 uma kuqhathaniswa namahora angama-96 ne-placebo noma iTamiflu. Lesi silingo sabhalisa ababambiqhaza abangaphezu kuka-2 000 futhi sabandakanya iziguli ezineminyaka engu-12 nangaphezulu.
KU-INi-hile Xofluza ibonakala isebenza kangcono, ukumelana negciwane sekuyinto ekhathazayo. Ku- EJapan ,ezinye izinhlobo zomkhuhlane kubikwe ukuthi ziye zamelana neXofluza, okwenza ingasebenzi kahle kwezinye izimo.
Ukuqhathaniswa kanye nezindleko zokuqhathaniswa kweTamiflu vs. Xofluza
I-Tamiflu ingathengwa ngemithi kadokotela futhi imbozwa umshwalense, iMedicare neMedicaid. Itholakala kuzinhlobo zombili zomkhiqizo neze-generic. Ukunikezwa kwezinsuku eziyishumi zegama lomkhiqizo iTamiflu capsules kungabiza phakathi kuka- $ 155 kuya ku- $ 170 ngaphandle komshwalense. Ukunikezwa kwezinsuku eziyi-10 zama-capsule ejwayelekile e-oseltamivir kungabiza phakathi kuka- $ 20 no- $ 50. Ungasebenzisa isigqebhezana sesaphulelo se-SingleCare ukusigcina kuTamiflu ekhemisi eliseduze nawe.
I-Xofluza nayo ithengwa ngomuthi kadokotela futhi imbozwe umshwalense, iMedicare, neMedicaid ngokuya ngohlelo. Itholakala kuphela njengephilisi legama lomkhiqizo. Izindleko zokuphuma ephaketheni zeXofluza zingaba phakathi kuka- $ 150 kuya ku- $ 180. Hlola ukubona ukuthi ungasisebenzisa yini isigqebhezana sesaphulelo se-SingleCare ukusigcina kuXofluza ekhemisi eliseduze nawe.
| UTamiflu | Xofluza | |
| Ngokuvamile embozwe umshwalense? | Yebo, kuya ngohlelo | Yebo, kuya ngohlelo |
| Imbozwe ngokwejwayelekile yi-Medicare Part D? | Yebo, kuya ngohlelo | Yebo, kuya ngohlelo |
| Umthamo ojwayelekile | 75 mg kabili ngosuku izinsuku ezi-5 | Amaphilisi amabili ama-20 mg athathwe ndawonye njengomthamo owodwa wama-40 mg |
| I-Medicare copay ejwayelekile | $ 10- $ 200 | $ 30- $ 170 |
| Izindleko ze-SingleCare | $ 30 | $ 160 |
Imiphumela emibi ejwayelekile yeTamiflu vs. Xofluza
UTamiflu noXofluza babelana ngemiphumela efanayo efana nesicanucanu nekhanda. Ngokuya ngokuhlolwa komtholampilo, iTamiflu ingaba nokuvela okuphezulu kwale miphumela emibi. Eminye imiphumela emibi ejwayelekile yeTamiflu ifaka ukuhlanza nobuhlungu, ngokusho kwe- ilebula kusuka eU.S. Food and Drug Administration. Eminye imiphumela emibi ejwayelekile yeXofluza ifaka uhudo, ukuvuvukala kwemigwaqo yomoya yamaphaphu (bronchitis), nokuvuvukala kwezono (sinusitis).
I-Tamiflu ingadala imiphumela emibi kakhulu efana nokusabela kwesikhumba noma kwe-hypersensitivity. Lokhu kusabela kokungezwani komzimba kungaqala njengokuqubuka futhi kube kubi ngokuhamba kwesikhathi. Kubuye kwaba nemibiko ye- imicimbi yezengqondo njenge-delirium, i-hallucinations, nokuziphatha okungajwayelekile kulabo abathatha i-Tamiflu.Le micimbi yezengqondo ibike kakhulu ezinganeni zaseJapan.
I-Xofluza nayo ingadala ukusabela kwesikhumba noma kwe-hypersensitivity. Lokhu kusabela kungabonakala njengokubomvu noma ukulunywa. Kukhona nengozi yokutheleleka ngamagciwane uma uthatha iXofluza.
| UTamiflu | Xofluza | |||
| Umphumela oseceleni | Kusebenza? | Imvamisa | Kusebenza? | Imvamisa |
| Isicanucanu | Yebo | 8-10% | Yebo | amaphesenti amabili |
| Ukuhlanza | Yebo | 2-8% | Akunjalo | - |
| Ubuhlungu bekhanda | Yebo | 2-17% | Yebo | 1% |
| Uhudo | Akunjalo | - | Yebo | 3% |
| I-bronchitis | Akunjalo | - | Yebo | 3% |
| Isinusitis | Akunjalo | - | Yebo | amaphesenti amabili |
Umthombo: I-DailyMed (Tamiflu) , I-DailyMed (Xofluza) .
Ukusebenzisana kwezidakamizwa zikaTamiflu noXofluza
Bobabili uTamiflu noXofluza bangaxhumana ne- umuthi womkhuhlane —Kakhulukazi, umuthi wokugomela umkhuhlane opholile. Ngenxa yokuthi le mishanguzo iyizidambisigciwane, ingathinta ukuthi umuthi wokugomela umkhuhlane usebenza kahle kangakanani futhi wehlise ukusebenza kwawo. Ngakho-ke, umuthi wokugomela umkhuhlane obukhoma akufanele unikezwe kungakapheli izinsuku eziyi-14 ngaphambi noma ezinsukwini ezimbili ngemuva kokuphathwa kweTamiflu noma i-Xofluza.
I-Xofluza ingaxhumana nemithi equkethe ama-cation polyvalent. Le mithi ingafaka ama-laxatives, ama-antacids, noma izithasiselo eziqukethe i-calcium, i-iron, i-magnesium, i-zinc, noma i-selenium. Uma isetshenziswa neXofluza, le mithi inganciphisa izinga leXofluza emzimbeni futhi yehlise ukusebenza kwayo.
| UTamiflu | Xofluza | |
| Umuthi wokugomela umkhuhlane bukhoma | Yebo | Yebo |
| Imithi equkethe i-cation Polyvalent (imikhiqizo equkethe i-calcium, i-iron, i-magnesium, i-selenium, i-zinc, njll.) | Akunjalo | Yebo |
Izexwayiso zikaTamiflu neXofluza
ITamiflu kufanele ibhekwe kulabo abanezinkinga zezinso. Lokhu kungenxa yokuthi ukukhubazeka kwezinso kungaholela emazingeni aphezulu eTamiflu emzimbeni, okuholele ezenzakalweni ezingezinhle.
Ukumuncwa kukaXofluza akwaziwa ukuthi kuthinteka ukusebenza kwezinso. Ngaphezu kwalokho, ukuphepha nokusebenza kwayo akukaze kufundwe kulabo abanesisindo esingaphansi kwamakhilogremu angama-40.
I-Tamiflu ne-Xofluza azinconyelwa noma ngubani onenkinga yokungezwani komzimba nezinto zakhe ezisebenzayo. UTamiflu noXofluza abakaze bafundwe kakhulu ekukhulelweni. Ukusetshenziswa kwabo ekukhulelweni kufanele kuhlolwe ngumhlinzeki wezokunakekelwa kwempilo njengoba izinzuzo zingadlula izingozi ezingaba khona.
Imibuzo ebuzwa njalo ngeTamiflu vs. Xofluza
Yini uTamiflu?
I-Tamiflu (oseltamivir) umuthi olwa namagciwane osetshenziselwa ukwelapha noma ukuvimbela umkhuhlane. Isebenza njenge-neuraminidase inhibitor evimba ukusabalala komkhuhlane A no-B emzimbeni. Ukusebenzisa i-Tamiflu kunganciphisa isikhathi esithathayo ukuze izimpawu zomkhuhlane zithuthuke. Imvamisa iphuzwa kabili ngosuku izinsuku ezinhlanu.
Kuyini iXofluza?
I-Xofluza (baloxavir marboxil) umuthi olwa namagciwane ongaphatha noma uvimbele umkhuhlane. Yi-PA endonuclease inhibitor evimba igciwane lomkhuhlane ukuthi lingazilingisi emzimbeni. NjengoTamiflu, inganciphisa isikhathi sokwenza ngcono izimpawu. IXofluza yasungulwa nguSionogi Pharma futhi yabekwa njengomthamo owodwaekwelashweni noma ekuvinjelweni umkhuhlane.
Ngabe uTamiflu noXofluza bayefana?
I-Tamiflu ne-Xofluza yimithi elwa namagciwane. Kepha awafani. Yize bobabili bethuthukisa izimpawu zomkhuhlane, basebenza ngokuhlukile futhi banemiphumela engemihle ehlukile.
Ngabe iTamiflu noma iXofluza ingcono?
I-Tamiflu ne-Xofluza zombili ziyasebenza ukulwa negciwane lomkhuhlane. IXofluza yisidakamizwa esisha esikhonjiswe ukuthuthukisa izimpawu zomkhuhlane ngokushesha kuneTamiflu. Iphinde idinga ukuthathwa njengomthamo owodwa, abanye abantu abangase bakhethe. Kubalulekile ukuxoxa ngalezi zinketho nodokotela ukuze unqume ukwelashwa okungcono kakhulu kuwe.
Ngingasebenzisa iTamiflu noma iXofluza ngenkathi ngikhulelwe?
Ayikho imininingwane eyanele yomtholampilo ekhombisa ukuthi iTamiflu neXofluza ziphephile kwabesifazane abakhulelwe. Yize ubufakazi bokusetshenziswa okuphephile ngesikhathi sokukhulelwa bungekho, izinzuzo zabo zingadlula izingozi zokutheleleka komkhuhlane. Xhumana nodokotela lapho unquma ukuthi iyiphi imithi oyisebenzisayo uma ukhulelwe.
Ngingasebenzisa i-Tamiflu noma i-Xofluza ngotshwala?
Akukho lwazi kumalebula ezidakamizwa echaza imiphumela yeTamiflu noma iXofluza ngotshwala. Kodwa-ke ukuphuza utshwala kungenza amasosha omzimba abe buthakathaka futhi kwenze kube nzima ukulwa nomkhuhlane. Ngakho-ke, akukhuthazwa ngokuvamile ukuphuza utshwala ngenkathi ugula.
Ungathatha iXofluza noTamiflu?
Cha. Akunconywa ukuthatha iXofluza neTamiflu ndawonye. Le mithi inqunywa njengezindlela ezihlukile, ezizodwa zomkhuhlane. Ngokuya ngomlando wakho wezokwelapha nesimo sonke, umuthi owodwa ungabekwa ngaphezulu komunye.
