I-Lomotil vs. Imodium: Umehluko, ukufana, nokuthi yikuphi okungcono kuwe

Imfundo Yezempilo

Ukubuka konke kwezidakamizwa nokwehluka okuyinhloko | Izimo zilashwa | Ukusebenza | Ukutholakala komshuwalense nokuqhathaniswa kwezindleko | Okuqhamuka uma udla imishanguzo | Ukusebenzisana kwezidakamizwa | Izexwayiso | Imibuzo evame ukubuzwa

I-Lomotil (diphenoxylate / atropine) ne-Imodium (loperamide) yimithi emibili elwa nohudo esetshenziselwa ukwelapha i-acute kanye uhudo olungamahlalakhona . Le mithi isebenza ngezindlela ezifanayo ukunciphisa inani nobuningi bokuhamba kwamathumbu. ILomotil ne-Imodium zenzelwe ukuphuzelwa isifo sohudo esifushane, esivame ukuxazululwa ezinsukwini ezimbalwa ngemuva kokuthatha umuthi.

Ezimweni eziningi, isifo sohudo, yize singokuhlangenwe nakho okungathandeki, kaningi sithamba futhi siyazimela. Ukwelashwa okuyinhloko kwesifo sohudo kufaka esikhundleni samanzi kanye nama-electrolyte ukuze kuvinjelwe ukoma. Kodwa-ke, imishanguzo efana neLomotil ne-Imodium ingaba wusizo kuhudo olunzima kanye nohudo olungamahlalakhona oluhambisana ne-irritable bowel syndrome (IBS).

Yize kufana ekusetshenzisweni, iLomotil ne-Imodium kunokunye umehluko okufanele bakukhumbule. Isibonelo, le mithi iqukethe izithako ezahlukahlukene futhi inemikhawulo ethile. Sizohlola umehluko wabo nokufana lapha.

Uyini umehluko omkhulu phakathi kweLomotil ne-Imodium?

Lomotil

I-Lomotil isidakamizwa esinegama lomkhiqizo esingatholwa kuphela ngemithi kadokotela. Iqukethe inhlanganisela ye-diphenoxylate (i-opioid) ne-atropine (umuthi we-anticholinergic).

IDiphenoxylate iyisithako esiyinhloko esibophezela kuma-opioid receptors emathunjini ukubambezela ukuhamba kwamathumbu. I-Atropine ingezwa ukudikibalisa ukusetshenziswa kabi kwezidakamizwa ngoba i-diphenoxylate yinto elawulwayo yodwa.

Imodium

I-Imodium, ebhalwe futhi njenge-Imodium AD, yigama lomkhiqizo le-loperamide. Ngokungafani neLomotil, i-Imodium ingathengwa ngaphezulu kwe-counter (OTC). Ngakho-ke, itholakala kabanzi.

I-Loperamide iyi-opioid yokwenziwa ebopha ama-opioid receptors odongeni lwamathumbu ukubambezela ukunyakaza kwamathumbu. Iphinde ivimbe ikhemikhali ebizwa nge-acetylcholine futhi iholele ekwehliseni ukulahleka koketshezi kanye ne-electrolyte. Ngoba i-Imodium inokumunca okuncane ohlelweni lwezinzwa oluphakathi (CNS), ikhiqiza imiphumela emibi ye-CNS ejwayelekile kwamanye ama-opioid, kufaka phakathi i-diphenoxylate.

Umehluko omkhulu phakathi kweLomotil ne-Imodium
	Lomotil	Imodium
Isigaba sezidakamizwa	Ukwehliswa isifo sohudo	Ukwehliswa isifo sohudo
Isimo somkhiqizo / ejwayelekile	Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala	Uhlobo lomkhiqizo nohlobo olujwayelekile luyatholakala
Ngubani igama elijwayelekile?	IDiphenoxylate / Atropine	I-Loperamide
Izidakamizwa zingena ngaziphi izinhlobo?	Ithebhulethi yomlomo Isixazululo se-Liquid	Ithebhulethi yomlomo Ama-capsules omlomo Ukumiswa kuketshezi
Uyini umthamo ojwayelekile?	Uhudo olunamandla: Amaphilisi ama-2 (2.5 mg diphenoxylate / 0.025 mg atropine) amahlandla amane nsuku zonke kuze kube kutholakala ukulawulwa kokuqala kohudo. Uhudo olungamahlalakhona: Nciphisa umthamo wokuqala kumthamo wesondlo (imvamisa amaphilisi ama-2 nsuku zonke) njengokuyalelwa ngudokotela. Yeka uma izimpawu zingathuthuki zingakapheli izinsuku eziyi-10.	Uhudo olunamandla: 4 mg ekuqaleni, bese kuba ngu-2 mg ngemuva kwesitulo ngasinye esivulekile. Umthamo omkhulu wansuku zonke: 16 mg Uhudo olungamahlalakhona: Sebenzisa umthamo wesondlo ka-4 kuye ku-8 mg ngosuku. Yeka uma izimpawu zingathuthuki zingakapheli izinsuku eziyi-10.
Yelashwa isikhathi esingakanani?	Uhudo lwesikhashana olufinyelela ezinsukwini eziyi-10. Ukusetshenziswa kwesikhathi eside kungadingeka kuhudo olungapheli.	Uhudo lwesikhashana olufinyelela ezinsukwini eziyi-10. Ukusetshenziswa kwesikhathi eside kungadingeka kuhudo olungapheli.
Ubani ovame ukusebenzisa umuthi?	Abantu abadala nezingane ezineminyaka engu-13 nangaphezulu.	Abantu abadala nezingane ezineminyaka engu-2 nangaphezulu. Izingane ezingaphansi kweminyaka engu-6 kufanele zibonane nodokotela ngaphambi kokuthatha i-Imodium liquid.

Ufuna intengo engcono kuLomotil?

Bhalisela izexwayiso zentengo yeLomotil bese uthola ukuthi intengo ishintsha nini!

Thola izexwayiso zentengo

Izimo eziphathwa yiLomotil ne-Imodium

I-Lomotil ivunyiwe yi-FDA njengokwelashwa okuhambisanayo kwesifo sohudo. Lokhu kusho ukuthi iLomotil inconyelwa njengokwelashwa okwengeziwe kanye nezindlela zokwelashwa eziyinhloko njengokuvimbela ukoma.

NjengoLomotil, i-Imodium ivunyiwe yi-FDA ukwelapha izinhlobo eziningana zohudo. Imodium ingasetshenziswa ukwelapha Uhudo lomhambi kanye nohudo olubangelwa yimithi efana nokwelashwa ngamakhemikhali. I-Lomotil ne-Imodium nazo zingaphatha isifo sohudo esingapheli esidalwa yisifo samathumbu (IBS).

Isifo sohudo sichazwa njengokuhlala phansi kathathu noma ngaphezulu ngosuku olulodwa. Uhudo olubi kakhulu luhlala lumnene futhi imvamisa aluthathi ngaphezu kosuku olulodwa noma ezimbili. Ubuthi bokudla bungezinye zezimbangela ezivame kakhulu zohudo olubi.

Uhudo olungamahlalakhona inzima kakhulu futhi ingahlala isikhathi esingaphezu kwamasonto amane ngesikhathi. Izimpawu zohudo zingasuka zodwa noma zihlale isikhathi eside, ezingadinga ukwelashwa ngemithi.

Isimo	Lomotil	Imodium
Uhudo olunamandla	Yebo	Yebo
Uhudo lomhambi	Yebo	Yebo
Uhudo olungamahlalakhona	Yebo	Yebo
Uhudo oluhlobene neChemotherapy	Yebo	Yebo

Ingabe iLomotil noma i-Imodium isebenza kangcono?

I-Lomotil ne-Imodium yizona zinto ezisetshenziswa kakhulu ukulwa nesifo sohudo. Zombili ziyasebenza futhi zisebenza ngokushesha okukhulu ukukhulula izimpawu zohudo. Isidakamizwa esingcono kakhulu kuwe sizoya ngesimo sakho sonke, okufanele sihlolwe ngumhlinzeki wakho wezokunakekelwa kwempilo.

Lokho kuthiwa, i-Imodium ingaba yimithi esebenza kahle kakhulu. Yize zingekho izivivinyo zokwelashwa eziqhathanisa ngqo i-Lomotil ne-Imodium, ezinye izifundo ziphakamisa ukuthi i-Imodium iyindlela ekhethwayo yokwelapha isifo sohudo. Impumputhe eyodwa, isifundo se-crossover ithole ukuthi i-loperamide ibingcono kune-diphenoxylate yokwelapha isifo sohudo ngisho nangomthamo ophansi ka-2.5.
Enye isifundo se-crossover kuqhathaniswa i-loperamide, i-diphenoxylate, ne-codeine yokwelapha isifo sohudo esingamahlalakhona. Ngaphambi kokwelashwa, ababambiqhaza abangama-95% babona ukuphuthuma njengezimpawu zabo eziphambili zohudo. Ucwaningo luthole ukuthi i-loperamide ne-codeine basebenza kangcono kune-diphenoxylate yokuthola usizo. IDiphenoxylate itholakale inemiphumela emibi kakhulu ngenkathi i-loperamide ikhonjiswa ukuthi inokuncane.

Ukuhlanganiswa nokuqhathaniswa kwezindleko kweLomotil vs. Imodium

Iningi le-Medicare Part D nezinhlelo zomshuwalense azibandakanyi igama lomkhiqizo elithi Lomotil. Kodwa-ke, izinhlelo eziningi zomshuwalense zimboza uhlobo olujwayelekile lomuthi. Amasu we-Medicare Part D kufanele ahlanganise i-diphenoxylate / atropine ngokuya ngesembozo sakho. Izindleko ezijwayelekile zokuthengisa zeLomotil ejwayelekile cishe zingama- $ 38. Buza ekhemisi lakho ukubona ukuthi ungalisebenzisa yini ikhadi lokonga lesaphulelo. Amakhuphoni e-SingleCare Lomotil angehlisa izindleko ukuze ukhokhe cishe u- $ 12.

I-Imodium yisidakamizwa se-OTC esingahle singambozwa yi-Medicare nezinhlelo zomshuwalense. Amanye amapulani angahlanganisa ifomu elejwayelekile ngomuthi kadokotela. Kungcono ukuhlola ifomula yohlelo lwakho lomshuwalense ukuze uqiniseke. Izindleko ezijwayelekile ze-loperamide cishe zingama- $ 26. Ngesaphulelo se-SingleCare, ungathola amaphilisi ejwayelekile we-loperamide cishe ngama- $ 14. Ukuze usebenzise ngokunenzuzo ukonga kwe-OTC, kusazodingeka uthole i- incwadi kadokotela .

	Lomotil	Imodium
Ngokuvamile embozwe umshwalense?	Akunjalo	Akunjalo
Imbozwe ngokujwayelekile yi-Medicare?	Akunjalo	Akunjalo
Umthamo ojwayelekile	2.5 mg diphenoxylate / 0.025 mg atropine, inani lamaphilisi angama-30	2 mg, inani lamaphilisi angama-30
I-Medicare copay ejwayelekile	$ 0– $ 150	$ 0– $ 99
Izindleko ze-SingleCare	$ 12	$ 14

Imiphumela emibi ejwayelekile yeLomotil vs. Imodium

Imiphumela emibi yeLomotil ifaka ukozela, isiyezi, nesicanucanu. Uma kuqhathaniswa ne-Imodium, iLomotil ingaba nemiphumela emibi kakhulu ye-CNS kufaka phakathi ikhanda, ukungahlaliseki nokudideka.

Umphumela ovame kakhulu ohambisana ne-Imodium yi ukuqunjelwa . Eminye imiphumela emibi ejwayelekile ifaka phakathi isiyezi, isicanucanu, isisu noma amajaqamba esiswini.

Emithamo ephakeme, imiphumela emibi yeLomotil ne-Imodium ingafaka ukozela okukhulu, ukubona izinto ezingekho kahle, kanye nobuthakathaka. Imiphumela emibi efana nokuphuza ukuphefumula (ukucindezeleka kokuphefumula) nayo ingenzeka ngamanani anobuthi.

	Lomotil	Imodium
Imiphumela emibi	Kusebenza?	Imvamisa	Kusebenza?	Imvamisa
Ukuqunjelwa	Akunjalo	-	Yebo	5.3%
Isiyezi	Yebo	* akubikiwe	Yebo	1.4%
Isicanucanu	Yebo	*	Yebo	1.8%
Amajaqamba esisu	Yebo	*	Yebo	1.4%
Ukuhlanza	Yebo	*	Yebo	*
Umlomo owomile	Yebo	*	Yebo	*
Ukozela	Yebo	*	Yebo	*
Ubuhlungu bekhanda	Yebo	*	Akunjalo	-
Ukungahlaliseki	Yebo	*	Akunjalo	-
Ukudideka	Yebo	*	Akunjalo	-

Lokhu kungenzeka kungabi uhlu oluphelele lwemiphumela emibi engenzeka. Sicela ubheke udokotela wakho noma umhlinzeki wezokunakekelwa kwempilo ukuze ufunde kabanzi.
Umthombo: DailyMed ( Lomotil ), IDailyMed ( Imodium )

Ukusebenzisana kwezidakamizwa kweLomotil vs. Imodium

I-Lomotil ingasebenzisana nezidakamizwa ezifana ne-monoamine oxidase inhibitors (MAOIs) kanye ne-CNS depressants. Ukuthatha i-MAOI, njenge-selegiline noma i-phenelzine, ne-Lomotil kungakhuphula ubungozi benkinga yomfutho wegazi ophakeme, noma umfutho wegazi oyingozi. Ingozi yemiphumela emibi nayo ingakhuphuka ngenkathi ithatha izidakamizwa ezicindezelayo ze-CNS ezinjenge-barbiturates, benzodiazepines, kanye ukuphumula kwemisipha .

Ngokungafani neLomotil, i-Imodium icutshungulwa kakhulu esibindini ngama-enzyme afana ne-CYP3A4 enzyme kanye ne-CYP2C8 enzyme. Izidakamizwa ezivimbela, noma ezivimba, la ma-enzyme angakhuphula amazinga e-Imodium egazini. Ngenxa yalokho, ukuthatha le mithi ndawonye kungakhuphula ubungozi bemiphumela emibi.

Izidakamizwa	Isigaba Sezidakamizwa	Lomotil	Imodium
USelegiline I-Phenelzine Isocarboxazid I-Tranylcypromine	I-Monoamine oxidase inhibitors (MAOIs)	Yebo	Akunjalo
I-Phenobarbital IPentobarbital I-Alprazolam I-Lorazepam I-Trazodone I-Oxycodone	Ukudangala kwe-CNS	Yebo	Yebo
I-Saquinavir I-Itraconazole	I-CYP3A4 inhibitors	Akunjalo	Yebo
Gemfibrozil	Ama-CYP2C8 inhibitors	Akunjalo	Yebo
I-Quinidine I-Ritonavir	Ama-P-glycoprotein inhibitors	Akunjalo	Yebo

Lolu akulona uhlu oluphelele lokusebenzisana kwezidakamizwa. Sicela uxhumane nodokotela wakho ngaphambi kokuthatha le mithi.

Izexwayiso zeLomotil ne-Imodium

I-Lomotil akufanele isetshenziswe ezinganeni ezingaphansi kweminyaka engu-6 ngenxa yengozi eyengeziwe yokuphefumula kanye nokudangala kwe-CNS. Labo abane-jaundice evimbelayo noma i-hypersensitivity eyaziwayo kwi-diphenoxylate noma i-atropine kufanele futhi bagweme ukusebenzisa iLomotil.

I-Imodium kubikwe ukuthi iyimbangela ITorsades de Pointes , ukuboshwa kwenhliziyo, nokufa lapho kuthathwe ngaphezulu kunamanani anconyiwe. Kunconywa ukuthatha kuphela isilinganiso esincane esidingekayo njengoba kuyalelwe ngumhlinzeki wakho wezokunakekelwa kwempilo. I-Imodium akufanele isetshenziswe ezinganeni nasezinsaneni ezingaphansi kweminyaka emibili ngenxa yengcuphe yokuphefumula kanye nokudangala kwe-CNS.

I-Lomotil ne-Imodium akufanele zisetshenziselwe ukwelapha isifo sohudo esibangelwe yizifo ezibangelwa amagciwane. Le mithi akufanele isetshenziselwe ukwelapha isifo sohudo esidalwa yizinto ezifana ne IClostridium difficile futhi Salmonella .

Xhumana nodokotela wakho uma unezimo ezithile zezokwelapha ngaphambi kokuthatha le mithi. Kunconywa ukuthatha le mithi ngezeluleko zezokwelapha ezivela kumhlinzeki wakho wezokunakekelwa kwempilo.

Imibuzo ebuzwa njalo mayelana neLomotil vs. Imodium

Yini iLomotil?

I-Lomotil ngumuthi kadokotela osetshenziswa njengokwelashwa okuhambisanayo kohudo. ILomotil itholakala ngegama lomkhiqizo nangohlobo olujwayelekile. Ingathathwa ngesifo sohudo esibuhlungu noma esingapheli kubantu abadala nasezinganeni ezineminyaka engu-13 ubudala nangaphezulu.

Yini i-Imodium?

I-Imodium yisidakamizwa esingaphezu kwe-the-counter (OTC) esivunyelwe yi-FDA ukwelapha isifo sohudo. I-Imodium ijwayele ukusetshenziselwa ukwelapha isifo sohudo se-Traveler yize ingaphinde ilaphe isifo sohudo esingapheli esidalwa yi-IBS. I-Imodium ingaphatha abantu abadala nezingane ezineminyaka emibili noma ngaphezulu ubudala.

Ngabe iLomotil ne-Imodium ziyafana?

Cha. I-Lomotil ne-Imodium azifani. Yize zisebenza ngezindlela ezifanayo, iLomotil ingatholakala kuphela ngemithi kadokotela. Imodium ingathengwa phezu kwekhawunta.

Ngabe i-Lomotil noma i-Imodium ingcono?

ILomotil ne-Imodium yizo zombili izidakamizwa eziphumelelayo zokwelapha isifo sohudo. Abanye ucwaningo kukhombisile ukuthi awukho umehluko ophawulekayo ekusebenzeni phakathi kwalaba ababili. Noma kunjalo, okunye izifundo kubonise ukuthi i-Imodium iyasebenza futhi ibekezeleleka kangcono. Xhumana nodokotela wakho ngenketho yokwelashwa engcono kakhulu ekufanele.

Ngingayisebenzisa yini iLomotil noma i-Imodium ngenkathi ngikhulelwe?

Abanye odokotela bangavumela ukusetshenziswa kweLomotil noma i-Imodium ngesikhathi sokukhulelwa kuphela uma kunesidingo. Ngaphandle kwalokho, iLomotil ne-Imodium ngokuvamile azinconywa ngesikhathi sokukhulelwa ngenxa yokulimala kombungu. Khuluma nodokotela wakho ngezinketho zokulwa nesifo sohudo ngenkathi ukhulelwe.

Ngingasebenzisa i-Lomotil noma i-Imodium ngotshwala?

Akunconyelwa ukuphuza utshwala ngenkathi usebenzisa i-Lomotil noma i-Imodium. I-Lomotil ne-Imodium zingadala imiphumela emibi njengokulala kanye nesiyezi. Ukuphuza utshwala kungakhuphula le miphumela engemihle.

Kungani iLomotil ivinjelwe?

ILomotil ayisona isidakamizwa esivinjelwe. Kodwa-ke, iyiSheduli V into elawulwayo njengoba ihlukaniswe yi-DEA. Lokhu kusho ukuthi kunethuba lokusebenzisa kabi nokuhlukumeza lapho usebenzisa lesi sidakamizwa. Ngokwalo, i-diphenoxylate, isithako esiyinhloko seLomotil, iyisidakamizwa seSheduli II esinamandla amakhulu okuhlukumeza.

Ungathatha uLomotil isikhathi eside?

I-Lomotil ayinconyelwe ukuthi isetshenziselwe izinsuku ezingaphezu kwezingu-10 ngesifo sohudo esibi. Kwezinye izimo, iLomotil ingasetshenziselwa ukusetshenziswa kwesikhathi eside, ikakhulukazi kuhudo olungapheli. Ukusetshenziswa kwesikhathi eside kweLomotil kufanele kuhlolwe udokotela.

Kwenzekani uma i-Imodium ingayeki uhudo?

I-Imodium kufanele iqede izimpawu zohudo oluncane kungakapheli amahora angama-48. Uma uhlangabezana nanoma ikuphi kokulandelayo, kufanele ushayele udokotela wakho ngokushesha:

• Igazi esitokisini
• Imfiva noma ukushisa okungaphezu kuka-101.3 ° F
• Ubuhlungu obukhulu besisu
• Ukudlula indle eyisithupha noma ngaphezulu ngosuku
• Isifo sohudo esihlala isikhathi eside kunamahora angama-48
• Izimpawu ezinjengekhanda elikhanyayo, ukudideka, ubuhlungu besifuba, noma i-malaise